2wsw - Revision history

OCA at 10:15, 20 December 2023

OCA — Wed, 20 Dec 2023 10:15:38 GMT

←Older revision		Revision as of 10:15, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Proteus_mirabilis Proteus mirabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WSW FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Proteus_mirabilis Proteus mirabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WSW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.294Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wsx\|2wsx]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsw OCA], [https://pdbe.org/2wsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wsw RCSB], [https://www.ebi.ac.uk/pdbsum/2wsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wsw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsw OCA], [https://pdbe.org/2wsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wsw RCSB], [https://www.ebi.ac.uk/pdbsum/2wsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wsw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~C2LLR0_PROMI C2LLR0_PROMI]~~] Catalyzes the exchange of L-carnitine for gamma-butyrobetaine ~~and related betaines (By similarity)~~.[HAMAP-Rule:MF_01049]	+	[https://www.uniprot.org/uniprot/CAIT_PROMH CAIT_PROMH] Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.[HAMAP-Rule:MF_01049]<ref>PMID:20829798</ref> <ref>PMID:24101465</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Proteus mirabilis]]		[[Category: Proteus mirabilis]]
-	[[Category: Kuehlbrandt, W]]	+	[[Category: Kuehlbrandt W]]
-	~~[[Category: Scheltinga, A C.Terwisscha van~~]]	+	[[Category: Schulze S]]
-	[[Category: Schulze, S]]	+	[[Category: Terwisscha van Scheltinga AC]]
-	[[Category: ~~Membrane protein]]~~	+
-	~~[[Category: Sd methionine]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 11:15, 6 April 2022

OCA — Wed, 06 Apr 2022 11:15:19 GMT

←Older revision		Revision as of 11:15, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2wsw' size='340' side='right'caption='[[2wsw]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='2wsw' size='340' side='right'caption='[[2wsw]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wsw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Proteus_mirabilis Proteus mirabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WSW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wsw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Proteus_mirabilis Proteus mirabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WSW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsx\|2wsx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wsx\|2wsx]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsw OCA], [~~http~~://pdbe.org/2wsw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wsw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wsw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wsw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsw OCA], [https://pdbe.org/2wsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wsw RCSB], [https://www.ebi.ac.uk/pdbsum/2wsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wsw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/C2LLR0_PROMI C2LLR0_PROMI]] Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines (By similarity).[HAMAP-Rule:MF_01049]	+	[[https://www.uniprot.org/uniprot/C2LLR0_PROMI C2LLR0_PROMI]] Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines (By similarity).[HAMAP-Rule:MF_01049]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:08, 1 July 2020

OCA — Wed, 01 Jul 2020 09:08:23 GMT

←Older revision		Revision as of 09:08, 1 July 2020
Line 1:		Line 1:

	==Crystal Structure of Carnitine Transporter from Proteus mirabilis==		==Crystal Structure of Carnitine Transporter from Proteus mirabilis==
-	<StructureSection load='2wsw' size='340' side='right' caption='[[2wsw]], [[Resolution\|resolution]] 2.29Å' scene=''>	+	<StructureSection load='2wsw' size='340' side='right'caption='[[2wsw]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Proteus_mirabilis Proteus mirabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WSW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Proteus_mirabilis Proteus mirabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WSW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsx\|2wsx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsx\|2wsx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsw OCA], [http://pdbe.org/2wsw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wsw RCSB], [http://www.ebi.ac.uk/pdbsum/2wsw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wsw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsw OCA], [http://pdbe.org/2wsw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wsw RCSB], [http://www.ebi.ac.uk/pdbsum/2wsw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wsw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Proteus mirabilis]]		[[Category: Proteus mirabilis]]
	[[Category: Kuehlbrandt, W]]		[[Category: Kuehlbrandt, W]]

