2wrh - Revision history

OCA at 11:14, 6 April 2022

OCA — Wed, 06 Apr 2022 11:14:37 GMT

←Older revision		Revision as of 11:14, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2wrh' size='340' side='right'caption='[[2wrh]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2wrh' size='340' side='right'caption='[[2wrh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wrh]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_a_virus_(a/mallard/alberta/35/1976(h1n1)) Influenza a virus (a/mallard/alberta/35/1976(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WRH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wrh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_a_virus_(a/mallard/alberta/35/1976(h1n1)) Influenza a virus (a/mallard/alberta/35/1976(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WRH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wrg\|2wrg]], [[2wr4\|2wr4]], [[2wr0\|2wr0]], [[2wr3\|2wr3]], [[2wrf\|2wrf]], [[2wrd\|2wrd]], [[2wr1\|2wr1]], [[2wr2\|2wr2]], [[2wr7\|2wr7]], [[2wre\|2wre]], [[2wrb\|2wrb]], [[2wrc\|2wrc]], [[2wr5\|2wr5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wrg\|2wrg]], [[2wr4\|2wr4]], [[2wr0\|2wr0]], [[2wr3\|2wr3]], [[2wrf\|2wrf]], [[2wrd\|2wrd]], [[2wr1\|2wr1]], [[2wr2\|2wr2]], [[2wr7\|2wr7]], [[2wre\|2wre]], [[2wrb\|2wrb]], [[2wrc\|2wrc]], [[2wr5\|2wr5]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrh OCA], [~~http~~://pdbe.org/2wrh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wrh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wrh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wrh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrh OCA], [https://pdbe.org/2wrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wrh RCSB], [https://www.ebi.ac.uk/pdbsum/2wrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wrh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q9WCE0_I76A4 Q9WCE0_I76A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]	+	[[https://www.uniprot.org/uniprot/Q9WCE0_I76A4 Q9WCE0_I76A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:06, 1 July 2020

OCA — Wed, 01 Jul 2020 09:06:55 GMT

←Older revision		Revision as of 09:06, 1 July 2020
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	==structure of H1 duck albert hemagglutinin with human receptor==		==structure of H1 duck albert hemagglutinin with human receptor==
-	<StructureSection load='2wrh' size='340' side='right' caption='[[2wrh]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='2wrh' size='340' side='right'caption='[[2wrh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/mallard/alberta/35/1976(h1n1)) Influenza a virus (a/mallard/alberta/35/1976(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WRH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/mallard/alberta/35/1976(h1n1)) Influenza a virus (a/mallard/alberta/35/1976(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WRH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wrg\|2wrg]], [[2wr4\|2wr4]], [[2wr0\|2wr0]], [[2wr3\|2wr3]], [[2wrf\|2wrf]], [[2wrd\|2wrd]], [[2wr1\|2wr1]], [[2wr2\|2wr2]], [[2wr7\|2wr7]], [[2wre\|2wre]], [[2wrb\|2wrb]], [[2wrc\|2wrc]], [[2wr5\|2wr5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wrg\|2wrg]], [[2wr4\|2wr4]], [[2wr0\|2wr0]], [[2wr3\|2wr3]], [[2wrf\|2wrf]], [[2wrd\|2wrd]], [[2wr1\|2wr1]], [[2wr2\|2wr2]], [[2wr7\|2wr7]], [[2wre\|2wre]], [[2wrb\|2wrb]], [[2wrc\|2wrc]], [[2wr5\|2wr5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrh OCA], [http://pdbe.org/2wrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wrh RCSB], [http://www.ebi.ac.uk/pdbsum/2wrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wrh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrh OCA], [http://pdbe.org/2wrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wrh RCSB], [http://www.ebi.ac.uk/pdbsum/2wrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wrh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Coombs, P J]]		[[Category: Coombs, P J]]
	[[Category: Gamblin, S J]]		[[Category: Gamblin, S J]]

