2wxx - Revision history

OCA at 12:44, 17 January 2024

OCA — Wed, 17 Jan 2024 12:44:36 GMT

←Older revision		Revision as of 12:44, 17 January 2024
Line 3:		Line 3:
	<StructureSection load='2wxx' size='340' side='right'caption='[[2wxx]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2wxx' size='340' side='right'caption='[[2wxx]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wxx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wxx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WXX FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2wxz\|2wxz]]~~, [[~~2x0b~~\|~~2x0b~~]]~~, [[2wxy\|2wxy]], [[2wy1\|2wy1]], [[2wy0\|2wy0]], [[2wxw\|2wxw]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxx OCA], [https://pdbe.org/2wxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wxx RCSB], [https://www.ebi.ac.uk/pdbsum/2wxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wxx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxx OCA], [https://pdbe.org/2wxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wxx RCSB], [https://www.ebi.ac.uk/pdbsum/2wxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wxx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ANGT_MOUSE ANGT_MOUSE]] Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin-3: stimulates aldosterone release (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref>	+	[https://www.uniprot.org/uniprot/ANGT_MOUSE ANGT_MOUSE] Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin-3: stimulates aldosterone release (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Carrell~~, R W~~]]	+	[[Category: Carrell RW]]
-	[[Category: Read~~, R J~~]]	+	[[Category: Read RJ]]
-	[[Category: Wei, Z]]	+	[[Category: Wei Z]]
-	[[Category: Zhou, A]]	+	[[Category: Zhou A]]
-	~~[[Category: Angiotensin]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Hypertension]]~~	+
-	~~[[Category: Renin]]~~	+
-	~~[[Category: Serpin]]~~	+
-	~~[[Category: Vasoactive]]~~	+
-	~~[[Category: Vasoconstrictor~~]]	+

OCA at 10:42, 13 April 2022

OCA — Wed, 13 Apr 2022 10:42:09 GMT

←Older revision		Revision as of 10:42, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='2wxx' size='340' side='right'caption='[[2wxx]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2wxx' size='340' side='right'caption='[[2wxx]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wxx]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wxx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WXX FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wxz\|2wxz]], [[2x0b\|2x0b]], [[2wxy\|2wxy]], [[2wy1\|2wy1]], [[2wy0\|2wy0]], [[2wxw\|2wxw]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wxz\|2wxz]], [[2x0b\|2x0b]], [[2wxy\|2wxy]], [[2wy1\|2wy1]], [[2wy0\|2wy0]], [[2wxw\|2wxw]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxx OCA], [~~http~~://pdbe.org/2wxx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wxx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wxx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wxx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxx OCA], [https://pdbe.org/2wxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wxx RCSB], [https://www.ebi.ac.uk/pdbsum/2wxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wxx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ANGT_MOUSE ANGT_MOUSE]] Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin-3: stimulates aldosterone release (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref>	+	[[https://www.uniprot.org/uniprot/ANGT_MOUSE ANGT_MOUSE]] Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin-3: stimulates aldosterone release (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:59, 8 July 2020

OCA — Wed, 08 Jul 2020 14:59:55 GMT

←Older revision		Revision as of 14:59, 8 July 2020
Line 1:		Line 1:

	==Crystal structure of mouse angiotensinogen in the oxidised form==		==Crystal structure of mouse angiotensinogen in the oxidised form==
-	<StructureSection load='2wxx' size='340' side='right' caption='[[2wxx]], [[Resolution\|resolution]] 2.95Å' scene=''>	+	<StructureSection load='2wxx' size='340' side='right'caption='[[2wxx]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wxx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wxx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WXX FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wxz\|2wxz]], [[2x0b\|2x0b]], [[2wxy\|2wxy]], [[2wy1\|2wy1]], [[2wy0\|2wy0]], [[2wxw\|2wxw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wxz\|2wxz]], [[2x0b\|2x0b]], [[2wxy\|2wxy]], [[2wy1\|2wy1]], [[2wy0\|2wy0]], [[2wxw\|2wxw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxx OCA], [http://pdbe.org/2wxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wxx RCSB], [http://www.ebi.ac.uk/pdbsum/2wxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wxx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxx OCA], [http://pdbe.org/2wxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wxx RCSB], [http://www.ebi.ac.uk/pdbsum/2wxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wxx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Hormone\|Hormone]]	+	*[[Serpin 3D structures\|Serpin 3D structures]]
-	*[[Serpin\|Serpin]]	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Carrell, R W]]		[[Category: Carrell, R W]]

