2x4o - Revision history

OCA at 10:23, 20 December 2023

OCA — Wed, 20 Dec 2023 10:23:43 GMT

OCA at 05:04, 19 November 2020

OCA — Thu, 19 Nov 2020 05:04:14 GMT

←Older revision		Revision as of 05:04, 19 November 2020
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	<table><tr><td colspan='2'>[[2x4o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X4O FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x4o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X4O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4m\|2x4m]], [[2x4r\|2x4r]], [[2x4q\|2x4q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4m\|2x4m]], [[2x4r\|2x4r]], [[2x4q\|2x4q]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4o OCA], [http://pdbe.org/2x4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4o RCSB], [http://www.ebi.ac.uk/pdbsum/2x4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4o OCA], [http://pdbe.org/2x4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4o RCSB], [http://www.ebi.ac.uk/pdbsum/2x4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4o ProSAT]</span></td></tr>
	</table>		</table>
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	==See Also==		==See Also==
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[MHC 3D structures ~~of MHC~~\|MHC 3D structures ~~of MHC~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:04, 8 July 2020

OCA — Wed, 08 Jul 2020 15:04:48 GMT

←Older revision		Revision as of 15:04, 8 July 2020
Line 1:		Line 1:

	==Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 envelope peptide env120-128==		==Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 envelope peptide env120-128==
-	<StructureSection load='2x4o' size='340' side='right' caption='[[2x4o]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2x4o' size='340' side='right'caption='[[2x4o]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x4o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x4o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X4O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4m\|2x4m]], [[2x4r\|2x4r]], [[2x4q\|2x4q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4m\|2x4m]], [[2x4r\|2x4r]], [[2x4q\|2x4q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4o OCA], [http://pdbe.org/2x4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4o RCSB], [http://www.ebi.ac.uk/pdbsum/2x4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4o OCA], [http://pdbe.org/2x4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4o RCSB], [http://www.ebi.ac.uk/pdbsum/2x4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[~~Major histocompatibility complex~~\|~~Major histocompatibility complex~~]]	+	*[[MHC 3D structures of MHC\|MHC 3D structures of MHC]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Celie, P H.N]]		[[Category: Celie, P H.N]]
	[[Category: Ovaa, H]]		[[Category: Ovaa, H]]

OCA at 09:49, 3 October 2018

OCA — Wed, 03 Oct 2018 09:49:12 GMT

←Older revision		Revision as of 09:49, 3 October 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF~~ MHC ~~CLASS~~ I HLA-A2.1 ~~BOUND TO~~ HIV-1 ~~ENVELOPE PEPTIDE ENV120~~-128==	+
		+	==Crystal structure of MHC CLass I HLA-A2.1 bound to HIV-1 envelope peptide env120-128==
	<StructureSection load='2x4o' size='340' side='right' caption='[[2x4o]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2x4o' size='340' side='right' caption='[[2x4o]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4m\|2x4m]], [[2x4r\|2x4r]], [[2x4q\|2x4q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4m\|2x4m]], [[2x4r\|2x4r]], [[2x4q\|2x4q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4o OCA], [http://pdbe.org/2x4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4o RCSB], [http://www.ebi.ac.uk/pdbsum/2x4o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4o OCA], [http://pdbe.org/2x4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4o RCSB], [http://www.ebi.ac.uk/pdbsum/2x4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:36, 7 February 2016

OCA — Sun, 07 Feb 2016 03:36:13 GMT

←Older revision		Revision as of 03:36, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2x4o' size='340' side='right' caption='[[2x4o]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2x4o' size='340' side='right' caption='[[2x4o]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x4o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x4o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4m\|2x4m]], [[2x4r\|2x4r]], [[2x4q\|2x4q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4m\|2x4m]], [[2x4r\|2x4r]], [[2x4q\|2x4q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4o RCSB], [http://www.ebi.ac.uk/pdbsum/2x4o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4o OCA], [http://pdbe.org/2x4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4o RCSB], [http://www.ebi.ac.uk/pdbsum/2x4o PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x4o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x4o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Celie, P H.N]]		[[Category: Celie, P H.N]]
	[[Category: Ovaa, H]]		[[Category: Ovaa, H]]

