2x1t - Revision history

OCA at 10:22, 20 December 2023

OCA — Wed, 20 Dec 2023 10:22:13 GMT

←Older revision		Revision as of 10:22, 20 December 2023
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	<StructureSection load='2x1t' size='340' side='right'caption='[[2x1t]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='2x1t' size='340' side='right'caption='[[2x1t]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x1t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trybb Trybb~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x1t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X1T FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=RES:4~~-~~PHOSPHO-D-ERYTHRONOHYDROXAMIC+ACID'>RES</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.83Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v2c\|2v2c]], [[1kv5\|1kv5]], [[1iih\|1iih]], [[6tim\|6tim]], [[2wsr\|2wsr]], [[3tim\|3tim]], [[2x16\|2x16]], [[1iig\|1iig]], [[2v2h\|2v2h]], [[1dkw\|1dkw]], [[1ttj\|1ttj]], [[2vem\|2vem]], [[2v5l\|2v5l]], [[4tim\|4tim]], [[2vei\|2vei]], [[5tim\|5tim]], [[1tsi\|1tsi]], [[1mss\|1mss]], [[2wsq\|2wsq]], [[2j27\|2j27]], [[1tpf\|1tpf]], [[1tpe\|1tpe]], [[1tpd\|1tpd]], [[2vek\|2vek]], [[2vel\|2vel]], [[2v0t\|2v0t]], [[1trd\|1trd]], [[1ml1\|1ml1]], [[2j24\|2j24]], [[1tri\|1tri]], [[1ag1\|1ag1]], [[1mtm\|1mtm]], [[2v2d\|2v2d]], [[2ven\|2ven]], [[1tti\|1tti]], [[2x1u\|2x1u]], [[2x1r\|2x1r]], [[2x1s\|2x1s]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RES:4-PHOSPHO-D-ERYTHRONOHYDROXAMIC+ACID'>RES</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Triose~~-~~phosphate_isomerase Triose~~-~~phosphate isomerase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1t OCA], [https://pdbe.org/2x1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x1t RCSB], [https://www.ebi.ac.uk/pdbsum/2x1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1t OCA], [https://pdbe.org/2x1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x1t RCSB], [https://www.ebi.ac.uk/pdbsum/2x1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1t ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TPIS_TRYBB TPIS_TRYBB]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Triose-phosphate isomerase]]~~	+	[[Category: Trypanosoma brucei brucei]]
-	~~[[Category: Trybb~~]]	+	[[Category: Casteleijn MG]]
-	[[Category: Casteleijn~~, M G~~]]	+	[[Category: Kapetaniou EG]]
-	[[Category: Kapetaniou~~, E G~~]]	+	[[Category: Lajunen M]]
-	[[Category: Lajunen, M]]	+	[[Category: Neubauer P]]
-	[[Category: Neubauer, P]]	+	[[Category: Salin M]]
-	[[Category: Salin, M]]	+	[[Category: Salmon L]]
-	[[Category: Salmon, L]]	+	[[Category: Vaismaa M]]
-	[[Category: Vaismaa, M]]	+	[[Category: Wierenga R]]
-	[[Category: Wierenga, R]]	+
-	~~[[Category: Fatty acid biosynthesis]]~~	+
-	~~[[Category: Gluconeogenesis]]~~	+
-	~~[[Category: Glycolysis]]~~	+
-	~~[[Category: Glycosome]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Lipid synthesis~~]]	+