OCA at 09:43, 3 October 2018

OCA — Wed, 03 Oct 2018 09:43:46 GMT

←Older revision		Revision as of 09:43, 3 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF MOUSE ANGIOTENSINOGEN IN THE OXIDISED FORM~~==	+	==Crystal structure of mouse angiotensinogen in the oxidised form==
	<StructureSection load='2wxx' size='340' side='right' caption='[[2wxx]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2wxx' size='340' side='right' caption='[[2wxx]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 16:35, 5 August 2016

OCA — Fri, 05 Aug 2016 16:35:44 GMT

←Older revision		Revision as of 16:35, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF MOUSE ANGIOTENSINOGEN IN THE OXIDISED FORM==		==CRYSTAL STRUCTURE OF MOUSE ANGIOTENSINOGEN IN THE OXIDISED FORM==
	<StructureSection load='2wxx' size='340' side='right' caption='[[2wxx]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2wxx' size='340' side='right' caption='[[2wxx]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wxx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wxx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WXX FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wxz\|2wxz]], [[2x0b\|2x0b]], [[2wxy\|2wxy]], [[2wy1\|2wy1]], [[2wy0\|2wy0]], [[2wxw\|2wxw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wxz\|2wxz]], [[2x0b\|2x0b]], [[2wxy\|2wxy]], [[2wy1\|2wy1]], [[2wy0\|2wy0]], [[2wxw\|2wxw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wxx RCSB], [http://www.ebi.ac.uk/pdbsum/2wxx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxx OCA], [http://pdbe.org/2wxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wxx RCSB], [http://www.ebi.ac.uk/pdbsum/2wxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wxx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wxx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Carrell, R W]]		[[Category: Carrell, R W]]
	[[Category: Read, R J]]		[[Category: Read, R J]]

OCA at 20:19, 25 December 2014

OCA — Thu, 25 Dec 2014 20:19:46 GMT

←Older revision		Revision as of 20:19, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wxx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WXX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wxx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WXX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wxz\|2wxz]], [[2x0b\|2x0b]], [[2wxy\|2wxy]], [[2wy1\|2wy1]], [[2wy0\|2wy0]], [[2wxw\|2wxw]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wxz\|2wxz]], [[2x0b\|2x0b]], [[2wxy\|2wxy]], [[2wy1\|2wy1]], [[2wy0\|2wy0]], [[2wxw\|2wxw]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wxx RCSB], [http://www.ebi.ac.uk/pdbsum/2wxx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wxx RCSB], [http://www.ebi.ac.uk/pdbsum/2wxx PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ANGT_MOUSE ANGT_MOUSE]] Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin-3: stimulates aldosterone release (By similarity).<ref>PMID:12829792</ref> <ref>PMID:18026570</ref> Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.<ref>PMID:12829792</ref> <ref>PMID:18026570</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Carrell, R W.]]	+	[[Category: Carrell, R W]]
-	[[Category: Read, R J.]]	+	[[Category: Read, R J]]
-	[[Category: Wei, Z.]]	+	[[Category: Wei, Z]]
-	[[Category: Zhou, A.]]	+	[[Category: Zhou, A]]
	[[Category: Angiotensin]]		[[Category: Angiotensin]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 00:59, 2 October 2014