OCA at 07:33, 24 December 2014

OCA — Wed, 24 Dec 2014 07:33:36 GMT

←Older revision		Revision as of 07:33, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x4o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4O FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x4o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4m\|2x4m]], [[2x4r\|2x4r]], [[2x4q\|2x4q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4m\|2x4m]], [[2x4r\|2x4r]], [[2x4q\|2x4q]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4o RCSB], [http://www.ebi.ac.uk/pdbsum/2x4o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4o RCSB], [http://www.ebi.ac.uk/pdbsum/2x4o PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/ENV_HV1MA ENV_HV1MA]] The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. Since CD4 also displays a binding site for the disulfide-isomerase P4HB/PDI, a P4HB/PDI-CD4-CXCR4-gp120 complex may form. In that complex, P4HB/PDI could reach and reduce gp120 disulfide bonds, causing major conformational changes in gp120. TXN, another PDI family member could also be involved in disulfide rearrangements in Env during fusion. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide. Surface protein gp120 (SU) may target the virus to gut-associated lymphoid tissue (GALT) by binding host ITGA4/ITGB7 (alpha-4/beta-7 integrins), a complex that mediates T-cell migration to the GALT. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS (By similarity). The surface protein gp120 is a ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses. These interactions allow capture of viral particles at mucosal surfaces by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they take up antigen, process it, and present it to T-cells following migration to lymphoid organs. HIV subverts the migration properties of dendritic cells to gain access to CD4+ T-cells in lymph nodes. Virus transmission to permissive T-cells occurs either in trans (without DCs infection, through viral capture and transmission), or in cis (following DCs productive infection, through the usual CD4-gp120 interaction), thereby inducing a robust infection. In trans infection, bound virions remain infectious over days and it is proposed that they are not degraded, but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the viral infectious potential during DCs' migration from the periphery to the lymphoid tissues. On arrival at lymphoid tissues, intact virions recycle back to DCs' cell surface allowing virus transmission to CD4+ T-cells. Virion capture also seems to lead to MHC-II-restricted viral antigen presentation, and probably to the activation of HIV-specific CD4+ cells (By similarity). The transmembrane protein gp41 (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane. The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity). The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity). The gp120-gp41 heterodimer seems to contribute to T-cell depletion during HIV-1 infection. The envelope glycoproteins expressed on the surface of infected cells induce apoptosis through an interaction with uninfected cells expressing the receptor (CD4) and the coreceptors CXCR4 or CCR5. This type of bystander killing may be obtained by at least three distinct mechanisms. First, the interaction between the 2 cells can induce cellular fusion followed by nuclear fusion within the syncytium. Syncytia are condemned to die from apoptosis. Second, the 2 interacting cells may not fuse entirely and simply exchange plasma membrane lipids, after a sort of hemifusion process, followed by rapid death. Third, it is possible that virus-infected cells, on the point of undergoing apoptosis, fuse with CD4-expressing cells, in which case apoptosis is rapidly transmitted from one cell to the other and thus occurs in a sort of contagious fashion (By similarity). The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Celie, P H.N.]]	+	[[Category: Celie, P H.N]]
-	[[Category: Ovaa, H.]]	+	[[Category: Ovaa, H]]
-	[[Category: Perrakis, A.]]	+	[[Category: Perrakis, A]]
-	[[Category: Rodenko, B.]]	+	[[Category: Rodenko, B]]
-	[[Category: Schumacher, T N.M.]]	+	[[Category: Schumacher, T N.M]]
-	[[Category: Toebes, M.]]	+	[[Category: Toebes, M]]
	[[Category: Amyloid]]		[[Category: Amyloid]]
	[[Category: Amyloidosis]]		[[Category: Amyloidosis]]

OCA at 01:42, 1 October 2014

OCA — Wed, 01 Oct 2014 01:42:56 GMT

←Older revision		Revision as of 01:42, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2x4o\| PDB=2x4o \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO HIV-1 ENVELOPE PEPTIDE ENV120-128==
-	===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO HIV-1 ENVELOPE PEPTIDE ENV120-128===	+	<StructureSection load='2x4o' size='340' side='right' caption='[[2x4o]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19655750}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x4o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4m\|2x4m]], [[2x4r\|2x4r]], [[2x4q\|2x4q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4o RCSB], [http://www.ebi.ac.uk/pdbsum/2x4o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-throughput structure determination of protein-ligand complexes is central in drug development and structural proteomics. To facilitate such high-throughput structure determination we designed an induced replacement strategy. Crystals of a protein complex bound to a photosensitive ligand are exposed to UV light, inducing the departure of the bound ligand, allowing a new ligand to soak in. We exemplify the approach for a class of protein complexes that is especially recalcitrant to high-throughput strategies: the MHC class I proteins. We developed a UV-sensitive, "conditional", peptide ligand whose UV-induced cleavage in the crystals leads to the exchange of the low-affinity lytic fragments for full-length peptides introduced in the crystallant solution. This "in crystallo" exchange is monitored by the loss of seleno-methionine anomalous diffraction signal of the conditional peptide compared to the signal of labeled MHC beta2m subunit. This method has the potential to facilitate high-throughput crystallography in various protein families.