OCA at 09:03, 26 September 2018

OCA — Wed, 26 Sep 2018 09:03:54 GMT

←Older revision		Revision as of 09:03, 26 September 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF CARNITINE TRANSPORTER FROM PROTEUS MIRABILIS~~==	+	==Crystal Structure of Carnitine Transporter from Proteus mirabilis==
	<StructureSection load='2wsw' size='340' side='right' caption='[[2wsw]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='2wsw' size='340' side='right' caption='[[2wsw]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/2wsw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/2wsw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	[[Category: Proteus mirabilis]]		[[Category: Proteus mirabilis]]
	[[Category: Kuehlbrandt, W]]		[[Category: Kuehlbrandt, W]]
-	[[Category: Scheltinga, A C.Terwisscha ~~Van~~]]	+	[[Category: Scheltinga, A C.Terwisscha van]]
	[[Category: Schulze, S]]		[[Category: Schulze, S]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Sd methionine]]		[[Category: Sd methionine]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 19:51, 5 August 2016

OCA — Fri, 05 Aug 2016 19:51:40 GMT

←Older revision		Revision as of 19:51, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF CARNITINE TRANSPORTER FROM PROTEUS MIRABILIS==		==CRYSTAL STRUCTURE OF CARNITINE TRANSPORTER FROM PROTEUS MIRABILIS==
	<StructureSection load='2wsw' size='340' side='right' caption='[[2wsw]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='2wsw' size='340' side='right' caption='[[2wsw]], [[Resolution\|resolution]] 2.29Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsx\|2wsx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsx\|2wsx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wsw RCSB], [http://www.ebi.ac.uk/pdbsum/2wsw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsw OCA], [http://pdbe.org/2wsw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wsw RCSB], [http://www.ebi.ac.uk/pdbsum/2wsw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wsw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wsw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wsw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:22, 25 December 2014

OCA — Thu, 25 Dec 2014 05:22:14 GMT

←Older revision		Revision as of 05:22, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wsw RCSB], [http://www.ebi.ac.uk/pdbsum/2wsw PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wsw RCSB], [http://www.ebi.ac.uk/pdbsum/2wsw PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C2LLR0_PROMI C2LLR0_PROMI]] Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines (By similarity).[HAMAP-Rule:MF_01049]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:00, 17 December 2014

OCA — Wed, 17 Dec 2014 14:00:34 GMT

←Older revision		Revision as of 14:00, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2wsw\| PDB=2wsw \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF CARNITINE TRANSPORTER FROM PROTEUS MIRABILIS==
-	===CRYSTAL STRUCTURE OF CARNITINE TRANSPORTER FROM PROTEUS MIRABILIS===	+	<StructureSection load='2wsw' size='340' side='right' caption='[[2wsw]], [[Resolution\|resolution]] 2.29Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20829798}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Proteus_mirabilis Proteus mirabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WSW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsx\|2wsx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wsw RCSB], [http://www.ebi.ac.uk/pdbsum/2wsw PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/2wsw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transport of solutes across biological membranes is performed by specialized secondary transport proteins in the lipid bilayer, and is essential for life. Here we report the structures of the sodium-independent carnitine/butyrobetaine antiporter CaiT from Proteus mirabilis (PmCaiT) at 2.3-A and from Escherichia coli (EcCaiT) at 3.5-A resolution. CaiT belongs to the family of betaine/carnitine/choline transporters (BCCT), which are mostly Na(+) or H(+) dependent, whereas EcCaiT is Na(+) and H(+) independent. The three-dimensional architecture of CaiT resembles that of the Na(+)-dependent transporters LeuT and BetP, but in CaiT a methionine sulphur takes the place of the Na(+) ion to coordinate the substrate in the central transport site, accounting for Na(+)-independent transport. Both CaiT structures show the fully open, inward-facing conformation, and thus complete the set of functional states that describe the alternating access mechanism. EcCaiT contains two bound butyrobetaine substrate molecules, one in the central transport site, the other in an extracellular binding pocket. In the structure of PmCaiT, a tryptophan side chain occupies the transport site, and access to the extracellular site is blocked. Binding of both substrates to CaiT reconstituted into proteoliposomes is cooperative, with Hill coefficients up to 1.7, indicating that the extracellular site is regulatory. We propose a mechanism whereby the occupied regulatory site increases the binding affinity of the transport site and initiates substrate translocation.

