2x24 - Revision history

OCA at 12:44, 17 January 2024

OCA — Wed, 17 Jan 2024 12:44:43 GMT

←Older revision		Revision as of 12:44, 17 January 2024
Line 3:		Line 3:
	<StructureSection load='2x24' size='340' side='right'caption='[[2x24]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2x24' size='340' side='right'caption='[[2x24]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X24 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X24 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X24:TERT-BUTYL+[(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE'>X24</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X24:TERT-BUTYL+[(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE'>X24</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x24 OCA], [https://pdbe.org/2x24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x24 RCSB], [https://www.ebi.ac.uk/pdbsum/2x24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x24 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x24 OCA], [https://pdbe.org/2x24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x24 RCSB], [https://www.ebi.ac.uk/pdbsum/2x24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x24 ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blaho, S]]	+	[[Category: Blaho S]]
-	[[Category: Folmer, R]]	+	[[Category: Folmer R]]
-	[[Category: Hallberg, K]]	+	[[Category: Hallberg K]]
-	[[Category: Oster, L]]	+	[[Category: Oster L]]
-	[[Category: Wiberg, F]]	+	[[Category: Wiberg F]]
-	~~[[Category: Fatty acid biosynthesis]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Lipid synthesis~~]]	+

OCA at 10:44, 13 April 2022

OCA — Wed, 13 Apr 2022 10:44:46 GMT

←Older revision		Revision as of 10:44, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='2x24' size='340' side='right'caption='[[2x24]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2x24' size='340' side='right'caption='[[2x24]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x24]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2X24 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X24 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X24:TERT-BUTYL+[(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE'>X24</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X24:TERT-BUTYL+[(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE'>X24</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2x24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x24 OCA], [~~http~~://pdbe.org/2x24 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x24 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x24 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x24 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x24 OCA], [https://pdbe.org/2x24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x24 RCSB], [https://www.ebi.ac.uk/pdbsum/2x24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x24 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:03, 8 July 2020

OCA — Wed, 08 Jul 2020 15:03:37 GMT

←Older revision		Revision as of 15:03, 8 July 2020
Line 1:		Line 1:

	==bovine ACC2 CT domain in complex with inhibitor==		==bovine ACC2 CT domain in complex with inhibitor==
-	<StructureSection load='2x24' size='340' side='right' caption='[[2x24]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2x24' size='340' side='right'caption='[[2x24]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X24 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X24 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=X24:TERT-BUTYL+[(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE'>X24</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X24:TERT-BUTYL+[(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE'>X24</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x24 OCA], [http://pdbe.org/2x24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x24 RCSB], [http://www.ebi.ac.uk/pdbsum/2x24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x24 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x24 OCA], [http://pdbe.org/2x24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x24 RCSB], [http://www.ebi.ac.uk/pdbsum/2x24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x24 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[Acetyl-CoA carboxylase\|Acetyl-CoA carboxylase]]	+	*[[Acetyl-CoA carboxylase 3D structures\|Acetyl-CoA carboxylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Blaho, S]]		[[Category: Blaho, S]]
	[[Category: Folmer, R]]		[[Category: Folmer, R]]

OCA at 09:39, 3 October 2018

OCA — Wed, 03 Oct 2018 09:39:10 GMT

←Older revision		Revision as of 09:39, 3 October 2018
Line 1:		Line 1:

-	==~~BOVINE~~ ACC2 CT ~~DOMAIN IN COMPLEX WITH INHIBITOR~~==	+	==bovine ACC2 CT domain in complex with inhibitor==
	<StructureSection load='2x24' size='340' side='right' caption='[[2x24]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2x24' size='340' side='right' caption='[[2x24]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 09:17, 4 August 2016

