2wyg - Revision history

OCA at 07:16, 9 August 2023

OCA — Wed, 09 Aug 2023 07:16:56 GMT

←Older revision		Revision as of 07:16, 9 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WYG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WYG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=461:(E)-2-(5-CHLOROTHIOPHEN-2-YL)-N-[(3S)-1-{4-[(1R)-1-(DIMETHYLAMINO)ETHYL]-2-FLUOROPHENYL}-2-OXOPYRROLIDIN-3-YL]ETHENESULFONAMIDE'>461</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.88Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2j34\|2j34]], [[1wu1\|1wu1]], [[2bq7\|2bq7]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2gd4\|2gd4]], [[2vvv\|2vvv]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[1z6e\|1z6e]], [[2jkh\|2jkh]], [[2uwp\|2uwp]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[1mq5\|1mq5]], [[2bmg\|2bmg]], [[1iqn\|1iqn]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2cji\|2cji]], [[2j95\|2j95]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[1iqk\|1iqk]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[1iql\|1iql]], [[1ksn\|1ksn]], [[2wyj\|2wyj]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=461:(E)-2-(5-CHLOROTHIOPHEN-2-YL)-N-[(3S)-1-{4-[(1R)-1-(DIMETHYLAMINO)ETHYL]-2-FLUOROPHENYL}-2-OXOPYRROLIDIN-3-YL]ETHENESULFONAMIDE'>461</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wyg OCA], [https://pdbe.org/2wyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wyg RCSB], [https://www.ebi.ac.uk/pdbsum/2wyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wyg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wyg OCA], [https://pdbe.org/2wyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wyg RCSB], [https://www.ebi.ac.uk/pdbsum/2wyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wyg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>	+	[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.	+	[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Borthwick~~, A D~~]]	+	[[Category: Borthwick AD]]
-	[[Category: Brown, D]]	+	[[Category: Brown D]]
-	[[Category: Burns-Kurtis~~, C L~~]]	+	[[Category: Burns-Kurtis CL]]
-	[[Category: Campbell, M]]	+	[[Category: Campbell M]]
-	[[Category: Chan, C]]	+	[[Category: Chan C]]
-	[[Category: Chaudry, L]]	+	[[Category: Chaudry L]]
-	[[Category: Clarte, M]]	+	[[Category: Clarte M]]
-	[[Category: Convery~~, M A~~]]	+	[[Category: Convery MA]]
-	[[Category: Harling~~, J D~~]]	+	[[Category: Harling JD]]
-	[[Category: Hortense, E]]	+	[[Category: Hortense E]]
-	[[Category: Irvine, S]]	+	[[Category: Irvine S]]
-	[[Category: Irving~~, W R~~]]	+	[[Category: Irving WR]]
-	[[Category: Kleanthous, S]]	+	[[Category: Kleanthous S]]
-	[[Category: Pateman~~, A J~~]]	+	[[Category: Pateman AJ]]
-	[[Category: Patikis, A]]	+	[[Category: Patikis A]]
-	[[Category: Pinto~~, I L~~]]	+	[[Category: Pinto IL]]
-	[[Category: Pollard~~, D R~~]]	+	[[Category: Pollard DR]]
-	[[Category: Roethka~~, T J~~]]	+	[[Category: Roethka TJ]]
-	[[Category: Senger, S]]	+	[[Category: Senger S]]
-	[[Category: Shah~~, G P~~]]	+	[[Category: Shah GP]]
-	[[Category: Stelman~~, G J~~]]	+	[[Category: Stelman GJ]]
-	[[Category: Toomey~~, J R~~]]	+	[[Category: Toomey JR]]
-	[[Category: Watson~~, N S~~]]	+	[[Category: Watson NS]]
-	[[Category: Whittaker, C]]	+	[[Category: Whittaker C]]
-	[[Category: Young~~, R J~~]]	+	[[Category: Young RJ]]
-	[[Category: Zhou, P]]	+	[[Category: Zhou P]]
-	~~[[Category: Blood clotting]]~~	+
-	~~[[Category: Blood coagulation]]~~	+
-	~~[[Category: Egf-like domain]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydroxylation]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Zymogen~~]]	+

