2x2d - Revision history

OCA at 16:48, 3 November 2021

OCA — Wed, 03 Nov 2021 16:48:12 GMT

←Older revision		Revision as of 16:48, 3 November 2021
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	<StructureSection load='2x2d' size='340' side='right'caption='[[2x2d]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2x2d' size='340' side='right'caption='[[2x2d]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x2d]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human] and [~~http~~://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X2D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x2d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X2D FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vbs\|1vbs]], [[1oca\|1oca]], [[1mf8\|1mf8]], [[2cyh\|2cyh]], [[1cwb\|1cwb]], [[1vbt\|1vbt]], [[1cwl\|1cwl]], [[1m9e\|1m9e]], [[1cwc\|1cwc]], [[1cwi\|1cwi]], [[1cwo\|1cwo]], [[1rmh\|1rmh]], [[1cwj\|1cwj]], [[2rmb\|2rmb]], [[1m9c\|1m9c]], [[1cwa\|1cwa]], [[1cwf\|1cwf]], [[1m9y\|1m9y]], [[3cyh\|3cyh]], [[4cyh\|4cyh]], [[1m9f\|1m9f]], [[1cwh\|1cwh]], [[1bck\|1bck]], [[1w8v\|1w8v]], [[1awr\|1awr]], [[1nmk\|1nmk]], [[1mik\|1mik]], [[1awv\|1awv]], [[1m9d\|1m9d]], [[2cpl\|2cpl]], [[2x2a\|2x2a]], [[1fgl\|1fgl]], [[1awt\|1awt]], [[1m9x\|1m9x]], [[1m63\|1m63]], [[1cwk\|1cwk]], [[5cyh\|5cyh]], [[1ak4\|1ak4]], [[1w8l\|1w8l]], [[1aws\|1aws]], [[3cys\|3cys]], [[2alf\|2alf]], [[2x25\|2x25]], [[1awu\|1awu]], [[1w8m\|1w8m]], [[2c55\|2c55]], [[1cwm\|1cwm]], [[2rma\|2rma]], [[1awq\|1awq]], [[2x2c\|2x2c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vbs\|1vbs]], [[1oca\|1oca]], [[1mf8\|1mf8]], [[2cyh\|2cyh]], [[1cwb\|1cwb]], [[1vbt\|1vbt]], [[1cwl\|1cwl]], [[1m9e\|1m9e]], [[1cwc\|1cwc]], [[1cwi\|1cwi]], [[1cwo\|1cwo]], [[1rmh\|1rmh]], [[1cwj\|1cwj]], [[2rmb\|2rmb]], [[1m9c\|1m9c]], [[1cwa\|1cwa]], [[1cwf\|1cwf]], [[1m9y\|1m9y]], [[3cyh\|3cyh]], [[4cyh\|4cyh]], [[1m9f\|1m9f]], [[1cwh\|1cwh]], [[1bck\|1bck]], [[1w8v\|1w8v]], [[1awr\|1awr]], [[1nmk\|1nmk]], [[1mik\|1mik]], [[1awv\|1awv]], [[1m9d\|1m9d]], [[2cpl\|2cpl]], [[2x2a\|2x2a]], [[1fgl\|1fgl]], [[1awt\|1awt]], [[1m9x\|1m9x]], [[1m63\|1m63]], [[1cwk\|1cwk]], [[5cyh\|5cyh]], [[1ak4\|1ak4]], [[1w8l\|1w8l]], [[1aws\|1aws]], [[3cys\|3cys]], [[2alf\|2alf]], [[2x25\|2x25]], [[1awu\|1awu]], [[1w8m\|1w8m]], [[2c55\|2c55]], [[1cwm\|1cwm]], [[2rma\|2rma]], [[1awq\|1awq]], [[2x2c\|2x2c]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2d OCA], [~~http~~://pdbe.org/2x2d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x2d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x2d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2d OCA], [https://pdbe.org/2x2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x2d RCSB], [https://www.ebi.ac.uk/pdbsum/2x2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.	+	[[https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]		*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
	*[[Gag polyprotein 3D structures\|Gag polyprotein 3D structures]]		*[[Gag polyprotein 3D structures\|Gag polyprotein 3D structures]]
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:52, 25 December 2019