OCA — Thu, 04 Aug 2016 09:17:23 GMT

←Older revision		Revision as of 09:17, 4 August 2016
Line 1:		Line 1:
		+
	==BOVINE ACC2 CT DOMAIN IN COMPLEX WITH INHIBITOR==		==BOVINE ACC2 CT DOMAIN IN COMPLEX WITH INHIBITOR==
	<StructureSection load='2x24' size='340' side='right' caption='[[2x24]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2x24' size='340' side='right' caption='[[2x24]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X24 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X24 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=X24:TERT-BUTYL+[(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE'>X24</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=X24:TERT-BUTYL+[(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE'>X24</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x24 RCSB], [http://www.ebi.ac.uk/pdbsum/2x24 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x24 OCA], [http://pdbe.org/2x24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x24 RCSB], [http://www.ebi.ac.uk/pdbsum/2x24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x24 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x24" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bos taurus~~]]	+	[[Category: Bovin]]
	[[Category: Blaho, S]]		[[Category: Blaho, S]]
	[[Category: Folmer, R]]		[[Category: Folmer, R]]

OCA at 23:10, 3 January 2015

OCA — Sat, 03 Jan 2015 23:10:46 GMT

←Older revision		Revision as of 23:10, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X24 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X24 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=X24:TERT-BUTYL+[(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE'>X24</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=X24:TERT-BUTYL+[(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE'>X24</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x24 RCSB], [http://www.ebi.ac.uk/pdbsum/2x24 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x24 RCSB], [http://www.ebi.ac.uk/pdbsum/2x24 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 12:		Line 12:
	Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.,Bengtsson C, Blaho S, Saitton DB, Brickmann K, Broddefalk J, Davidsson O, Drmota T, Folmer R, Hallberg K, Hallen S, Hovland R, Isin E, Johannesson P, Kull B, Larsson LO, Lofgren L, Nilsson KE, Noeske T, Oakes N, Plowright AT, Schnecke V, Stahlberg P, Sorme P, Wan H, Wellner E, Oster L Bioorg Med Chem. 2011 May 15;19(10):3039-53. Epub 2011 Apr 13. PMID:21515056<ref>PMID:21515056</ref>		Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.,Bengtsson C, Blaho S, Saitton DB, Brickmann K, Broddefalk J, Davidsson O, Drmota T, Folmer R, Hallberg K, Hallen S, Hovland R, Isin E, Johannesson P, Kull B, Larsson LO, Lofgren L, Nilsson KE, Noeske T, Oakes N, Plowright AT, Schnecke V, Stahlberg P, Sorme P, Wan H, Wellner E, Oster L Bioorg Med Chem. 2011 May 15;19(10):3039-53. Epub 2011 Apr 13. PMID:21515056<ref>PMID:21515056</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Acetyl-CoA carboxylase\|Acetyl-CoA carboxylase]]
	== References ==		== References ==
	<references/>		<references/>
Line 19:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Blaho, S.]]	+	[[Category: Blaho, S]]
-	[[Category: Folmer, R.]]	+	[[Category: Folmer, R]]
-	[[Category: Hallberg, K.]]	+	[[Category: Hallberg, K]]
-	[[Category: Oster, L.]]	+	[[Category: Oster, L]]
-	[[Category: Wiberg, F.]]	+	[[Category: Wiberg, F]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]
	[[Category: Ligase]]		[[Category: Ligase]]
	[[Category: Lipid synthesis]]		[[Category: Lipid synthesis]]

OCA at 11:07, 14 May 2014

OCA — Wed, 14 May 2014 11:07:10 GMT

←Older revision		Revision as of 11:07, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2x24.~~png~~\|~~left\|200px~~]]	+	==BOVINE ACC2 CT DOMAIN IN COMPLEX WITH INHIBITOR==
		+	<StructureSection load='2x24' size='340' side='right' caption='[[2x24]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X24 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=X24:TERT-BUTYL+[(TRANS-4-{[({2-[4-(AMINOMETHYL)PHENYL]QUINOLIN-4-YL}CARBONYL)AMINO]METHYL}CYCLOHEXYL)METHYL]CARBAMATE'>X24</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x24 RCSB], [http://www.ebi.ac.uk/pdbsum/2x24 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibition of acetyl-CoA carboxylases has the potential for modulating long chain fatty acid biosynthesis and mitochondrial fatty acid oxidation. Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series. Optimization led to compounds 33 and 37, which exhibit potent inhibition of human ACC2, 10-fold selectivity over inhibition of human ACC1, good physical and in vitro ADME properties and good bioavailability. X-ray crystallography has shown this series binding in the CT-domain of ACC2 and revealed two key hydrogen bonding interactions. Both 33 and 37 lower levels of hepatic malonyl-CoA in vivo in obese Zucker rats.