OCA at 16:47, 3 November 2021

OCA — Wed, 03 Nov 2021 16:47:58 GMT

←Older revision		Revision as of 16:47, 3 November 2021
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	<StructureSection load='2x1t' size='340' side='right'caption='[[2x1t]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='2x1t' size='340' side='right'caption='[[2x1t]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x1t]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x1t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X1T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RES:4-PHOSPHO-D-ERYTHRONOHYDROXAMIC+ACID'>RES</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RES:4-PHOSPHO-D-ERYTHRONOHYDROXAMIC+ACID'>RES</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2c\|2v2c]], [[1kv5\|1kv5]], [[1iih\|1iih]], [[6tim\|6tim]], [[2wsr\|2wsr]], [[3tim\|3tim]], [[2x16\|2x16]], [[1iig\|1iig]], [[2v2h\|2v2h]], [[1dkw\|1dkw]], [[1ttj\|1ttj]], [[2vem\|2vem]], [[2v5l\|2v5l]], [[4tim\|4tim]], [[2vei\|2vei]], [[5tim\|5tim]], [[1tsi\|1tsi]], [[1mss\|1mss]], [[2wsq\|2wsq]], [[2j27\|2j27]], [[1tpf\|1tpf]], [[1tpe\|1tpe]], [[1tpd\|1tpd]], [[2vek\|2vek]], [[2vel\|2vel]], [[2v0t\|2v0t]], [[1trd\|1trd]], [[1ml1\|1ml1]], [[2j24\|2j24]], [[1tri\|1tri]], [[1ag1\|1ag1]], [[1mtm\|1mtm]], [[2v2d\|2v2d]], [[2ven\|2ven]], [[1tti\|1tti]], [[2x1u\|2x1u]], [[2x1r\|2x1r]], [[2x1s\|2x1s]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v2c\|2v2c]], [[1kv5\|1kv5]], [[1iih\|1iih]], [[6tim\|6tim]], [[2wsr\|2wsr]], [[3tim\|3tim]], [[2x16\|2x16]], [[1iig\|1iig]], [[2v2h\|2v2h]], [[1dkw\|1dkw]], [[1ttj\|1ttj]], [[2vem\|2vem]], [[2v5l\|2v5l]], [[4tim\|4tim]], [[2vei\|2vei]], [[5tim\|5tim]], [[1tsi\|1tsi]], [[1mss\|1mss]], [[2wsq\|2wsq]], [[2j27\|2j27]], [[1tpf\|1tpf]], [[1tpe\|1tpe]], [[1tpd\|1tpd]], [[2vek\|2vek]], [[2vel\|2vel]], [[2v0t\|2v0t]], [[1trd\|1trd]], [[1ml1\|1ml1]], [[2j24\|2j24]], [[1tri\|1tri]], [[1ag1\|1ag1]], [[1mtm\|1mtm]], [[2v2d\|2v2d]], [[2ven\|2ven]], [[1tti\|1tti]], [[2x1u\|2x1u]], [[2x1r\|2x1r]], [[2x1s\|2x1s]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1t OCA], [~~http~~://pdbe.org/2x1t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x1t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x1t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1t OCA], [https://pdbe.org/2x1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x1t RCSB], [https://www.ebi.ac.uk/pdbsum/2x1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1t ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[Triose ~~Phosphate Isomerase~~\|Triose ~~Phosphate Isomerase~~]]	+	*[[Triose phosphate isomerase 3D structures\|Triose phosphate isomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:45, 24 July 2019

OCA — Wed, 24 Jul 2019 07:45:11 GMT

←Older revision		Revision as of 07:45, 24 July 2019
Line 1:		Line 1:

	==Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase==		==Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase==
-	<StructureSection load='2x1t' size='340' side='right' caption='[[2x1t]], [[Resolution\|resolution]] 1.83Å' scene=''>	+	<StructureSection load='2x1t' size='340' side='right'caption='[[2x1t]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1T FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1T FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Trybb]]		[[Category: Trybb]]