OCA — Wed, 25 Dec 2019 13:52:05 GMT

←Older revision		Revision as of 13:52, 25 December 2019
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	==acetyl-CypA:HIV-1 N-term capsid domain complex==		==acetyl-CypA:HIV-1 N-term capsid domain complex==
-	<StructureSection load='2x2d' size='340' side='right' caption='[[2x2d]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='2x2d' size='340' side='right'caption='[[2x2d]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2D FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 2x2d" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2x2d" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
		+	*[[Gag polyprotein 3D structures\|Gag polyprotein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Human]]		[[Category: Human]]
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Large Structures]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Chin, J W]]		[[Category: Chin, J W]]

OCA at 19:06, 24 January 2018

OCA — Wed, 24 Jan 2018 19:06:36 GMT

←Older revision		Revision as of 19:06, 24 January 2018
Line 1:		Line 1:

-	==~~ACETYL~~-~~CYPA~~:HIV-1 N-~~TERM CAPSID DOMAIN COMPLEX~~==	+	==acetyl-CypA:HIV-1 N-term capsid domain complex==
	<StructureSection load='2x2d' size='340' side='right' caption='[[2x2d]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2x2d' size='340' side='right' caption='[[2x2d]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~] and [http://en.wikipedia.org/wiki/Human ~~Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2D FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vbs\|1vbs]], [[1oca\|1oca]], [[1mf8\|1mf8]], [[2cyh\|2cyh]], [[1cwb\|1cwb]], [[1vbt\|1vbt]], [[1cwl\|1cwl]], [[1m9e\|1m9e]], [[1cwc\|1cwc]], [[1cwi\|1cwi]], [[1cwo\|1cwo]], [[1rmh\|1rmh]], [[1cwj\|1cwj]], [[2rmb\|2rmb]], [[1m9c\|1m9c]], [[1cwa\|1cwa]], [[1cwf\|1cwf]], [[1m9y\|1m9y]], [[3cyh\|3cyh]], [[4cyh\|4cyh]], [[1m9f\|1m9f]], [[1cwh\|1cwh]], [[1bck\|1bck]], [[1w8v\|1w8v]], [[1awr\|1awr]], [[1nmk\|1nmk]], [[1mik\|1mik]], [[1awv\|1awv]], [[1m9d\|1m9d]], [[2cpl\|2cpl]], [[2x2a\|2x2a]], [[1fgl\|1fgl]], [[1awt\|1awt]], [[1m9x\|1m9x]], [[1m63\|1m63]], [[1cwk\|1cwk]], [[5cyh\|5cyh]], [[1ak4\|1ak4]], [[1w8l\|1w8l]], [[1aws\|1aws]], [[3cys\|3cys]], [[2alf\|2alf]], [[2x25\|2x25]], [[1awu\|1awu]], [[1w8m\|1w8m]], [[2c55\|2c55]], [[1cwm\|1cwm]], [[2rma\|2rma]], [[1awq\|1awq]], [[2x2c\|2x2c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vbs\|1vbs]], [[1oca\|1oca]], [[1mf8\|1mf8]], [[2cyh\|2cyh]], [[1cwb\|1cwb]], [[1vbt\|1vbt]], [[1cwl\|1cwl]], [[1m9e\|1m9e]], [[1cwc\|1cwc]], [[1cwi\|1cwi]], [[1cwo\|1cwo]], [[1rmh\|1rmh]], [[1cwj\|1cwj]], [[2rmb\|2rmb]], [[1m9c\|1m9c]], [[1cwa\|1cwa]], [[1cwf\|1cwf]], [[1m9y\|1m9y]], [[3cyh\|3cyh]], [[4cyh\|4cyh]], [[1m9f\|1m9f]], [[1cwh\|1cwh]], [[1bck\|1bck]], [[1w8v\|1w8v]], [[1awr\|1awr]], [[1nmk\|1nmk]], [[1mik\|1mik]], [[1awv\|1awv]], [[1m9d\|1m9d]], [[2cpl\|2cpl]], [[2x2a\|2x2a]], [[1fgl\|1fgl]], [[1awt\|1awt]], [[1m9x\|1m9x]], [[1m63\|1m63]], [[1cwk\|1cwk]], [[5cyh\|5cyh]], [[1ak4\|1ak4]], [[1w8l\|1w8l]], [[1aws\|1aws]], [[3cys\|3cys]], [[2alf\|2alf]], [[2x25\|2x25]], [[1awu\|1awu]], [[1w8m\|1w8m]], [[2c55\|2c55]], [[1cwm\|1cwm]], [[2rma\|2rma]], [[1awq\|1awq]], [[2x2c\|2x2c]]</td></tr>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/2x2d_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/2x2d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2x2d" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2x2d" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cyclophilin\|Cyclophilin]]
-	*[[Gag polyprotein\|Gag polyprotein]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Chin, J W]]		[[Category: Chin, J W]]