-	~~{{STRUCTURE_2x24\| PDB=2x24 \| SCENE= }}~~	+	Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.,Bengtsson C, Blaho S, Saitton DB, Brickmann K, Broddefalk J, Davidsson O, Drmota T, Folmer R, Hallberg K, Hallen S, Hovland R, Isin E, Johannesson P, Kull B, Larsson LO, Lofgren L, Nilsson KE, Noeske T, Oakes N, Plowright AT, Schnecke V, Stahlberg P, Sorme P, Wan H, Wellner E, Oster L Bioorg Med Chem. 2011 May 15;19(10):3039-53. Epub 2011 Apr 13. PMID:21515056<ref>PMID:21515056</ref>

-	~~===BOVINE ACC2 CT DOMAIN IN COMPLEX WITH INHIBITOR===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21515056}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2x24]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA].~~	+	</StructureSection>
-		+
-	==~~See Also==~~	+
-	*[[Acetyl-CoA carboxylase\|Acetyl-CoA carboxylase]]	+
-		+
-	~~==Reference~~==	+
-	<~~ref group="xtra">PMID:021515056<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Blaho, S.]]		[[Category: Blaho, S.]]

OCA at 05:41, 20 October 2012

OCA — Sat, 20 Oct 2012 05:41:29 GMT

←Older revision		Revision as of 05:41, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x24]] is a 2 chain structure ~~of [[Acetyl-CoA carboxylase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA].	+	[[2x24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA].

	==See Also==		==See Also==

OCA at 10:50, 25 July 2012

OCA — Wed, 25 Jul 2012 10:50:15 GMT

←Older revision		Revision as of 10:50, 25 July 2012
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	[[Image:2x24.png\|left\|200px]]		[[Image:2x24.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2x24", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2x24\| PDB=2x24 \| SCENE= }}		{{STRUCTURE_2x24\| PDB=2x24 \| SCENE= }}

	===BOVINE ACC2 CT DOMAIN IN COMPLEX WITH INHIBITOR===		===BOVINE ACC2 CT DOMAIN IN COMPLEX WITH INHIBITOR===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21515056}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21515056 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21515056}}		{{ABSTRACT_PUBMED_21515056}}

	==About this Structure==		==About this Structure==
-	[[2x24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA].	+	[[2x24]] is a 2 chain structure of [[Acetyl-CoA carboxylase]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA].
		+
		+	==See Also==
		+	*[[Acetyl-CoA carboxylase\|Acetyl-CoA carboxylase]]

	==Reference==		==Reference==

OCA at 07:36, 13 July 2011

OCA — Wed, 13 Jul 2011 07:36:58 GMT

←Older revision		Revision as of 07:36, 13 July 2011
Line 1:		Line 1:
-	[[Image:2x24.~~jpg~~\|left\|200px]]	+	[[Image:2x24.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===BOVINE ACC2 CT DOMAIN IN COMPLEX WITH INHIBITOR===		===BOVINE ACC2 CT DOMAIN IN COMPLEX WITH INHIBITOR===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21515056}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21515056 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21515056}}

	==About this Structure==		==About this Structure==
	[[2x24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA].		[[2x24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X24 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021515056</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Blaho, S.]]		[[Category: Blaho, S.]]
Line 20:		Line 29:
	[[Category: Oster, L.]]		[[Category: Oster, L.]]
	[[Category: Wiberg, F.]]		[[Category: Wiberg, F.]]
		+	[[Category: Fatty acid biosynthesis]]
		+	[[Category: Ligase]]
		+	[[Category: Lipid synthesis]]