2wzt - Revision history

OCA at 10:20, 20 December 2023

OCA — Wed, 20 Dec 2023 10:20:41 GMT

←Older revision		Revision as of 10:20, 20 December 2023
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	<StructureSection load='2wzt' size='340' side='right'caption='[[2wzt]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2wzt' size='340' side='right'caption='[[2wzt]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mycs2 Mycs2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZT FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2wzm\|2wzm]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Morphine_6~~-~~dehydrogenase Morphine 6-dehydrogenase]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~1.~~1.1.218 1.1.1.218] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzt OCA], [https://pdbe.org/2wzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wzt RCSB], [https://www.ebi.ac.uk/pdbsum/2wzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzt OCA], [https://pdbe.org/2wzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wzt RCSB], [https://www.ebi.ac.uk/pdbsum/2wzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzt ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Y2407_MYCS2 Y2407_MYCS2]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Morphine 6-dehydrogenase]]~~	+	[[Category: Mycolicibacterium smegmatis MC2 155]]
-	~~[[Category: Mycs2~~]]	+	[[Category: Beddoe T]]
-	[[Category: Beddoe, T]]	+	[[Category: Brammananth R]]
-	[[Category: Brammananth, R]]	+	[[Category: Byres E]]
-	[[Category: Byres, E]]	+	[[Category: Coppel RL]]
-	[[Category: Coppel~~, R L~~]]	+	[[Category: Crellin PK]]
-	[[Category: Crellin~~, P K~~]]	+	[[Category: Fulton Z]]
-	[[Category: Fulton, Z]]	+	[[Category: Le Nours J]]
-	[[Category: ~~McAlister, A D~~]]	+	[[Category: McAlister AD]]
-	[[Category: ~~Nours, J Le~~]]	+	[[Category: Rossjohn J]]
-	[[Category: Rossjohn, J]]	+	[[Category: Scoble J]]
-	[[Category: Scoble, J]]	+	[[Category: Troy S]]
-	[[Category: Troy, S]]	+	[[Category: Vivian JP]]
-	[[Category: Vivian~~, J P~~]]	+	[[Category: Wilce MCJ]]
-	[[Category: Wilce~~, M C.J~~]]	+	[[Category: Zaker-Tabrizi L]]
-	[[Category: Zaker-Tabrizi, L]]	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 10:43, 13 April 2022

OCA — Wed, 13 Apr 2022 10:43:23 GMT

←Older revision		Revision as of 10:43, 13 April 2022
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	<StructureSection load='2wzt' size='340' side='right'caption='[[2wzt]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2wzt' size='340' side='right'caption='[[2wzt]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wzt]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WZT FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wzm\|2wzm]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wzm\|2wzm]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Morphine_6-dehydrogenase Morphine 6-dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.218 1.1.1.218] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Morphine_6-dehydrogenase Morphine 6-dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.218 1.1.1.218] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzt OCA], [~~http~~://pdbe.org/2wzt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wzt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wzt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzt OCA], [https://pdbe.org/2wzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wzt RCSB], [https://www.ebi.ac.uk/pdbsum/2wzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 15:01, 8 July 2020

OCA — Wed, 08 Jul 2020 15:01:36 GMT

←Older revision		Revision as of 15:01, 8 July 2020
Line 1:		Line 1:

	==Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form==		==Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form==
-	<StructureSection load='2wzt' size='340' side='right' caption='[[2wzt]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2wzt' size='340' side='right'caption='[[2wzt]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WZT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wzm\|2wzm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wzm\|2wzm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Morphine_6-dehydrogenase Morphine 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.218 1.1.1.218] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Morphine_6-dehydrogenase Morphine 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.218 1.1.1.218] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzt OCA], [http://pdbe.org/2wzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wzt RCSB], [http://www.ebi.ac.uk/pdbsum/2wzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzt OCA], [http://pdbe.org/2wzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wzt RCSB], [http://www.ebi.ac.uk/pdbsum/2wzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Aldo-keto reductase\|Aldo-keto reductase]]	+	*[[Aldo-keto reductase 3D structures\|Aldo-keto reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Morphine 6-dehydrogenase]]		[[Category: Morphine 6-dehydrogenase]]
	[[Category: Mycs2]]		[[Category: Mycs2]]

OCA at 09:34, 3 October 2018

OCA — Wed, 03 Oct 2018 09:34:26 GMT

←Older revision		Revision as of 09:34, 3 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF A MYCOBACTERIUM ALDO~~-~~KETO REDUCTASE IN ITS APO AND LIGANDED FORM~~==	+	==Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form==
	<StructureSection load='2wzt' size='340' side='right' caption='[[2wzt]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2wzt' size='340' side='right' caption='[[2wzt]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/2wzt_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/2wzt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2wzt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wzt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aldo-keto reductase\|Aldo-keto reductase]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 42:
	[[Category: Crellin, P K]]		[[Category: Crellin, P K]]
	[[Category: Fulton, Z]]		[[Category: Fulton, Z]]
-	[[Category: ~~Mcalister~~, A D]]	+	[[Category: McAlister, A D]]
	[[Category: Nours, J Le]]		[[Category: Nours, J Le]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]

