2wqd - Revision history

OCA at 10:16, 9 May 2024

OCA — Thu, 09 May 2024 10:16:25 GMT

←Older revision		Revision as of 10:16, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2wqd' size='340' side='right'caption='[[2wqd]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2wqd' size='340' side='right'caption='[[2wqd]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [https://pdbe.org/2wqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [https://www.ebi.ac.uk/pdbsum/2wqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [https://pdbe.org/2wqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [https://www.ebi.ac.uk/pdbsum/2wqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PT1_STAAU PT1_STAAU]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).	+	[https://www.uniprot.org/uniprot/PT1_STAAU PT1_STAAU] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baumann, U]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Erni, B]]	+	[[Category: Baumann U]]
-	[[Category: Oberholzer~~, A E~~]]	+	[[Category: Erni B]]
-	[[Category: Schneider, P]]	+	[[Category: Oberholzer AE]]
-	[[Category: Siebold, C]]	+	[[Category: Schneider P]]
-	~~[[Category: Cytoplasm]]~~	+	[[Category: Siebold C]]
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Magnesium]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Pep-utilising enzyme]]~~	+
-	~~[[Category: Phosphoenolpyruvate]]~~	+
-	~~[[Category: Phosphotransferase system]]~~	+
-	~~[[Category: Sugar transport]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 11:13, 6 April 2022

OCA — Wed, 06 Apr 2022 11:13:30 GMT

←Older revision		Revision as of 11:13, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2wqd' size='340' side='right'caption='[[2wqd]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2wqd' size='340' side='right'caption='[[2wqd]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WQD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WQD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [~~http~~://pdbe.org/2wqd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wqd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [https://pdbe.org/2wqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [https://www.ebi.ac.uk/pdbsum/2wqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PT1_STAAU PT1_STAAU]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).	+	[[https://www.uniprot.org/uniprot/PT1_STAAU PT1_STAAU]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Enzyme I of the S. aureus PTS\|Enzyme I of the S. aureus PTS]]
	*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]		*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]
	== References ==		== References ==

OCA at 09:03, 1 July 2020

OCA — Wed, 01 Jul 2020 09:03:59 GMT

←Older revision		Revision as of 09:03, 1 July 2020
Line 1:		Line 1:

	==Crystal structure of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system in the dephosphorylated state==		==Crystal structure of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system in the dephosphorylated state==
-	<StructureSection load='2wqd' size='340' side='right' caption='[[2wqd]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2wqd' size='340' side='right'caption='[[2wqd]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WQD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WQD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [http://pdbe.org/2wqd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [http://www.ebi.ac.uk/pdbsum/2wqd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [http://pdbe.org/2wqd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [http://www.ebi.ac.uk/pdbsum/2wqd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:
	==See Also==		==See Also==
	*[[Enzyme I of the S. aureus PTS\|Enzyme I of the S. aureus PTS]]		*[[Enzyme I of the S. aureus PTS\|Enzyme I of the S. aureus PTS]]
-	*[[Phosphotransferase\|Phosphotransferase]]	+	*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Baumann, U]]		[[Category: Baumann, U]]
	[[Category: Erni, B]]		[[Category: Erni, B]]

OCA at 09:24, 26 September 2018

OCA — Wed, 26 Sep 2018 09:24:04 GMT

←Older revision		Revision as of 09:24, 26 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF ENZYME~~ I ~~OF THE PHOSPHOENOLPYRUVATE~~:~~SUGAR PHOSPHOTRANSFERASE SYSTEM IN THE DEPHOSPHORYLATED STATE~~==	+
		+	==Crystal structure of enzyme I of the phosphoenolpyruvate:sugar phosphotransferase system in the dephosphorylated state==
	<StructureSection load='2wqd' size='340' side='right' caption='[[2wqd]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2wqd' size='340' side='right' caption='[[2wqd]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WQD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WQD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [http://pdbe.org/2wqd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [http://www.ebi.ac.uk/pdbsum/2wqd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [http://pdbe.org/2wqd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [http://www.ebi.ac.uk/pdbsum/2wqd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/2wqd_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/2wqd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 40:		Line 41:
	[[Category: Schneider, P]]		[[Category: Schneider, P]]
	[[Category: Siebold, C]]		[[Category: Siebold, C]]
		+	[[Category: Cytoplasm]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Magnesium]]		[[Category: Magnesium]]

OCA at 05:01, 7 February 2016

OCA — Sun, 07 Feb 2016 05:01:40 GMT

←Older revision		Revision as of 05:01, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2wqd' size='340' side='right' caption='[[2wqd]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2wqd' size='340' side='right' caption='[[2wqd]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WQD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WQD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [http://www.ebi.ac.uk/pdbsum/2wqd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [http://pdbe.org/2wqd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [http://www.ebi.ac.uk/pdbsum/2wqd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wqd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wqd" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Staphylococcus aureus]]
	[[Category: Baumann, U]]		[[Category: Baumann, U]]
	[[Category: Erni, B]]		[[Category: Erni, B]]

