2wor - Revision history

OCA at 10:12, 20 December 2023

OCA — Wed, 20 Dec 2023 10:12:37 GMT

←Older revision		Revision as of 10:12, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2wor' size='340' side='right'caption='[[2wor]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2wor' size='340' side='right'caption='[[2wor]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wor]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wor]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [https://pdbe.org/2wor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [https://www.ebi.ac.uk/pdbsum/2wor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wor ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [https://pdbe.org/2wor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [https://www.ebi.ac.uk/pdbsum/2wor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wor ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/S10A7_HUMAN S10A7_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boulanger~~, M J~~]]	+	[[Category: Boulanger MJ]]
-	[[Category: Hof, F]]	+	[[Category: Hof F]]
-	[[Category: Leon, R]]	+	[[Category: Leon R]]
-	~~[[Category: Calcium-binding protein~~]]	+

OCA at 11:12, 6 April 2022

OCA — Wed, 06 Apr 2022 11:12:38 GMT

←Older revision		Revision as of 11:12, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2wor' size='340' side='right'caption='[[2wor]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2wor' size='340' side='right'caption='[[2wor]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wor]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WOR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wor]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [~~http~~://pdbe.org/2wor PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wor PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wor ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [https://pdbe.org/2wor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [https://www.ebi.ac.uk/pdbsum/2wor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wor ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:00, 1 July 2020

OCA — Wed, 01 Jul 2020 09:00:35 GMT

←Older revision		Revision as of 09:00, 1 July 2020
Line 1:		Line 1:

	==co-structure of S100A7 with 1,8 ANS==		==co-structure of S100A7 with 1,8 ANS==
-	<StructureSection load='2wor' size='340' side='right' caption='[[2wor]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2wor' size='340' side='right'caption='[[2wor]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WOR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WOR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [http://pdbe.org/2wor PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [http://www.ebi.ac.uk/pdbsum/2wor PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wor ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [http://pdbe.org/2wor PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [http://www.ebi.ac.uk/pdbsum/2wor PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wor ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[S100 ~~protein~~\|S100 ~~protein~~]]	+	*[[S100 proteins 3D structures\|S100 proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]
	[[Category: Hof, F]]		[[Category: Hof, F]]
	[[Category: Leon, R]]		[[Category: Leon, R]]
	[[Category: Calcium-binding protein]]		[[Category: Calcium-binding protein]]

OCA at 09:17, 26 September 2018

OCA — Wed, 26 Sep 2018 09:17:14 GMT

←Older revision		Revision as of 09:17, 26 September 2018
Line 1:		Line 1:
-	==CO-~~STRUCTURE OF~~ S100A7 ~~WITH~~ 1,8 ANS==	+
		+	==co-structure of S100A7 with 1,8 ANS==
	<StructureSection load='2wor' size='340' side='right' caption='[[2wor]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2wor' size='340' side='right' caption='[[2wor]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [http://pdbe.org/2wor PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [http://www.ebi.ac.uk/pdbsum/2wor PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [http://pdbe.org/2wor PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [http://www.ebi.ac.uk/pdbsum/2wor PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wor ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wor_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wor_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:02, 8 February 2016

OCA — Mon, 08 Feb 2016 06:02:41 GMT

←Older revision		Revision as of 06:02, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2wor' size='340' side='right' caption='[[2wor]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2wor' size='340' side='right' caption='[[2wor]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [http://www.ebi.ac.uk/pdbsum/2wor PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [http://pdbe.org/2wor PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [http://www.ebi.ac.uk/pdbsum/2wor PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wor ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wor" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]
	[[Category: Hof, F]]		[[Category: Hof, F]]
	[[Category: Leon, R]]		[[Category: Leon, R]]
	[[Category: Calcium-binding protein]]		[[Category: Calcium-binding protein]]

OCA at 10:23, 20 January 2015

OCA — Tue, 20 Jan 2015 10:23:49 GMT

←Older revision		Revision as of 10:23, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [http://www.ebi.ac.uk/pdbsum/2wor PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [http://www.ebi.ac.uk/pdbsum/2wor PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Boulanger, M J.]]	+	[[Category: Boulanger, M J]]
-	[[Category: Hof, F.]]	+	[[Category: Hof, F]]
-	[[Category: Leon, R.]]	+	[[Category: Leon, R]]
	[[Category: Calcium-binding protein]]		[[Category: Calcium-binding protein]]

