2x0c - Revision history

OCA at 06:06, 2 March 2023

OCA — Thu, 02 Mar 2023 06:06:43 GMT

←Older revision		Revision as of 06:06, 2 March 2023
Line 1:		Line 1:

-	==~~STRUCTURE OF THE TALIN ROD RESIDUES 1359-1659~~==	+	==Crystal Structure of the R7R8 domains of Talin==
	<StructureSection load='2x0c' size='340' side='right'caption='[[2x0c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2x0c' size='340' side='right'caption='[[2x0c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x0c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X0C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x0c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X0C FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1y19\|1y19]], [[1u89\|1u89]], [[1t01\|1t01]], [[2b0h\|2b0h]], [[2g35\|2g35]], [[1zw3\|1zw3]], [[1sj8\|1sj8]], [[1sj7\|1sj7]]</div></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0c OCA], [https://pdbe.org/2x0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x0c RCSB], [https://www.ebi.ac.uk/pdbsum/2x0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x0c ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0c OCA], [https://pdbe.org/2x0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x0c RCSB], [https://www.ebi.ac.uk/pdbsum/2x0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x0c ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.	+	[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Barsukov~~, I L~~]]	+	[[Category: Barsukov IL]]
-	[[Category: Bate, N]]	+	[[Category: Bate N]]
-	[[Category: Critchely~~, D R~~]]	+	[[Category: Critchely DR]]
-	[[Category: Emsley, J]]	+	[[Category: Emsley J]]
-	[[Category: Gingras~~, A R~~]]	+	[[Category: Gingras AR]]
-	[[Category: Goult~~, B T]]~~	+	[[Category: Goult BT]]
-	~~[[Category: Actin]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Cell projection]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Integrin]]~~	+
-	~~[[Category: Synemin]]~~	+
-	~~[[Category: Vinculin~~]]	+

OCA at 10:43, 13 April 2022

OCA — Wed, 13 Apr 2022 10:43:48 GMT

←Older revision		Revision as of 10:43, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='2x0c' size='340' side='right'caption='[[2x0c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2x0c' size='340' side='right'caption='[[2x0c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x0c]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2X0C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x0c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X0C FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y19\|1y19]], [[1u89\|1u89]], [[1t01\|1t01]], [[2b0h\|2b0h]], [[2g35\|2g35]], [[1zw3\|1zw3]], [[1sj8\|1sj8]], [[1sj7\|1sj7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1y19\|1y19]], [[1u89\|1u89]], [[1t01\|1t01]], [[2b0h\|2b0h]], [[2g35\|2g35]], [[1zw3\|1zw3]], [[1sj8\|1sj8]], [[1sj7\|1sj7]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2x0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0c OCA], [~~http~~://pdbe.org/2x0c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x0c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x0c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x0c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0c OCA], [https://pdbe.org/2x0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x0c RCSB], [https://www.ebi.ac.uk/pdbsum/2x0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x0c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.	+	[[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:02, 8 July 2020

OCA — Wed, 08 Jul 2020 15:02:11 GMT

←Older revision		Revision as of 15:02, 8 July 2020
Line 1:		Line 1:

	==STRUCTURE OF THE TALIN ROD RESIDUES 1359-1659==		==STRUCTURE OF THE TALIN ROD RESIDUES 1359-1659==
-	<StructureSection load='2x0c' size='340' side='right' caption='[[2x0c]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2x0c' size='340' side='right'caption='[[2x0c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x0c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X0C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x0c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X0C FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y19\|1y19]], [[1u89\|1u89]], [[1t01\|1t01]], [[2b0h\|2b0h]], [[2g35\|2g35]], [[1zw3\|1zw3]], [[1sj8\|1sj8]], [[1sj7\|1sj7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y19\|1y19]], [[1u89\|1u89]], [[1t01\|1t01]], [[2b0h\|2b0h]], [[2g35\|2g35]], [[1zw3\|1zw3]], [[1sj8\|1sj8]], [[1sj7\|1sj7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0c OCA], [http://pdbe.org/2x0c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x0c RCSB], [http://www.ebi.ac.uk/pdbsum/2x0c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x0c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0c OCA], [http://pdbe.org/2x0c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x0c RCSB], [http://www.ebi.ac.uk/pdbsum/2x0c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x0c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Barsukov, I L]]		[[Category: Barsukov, I L]]

OCA at 09:41, 3 October 2018

OCA — Wed, 03 Oct 2018 09:41:51 GMT

←Older revision		Revision as of 09:41, 3 October 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x0/2x0c_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x0/2x0c_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:51, 5 August 2016

OCA — Fri, 05 Aug 2016 08:51:40 GMT

←Older revision		Revision as of 08:51, 5 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF THE TALIN ROD RESIDUES 1359-1659==		==STRUCTURE OF THE TALIN ROD RESIDUES 1359-1659==
	<StructureSection load='2x0c' size='340' side='right' caption='[[2x0c]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2x0c' size='340' side='right' caption='[[2x0c]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x0c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X0C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x0c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X0C FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y19\|1y19]], [[1u89\|1u89]], [[1t01\|1t01]], [[2b0h\|2b0h]], [[2g35\|2g35]], [[1zw3\|1zw3]], [[1sj8\|1sj8]], [[1sj7\|1sj7]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y19\|1y19]], [[1u89\|1u89]], [[1t01\|1t01]], [[2b0h\|2b0h]], [[2g35\|2g35]], [[1zw3\|1zw3]], [[1sj8\|1sj8]], [[1sj7\|1sj7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x0c RCSB], [http://www.ebi.ac.uk/pdbsum/2x0c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0c OCA], [http://pdbe.org/2x0c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x0c RCSB], [http://www.ebi.ac.uk/pdbsum/2x0c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x0c ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x0c ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x0c" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Barsukov, I L]]		[[Category: Barsukov, I L]]
	[[Category: Bate, N]]		[[Category: Bate, N]]

