2wzl - Revision history

OCA at 10:20, 20 December 2023

OCA — Wed, 20 Dec 2023 10:20:31 GMT

←Older revision		Revision as of 10:20, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2wzl' size='340' side='right'caption='[[2wzl]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2wzl' size='340' side='right'caption='[[2wzl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mokv Mokv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mokola_lyssavirus Mokola lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [https://pdbe.org/2wzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [https://www.ebi.ac.uk/pdbsum/2wzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [https://pdbe.org/2wzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [https://www.ebi.ac.uk/pdbsum/2wzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PHOSP_MOKV PHOSP_MOKV]] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity).	+	[https://www.uniprot.org/uniprot/PHOSP_MOKV PHOSP_MOKV] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mokv~~]]	+	[[Category: Mokola lyssavirus]]
-	[[Category: Assenberg, R]]	+	[[Category: Assenberg R]]
-	[[Category: Bourhy, H]]	+	[[Category: Bourhy H]]
-	[[Category: Delmas, O]]	+	[[Category: Delmas O]]
-	[[Category: Graham, S]]	+	[[Category: Graham S]]
-	[[Category: Grimes, J]]	+	[[Category: Grimes J]]
-	[[Category: Larrous, F]]	+	[[Category: Larrous F]]
-	[[Category: Ren, J]]	+	[[Category: Ren J]]
-	[[Category: Tangy, F]]	+	[[Category: Tangy F]]
-	[[Category: Verma, A]]	+	[[Category: Verma A]]
-	[[Category: Vidalain, P]]	+	[[Category: Vidalain P]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Nucleoprotein]]~~	+
-	~~[[Category: Rabies]]~~	+
-	~~[[Category: Rna replication]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Virion~~]]	+

OCA at 10:43, 13 April 2022

OCA — Wed, 13 Apr 2022 10:43:11 GMT

←Older revision		Revision as of 10:43, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='2wzl' size='340' side='right'caption='[[2wzl]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2wzl' size='340' side='right'caption='[[2wzl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mokv Mokv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mokv Mokv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [~~http~~://pdbe.org/2wzl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wzl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [https://pdbe.org/2wzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [https://www.ebi.ac.uk/pdbsum/2wzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PHOSP_MOKV PHOSP_MOKV]] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity).	+	[[https://www.uniprot.org/uniprot/PHOSP_MOKV PHOSP_MOKV]] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:01, 8 July 2020

OCA — Wed, 08 Jul 2020 15:01:20 GMT

←Older revision		Revision as of 15:01, 8 July 2020
Line 1:		Line 1:

	==The Structure of the N-RNA Binding Domain of the Mokola virus Phosphoprotein==		==The Structure of the N-RNA Binding Domain of the Mokola virus Phosphoprotein==
-	<StructureSection load='2wzl' size='340' side='right' caption='[[2wzl]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2wzl' size='340' side='right'caption='[[2wzl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokv Mokv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokv Mokv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WZL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [http://pdbe.org/2wzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [http://www.ebi.ac.uk/pdbsum/2wzl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [http://pdbe.org/2wzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [http://www.ebi.ac.uk/pdbsum/2wzl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mokv]]		[[Category: Mokv]]
	[[Category: Assenberg, R]]		[[Category: Assenberg, R]]

OCA at 09:18, 3 October 2018

OCA — Wed, 03 Oct 2018 09:18:50 GMT

←Older revision		Revision as of 09:18, 3 October 2018
Line 1:		Line 1:

-	==~~THE STRUCTURE OF THE~~ N-RNA ~~BINDING DOMAIN OF THE MOKOLA VIRUS PHOSPHOPROTEIN~~==	+	==The Structure of the N-RNA Binding Domain of the Mokola virus Phosphoprotein==
	<StructureSection load='2wzl' size='340' side='right' caption='[[2wzl]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2wzl' size='340' side='right' caption='[[2wzl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/2wzl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/2wzl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:40, 5 August 2016

OCA — Fri, 05 Aug 2016 14:40:58 GMT

←Older revision		Revision as of 14:40, 5 August 2016
Line 1:		Line 1:
		+
	==THE STRUCTURE OF THE N-RNA BINDING DOMAIN OF THE MOKOLA VIRUS PHOSPHOPROTEIN==		==THE STRUCTURE OF THE N-RNA BINDING DOMAIN OF THE MOKOLA VIRUS PHOSPHOPROTEIN==
	<StructureSection load='2wzl' size='340' side='right' caption='[[2wzl]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2wzl' size='340' side='right' caption='[[2wzl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mokola_virus Mokola virus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokv Mokv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [http://www.ebi.ac.uk/pdbsum/2wzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [http://pdbe.org/2wzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [http://www.ebi.ac.uk/pdbsum/2wzl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wzl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wzl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mokola virus~~]]	+	[[Category: Mokv]]
	[[Category: Assenberg, R]]		[[Category: Assenberg, R]]
	[[Category: Bourhy, H]]		[[Category: Bourhy, H]]