OCA at 01:26, 1 October 2014

OCA — Wed, 01 Oct 2014 01:26:58 GMT

←Older revision		Revision as of 01:26, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2wor.~~png~~\|~~left~~\|200px]]	+	==CO-STRUCTURE OF S100A7 WITH 1,8 ANS==
		+	<StructureSection load='2wor' size='340' side='right' caption='[[2wor]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AN:8-ANILINO-1-NAPHTHALENE+SULFONATE'>2AN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wnd\|2wnd]], [[1psr\|1psr]], [[3psr\|3psr]], [[2psr\|2psr]], [[2wos\|2wos]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wor OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wor RCSB], [http://www.ebi.ac.uk/pdbsum/2wor PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wor_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	S100A7 (psoriasin) is a member of the S100 family of signaling proteins. It is implicated in and considered a therapeutic target for inflammation and cancer, yet no small molecule ligands for S100A7 have been identified. To begin the development of specific small molecule inhibitors of S100A7 function, we have used a series of surface binding fluorescent dyes to probe the surface hydrophobic sites. Two naphthalene-based dyes (2,6-ANS and 1,8-ANS) were found to bind S100A7 in a distinct cleft. We characterized the binding interaction by determining both the structure of S100A7 bound to 2,6-ANS and the structure of S100A7 bound to 1,8-ANS to 1.6 A. In both cases, two molecules of dye were docked such that the naphthalene groups were positioned in two symmetry-related grooves that are formed by the N-terminal helices of each monomer. We observed that Met12 acts as a gatekeeper to the binding cleft, adopting an "open" conformation for the more elongated 2,6-ANS while remaining in a "closed" conformation for the more compact 1,8-ANS. Steady-state fluorescence experiments revealed that S100A7 binds two copies of 2,6-ANS, each with a K(d) of 125 muM. Time-resolved fluorescence lifetime measurements indicated that the two molecules of 2,6-ANS bind in two independent binding sites with different fluorescence lifetimes, suggesting that the S100A7 homodimer is not perfectly symmetric in solution. Isothermal titration calorimetry studies demonstrate that S100A7 has a higher affinity for 2,6-ANS than 1,8-ANS. Yeast two-hybrid studies were also used to probe contributions of individual residues of an S100A7 triple mutant with respect to Jab1 binding. Mutation of Leu78, which forms part of the Met12 cleft occupied by 2,6-ANS, reduced the level of Jab1 binding, suggesting a potentially important role for the Met12 hydrophobic pocket in defining a Jab1 interface. Additional Y2H studies also delineate contributions of Gln88 and in particular Asp56 that shows the most significant abrogated binding to Jab1. Collectively, these data suggest a complex interaction between S100A7 and the much larger Jab1. These studies form the basis for the development of small molecule reporters and modifiers of S100A7 form and function.

-	~~{{STRUCTURE_2wor\| PDB=2wor \| SCENE= }}~~	+	Identification and Characterization of Binding Sites on S100A7, a Participant in Cancer and Inflammation Pathways.,Leon R, Murray JI, Cragg G, Farnell B, West NR, Pace TC, Watson PH, Bohne C, Boulanger MJ, Hof F Biochemistry. 2009 Oct 16. PMID:19810752<ref>PMID:19810752</ref>

-	~~===CO-STRUCTURE OF S100A7 WITH 1~~,~~8 ANS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_19810752}}~~	+	==See Also==
-		+	*[[S100 protein\|S100 protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2wor~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:019810752<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Boulanger, M J.]]		[[Category: Boulanger, M J.]]

OCA at 22:08, 7 January 2013

OCA — Mon, 07 Jan 2013 22:08:23 GMT

←Older revision		Revision as of 22:08, 7 January 2013
Line 1:		Line 1:
	[[Image:2wor.png\|left\|200px]]		[[Image:2wor.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wor", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wor\| PDB=2wor \| SCENE= }}		{{STRUCTURE_2wor\| PDB=2wor \| SCENE= }}

	===CO-STRUCTURE OF S100A7 WITH 1,8 ANS===		===CO-STRUCTURE OF S100A7 WITH 1,8 ANS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19810752}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19810752 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19810752}}		{{ABSTRACT_PUBMED_19810752}}

Line 22:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19810752~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019810752</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Boulanger, M J.]]		[[Category: Boulanger, M J.]]
	[[Category: Hof, F.]]		[[Category: Hof, F.]]
	[[Category: Leon, R.]]		[[Category: Leon, R.]]
		+	[[Category: Calcium-binding protein]]

OCA: Protected "2wor" [edit=sysop:move=sysop]

OCA — Wed, 02 Feb 2011 05:54:30 GMT

Protected "2wor" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:54, 2 February 2011

OCA at 05:54, 2 February 2011

OCA — Wed, 02 Feb 2011 05:54:29 GMT

←Older revision		Revision as of 05:54, 2 February 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2wor.png\|left\|200px]]		[[Image:2wor.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~2WOR~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA].	+	[[2wor]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOR OCA].

	==Reference==		==Reference==
Line 28:		Line 27:
	[[Category: Hof, F.]]		[[Category: Hof, F.]]
	[[Category: Leon, R.]]		[[Category: Leon, R.]]
-	[[Category: Acetylation]]
-	[[Category: Calcium]]
-	[[Category: Calcium-binding protein]]
-	[[Category: Cytoplasm]]
-	[[Category: Disulfide bond]]
-	[[Category: Metal-binding]]
-	[[Category: Polymorphism]]
-	[[Category: S100a7]]
-	[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 15:06:16 2010''