OCA at 01:50, 5 August 2016

OCA — Fri, 05 Aug 2016 01:50:26 GMT

←Older revision		Revision as of 01:50, 5 August 2016
Line 1:		Line 1:
		+
	==ACETYL-CYPA:HIV-1 N-TERM CAPSID DOMAIN COMPLEX==		==ACETYL-CYPA:HIV-1 N-TERM CAPSID DOMAIN COMPLEX==
	<StructureSection load='2x2d' size='340' side='right' caption='[[2x2d]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2x2d' size='340' side='right' caption='[[2x2d]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~] and [http://en.wikipedia.org/wiki/~~Human_immunodeficiency_virus_1~~ Human ~~immunodeficiency virus 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2D FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vbs\|1vbs]], [[1oca\|1oca]], [[1mf8\|1mf8]], [[2cyh\|2cyh]], [[1cwb\|1cwb]], [[1vbt\|1vbt]], [[1cwl\|1cwl]], [[1m9e\|1m9e]], [[1cwc\|1cwc]], [[1cwi\|1cwi]], [[1cwo\|1cwo]], [[1rmh\|1rmh]], [[1cwj\|1cwj]], [[2rmb\|2rmb]], [[1m9c\|1m9c]], [[1cwa\|1cwa]], [[1cwf\|1cwf]], [[1m9y\|1m9y]], [[3cyh\|3cyh]], [[4cyh\|4cyh]], [[1m9f\|1m9f]], [[1cwh\|1cwh]], [[1bck\|1bck]], [[1w8v\|1w8v]], [[1awr\|1awr]], [[1nmk\|1nmk]], [[1mik\|1mik]], [[1awv\|1awv]], [[1m9d\|1m9d]], [[2cpl\|2cpl]], [[2x2a\|2x2a]], [[1fgl\|1fgl]], [[1awt\|1awt]], [[1m9x\|1m9x]], [[1m63\|1m63]], [[1cwk\|1cwk]], [[5cyh\|5cyh]], [[1ak4\|1ak4]], [[1w8l\|1w8l]], [[1aws\|1aws]], [[3cys\|3cys]], [[2alf\|2alf]], [[2x25\|2x25]], [[1awu\|1awu]], [[1w8m\|1w8m]], [[2c55\|2c55]], [[1cwm\|1cwm]], [[2rma\|2rma]], [[1awq\|1awq]], [[2x2c\|2x2c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vbs\|1vbs]], [[1oca\|1oca]], [[1mf8\|1mf8]], [[2cyh\|2cyh]], [[1cwb\|1cwb]], [[1vbt\|1vbt]], [[1cwl\|1cwl]], [[1m9e\|1m9e]], [[1cwc\|1cwc]], [[1cwi\|1cwi]], [[1cwo\|1cwo]], [[1rmh\|1rmh]], [[1cwj\|1cwj]], [[2rmb\|2rmb]], [[1m9c\|1m9c]], [[1cwa\|1cwa]], [[1cwf\|1cwf]], [[1m9y\|1m9y]], [[3cyh\|3cyh]], [[4cyh\|4cyh]], [[1m9f\|1m9f]], [[1cwh\|1cwh]], [[1bck\|1bck]], [[1w8v\|1w8v]], [[1awr\|1awr]], [[1nmk\|1nmk]], [[1mik\|1mik]], [[1awv\|1awv]], [[1m9d\|1m9d]], [[2cpl\|2cpl]], [[2x2a\|2x2a]], [[1fgl\|1fgl]], [[1awt\|1awt]], [[1m9x\|1m9x]], [[1m63\|1m63]], [[1cwk\|1cwk]], [[5cyh\|5cyh]], [[1ak4\|1ak4]], [[1w8l\|1w8l]], [[1aws\|1aws]], [[3cys\|3cys]], [[2alf\|2alf]], [[2x25\|2x25]], [[1awu\|1awu]], [[1w8m\|1w8m]], [[2c55\|2c55]], [[1cwm\|1cwm]], [[2rma\|2rma]], [[1awq\|1awq]], [[2x2c\|2x2c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x2d RCSB], [http://www.ebi.ac.uk/pdbsum/2x2d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2d OCA], [http://pdbe.org/2x2d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x2d RCSB], [http://www.ebi.ac.uk/pdbsum/2x2d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x2d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x2d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	~~[[Category: Homo sapiens]]~~	+	[[Category: Human]]
-	[[Category: Human ~~immunodeficiency virus 1~~]]	+
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Chin, J W]]		[[Category: Chin, J W]]