OCA at 09:04, 26 September 2018

OCA — Wed, 26 Sep 2018 09:04:05 GMT

←Older revision		Revision as of 09:04, 26 September 2018
Line 1:		Line 1:
		+
	==structure of H1 duck albert hemagglutinin with human receptor==		==structure of H1 duck albert hemagglutinin with human receptor==
	<StructureSection load='2wrh' size='340' side='right' caption='[[2wrh]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2wrh' size='340' side='right' caption='[[2wrh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~I76a4 I76a4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/mallard/alberta/35/1976(h1n1)) Influenza a virus (a/mallard/alberta/35/1976(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wrg\|2wrg]], [[2wr4\|2wr4]], [[2wr0\|2wr0]], [[2wr3\|2wr3]], [[2wrf\|2wrf]], [[2wrd\|2wrd]], [[2wr1\|2wr1]], [[2wr2\|2wr2]], [[2wr7\|2wr7]], [[2wre\|2wre]], [[2wrb\|2wrb]], [[2wrc\|2wrc]], [[2wr5\|2wr5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wrg\|2wrg]], [[2wr4\|2wr4]], [[2wr0\|2wr0]], [[2wr3\|2wr3]], [[2wrf\|2wrf]], [[2wrd\|2wrd]], [[2wr1\|2wr1]], [[2wr2\|2wr2]], [[2wr7\|2wr7]], [[2wre\|2wre]], [[2wrb\|2wrb]], [[2wrc\|2wrc]], [[2wr5\|2wr5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrh OCA], [http://pdbe.org/2wrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wrh RCSB], [http://www.ebi.ac.uk/pdbsum/2wrh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrh OCA], [http://pdbe.org/2wrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wrh RCSB], [http://www.ebi.ac.uk/pdbsum/2wrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wrh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/2wrh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/2wrh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: I76a4]]
	[[Category: Coombs, P J]]		[[Category: Coombs, P J]]
	[[Category: Gamblin, S J]]		[[Category: Gamblin, S J]]

OCA at 10:54, 9 February 2016

OCA — Tue, 09 Feb 2016 10:54:55 GMT

←Older revision		Revision as of 10:54, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2wrh' size='340' side='right' caption='[[2wrh]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='2wrh' size='340' side='right' caption='[[2wrh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_a_virus_(a/mallard/alberta/35/1976(h1n1)) Influenza a virus (a/mallard/alberta/35/1976(h1n1))~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/I76a4 I76a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wrg\|2wrg]], [[2wr4\|2wr4]], [[2wr0\|2wr0]], [[2wr3\|2wr3]], [[2wrf\|2wrf]], [[2wrd\|2wrd]], [[2wr1\|2wr1]], [[2wr2\|2wr2]], [[2wr7\|2wr7]], [[2wre\|2wre]], [[2wrb\|2wrb]], [[2wrc\|2wrc]], [[2wr5\|2wr5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wrg\|2wrg]], [[2wr4\|2wr4]], [[2wr0\|2wr0]], [[2wr3\|2wr3]], [[2wrf\|2wrf]], [[2wrd\|2wrd]], [[2wr1\|2wr1]], [[2wr2\|2wr2]], [[2wr7\|2wr7]], [[2wre\|2wre]], [[2wrb\|2wrb]], [[2wrc\|2wrc]], [[2wr5\|2wr5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wrh RCSB], [http://www.ebi.ac.uk/pdbsum/2wrh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrh OCA], [http://pdbe.org/2wrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wrh RCSB], [http://www.ebi.ac.uk/pdbsum/2wrh PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wrh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wrh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: I76a4]]
	[[Category: Coombs, P J]]		[[Category: Coombs, P J]]
	[[Category: Gamblin, S J]]		[[Category: Gamblin, S J]]