OCA at 08:03, 24 December 2014

OCA — Wed, 24 Dec 2014 08:03:23 GMT

←Older revision		Revision as of 08:03, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WQD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WQD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [http://www.ebi.ac.uk/pdbsum/2wqd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [http://www.ebi.ac.uk/pdbsum/2wqd PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PT1_STAAU PT1_STAAU]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
-	[[Category: Baumann, U.]]	+	[[Category: Baumann, U]]
-	[[Category: Erni, B.]]	+	[[Category: Erni, B]]
-	[[Category: Oberholzer, A E.]]	+	[[Category: Oberholzer, A E]]
-	[[Category: Schneider, P.]]	+	[[Category: Schneider, P]]
-	[[Category: Siebold, C.]]	+	[[Category: Siebold, C]]
	[[Category: Kinase]]		[[Category: Kinase]]
	[[Category: Magnesium]]		[[Category: Magnesium]]

OCA at 02:05, 1 October 2014

OCA — Wed, 01 Oct 2014 02:05:54 GMT

←Older revision		Revision as of 02:05, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2wqd\| PDB=2wqd \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF ENZYME I OF THE PHOSPHOENOLPYRUVATE:SUGAR PHOSPHOTRANSFERASE SYSTEM IN THE DEPHOSPHORYLATED STATE==
-	===CRYSTAL STRUCTURE OF ENZYME I OF THE PHOSPHOENOLPYRUVATE:SUGAR PHOSPHOTRANSFERASE SYSTEM IN THE DEPHOSPHORYLATED STATE===	+	<StructureSection load='2wqd' size='340' side='right' caption='[[2wqd]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19801641}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WQD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wqd RCSB], [http://www.ebi.ac.uk/pdbsum/2wqd PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/2wqd_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial phosphoenolpyruvate (PEP) sugar phosphotransferase system mediates sugar uptake and controls the carbon metabolism in response to carbohydrate availability. Enzyme I (EI), the first component of the phosphotransferase system, consists of an N-terminal protein binding domain (EIN) and a C-terminal PEP binding domain (EIC). EI transfers phosphate from PEP by double displacement via a histidine residue on EIN to the general phosphoryl carrier protein HPr. Here we report the 2.4 A crystal structure of the homodimeric EI from Staphylococcus aureus. EIN consists of the helical hairpin HPr binding subdomain and the phosphorylatable betaalpha phospho-histidine (P-His) domain. EIC folds into an (betaalpha)(8) barrel. The dimer interface of EIC buries 1833 A(2) of accessible surface per monomer and contains two Ca(2+) binding sites per dimer. The structures of the S. aureus and Escherichia coli EI domains (Teplyakov, A., Lim, K., Zhu, P. P., Kapadia, G., Chen, C. C., Schwartz, J., Howard, A., Reddy, P. T., Peterkofsky, A., and Herzberg, O. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 16218-16223) are very similar. The orientation of the domains relative to each other, however, is different. In the present structure the P-His domain is docked to the HPr binding domain in an orientation appropriate for in-line transfer of the phosphate to the active site histidine of the acceptor HPr. In the E. coli structure the phospho-His of the P-His domain projects into the PEP binding site of EIC. In the S. aureus structure the crystallographic temperature factors are lower for the HPr binding domain in contact with the P-His domain and higher for EIC. In the E. coli structure it is the reverse.

-	~~==About this Structure==~~	+	Crystal structure of enzyme I of the phosphoenolpyruvate sugar phosphotransferase system in the dephosphorylated state.,Oberholzer AE, Schneider P, Siebold C, Baumann U, Erni B J Biol Chem. 2009 Nov 27;284(48):33169-76. Epub 2009 Sep 28. PMID:19801641<ref>PMID:19801641</ref>
-	~~[[2wqd]] is a 1 chain~~ structure ~~with sequence from [http~~:~~//en~~.~~wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2WQD OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Enzyme I of the S. aureus PTS\|Enzyme I of the S. aureus PTS]]		*[[Enzyme I of the S. aureus PTS\|Enzyme I of the S. aureus PTS]]
	*[[Phosphotransferase\|Phosphotransferase]]		*[[Phosphotransferase\|Phosphotransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019801641<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Baumann, U.]]		[[Category: Baumann, U.]]

OCA at 09:58, 11 March 2013

OCA — Mon, 11 Mar 2013 09:58:33 GMT

←Older revision		Revision as of 09:58, 11 March 2013
Line 1:		Line 1:
-	[[Image:2wqd.png\|left\|200px]]
-
	{{STRUCTURE_2wqd\| PDB=2wqd \| SCENE= }}		{{STRUCTURE_2wqd\| PDB=2wqd \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF ENZYME I OF THE PHOSPHOENOLPYRUVATE:SUGAR PHOSPHOTRANSFERASE SYSTEM IN THE DEPHOSPHORYLATED STATE===		===CRYSTAL STRUCTURE OF ENZYME I OF THE PHOSPHOENOLPYRUVATE:SUGAR PHOSPHOTRANSFERASE SYSTEM IN THE DEPHOSPHORYLATED STATE===
-
	{{ABSTRACT_PUBMED_19801641}}		{{ABSTRACT_PUBMED_19801641}}

OCA at 05:38, 20 October 2012

OCA — Sat, 20 Oct 2012 05:38:49 GMT

←Older revision		Revision as of 05:38, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wqd]] is a 1 chain structure ~~of [[Phosphotransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA].	+	[[2wqd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQD OCA].

	==See Also==		==See Also==
		+	*[[Enzyme I of the S. aureus PTS\|Enzyme I of the S. aureus PTS]]
	*[[Phosphotransferase\|Phosphotransferase]]		*[[Phosphotransferase\|Phosphotransferase]]

OCA: Protected "2wqd" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 10:43:29 GMT

Protected "2wqd" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:43, 25 July 2012