OCA at 21:45, 24 December 2014

OCA — Wed, 24 Dec 2014 21:45:26 GMT

←Older revision		Revision as of 21:45, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vbs\|1vbs]], [[1oca\|1oca]], [[1mf8\|1mf8]], [[2cyh\|2cyh]], [[1cwb\|1cwb]], [[1vbt\|1vbt]], [[1cwl\|1cwl]], [[1m9e\|1m9e]], [[1cwc\|1cwc]], [[1cwi\|1cwi]], [[1cwo\|1cwo]], [[1rmh\|1rmh]], [[1cwj\|1cwj]], [[2rmb\|2rmb]], [[1m9c\|1m9c]], [[1cwa\|1cwa]], [[1cwf\|1cwf]], [[1m9y\|1m9y]], [[3cyh\|3cyh]], [[4cyh\|4cyh]], [[1m9f\|1m9f]], [[1cwh\|1cwh]], [[1bck\|1bck]], [[1w8v\|1w8v]], [[1awr\|1awr]], [[1nmk\|1nmk]], [[1mik\|1mik]], [[1awv\|1awv]], [[1m9d\|1m9d]], [[2cpl\|2cpl]], [[2x2a\|2x2a]], [[1fgl\|1fgl]], [[1awt\|1awt]], [[1m9x\|1m9x]], [[1m63\|1m63]], [[1cwk\|1cwk]], [[5cyh\|5cyh]], [[1ak4\|1ak4]], [[1w8l\|1w8l]], [[1aws\|1aws]], [[3cys\|3cys]], [[2alf\|2alf]], [[2x25\|2x25]], [[1awu\|1awu]], [[1w8m\|1w8m]], [[2c55\|2c55]], [[1cwm\|1cwm]], [[2rma\|2rma]], [[1awq\|1awq]], [[2x2c\|2x2c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vbs\|1vbs]], [[1oca\|1oca]], [[1mf8\|1mf8]], [[2cyh\|2cyh]], [[1cwb\|1cwb]], [[1vbt\|1vbt]], [[1cwl\|1cwl]], [[1m9e\|1m9e]], [[1cwc\|1cwc]], [[1cwi\|1cwi]], [[1cwo\|1cwo]], [[1rmh\|1rmh]], [[1cwj\|1cwj]], [[2rmb\|2rmb]], [[1m9c\|1m9c]], [[1cwa\|1cwa]], [[1cwf\|1cwf]], [[1m9y\|1m9y]], [[3cyh\|3cyh]], [[4cyh\|4cyh]], [[1m9f\|1m9f]], [[1cwh\|1cwh]], [[1bck\|1bck]], [[1w8v\|1w8v]], [[1awr\|1awr]], [[1nmk\|1nmk]], [[1mik\|1mik]], [[1awv\|1awv]], [[1m9d\|1m9d]], [[2cpl\|2cpl]], [[2x2a\|2x2a]], [[1fgl\|1fgl]], [[1awt\|1awt]], [[1m9x\|1m9x]], [[1m63\|1m63]], [[1cwk\|1cwk]], [[5cyh\|5cyh]], [[1ak4\|1ak4]], [[1w8l\|1w8l]], [[1aws\|1aws]], [[3cys\|3cys]], [[2alf\|2alf]], [[2x25\|2x25]], [[1awu\|1awu]], [[1w8m\|1w8m]], [[2c55\|2c55]], [[1cwm\|1cwm]], [[2rma\|2rma]], [[1awq\|1awq]], [[2x2c\|2x2c]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x2d RCSB], [http://www.ebi.ac.uk/pdbsum/2x2d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x2d RCSB], [http://www.ebi.ac.uk/pdbsum/2x2d PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 39:
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
-	[[Category: Chin, J W.]]	+	[[Category: Chin, J W]]
-	[[Category: James, L C.]]	+	[[Category: James, L C]]
-	[[Category: Lammers, M.]]	+	[[Category: Lammers, M]]
-	[[Category: Neumann, H.]]	+	[[Category: Neumann, H]]
	[[Category: Host-virus interaction]]		[[Category: Host-virus interaction]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 01:05, 2 October 2014