OCA at 19:38, 25 December 2014

OCA — Thu, 25 Dec 2014 19:38:55 GMT

←Older revision		Revision as of 19:38, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokola_virus Mokola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokola_virus Mokola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [http://www.ebi.ac.uk/pdbsum/2wzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [http://www.ebi.ac.uk/pdbsum/2wzl PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PHOSP_MOKV PHOSP_MOKV]] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Mokola virus]]		[[Category: Mokola virus]]
-	[[Category: Assenberg, R.]]	+	[[Category: Assenberg, R]]
-	[[Category: Bourhy, H.]]	+	[[Category: Bourhy, H]]
-	[[Category: Delmas, O.]]	+	[[Category: Delmas, O]]
-	[[Category: Graham, S.]]	+	[[Category: Graham, S]]
-	[[Category: Grimes, J.]]	+	[[Category: Grimes, J]]
-	[[Category: Larrous, F.]]	+	[[Category: Larrous, F]]
-	[[Category: Ren, J.]]	+	[[Category: Ren, J]]
-	[[Category: Tangy, F.]]	+	[[Category: Tangy, F]]
-	[[Category: Verma, A.]]	+	[[Category: Verma, A]]
-	[[Category: Vidalain, P.]]	+	[[Category: Vidalain, P]]
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Nucleoprotein]]		[[Category: Nucleoprotein]]

OCA at 01:56, 1 October 2014

OCA — Wed, 01 Oct 2014 01:56:19 GMT

←Older revision		Revision as of 01:56, 1 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2wzl.~~png\|left~~\|200px]]	+	==THE STRUCTURE OF THE N-RNA BINDING DOMAIN OF THE MOKOLA VIRUS PHOSPHOPROTEIN==
		+	<StructureSection load='2wzl' size='340' side='right' caption='[[2wzl]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokola_virus Mokola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzl RCSB], [http://www.ebi.ac.uk/pdbsum/2wzl PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/2wzl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mokola virus (MOKV) is a nonsegmented, negative-sense RNA virus that belongs to the Lyssavirus genus and Rhabdoviridae family. MOKV phosphoprotein P is an essential component of the replication and transcription complex and acts as a cofactor for the viral RNA-dependent RNA polymerase. P recruits the viral polymerase to the nucleoprotein-bound viral RNA (N-RNA) via an interaction between its C-terminal domain and the N-RNA complex. Here we present a structure for this domain of MOKV P, obtained by expression of full-length P in Escherichia coli, which was subsequently truncated during crystallization. The structure has a high degree of homology with P of rabies virus, another member of Lyssavirus genus, and to a lesser degree with P of vesicular stomatitis virus (VSV), a member of the related Vesiculovirus genus. In addition, analysis of the crystal packing of this domain reveals a potential binding site for the nucleoprotein N. Using both site-directed mutagenesis and yeast two-hybrid experiments to measure P-N interaction, we have determined the relative roles of key amino acids involved in this interaction to map the region of P that binds N. This analysis also reveals a structural relationship between the N-RNA binding domain of the P proteins of the Rhabdoviridae and the Paramyxoviridae.

-	~~{{STRUCTURE_2wzl\| PDB=2wzl \| SCENE= }}~~	+	Structure of the nucleoprotein binding domain of Mokola virus phosphoprotein.,Assenberg R, Delmas O, Ren J, Vidalain PO, Verma A, Larrous F, Graham SC, Tangy F, Grimes JM, Bourhy H J Virol. 2010 Jan;84(2):1089-96. Epub 2009 Nov 11. PMID:19906936<ref>PMID:19906936</ref>

-	~~===THE STRUCTURE OF THE N-RNA BINDING DOMAIN OF THE MOKOLA VIRUS PHOSPHOPROTEIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19906936}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2wzl]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mokola_virus Mokola virus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019906936<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mokola virus]]		[[Category: Mokola virus]]
	[[Category: Assenberg, R.]]		[[Category: Assenberg, R.]]

OCA: Protected "2wzl" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:39:33 GMT

Protected "2wzl" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:39, 7 January 2013

OCA at 18:39, 7 January 2013

OCA — Mon, 07 Jan 2013 18:39:29 GMT

←Older revision		Revision as of 18:39, 7 January 2013
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-	{{Seed}}
	[[Image:2wzl.png\|left\|200px]]		[[Image:2wzl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wzl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wzl\| PDB=2wzl \| SCENE= }}		{{STRUCTURE_2wzl\| PDB=2wzl \| SCENE= }}

	===THE STRUCTURE OF THE N-RNA BINDING DOMAIN OF THE MOKOLA VIRUS PHOSPHOPROTEIN===		===THE STRUCTURE OF THE N-RNA BINDING DOMAIN OF THE MOKOLA VIRUS PHOSPHOPROTEIN===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19906936}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19906936 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19906936}}		{{ABSTRACT_PUBMED_19906936}}

	==About this Structure==		==About this Structure==
-	~~2WZL~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokola_virus Mokola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA].	+	[[2wzl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokola_virus Mokola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19906936~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019906936</ref><references group="xtra"/>
	[[Category: Mokola virus]]		[[Category: Mokola virus]]
	[[Category: Assenberg, R.]]		[[Category: Assenberg, R.]]
Line 41:		Line 29:
	[[Category: Viral protein]]		[[Category: Viral protein]]
	[[Category: Virion]]		[[Category: Virion]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 08:55:33 2010''

OCA at 06:55, 3 February 2010

OCA — Wed, 03 Feb 2010 06:55:34 GMT

←Older revision		Revision as of 06:55, 3 February 2010
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2WZL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mokola_virus Mokola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA].	+	2WZL is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mokola_virus Mokola virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZL OCA].

	==Reference==		==Reference==
Line 37:		Line 37:
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Nucleoprotein]]		[[Category: Nucleoprotein]]
-	[[Category: Phosphoprotein]]
	[[Category: Rabies]]		[[Category: Rabies]]
	[[Category: Rna replication]]		[[Category: Rna replication]]
Line 43:		Line 42:
	[[Category: Virion]]		[[Category: Virion]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 13 13:~~08:12 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 3 08:55:33 2010''