OCA — Thu, 02 Oct 2014 00:59:58 GMT

←Older revision		Revision as of 00:59, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2wxx.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF MOUSE ANGIOTENSINOGEN IN THE OXIDISED FORM==
		+	<StructureSection load='2wxx' size='340' side='right' caption='[[2wxx]], [[Resolution\|resolution]] 2.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wxx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WXX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wxz\|2wxz]], [[2x0b\|2x0b]], [[2wxy\|2wxy]], [[2wy1\|2wy1]], [[2wy0\|2wy0]], [[2wxw\|2wxw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wxx RCSB], [http://www.ebi.ac.uk/pdbsum/2wxx PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Blood pressure is critically controlled by angiotensins, which are vasopressor peptides specifically released by the enzyme renin from the tail of angiotensinogen-a non-inhibitory member of the serpin family of protease inhibitors. Although angiotensinogen has long been regarded as a passive substrate, the crystal structures solved here to 2.1 A resolution show that the angiotensin cleavage site is inaccessibly buried in its amino-terminal tail. The conformational rearrangement that makes this site accessible for proteolysis is revealed in our 4.4 A structure of the complex of human angiotensinogen with renin. The co-ordinated changes involved are seen to be critically linked by a conserved but labile disulphide bridge. Here we show that the reduced unbridged form of angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized sulphydryl-bridged form, which preferentially interacts with receptor-bound renin. We propose that this redox-responsive transition of angiotensinogen to a form that will more effectively release angiotensin at a cellular level contributes to the modulation of blood pressure. Specifically, we demonstrate the oxidative switch of angiotensinogen to its more active sulphydryl-bridged form in the maternal circulation in pre-eclampsia-the hypertensive crisis of pregnancy that threatens the health and survival of both mother and child.

-	~~{{STRUCTURE_2wxx\| PDB=2wxx \| SCENE= }}~~	+	A redox switch in angiotensinogen modulates angiotensin release.,Zhou A, Carrell RW, Murphy MP, Wei Z, Yan Y, Stanley PL, Stein PE, Pipkin FB, Read RJ Nature. 2010 Oct 6. PMID:20927107<ref>PMID:20927107</ref>

-	~~===CRYSTAL STRUCTURE OF MOUSE ANGIOTENSINOGEN IN THE OXIDISED FORM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20927107}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2wxx]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA].~~	+

	==See Also==		==See Also==
	*[[Hormone\|Hormone]]		*[[Hormone\|Hormone]]
	*[[Serpin\|Serpin]]		*[[Serpin\|Serpin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020927107<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Carrell, R W.]]		[[Category: Carrell, R W.]]

OCA at 21:02, 20 October 2012

OCA — Sat, 20 Oct 2012 21:02:25 GMT

←Older revision		Revision as of 21:02, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wxx]] is a 4 chain structure ~~of [[Hormone]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA].	+	[[2wxx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA].

	==See Also==		==See Also==
	*[[Hormone\|Hormone]]		*[[Hormone\|Hormone]]
		+	*[[Serpin\|Serpin]]

	==Reference==		==Reference==

OCA: Protected "2wxx" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 12:24:23 GMT

Protected "2wxx" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:24, 27 July 2012

OCA at 12:24, 27 July 2012

OCA — Fri, 27 Jul 2012 12:24:22 GMT

←Older revision		Revision as of 12:24, 27 July 2012
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-	{{Seed}}
	[[Image:2wxx.png\|left\|200px]]		[[Image:2wxx.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2wxx\| PDB=2wxx \| SCENE= }}		{{STRUCTURE_2wxx\| PDB=2wxx \| SCENE= }}

	===CRYSTAL STRUCTURE OF MOUSE ANGIOTENSINOGEN IN THE OXIDISED FORM===		===CRYSTAL STRUCTURE OF MOUSE ANGIOTENSINOGEN IN THE OXIDISED FORM===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20927107}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20927107 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20927107}}		{{ABSTRACT_PUBMED_20927107}}

	==About this Structure==		==About this Structure==
-	~~2WXX~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA].	+	[[2wxx]] is a 4 chain structure of [[Hormone]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXX OCA].
		+
		+	==See Also==
		+	*[[Hormone\|Hormone]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20927107~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020927107</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Carrell, R W.]]		[[Category: Carrell, R W.]]
Line 37:		Line 28:
	[[Category: Vasoactive]]		[[Category: Vasoactive]]
	[[Category: Vasoconstrictor]]		[[Category: Vasoconstrictor]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 10 06:53:50 2010''