OCA at 16:46, 3 November 2021

OCA — Wed, 03 Nov 2021 16:46:37 GMT

OCA at 06:12, 16 October 2019

OCA — Wed, 16 Oct 2019 06:12:20 GMT

←Older revision		Revision as of 06:12, 16 October 2019
Line 1:		Line 1:

	==Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs==		==Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs==
-	<StructureSection load='2wyg' size='340' side='right' caption='[[2wyg]], [[Resolution\|resolution]] 1.88Å' scene=''>	+	<StructureSection load='2wyg' size='340' side='right'caption='[[2wyg]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WYG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WYG FirstGlance]. <br>
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	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Borthwick, A D]]		[[Category: Borthwick, A D]]
	[[Category: Brown, D]]		[[Category: Brown, D]]

OCA at 09:54, 3 October 2018

OCA — Wed, 03 Oct 2018 09:54:29 GMT

←Older revision		Revision as of 09:54, 3 October 2018
Line 1:		Line 1:

-	==~~STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS~~: ~~PYRROLIDIN~~-2-~~ONES WITH MONOARYL~~ P4 ~~MOTIFS~~==	+	==Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs==
	<StructureSection load='2wyg' size='340' side='right' caption='[[2wyg]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='2wyg' size='340' side='right' caption='[[2wyg]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 16:49, 4 August 2016

OCA — Thu, 04 Aug 2016 16:49:31 GMT

←Older revision		Revision as of 16:49, 4 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH MONOARYL P4 MOTIFS==		==STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH MONOARYL P4 MOTIFS==
	<StructureSection load='2wyg' size='340' side='right' caption='[[2wyg]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='2wyg' size='340' side='right' caption='[[2wyg]], [[Resolution\|resolution]] 1.88Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2j34\|2j34]], [[1wu1\|1wu1]], [[2bq7\|2bq7]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2gd4\|2gd4]], [[2vvv\|2vvv]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[1z6e\|1z6e]], [[2jkh\|2jkh]], [[2uwp\|2uwp]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[1mq5\|1mq5]], [[2bmg\|2bmg]], [[1iqn\|1iqn]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2cji\|2cji]], [[2j95\|2j95]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[1iqk\|1iqk]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[1iql\|1iql]], [[1ksn\|1ksn]], [[2wyj\|2wyj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2j34\|2j34]], [[1wu1\|1wu1]], [[2bq7\|2bq7]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2gd4\|2gd4]], [[2vvv\|2vvv]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[1z6e\|1z6e]], [[2jkh\|2jkh]], [[2uwp\|2uwp]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[1mq5\|1mq5]], [[2bmg\|2bmg]], [[1iqn\|1iqn]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2cji\|2cji]], [[2j95\|2j95]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[1iqk\|1iqk]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[1iql\|1iql]], [[1ksn\|1ksn]], [[2wyj\|2wyj]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wyg RCSB], [http://www.ebi.ac.uk/pdbsum/2wyg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wyg OCA], [http://pdbe.org/2wyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wyg RCSB], [http://www.ebi.ac.uk/pdbsum/2wyg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wyg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wyg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 12:59, 18 December 2014