OCA — Thu, 02 Oct 2014 01:05:23 GMT

←Older revision		Revision as of 01:05, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2x2d.~~png~~\|~~left~~\|200px]]	+	==ACETYL-CYPA:HIV-1 N-TERM CAPSID DOMAIN COMPLEX==
		+	<StructureSection load='2x2d' size='340' side='right' caption='[[2x2d]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vbs\|1vbs]], [[1oca\|1oca]], [[1mf8\|1mf8]], [[2cyh\|2cyh]], [[1cwb\|1cwb]], [[1vbt\|1vbt]], [[1cwl\|1cwl]], [[1m9e\|1m9e]], [[1cwc\|1cwc]], [[1cwi\|1cwi]], [[1cwo\|1cwo]], [[1rmh\|1rmh]], [[1cwj\|1cwj]], [[2rmb\|2rmb]], [[1m9c\|1m9c]], [[1cwa\|1cwa]], [[1cwf\|1cwf]], [[1m9y\|1m9y]], [[3cyh\|3cyh]], [[4cyh\|4cyh]], [[1m9f\|1m9f]], [[1cwh\|1cwh]], [[1bck\|1bck]], [[1w8v\|1w8v]], [[1awr\|1awr]], [[1nmk\|1nmk]], [[1mik\|1mik]], [[1awv\|1awv]], [[1m9d\|1m9d]], [[2cpl\|2cpl]], [[2x2a\|2x2a]], [[1fgl\|1fgl]], [[1awt\|1awt]], [[1m9x\|1m9x]], [[1m63\|1m63]], [[1cwk\|1cwk]], [[5cyh\|5cyh]], [[1ak4\|1ak4]], [[1w8l\|1w8l]], [[1aws\|1aws]], [[3cys\|3cys]], [[2alf\|2alf]], [[2x25\|2x25]], [[1awu\|1awu]], [[1w8m\|1w8m]], [[2c55\|2c55]], [[1cwm\|1cwm]], [[2rma\|2rma]], [[1awq\|1awq]], [[2x2c\|2x2c]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x2d RCSB], [http://www.ebi.ac.uk/pdbsum/2x2d PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/2x2d_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclophilin A (CypA) is a ubiquitous cis-trans prolyl isomerase with key roles in immunity and viral infection. CypA suppresses T-cell activation through cyclosporine complexation and is required for effective HIV-1 replication in host cells. We show that CypA is acetylated in diverse human cell lines and use a synthetically evolved acetyllysyl-tRNA synthetase/tRNA(CUA) pair to produce recombinant acetylated CypA in Escherichia coli. We determined atomic-resolution structures of acetylated CypA and its complexes with cyclosporine and HIV-1 capsid. Acetylation markedly inhibited CypA catalysis of cis to trans isomerization and stabilized cis rather than trans forms of the HIV-1 capsid. Furthermore, CypA acetylation antagonized the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition. Our results reveal that acetylation regulates key functions of CypA in immunity and viral infection and provide a general set of mechanisms by which acetylation modulates interactions to regulate cell function.