OCA at 09:04, 3 October 2018

OCA — Wed, 03 Oct 2018 09:04:06 GMT

←Older revision		Revision as of 09:04, 3 October 2018
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		+
	==Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase==		==Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase==
	<StructureSection load='2x1t' size='340' side='right' caption='[[2x1t]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='2x1t' size='340' side='right' caption='[[2x1t]], [[Resolution\|resolution]] 1.83Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2c\|2v2c]], [[1kv5\|1kv5]], [[1iih\|1iih]], [[6tim\|6tim]], [[2wsr\|2wsr]], [[3tim\|3tim]], [[2x16\|2x16]], [[1iig\|1iig]], [[2v2h\|2v2h]], [[1dkw\|1dkw]], [[1ttj\|1ttj]], [[2vem\|2vem]], [[2v5l\|2v5l]], [[4tim\|4tim]], [[2vei\|2vei]], [[5tim\|5tim]], [[1tsi\|1tsi]], [[1mss\|1mss]], [[2wsq\|2wsq]], [[2j27\|2j27]], [[1tpf\|1tpf]], [[1tpe\|1tpe]], [[1tpd\|1tpd]], [[2vek\|2vek]], [[2vel\|2vel]], [[2v0t\|2v0t]], [[1trd\|1trd]], [[1ml1\|1ml1]], [[2j24\|2j24]], [[1tri\|1tri]], [[1ag1\|1ag1]], [[1mtm\|1mtm]], [[2v2d\|2v2d]], [[2ven\|2ven]], [[1tti\|1tti]], [[2x1u\|2x1u]], [[2x1r\|2x1r]], [[2x1s\|2x1s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2c\|2v2c]], [[1kv5\|1kv5]], [[1iih\|1iih]], [[6tim\|6tim]], [[2wsr\|2wsr]], [[3tim\|3tim]], [[2x16\|2x16]], [[1iig\|1iig]], [[2v2h\|2v2h]], [[1dkw\|1dkw]], [[1ttj\|1ttj]], [[2vem\|2vem]], [[2v5l\|2v5l]], [[4tim\|4tim]], [[2vei\|2vei]], [[5tim\|5tim]], [[1tsi\|1tsi]], [[1mss\|1mss]], [[2wsq\|2wsq]], [[2j27\|2j27]], [[1tpf\|1tpf]], [[1tpe\|1tpe]], [[1tpd\|1tpd]], [[2vek\|2vek]], [[2vel\|2vel]], [[2v0t\|2v0t]], [[1trd\|1trd]], [[1ml1\|1ml1]], [[2j24\|2j24]], [[1tri\|1tri]], [[1ag1\|1ag1]], [[1mtm\|1mtm]], [[2v2d\|2v2d]], [[2ven\|2ven]], [[1tti\|1tti]], [[2x1u\|2x1u]], [[2x1r\|2x1r]], [[2x1s\|2x1s]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1t OCA], [http://pdbe.org/2x1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x1t RCSB], [http://www.ebi.ac.uk/pdbsum/2x1t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1t OCA], [http://pdbe.org/2x1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x1t RCSB], [http://www.ebi.ac.uk/pdbsum/2x1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1t ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x1/2x1t_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x1/2x1t_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:01, 7 February 2016