OCA — Thu, 18 Dec 2014 12:59:04 GMT

←Older revision		Revision as of 12:59, 18 December 2014
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-	~~{{STRUCTURE_2wyg\| PDB=2wyg \| SCENE= }}~~	+	==STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH MONOARYL P4 MOTIFS==
-	===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH MONOARYL P4 MOTIFS===	+	<StructureSection load='2wyg' size='340' side='right' caption='[[2wyg]], [[Resolution\|resolution]] 1.88Å' scene=''>
-	{~~{ABSTRACT_PUBMED_20006499}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WYG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=461:(E)-2-(5-CHLOROTHIOPHEN-2-YL)-N-[(3S)-1-{4-[(1R)-1-(DIMETHYLAMINO)ETHYL]-2-FLUOROPHENYL}-2-OXOPYRROLIDIN-3-YL]ETHENESULFONAMIDE'>461</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2j34\|2j34]], [[1wu1\|1wu1]], [[2bq7\|2bq7]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2gd4\|2gd4]], [[2vvv\|2vvv]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[1z6e\|1z6e]], [[2jkh\|2jkh]], [[2uwp\|2uwp]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[1mq5\|1mq5]], [[2bmg\|2bmg]], [[1iqn\|1iqn]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2cji\|2cji]], [[2j95\|2j95]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[1iqk\|1iqk]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[1iql\|1iql]], [[1ksn\|1ksn]], [[2wyj\|2wyj]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wyg RCSB], [http://www.ebi.ac.uk/pdbsum/2wyg PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa inhibitors, incorporating neutral and basic monoaryl P4 groups, ultimately producing potent inhibitors with effective levels of anticoagulant activity and extended oral pharmacokinetic profiles. However, time dependant inhibition of Cytochrome P450 3A4 was a particular issue with this series.

-	~~==Disease==~~	+	Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs.,Kleanthous S, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chaudry L, Chan C, Clarte MO, Convery MA, Harling JD, Hortense E, Irving WR, Irvine S, Pateman AJ, Patikis AN, Pinto IL, Pollard DR, Roethka TJ, Senger S, Shah GP, Stelman GJ, Toomey JR, Watson NS, West RI, Whittaker C, Zhou P, Young RJ Bioorg Med Chem Lett. 2010 Jan 15;20(2):618-22. Epub 2009 Nov 20. PMID:20006499<ref>PMID:20006499</ref>
-	~~[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause~~ of factor ~~X deficiency (FA10D) [MIM~~:~~[http://omim.org/entry/227600 227600]]. A hemorrhagic disease~~ with ~~variable presentation~~. ~~Affected individuals can manifest prolonged nasal and mucosal hemorrhage~~, ~~menorrhagia~~, ~~hematuria~~, ~~and occasionally hemarthrosis~~. ~~Some patients do not have clinical bleeding diathesis~~.~~<ref>~~PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:~~19135706~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence~~ of ~~factor Va, calcium and phospholipid during blood clotting~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[2wyg]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA].~~	+

	==See Also==		==See Also==
	*[[Factor Xa\|Factor Xa]]		*[[Factor Xa\|Factor Xa]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020006499</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Borthwick, A D.]]	+	[[Category: Borthwick, A D]]
-	[[Category: Brown, D.]]	+	[[Category: Brown, D]]
-	[[Category: Burns-Kurtis, C L.]]	+	[[Category: Burns-Kurtis, C L]]
-	[[Category: Campbell, M.]]	+	[[Category: Campbell, M]]
-	[[Category: Chan, C.]]	+	[[Category: Chan, C]]
-	[[Category: Chaudry, L.]]	+	[[Category: Chaudry, L]]
-	[[Category: Clarte, M.]]	+	[[Category: Clarte, M]]
-	[[Category: Convery, M A.]]	+	[[Category: Convery, M A]]
-	[[Category: Harling, J D.]]	+	[[Category: Harling, J D]]
-	[[Category: Hortense, E.]]	+	[[Category: Hortense, E]]
-	[[Category: Irvine, S.]]	+	[[Category: Irvine, S]]
-	[[Category: Irving, W R.]]	+	[[Category: Irving, W R]]
-	[[Category: Kleanthous, S.]]	+	[[Category: Kleanthous, S]]
-	[[Category: Pateman, A J.]]	+	[[Category: Pateman, A J]]
-	[[Category: Patikis, A.]]	+	[[Category: Patikis, A]]
-	[[Category: Pinto, I L.]]	+	[[Category: Pinto, I L]]
-	[[Category: Pollard, D R.]]	+	[[Category: Pollard, D R]]
-	[[Category: Roethka, T J.]]	+	[[Category: Roethka, T J]]
-	[[Category: Senger, S.]]	+	[[Category: Senger, S]]
-	[[Category: Shah, G P.]]	+	[[Category: Shah, G P]]
-	[[Category: Stelman, G J.]]	+	[[Category: Stelman, G J]]
-	[[Category: Toomey, J R.]]	+	[[Category: Toomey, J R]]
-	[[Category: Watson, N S.]]	+	[[Category: Watson, N S]]
-	[[Category: Whittaker, C.]]	+	[[Category: Whittaker, C]]
-	[[Category: Young, R J.]]	+	[[Category: Young, R J]]
-	[[Category: Zhou, P.]]	+	[[Category: Zhou, P]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]
	[[Category: Blood coagulation]]		[[Category: Blood coagulation]]