OCA at 06:24, 25 December 2014

OCA — Thu, 25 Dec 2014 06:24:40 GMT

←Older revision		Revision as of 06:24, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/mallard/alberta/35/1976(h1n1)) Influenza a virus (a/mallard/alberta/35/1976(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/mallard/alberta/35/1976(h1n1)) Influenza a virus (a/mallard/alberta/35/1976(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wrg\|2wrg]], [[2wr4\|2wr4]], [[2wr0\|2wr0]], [[2wr3\|2wr3]], [[2wrf\|2wrf]], [[2wrd\|2wrd]], [[2wr1\|2wr1]], [[2wr2\|2wr2]], [[2wr7\|2wr7]], [[2wre\|2wre]], [[2wrb\|2wrb]], [[2wrc\|2wrc]], [[2wr5\|2wr5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wrg\|2wrg]], [[2wr4\|2wr4]], [[2wr0\|2wr0]], [[2wr3\|2wr3]], [[2wrf\|2wrf]], [[2wrd\|2wrd]], [[2wr1\|2wr1]], [[2wr2\|2wr2]], [[2wr7\|2wr7]], [[2wre\|2wre]], [[2wrb\|2wrb]], [[2wrc\|2wrc]], [[2wr5\|2wr5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wrh RCSB], [http://www.ebi.ac.uk/pdbsum/2wrh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wrh RCSB], [http://www.ebi.ac.uk/pdbsum/2wrh PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q9WCE0_I76A4 Q9WCE0_I76A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Coombs, P J.]]	+	[[Category: Coombs, P J]]
-	[[Category: Gamblin, S J.]]	+	[[Category: Gamblin, S J]]
-	[[Category: Haire, L F.]]	+	[[Category: Haire, L F]]
-	[[Category: Liu, J.]]	+	[[Category: Liu, J]]
-	[[Category: Russell, R J.]]	+	[[Category: Russell, R J]]
-	[[Category: Skehel, J J.]]	+	[[Category: Skehel, J J]]
-	[[Category: Stevens, D J.]]	+	[[Category: Stevens, D J]]
-	[[Category: Walker, P A.]]	+	[[Category: Walker, P A]]
	[[Category: Envelope protein]]		[[Category: Envelope protein]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Lipoprotein]]		[[Category: Lipoprotein]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 01:53, 1 October 2014

OCA — Wed, 01 Oct 2014 01:53:54 GMT

←Older revision		Revision as of 01:53, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2wrh~~\| ~~PDB~~=2wrh \| ~~SCENE~~= }}	+	==structure of H1 duck albert hemagglutinin with human receptor==
-	===structure of H1 ~~duck albert~~ hemagglutinin with human receptor~~===~~	+	<StructureSection load='2wrh' size='340' side='right' caption='[[2wrh]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19805083}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/mallard/alberta/35/1976(h1n1)) Influenza a virus (a/mallard/alberta/35/1976(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wrg\|2wrg]], [[2wr4\|2wr4]], [[2wr0\|2wr0]], [[2wr3\|2wr3]], [[2wrf\|2wrf]], [[2wrd\|2wrd]], [[2wr1\|2wr1]], [[2wr2\|2wr2]], [[2wr7\|2wr7]], [[2wre\|2wre]], [[2wrb\|2wrb]], [[2wrc\|2wrc]], [[2wr5\|2wr5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wrh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wrh RCSB], [http://www.ebi.ac.uk/pdbsum/2wrh PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/2wrh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The viruses that caused the three influenza pandemics of the twentieth century in 1918, 1957, and 1968 had distinct hemagglutinin receptor binding glycoproteins that had evolved the capacity to recognize human cell receptors. We have determined the structure of the H2 hemagglutinin from the second pandemic, the "Asian Influenza" of 1957. We compare it with the 1918 "Spanish Influenza" hemagglutinin, H1, and the 1968 "Hong Kong Influenza" hemagglutinin, H3, and show that despite its close overall structural similarity to H1, and its more distant relationship to H3, the H2 receptor binding site is closely related to that of H3 hemagglutinin. By analyzing hemagglutinins of potential H2 avian precursors of the pandemic virus, we show that the human receptor can be bound by avian hemagglutinins that lack the human-specific mutations of H2 and H3 pandemic viruses, Gln-226Leu, and Gly-228Ser. We show how Gln-226 in the avian H2 receptor binding site, together with Asn-186, form hydrogen bond networks through bound water molecules to mediate binding to human receptor. We show that the human receptor adopts a very similar conformation in both human and avian hemagglutinin-receptor complexes. We also show that Leu-226 in the receptor binding site of human virus hemagglutinins creates a hydrophobic environment near the Sia-1-Gal-2 glycosidic linkage that favors binding of the human receptor and is unfavorable for avian receptor binding. We consider the significance for the development of pandemics, of the existence of avian viruses that can bind to both avian and human receptors.