OCA — Sun, 07 Feb 2016 20:01:43 GMT

←Older revision		Revision as of 20:01, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2x1t' size='340' side='right' caption='[[2x1t]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='2x1t' size='340' side='right' caption='[[2x1t]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_brucei_brucei Trypanosoma brucei brucei~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RES:4-PHOSPHO-D-ERYTHRONOHYDROXAMIC+ACID'>RES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RES:4-PHOSPHO-D-ERYTHRONOHYDROXAMIC+ACID'>RES</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2c\|2v2c]], [[1kv5\|1kv5]], [[1iih\|1iih]], [[6tim\|6tim]], [[2wsr\|2wsr]], [[3tim\|3tim]], [[2x16\|2x16]], [[1iig\|1iig]], [[2v2h\|2v2h]], [[1dkw\|1dkw]], [[1ttj\|1ttj]], [[2vem\|2vem]], [[2v5l\|2v5l]], [[4tim\|4tim]], [[2vei\|2vei]], [[5tim\|5tim]], [[1tsi\|1tsi]], [[1mss\|1mss]], [[2wsq\|2wsq]], [[2j27\|2j27]], [[1tpf\|1tpf]], [[1tpe\|1tpe]], [[1tpd\|1tpd]], [[2vek\|2vek]], [[2vel\|2vel]], [[2v0t\|2v0t]], [[1trd\|1trd]], [[1ml1\|1ml1]], [[2j24\|2j24]], [[1tri\|1tri]], [[1ag1\|1ag1]], [[1mtm\|1mtm]], [[2v2d\|2v2d]], [[2ven\|2ven]], [[1tti\|1tti]], [[2x1u\|2x1u]], [[2x1r\|2x1r]], [[2x1s\|2x1s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2c\|2v2c]], [[1kv5\|1kv5]], [[1iih\|1iih]], [[6tim\|6tim]], [[2wsr\|2wsr]], [[3tim\|3tim]], [[2x16\|2x16]], [[1iig\|1iig]], [[2v2h\|2v2h]], [[1dkw\|1dkw]], [[1ttj\|1ttj]], [[2vem\|2vem]], [[2v5l\|2v5l]], [[4tim\|4tim]], [[2vei\|2vei]], [[5tim\|5tim]], [[1tsi\|1tsi]], [[1mss\|1mss]], [[2wsq\|2wsq]], [[2j27\|2j27]], [[1tpf\|1tpf]], [[1tpe\|1tpe]], [[1tpd\|1tpd]], [[2vek\|2vek]], [[2vel\|2vel]], [[2v0t\|2v0t]], [[1trd\|1trd]], [[1ml1\|1ml1]], [[2j24\|2j24]], [[1tri\|1tri]], [[1ag1\|1ag1]], [[1mtm\|1mtm]], [[2v2d\|2v2d]], [[2ven\|2ven]], [[1tti\|1tti]], [[2x1u\|2x1u]], [[2x1r\|2x1r]], [[2x1s\|2x1s]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x1t RCSB], [http://www.ebi.ac.uk/pdbsum/2x1t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1t OCA], [http://pdbe.org/2x1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x1t RCSB], [http://www.ebi.ac.uk/pdbsum/2x1t PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x1t ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x1t" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
-	[[Category: ~~Trypanosoma brucei brucei~~]]	+	[[Category: Trybb]]
	[[Category: Casteleijn, M G]]		[[Category: Casteleijn, M G]]
	[[Category: Kapetaniou, E G]]		[[Category: Kapetaniou, E G]]