OCA at 22:39, 24 March 2013

OCA — Sun, 24 Mar 2013 22:39:05 GMT

←Older revision		Revision as of 22:39, 24 March 2013
Line 1:		Line 1:
-	[[Image:2wyg.png\|left\|200px]]
-
	{{STRUCTURE_2wyg\| PDB=2wyg \| SCENE= }}		{{STRUCTURE_2wyg\| PDB=2wyg \| SCENE= }}
-
	===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH MONOARYL P4 MOTIFS===		===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH MONOARYL P4 MOTIFS===
		+	{{ABSTRACT_PUBMED_20006499}}

-	~~{{ABSTRACT_PUBMED_20006499}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref><ref>PMID:1973167</ref><ref>PMID:1985698</ref><ref>PMID:7669671</ref><ref>PMID:8529633</ref><ref>PMID:7860069</ref><ref>PMID:8845463</ref><ref>PMID:8910490</ref><ref>PMID:10468877</ref><ref>PMID:10746568</ref><ref>PMID:10739379</ref><ref>PMID:11248282</ref><ref>PMID:11728527</ref><ref>PMID:12945883</ref><ref>PMID:15650540</ref><ref>PMID:17393015</ref><ref>PMID:19135706</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020006499</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020006499</ref><references group="xtra"/><references/>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 07:25, 20 October 2012

OCA — Sat, 20 Oct 2012 07:25:59 GMT

←Older revision		Revision as of 07:25, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wyg]] is a 2 chain structure ~~of [[Factor Xa]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA].	+	[[2wyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA].

	==See Also==		==See Also==

OCA: Protected "2wyg" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 16:17:33 GMT

Protected "2wyg" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:17, 25 July 2012

OCA at 16:17, 25 July 2012

OCA — Wed, 25 Jul 2012 16:17:32 GMT

←Older revision		Revision as of 16:17, 25 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2wyg.png\|left\|200px]]
-	[[Image:2wyg.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wyg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wyg\| PDB=2wyg \| SCENE= }}		{{STRUCTURE_2wyg\| PDB=2wyg \| SCENE= }}

	===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH MONOARYL P4 MOTIFS===		===STRUCTURE AND PROPERTY BASED DESIGN OF FACTOR XA INHIBITORS: PYRROLIDIN-2-ONES WITH MONOARYL P4 MOTIFS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20006499}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20006499 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20006499}}		{{ABSTRACT_PUBMED_20006499}}

	==About this Structure==		==About this Structure==
-	~~2WYG~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA].	+	[[2wyg]] is a 2 chain structure of [[Factor Xa]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA].
		+
		+	==See Also==
		+	*[[Factor Xa\|Factor Xa]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20006499~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020006499</ref><references group="xtra"/>
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 59:		Line 50:
	[[Category: Serine protease]]		[[Category: Serine protease]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:26:42 2010''