OCA at 21:03, 11 August 2016

OCA — Thu, 11 Aug 2016 21:03:42 GMT

←Older revision		Revision as of 21:03, 11 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF A MYCOBACTERIUM ALDO-KETO REDUCTASE IN ITS APO AND LIGANDED FORM==		==CRYSTAL STRUCTURE OF A MYCOBACTERIUM ALDO-KETO REDUCTASE IN ITS APO AND LIGANDED FORM==
	<StructureSection load='2wzt' size='340' side='right' caption='[[2wzt]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2wzt' size='340' side='right' caption='[[2wzt]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_smegmatis Mycobacterium smegmatis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wzm\|2wzm]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wzm\|2wzm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Morphine_6-dehydrogenase Morphine 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.218 1.1.1.218] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Morphine_6-dehydrogenase Morphine 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.218 1.1.1.218] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzt RCSB], [http://www.ebi.ac.uk/pdbsum/2wzt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzt OCA], [http://pdbe.org/2wzt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wzt RCSB], [http://www.ebi.ac.uk/pdbsum/2wzt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wzt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wzt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wzt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Morphine 6-dehydrogenase]]		[[Category: Morphine 6-dehydrogenase]]
-	[[Category: ~~Mycobacterium smegmatis~~]]	+	[[Category: Mycs2]]
	[[Category: Beddoe, T]]		[[Category: Beddoe, T]]
	[[Category: Brammananth, R]]		[[Category: Brammananth, R]]

OCA at 11:34, 20 January 2015

OCA — Tue, 20 Jan 2015 11:34:03 GMT

←Older revision		Revision as of 11:34, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wzm\|2wzm]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wzm\|2wzm]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Morphine_6-dehydrogenase Morphine 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.218 1.1.1.218] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Morphine_6-dehydrogenase Morphine 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.218 1.1.1.218] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzt RCSB], [http://www.ebi.ac.uk/pdbsum/2wzt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzt RCSB], [http://www.ebi.ac.uk/pdbsum/2wzt PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	[[Category: Morphine 6-dehydrogenase]]		[[Category: Morphine 6-dehydrogenase]]
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]
-	[[Category: Beddoe, T.]]	+	[[Category: Beddoe, T]]
-	[[Category: Brammananth, R.]]	+	[[Category: Brammananth, R]]
-	[[Category: Byres, E.]]	+	[[Category: Byres, E]]
-	[[Category: Coppel, R L.]]	+	[[Category: Coppel, R L]]
-	[[Category: Crellin, P K.]]	+	[[Category: Crellin, P K]]
-	[[Category: Fulton, Z.]]	+	[[Category: Fulton, Z]]
-	[[Category: Mcalister, A D.]]	+	[[Category: Mcalister, A D]]
-	[[Category: Nours, J Le.]]	+	[[Category: Nours, J Le]]
-	[[Category: Rossjohn, J.]]	+	[[Category: Rossjohn, J]]
-	[[Category: Scoble, J.]]	+	[[Category: Scoble, J]]
-	[[Category: Troy, S.]]	+	[[Category: Troy, S]]
-	[[Category: Vivian, J P.]]	+	[[Category: Vivian, J P]]
-	[[Category: Wilce, M C.J.]]	+	[[Category: Wilce, M C.J]]
-	[[Category: Zaker-Tabrizi, L.]]	+	[[Category: Zaker-Tabrizi, L]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 02:06, 1 October 2014