OCA at 08:49, 20 January 2015

OCA — Tue, 20 Jan 2015 08:49:53 GMT

←Older revision		Revision as of 08:49, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1T FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1T FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RES:4-PHOSPHO-D-ERYTHRONOHYDROXAMIC+ACID'>RES</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RES:4-PHOSPHO-D-ERYTHRONOHYDROXAMIC+ACID'>RES</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2c\|2v2c]], [[1kv5\|1kv5]], [[1iih\|1iih]], [[6tim\|6tim]], [[2wsr\|2wsr]], [[3tim\|3tim]], [[2x16\|2x16]], [[1iig\|1iig]], [[2v2h\|2v2h]], [[1dkw\|1dkw]], [[1ttj\|1ttj]], [[2vem\|2vem]], [[2v5l\|2v5l]], [[4tim\|4tim]], [[2vei\|2vei]], [[5tim\|5tim]], [[1tsi\|1tsi]], [[1mss\|1mss]], [[2wsq\|2wsq]], [[2j27\|2j27]], [[1tpf\|1tpf]], [[1tpe\|1tpe]], [[1tpd\|1tpd]], [[2vek\|2vek]], [[2vel\|2vel]], [[2v0t\|2v0t]], [[1trd\|1trd]], [[1ml1\|1ml1]], [[2j24\|2j24]], [[1tri\|1tri]], [[1ag1\|1ag1]], [[1mtm\|1mtm]], [[2v2d\|2v2d]], [[2ven\|2ven]], [[1tti\|1tti]], [[2x1u\|2x1u]], [[2x1r\|2x1r]], [[2x1s\|2x1s]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2c\|2v2c]], [[1kv5\|1kv5]], [[1iih\|1iih]], [[6tim\|6tim]], [[2wsr\|2wsr]], [[3tim\|3tim]], [[2x16\|2x16]], [[1iig\|1iig]], [[2v2h\|2v2h]], [[1dkw\|1dkw]], [[1ttj\|1ttj]], [[2vem\|2vem]], [[2v5l\|2v5l]], [[4tim\|4tim]], [[2vei\|2vei]], [[5tim\|5tim]], [[1tsi\|1tsi]], [[1mss\|1mss]], [[2wsq\|2wsq]], [[2j27\|2j27]], [[1tpf\|1tpf]], [[1tpe\|1tpe]], [[1tpd\|1tpd]], [[2vek\|2vek]], [[2vel\|2vel]], [[2v0t\|2v0t]], [[1trd\|1trd]], [[1ml1\|1ml1]], [[2j24\|2j24]], [[1tri\|1tri]], [[1ag1\|1ag1]], [[1mtm\|1mtm]], [[2v2d\|2v2d]], [[2ven\|2ven]], [[1tti\|1tti]], [[2x1u\|2x1u]], [[2x1r\|2x1r]], [[2x1s\|2x1s]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x1t RCSB], [http://www.ebi.ac.uk/pdbsum/2x1t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x1t RCSB], [http://www.ebi.ac.uk/pdbsum/2x1t PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Trypanosoma brucei brucei]]		[[Category: Trypanosoma brucei brucei]]
-	[[Category: Casteleijn, M G.]]	+	[[Category: Casteleijn, M G]]
-	[[Category: Kapetaniou, E G.]]	+	[[Category: Kapetaniou, E G]]
-	[[Category: Lajunen, M.]]	+	[[Category: Lajunen, M]]
-	[[Category: Neubauer, P.]]	+	[[Category: Neubauer, P]]
-	[[Category: Salin, M.]]	+	[[Category: Salin, M]]
-	[[Category: Salmon, L.]]	+	[[Category: Salmon, L]]
-	[[Category: Vaismaa, M.]]	+	[[Category: Vaismaa, M]]
-	[[Category: Wierenga, R.]]	+	[[Category: Wierenga, R]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]
	[[Category: Gluconeogenesis]]		[[Category: Gluconeogenesis]]