←Older revision		Revision as of 16:46, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='2wyg' size='340' side='right'caption='[[2wyg]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='2wyg' size='340' side='right'caption='[[2wyg]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wyg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WYG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WYG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=461:(E)-2-(5-CHLOROTHIOPHEN-2-YL)-N-[(3S)-1-{4-[(1R)-1-(DIMETHYLAMINO)ETHYL]-2-FLUOROPHENYL}-2-OXOPYRROLIDIN-3-YL]ETHENESULFONAMIDE'>461</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=461:(E)-2-(5-CHLOROTHIOPHEN-2-YL)-N-[(3S)-1-{4-[(1R)-1-(DIMETHYLAMINO)ETHYL]-2-FLUOROPHENYL}-2-OXOPYRROLIDIN-3-YL]ETHENESULFONAMIDE'>461</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2j34\|2j34]], [[1wu1\|1wu1]], [[2bq7\|2bq7]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2gd4\|2gd4]], [[2vvv\|2vvv]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[1z6e\|1z6e]], [[2jkh\|2jkh]], [[2uwp\|2uwp]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[1mq5\|1mq5]], [[2bmg\|2bmg]], [[1iqn\|1iqn]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2cji\|2cji]], [[2j95\|2j95]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[1iqk\|1iqk]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[1iql\|1iql]], [[1ksn\|1ksn]], [[2wyj\|2wyj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2j34\|2j34]], [[1wu1\|1wu1]], [[2bq7\|2bq7]], [[2w3k\|2w3k]], [[2vwo\|2vwo]], [[1xka\|1xka]], [[1nfw\|1nfw]], [[2gd4\|2gd4]], [[2vvv\|2vvv]], [[1lpg\|1lpg]], [[1msx\|1msx]], [[2vvu\|2vvu]], [[1p0s\|1p0s]], [[2g00\|2g00]], [[1mq6\|1mq6]], [[1xkb\|1xkb]], [[1iqe\|1iqe]], [[1g2m\|1g2m]], [[2vh0\|2vh0]], [[1nfy\|1nfy]], [[2uwl\|2uwl]], [[2bok\|2bok]], [[1hcg\|1hcg]], [[1lpz\|1lpz]], [[2w3i\|2w3i]], [[1z6e\|1z6e]], [[2jkh\|2jkh]], [[2uwp\|2uwp]], [[1g2l\|1g2l]], [[1nfu\|1nfu]], [[1fax\|1fax]], [[2bq6\|2bq6]], [[1iqf\|1iqf]], [[1nl8\|1nl8]], [[1iqg\|1iqg]], [[1iqh\|1iqh]], [[1lqd\|1lqd]], [[2uwo\|2uwo]], [[1c5m\|1c5m]], [[1ioe\|1ioe]], [[1f0s\|1f0s]], [[1f0r\|1f0r]], [[1mq5\|1mq5]], [[2bmg\|2bmg]], [[1iqn\|1iqn]], [[2bqw\|2bqw]], [[1iqm\|1iqm]], [[1ezq\|1ezq]], [[2vwl\|2vwl]], [[2vh6\|2vh6]], [[1fjs\|1fjs]], [[1lpk\|1lpk]], [[2j4i\|2j4i]], [[1nfx\|1nfx]], [[2vwn\|2vwn]], [[1iqj\|1iqj]], [[2j94\|2j94]], [[2cji\|2cji]], [[2j95\|2j95]], [[2j38\|2j38]], [[2boh\|2boh]], [[2vvc\|2vvc]], [[2w26\|2w26]], [[1iqi\|1iqi]], [[2vwm\|2vwm]], [[1kye\|1kye]], [[1iqk\|1iqk]], [[1v3x\|1v3x]], [[2fzz\|2fzz]], [[2j2u\|2j2u]], [[1iql\|1iql]], [[1ksn\|1ksn]], [[2wyj\|2wyj]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wyg OCA], [~~http~~://pdbe.org/2wyg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wyg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wyg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wyg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wyg OCA], [https://pdbe.org/2wyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wyg RCSB], [https://www.ebi.ac.uk/pdbsum/2wyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wyg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[~~http~~://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>	+	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.	+	[[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==