OCA — Wed, 01 Oct 2014 02:06:54 GMT

←Older revision		Revision as of 02:06, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2wzt.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF A MYCOBACTERIUM ALDO-KETO REDUCTASE IN ITS APO AND LIGANDED FORM==
		+	<StructureSection load='2wzt' size='340' side='right' caption='[[2wzt]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WZT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wzm\|2wzm]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Morphine_6-dehydrogenase Morphine 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.218 1.1.1.218] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wzt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wzt RCSB], [http://www.ebi.ac.uk/pdbsum/2wzt PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wz/2wzt_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aldo-keto reductases (AKRs) are a large superfamily of NADPH-dependent enzymes that catalyze the reduction of aldehydes, aldoses, dicarbonyls, steroids, and monosaccharides. While their precise physiological role is generally unknown, AKRs are nevertheless involved in the detoxification of a broad range of toxic metabolites. Mycobacteria contain a number of AKRs, the majority of which are uncharacterised. Here, we report the 1.9 and 1.6 A resolution structures of the apoenzyme and NADPH-bound forms, respectively, of an AKR (MSMEG_2407) from Mycobacterium smegmatis, a close homologue of the M. tuberculosis enzyme Rv2971, whose function is essential to this bacterium. MSMEG_2407 adopted the triosephosphate isomerase (alpha/beta)(8)-barrel fold exhibited by other AKRs. MSMEG_2407 (AKR5H1) bound NADPH via an induced-fit mechanism, in which the NADPH was ligated in an extended fashion. Polar-mediated interactions dominated the interactions with the cofactor, which is atypical of the mode of NADPH binding within the AKR family. Moreover, the nicotinamide ring of NADPH was disordered, and this was attributed to the lack of an "AKR-conserved" bulky residue within the nicotinamide-binding cavity of MSMEG_2407. Enzymatic characterisation of MSMEG_2407 and Rv2971 identified dicarbonyls as a preferred substrate family for hydrolysis, and the frontline antituberculosis drug isoniazid (INH) was shown to inhibit the enzyme activity of both recombinant MSMEG_2407 and Rv2971. However, differences between the affinities of MSMEG_2407 and Rv2971 for dicarbonyls and INH were observed, and this was attributable to amino acid substitutions within the cofactor- and substrate-binding sites. The structures of MSMEG_2407 and the accompanying biochemical characterisation of MSMEG_2407 and Rv2971 provide insight into the structure and function of AKRs from mycobacteria.

-	~~{{STRUCTURE_2wzt\| PDB=2wzt \| SCENE= }}~~	+	Crystal structure and comparative functional analyses of a Mycobacterium aldo-keto reductase.,Scoble J, McAlister AD, Fulton Z, Troy S, Byres E, Vivian JP, Brammananth R, Wilce MC, Le Nours J, Zaker-Tabrizi L, Coppel RL, Crellin PK, Rossjohn J, Beddoe T J Mol Biol. 2010 Apr 23;398(1):26-39. Epub 2010 Feb 25. PMID:20188740<ref>PMID:20188740</ref>

-	~~===CRYSTAL STRUCTURE OF A MYCOBACTERIUM ALDO-KETO REDUCTASE IN ITS APO AND LIGANDED FORM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20188740}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2wzt]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020188740<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Morphine 6-dehydrogenase]]		[[Category: Morphine 6-dehydrogenase]]
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]

OCA: Protected "2wzt" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 23:04:07 GMT

Protected "2wzt" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:04, 7 January 2013

OCA at 23:04, 7 January 2013

OCA — Mon, 07 Jan 2013 23:04:03 GMT

←Older revision		Revision as of 23:04, 7 January 2013
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-	{{Seed}}
	[[Image:2wzt.png\|left\|200px]]		[[Image:2wzt.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wzt", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wzt\| PDB=2wzt \| SCENE= }}		{{STRUCTURE_2wzt\| PDB=2wzt \| SCENE= }}

	===CRYSTAL STRUCTURE OF A MYCOBACTERIUM ALDO-KETO REDUCTASE IN ITS APO AND LIGANDED FORM===		===CRYSTAL STRUCTURE OF A MYCOBACTERIUM ALDO-KETO REDUCTASE IN ITS APO AND LIGANDED FORM===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20188740}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20188740 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20188740}}		{{ABSTRACT_PUBMED_20188740}}

	==About this Structure==		==About this Structure==
-	~~2WZT~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA].	+	[[2wzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20188740~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020188740</ref><references group="xtra"/>
	[[Category: Morphine 6-dehydrogenase]]		[[Category: Morphine 6-dehydrogenase]]
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]
Line 41:		Line 29:
	[[Category: Zaker-Tabrizi, L.]]		[[Category: Zaker-Tabrizi, L.]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 08:59:16 2010''

OCA at 06:59, 17 March 2010

OCA — Wed, 17 Mar 2010 06:59:17 GMT

←Older revision		Revision as of 06:59, 17 March 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2wzt.~~jpg~~\|left\|200px]]	+	[[Image:2wzt.png\|left\|200px]]

	<!--		<!--
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	===CRYSTAL STRUCTURE OF A MYCOBACTERIUM ALDO-KETO REDUCTASE IN ITS APO AND LIGANDED FORM===		===CRYSTAL STRUCTURE OF A MYCOBACTERIUM ALDO-KETO REDUCTASE IN ITS APO AND LIGANDED FORM===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20188740}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20188740 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20188740}}

	==About this Structure==		==About this Structure==
	2WZT is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA].		2WZT is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WZT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20188740</ref><references group="xtra"/>
	[[Category: Morphine 6-dehydrogenase]]		[[Category: Morphine 6-dehydrogenase]]
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]
Line 33:		Line 42:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb~~ 17 10:41:07 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 08:59:16 2010''