-	~~{{STRUCTURE_2x2d\| PDB=2x2d \| SCENE= }}~~	+	Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization.,Lammers M, Neumann H, Chin JW, James LC Nat Chem Biol. 2010 May;6(5):331-7. Epub 2010 Apr 4. PMID:20364129<ref>PMID:20364129</ref>

-	~~===ACETYL-CYPA:HIV-1 N-TERM CAPSID DOMAIN COMPLEX===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20364129}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2x2d]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens] and [http://en~~.~~wikipedia.org~~/~~wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA].~~	+

	==See Also==		==See Also==
	*[[Cyclophilin\|Cyclophilin]]		*[[Cyclophilin\|Cyclophilin]]
	*[[Gag polyprotein\|Gag polyprotein]]		*[[Gag polyprotein\|Gag polyprotein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020364129<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]

OCA at 09:26, 20 October 2012

OCA — Sat, 20 Oct 2012 09:26:48 GMT

←Older revision		Revision as of 09:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x2d]] is a 4 chain structure ~~of [[Cyclophilin]] and [[Gag polyprotein]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA].	+	[[2x2d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2D OCA].

	==See Also==		==See Also==

OCA at 22:52, 25 July 2012

OCA — Wed, 25 Jul 2012 22:52:11 GMT

←Older revision		Revision as of 22:52, 25 July 2012
Line 1:		Line 1:
	[[Image:2x2d.png\|left\|200px]]		[[Image:2x2d.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2x2d", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2x2d\| PDB=2x2d \| SCENE= }}		{{STRUCTURE_2x2d\| PDB=2x2d \| SCENE= }}

	===ACETYL-CYPA:HIV-1 N-TERM CAPSID DOMAIN COMPLEX===		===ACETYL-CYPA:HIV-1 N-TERM CAPSID DOMAIN COMPLEX===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20364129}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20364129 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20364129}}		{{ABSTRACT_PUBMED_20364129}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Cyclophilin]]	+	*[[Cyclophilin\|Cyclophilin]]
-	*[[Gag polyprotein]]	+	*[[Gag polyprotein\|Gag polyprotein]]

	==Reference==		==Reference==

OCA at 08:21, 30 October 2011

OCA — Sun, 30 Oct 2011 08:21:50 GMT

←Older revision		Revision as of 08:21, 30 October 2011
Line 11:		Line 11:
	===ACETYL-CYPA:HIV-1 N-TERM CAPSID DOMAIN COMPLEX===		===ACETYL-CYPA:HIV-1 N-TERM CAPSID DOMAIN COMPLEX===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20364129}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20364129 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20364129}}

	==About this Structure==		==About this Structure==
Line 18:		Line 24:
	*[[Cyclophilin]]		*[[Cyclophilin]]
	*[[Gag polyprotein]]		*[[Gag polyprotein]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:020364129</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]

OCA: Protected "2x2d" [edit=sysop:move=sysop]

OCA — Wed, 24 Aug 2011 05:50:14 GMT

Protected "2x2d" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:50, 24 August 2011