-	~~==About this Structure==~~	+	Structural basis of Na(+)-independent and cooperative substrate/product antiport in CaiT.,Schulze S, Koster S, Geldmacher U, Terwisscha van Scheltinga AC, Kuhlbrandt W Nature. 2010 Sep 9;467(7312):233-6. PMID:20829798<ref>PMID:20829798</ref>
-	~~[[2wsw]] is a 1 chain structure with sequence from [http:~~/~~/en~~.~~wikipedia~~.~~org/wiki/Proteus_mirabilis Proteus mirabilis]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WSW OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<~~ref group="xtra">PMID:020829798<~~/~~ref~~><~~references group="xtra"~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Proteus mirabilis]]		[[Category: Proteus mirabilis]]
-	[[Category: Kuehlbrandt, W.]]	+	[[Category: Kuehlbrandt, W]]
-	[[Category: Scheltinga, A C.Terwisscha Van.]]	+	[[Category: Scheltinga, A C.Terwisscha Van]]
-	[[Category: Schulze, S.]]	+	[[Category: Schulze, S]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Sd methionine]]		[[Category: Sd methionine]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 10:57, 13 March 2013

OCA — Wed, 13 Mar 2013 10:57:02 GMT

←Older revision		Revision as of 10:57, 13 March 2013
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-	[[Image:2wsw.png\|left\|200px]]
-
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	{{STRUCTURE_2wsw\| PDB=2wsw \| SCENE= }}		{{STRUCTURE_2wsw\| PDB=2wsw \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF CARNITINE TRANSPORTER FROM PROTEUS MIRABILIS===		===CRYSTAL STRUCTURE OF CARNITINE TRANSPORTER FROM PROTEUS MIRABILIS===
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	[[Category: Scheltinga, A C.Terwisscha Van.]]		[[Category: Scheltinga, A C.Terwisscha Van.]]
	[[Category: Schulze, S.]]		[[Category: Schulze, S.]]
		+	[[Category: Membrane protein]]
		+	[[Category: Sd methionine]]
		+	[[Category: Transport protein]]

OCA: Protected "2wsw" [edit=sysop:move=sysop]

OCA — Thu, 12 May 2011 04:06:00 GMT

Protected "2wsw" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:06, 12 May 2011

OCA at 04:05, 12 May 2011

OCA — Thu, 12 May 2011 04:05:58 GMT

←Older revision		Revision as of 04:05, 12 May 2011
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-	~~{{Seed}}~~	+	[[Image:2wsw.png\|left\|200px]]
-	[[Image:2wsw.~~jpg~~\|left\|200px]]	+

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	===CRYSTAL STRUCTURE OF CARNITINE TRANSPORTER FROM PROTEUS MIRABILIS===		===CRYSTAL STRUCTURE OF CARNITINE TRANSPORTER FROM PROTEUS MIRABILIS===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20829798}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20829798 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20829798}}

	==About this Structure==		==About this Structure==
-	~~2WSW~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Proteus_mirabilis Proteus mirabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSW OCA].	+	[[2wsw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Proteus_mirabilis Proteus mirabilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSW OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:020829798</ref><references group="xtra"/>
	[[Category: Proteus mirabilis]]		[[Category: Proteus mirabilis]]
	[[Category: Kuehlbrandt, W.]]		[[Category: Kuehlbrandt, W.]]
	[[Category: Scheltinga, A C.Terwisscha Van.]]		[[Category: Scheltinga, A C.Terwisscha Van.]]
	[[Category: Schulze, S.]]		[[Category: Schulze, S.]]
-	[[Category: Membrane protein]]
-	[[Category: Sd methionine]]
-	[[Category: Transport protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Sep 10 13:53:05 2010''