OCA at 00:56, 25 December 2014

OCA — Thu, 25 Dec 2014 00:56:05 GMT

←Older revision		Revision as of 00:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x0c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X0C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x0c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X0C FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y19\|1y19]], [[1u89\|1u89]], [[1t01\|1t01]], [[2b0h\|2b0h]], [[2g35\|2g35]], [[1zw3\|1zw3]], [[1sj8\|1sj8]], [[1sj7\|1sj7]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y19\|1y19]], [[1u89\|1u89]], [[1t01\|1t01]], [[2b0h\|2b0h]], [[2g35\|2g35]], [[1zw3\|1zw3]], [[1sj8\|1sj8]], [[1sj7\|1sj7]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x0c RCSB], [http://www.ebi.ac.uk/pdbsum/2x0c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x0c RCSB], [http://www.ebi.ac.uk/pdbsum/2x0c PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Barsukov, I L.]]	+	[[Category: Barsukov, I L]]
-	[[Category: Bate, N.]]	+	[[Category: Bate, N]]
-	[[Category: Critchely, D R.]]	+	[[Category: Critchely, D R]]
-	[[Category: Emsley, J.]]	+	[[Category: Emsley, J]]
-	[[Category: Gingras, A R.]]	+	[[Category: Gingras, A R]]
-	[[Category: Goult, B T.]]	+	[[Category: Goult, B T]]
	[[Category: Actin]]		[[Category: Actin]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 00:58, 2 October 2014

OCA — Thu, 02 Oct 2014 00:58:55 GMT

←Older revision		Revision as of 00:58, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2x0c.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF THE TALIN ROD RESIDUES 1359-1659==
		+	<StructureSection load='2x0c' size='340' side='right' caption='[[2x0c]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x0c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X0C FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y19\|1y19]], [[1u89\|1u89]], [[1t01\|1t01]], [[2b0h\|2b0h]], [[2g35\|2g35]], [[1zw3\|1zw3]], [[1sj8\|1sj8]], [[1sj7\|1sj7]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x0c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x0c RCSB], [http://www.ebi.ac.uk/pdbsum/2x0c PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x0/2x0c_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Talin is an adaptor protein that couples integrins to F-actin. Structural studies show that the N-terminal talin head contains an atypical FERM domain while the N- and C-terminal parts of the talin rod comprise a series of alpha-helical bundles. However, determining the structure of the central part of the rod has proved problematic. Residues 1359-1659 are homologous to the MESDc1 gene product, and we therefore expressed this region of talin in E. coli. The crystal structure shows a unique fold comprised of a 5- and 4-helix bundle. The 5-helix bundle is composed of non-sequential helices due to insertion of the 4-helix bundle into the loop at the C-terminus of helix alpha3. The linker connecting the bundles forms a two-stranded anti-parallel beta-sheet likely limiting the relative movement of the two bundles. Because the 5-helix bundle contains the N- and C-termini of this module, we propose that it is linked by short loops to adjacent bundles while the 4-helix bundle protrudes from the rod. This suggests the 4-helix bundle has a unique role, and its pI (7.8) is higher than other rod domains. Both helical bundles contain vinculin-binding sites, but that in the isolated 5-helix bundle is cryptic whereas that in the isolated 4-helix bundle is constitutively active. In contrast, both bundles are required for actin binding. Finally, we show that the MESDc1 protein, which is predicted to have a similar fold, is a novel actin binding protein.

-	~~{{STRUCTURE_2x0c\| PDB=2x0c \| SCENE= }}~~	+	The central region of talin has a unique fold that binds vinculin and actin.,Gingras AR, Bate N, Goult BT, Patel B, Kopp PM, Emsley J, Barsukov IL, Roberts GC, Critchley DR J Biol Chem. 2010 Jul 7. PMID:20610383<ref>PMID:20610383</ref>

-	~~===STRUCTURE OF THE TALIN ROD RESIDUES 1359-1659===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20610383}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2x0c]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA].~~	+

	==See Also==		==See Also==
	*[[Talin\|Talin]]		*[[Talin\|Talin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020610383<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Barsukov, I L.]]		[[Category: Barsukov, I L.]]

OCA at 10:52, 20 October 2012

OCA — Sat, 20 Oct 2012 10:52:31 GMT

←Older revision		Revision as of 10:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x0c]] is a 1 chain structure ~~of [[Talin]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA].	+	[[2x0c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0C OCA].

	==See Also==		==See Also==

OCA at 03:32, 26 July 2012

OCA — Thu, 26 Jul 2012 03:32:24 GMT

←Older revision		Revision as of 03:32, 26 July 2012
Line 1:		Line 1:
	[[Image:2x0c.png\|left\|200px]]		[[Image:2x0c.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2x0c", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2x0c\| PDB=2x0c \| SCENE= }}		{{STRUCTURE_2x0c\| PDB=2x0c \| SCENE= }}

	===STRUCTURE OF THE TALIN ROD RESIDUES 1359-1659===		===STRUCTURE OF THE TALIN ROD RESIDUES 1359-1659===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20610383}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20610383 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20610383}}		{{ABSTRACT_PUBMED_20610383}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Talin]]	+	*[[Talin\|Talin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20610383~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020610383</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Barsukov, I L.]]		[[Category: Barsukov, I L.]]

OCA: Protected "2x0c" [edit=sysop:move=sysop]

OCA — Mon, 27 Dec 2010 00:27:26 GMT

Protected "2x0c" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:27, 27 December 2010