OCA at 01:47, 1 October 2014

OCA — Wed, 01 Oct 2014 01:47:29 GMT

←Older revision		Revision as of 01:47, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2x1t\| PDB=2x1t \| SCENE= }}~~	+	==Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase==
-	===Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase===	+	<StructureSection load='2x1t' size='340' side='right' caption='[[2x1t]], [[Resolution\|resolution]] 1.83Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20693693}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1T FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RES:4-PHOSPHO-D-ERYTHRONOHYDROXAMIC+ACID'>RES</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2c\|2v2c]], [[1kv5\|1kv5]], [[1iih\|1iih]], [[6tim\|6tim]], [[2wsr\|2wsr]], [[3tim\|3tim]], [[2x16\|2x16]], [[1iig\|1iig]], [[2v2h\|2v2h]], [[1dkw\|1dkw]], [[1ttj\|1ttj]], [[2vem\|2vem]], [[2v5l\|2v5l]], [[4tim\|4tim]], [[2vei\|2vei]], [[5tim\|5tim]], [[1tsi\|1tsi]], [[1mss\|1mss]], [[2wsq\|2wsq]], [[2j27\|2j27]], [[1tpf\|1tpf]], [[1tpe\|1tpe]], [[1tpd\|1tpd]], [[2vek\|2vek]], [[2vel\|2vel]], [[2v0t\|2v0t]], [[1trd\|1trd]], [[1ml1\|1ml1]], [[2j24\|2j24]], [[1tri\|1tri]], [[1ag1\|1ag1]], [[1mtm\|1mtm]], [[2v2d\|2v2d]], [[2ven\|2ven]], [[1tti\|1tti]], [[2x1u\|2x1u]], [[2x1r\|2x1r]], [[2x1s\|2x1s]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x1t RCSB], [http://www.ebi.ac.uk/pdbsum/2x1t PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x1/2x1t_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Crystallographic binding studies have been carried out to probe the active-site binding properties of a monomeric variant (A-TIM) of triosephosphate isomerase (TIM). These binding studies are part of a structure-based directed-evolution project aimed towards changing the substrate specificity of monomeric TIM and are therefore aimed at finding binders which are substrate-like molecules. A-TIM has a modified more extended binding pocket between loop-7 and loop-8 compared with wild-type TIM. The A-TIM crystals were grown in the presence of citrate, which is bound in the active site of each of the two molecules in the asymmetric unit. In this complex, the active-site loops loop-6 and loop-7 adopt the closed conformation, similar to that observed in liganded wild-type TIM. Extensive crystal-soaking protocols have been developed to flush the bound citrate out of the active-site pocket of both molecules and the crystal structure shows that the unliganded open conformation of the A-TIM active site is the same as in unliganded wild-type TIM. It is also shown that sulfonate compounds corresponding to the transition-state analogue 2-phosphoglycolate bind in the active site, which has a closed conformation. It is also shown that the new binding pocket of A-TIM can bind 3-phosphoglycerate (3PGA; an analogue of a C4-sugar phosphate) and 4-phospho-D-erythronohydroxamic acid (4PEH; an analogue of a C5-sugar phosphate). Therefore, these studies have provided a rationale for starting directed-evolution experiments aimed at generating the catalytic properties of a C5-sugar phosphate isomerase on the A-TIM framework.

-	~~==About this Structure==~~	+	Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase.,Salin M, Kapetaniou EG, Vaismaa M, Lajunen M, Casteleijn MG, Neubauer P, Salmon L, Wierenga RK Acta Crystallogr D Biol Crystallogr. 2010 Aug;66(Pt 8):934-44. Epub 2010, Jul 14. PMID:20693693<ref>PMID:20693693</ref>
-	~~[[2x1t]] is a 2 chain structure~~ with ~~sequence from [http~~:~~//en~~.~~wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2X1T OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]		*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020693693<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Trypanosoma brucei brucei]]		[[Category: Trypanosoma brucei brucei]]

OCA at 09:39, 11 March 2013

OCA — Mon, 11 Mar 2013 09:39:55 GMT

←Older revision		Revision as of 09:39, 11 March 2013
Line 1:		Line 1:
-	[[Image:2x1t.png\|left\|200px]]
-
	{{STRUCTURE_2x1t\| PDB=2x1t \| SCENE= }}		{{STRUCTURE_2x1t\| PDB=2x1t \| SCENE= }}
-
	===Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase===		===Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase===
-
	{{ABSTRACT_PUBMED_20693693}}		{{ABSTRACT_PUBMED_20693693}}

OCA at 07:43, 20 October 2012

OCA — Sat, 20 Oct 2012 07:43:03 GMT

←Older revision		Revision as of 07:43, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x1t]] is a 2 chain structure ~~of [[Triose Phosphate Isomerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA].	+	[[2x1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA].

	==See Also==		==See Also==

OCA at 02:46, 29 August 2012

OCA — Wed, 29 Aug 2012 02:46:26 GMT

←Older revision		Revision as of 02:46, 29 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x1t]] is a 2 chain structure of ~~[[TIM test]] and~~ [[Triose Phosphate Isomerase]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA].	+	[[2x1t]] is a 2 chain structure of [[Triose Phosphate Isomerase]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1T OCA].

	==See Also==		==See Also==
-	*[[TIM test\|TIM test]]
	*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]		*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]