-	~~==About this Structure==~~	+	Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957.,Liu J, Stevens DJ, Haire LF, Walker PA, Coombs PJ, Russell RJ, Gamblin SJ, Skehel JJ Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17175-80. Epub 2009 Sep 28. PMID:19805083<ref>PMID:19805083</ref>
-	~~[[2wrh]] is a 6 chain structure with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Influenza_a_virus_~~(~~a/mallard/alberta/35/1976(h1n1~~)~~) Influenza a virus (a/mallard/alberta/35/1976(h1n1))]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2WRH OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin\|Hemagglutinin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019805083<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Coombs, P J.]]		[[Category: Coombs, P J.]]
	[[Category: Gamblin, S J.]]		[[Category: Gamblin, S J.]]

OCA at 10:52, 11 March 2013

OCA — Mon, 11 Mar 2013 10:52:01 GMT

←Older revision		Revision as of 10:52, 11 March 2013
Line 1:		Line 1:
-	[[Image:2wrh.png\|left\|200px]]
-
	{{STRUCTURE_2wrh\| PDB=2wrh \| SCENE= }}		{{STRUCTURE_2wrh\| PDB=2wrh \| SCENE= }}
-
	===structure of H1 duck albert hemagglutinin with human receptor===		===structure of H1 duck albert hemagglutinin with human receptor===
-
	{{ABSTRACT_PUBMED_19805083}}		{{ABSTRACT_PUBMED_19805083}}

OCA at 14:43, 28 November 2012

OCA — Wed, 28 Nov 2012 14:43:33 GMT

←Older revision		Revision as of 14:43, 28 November 2012
Line 3:		Line 3:
	{{STRUCTURE_2wrh\| PDB=2wrh \| SCENE= }}		{{STRUCTURE_2wrh\| PDB=2wrh \| SCENE= }}

-	===~~STRUCTURE OF~~ H1 ~~DUCK ALBERT HEMAGGLUTININ WITH HUMAN RECEPTOR~~===	+	===structure of H1 duck albert hemagglutinin with human receptor===

	{{ABSTRACT_PUBMED_19805083}}		{{ABSTRACT_PUBMED_19805083}}

	==About this Structure==		==About this Structure==
-	[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Viruses Viruses~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA].	+	[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/mallard/alberta/35/1976(h1n1)) Influenza a virus (a/mallard/alberta/35/1976(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA].

	==See Also==		==See Also==
Line 15:		Line 15:
	==Reference==		==Reference==
	<ref group="xtra">PMID:019805083</ref><references group="xtra"/>		<ref group="xtra">PMID:019805083</ref><references group="xtra"/>
-	[[Category: Viruses]]
	[[Category: Coombs, P J.]]		[[Category: Coombs, P J.]]
	[[Category: Gamblin, S J.]]		[[Category: Gamblin, S J.]]

OCA at 13:38, 20 October 2012

OCA — Sat, 20 Oct 2012 13:38:54 GMT

←Older revision		Revision as of 13:38, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wrh]] is a 6 chain structure ~~of [[Hemagglutinin]]~~ with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA].	+	[[2wrh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRH OCA].

	==See Also==		==See Also==

OCA: Protected "2wrh" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 12:38:08 GMT

Protected "2wrh" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:38, 26 July 2012