-	~~==Function==~~	+	UV-induced ligand exchange in MHC class I protein crystals.,Celie PH, Toebes M, Rodenko B, Ovaa H, Perrakis A, Schumacher TN J Am Chem Soc. 2009 Sep 2;131(34):12298-304. PMID:19655750<ref>PMID:19655750</ref>
-	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/ENV_HV1MA ENV_HV1MA]] The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. Since CD4 also displays a binding site for the disulfide-isomerase P4HB/PDI, a P4HB/PDI-CD4-CXCR4-gp120 complex may form. In that complex, P4HB/PDI could reach and reduce gp120 disulfide bonds, causing major conformational changes in gp120. TXN, another PDI family member could also be involved in disulfide rearrangements in Env during fusion. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide. Surface protein gp120 (SU) may target the virus to gut-associated lymphoid tissue (GALT) by binding host ITGA4/ITGB7 (alpha-4/beta-7 integrins), a complex that mediates T-cell migration to the GALT. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS (By similarity). The surface protein gp120 is a ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses. These interactions allow capture of viral particles at mucosal surfaces by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they take up antigen, process it, and present it to T-cells following migration to lymphoid organs. HIV subverts the migration properties of dendritic cells to gain access to CD4+ T-cells in lymph nodes. Virus transmission to permissive T-cells occurs either in trans (without DCs infection, through viral capture and transmission), or in cis (following DCs productive infection, through the usual CD4-gp120 interaction), thereby inducing a robust infection. In trans infection, bound virions remain infectious over days and it is proposed that they are not degraded, but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the viral infectious potential during DCs' migration from the periphery to the lymphoid tissues. On arrival at lymphoid tissues, intact virions recycle back to DCs' cell surface allowing virus transmission to CD4+ T-cells. Virion capture also seems to lead to MHC~~-II-restricted viral antigen presentation, and probably to the activation of HIV-specific CD4+ cells (By similarity). The transmembrane protein gp41 (TM) acts as a~~ class I ~~viral fusion~~ protein. ~~Under the current model~~, ~~the protein has at least 3 conformational states: pre-fusion native state~~, ~~pre-hairpin intermediate state~~, ~~and post-fusion hairpin state. During fusion of viral and target intracellular membranes~~, ~~the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure~~, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Complete fusion occurs in host cell endosomes and is dynamin-dependent, ~~however some lipid transfer might occur at the plasma membrane~~. The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity). The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity). The gp120-gp41 heterodimer seems to contribute to T-cell depletion during HIV-1 infection. The envelope glycoproteins expressed on the surface of infected cells induce apoptosis through an interaction with uninfected cells expressing the receptor (CD4) and the coreceptors CXCR4 or CCR5. This type of bystander killing may be obtained by at least three distinct mechanisms. First, the interaction between the 2 cells can induce cellular fusion followed by nuclear fusion within the syncytium. Syncytia are condemned to die from apoptosis. Second, the 2 interacting cells may not fuse entirely and simply exchange plasma membrane lipids, after a sort of hemifusion process, followed by rapid death. Third, it is possible that virus-infected cells, on the point of undergoing apoptosis, fuse with CD4-expressing cells, in which case apoptosis is rapidly transmitted from one cell to the other and thus occurs in a sort of contagious fashion (~~By similarity~~)~~. The gp120~~-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2x4o]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019655750</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Celie, P H.N.]]		[[Category: Celie, P H.N.]]

OCA at 10:24, 24 March 2013

OCA — Sun, 24 Mar 2013 10:24:17 GMT

←Older revision		Revision as of 10:24, 24 March 2013
Line 1:		Line 1:
-	[[Image:2x4o.png\|left\|200px]]
-
	{{STRUCTURE_2x4o\| PDB=2x4o \| SCENE= }}		{{STRUCTURE_2x4o\| PDB=2x4o \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO HIV-1 ENVELOPE PEPTIDE ENV120-128===		===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO HIV-1 ENVELOPE PEPTIDE ENV120-128===
		+	{{ABSTRACT_PUBMED_19655750}}

-	~~{{ABSTRACT_PUBMED_19655750}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/ENV_HV1MA ENV_HV1MA]] The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. Since CD4 also displays a binding site for the disulfide-isomerase P4HB/PDI, a P4HB/PDI-CD4-CXCR4-gp120 complex may form. In that complex, P4HB/PDI could reach and reduce gp120 disulfide bonds, causing major conformational changes in gp120. TXN, another PDI family member could also be involved in disulfide rearrangements in Env during fusion. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide. Surface protein gp120 (SU) may target the virus to gut-associated lymphoid tissue (GALT) by binding host ITGA4/ITGB7 (alpha-4/beta-7 integrins), a complex that mediates T-cell migration to the GALT. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS (By similarity). The surface protein gp120 is a ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses. These interactions allow capture of viral particles at mucosal surfaces by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they take up antigen, process it, and present it to T-cells following migration to lymphoid organs. HIV subverts the migration properties of dendritic cells to gain access to CD4+ T-cells in lymph nodes. Virus transmission to permissive T-cells occurs either in trans (without DCs infection, through viral capture and transmission), or in cis (following DCs productive infection, through the usual CD4-gp120 interaction), thereby inducing a robust infection. In trans infection, bound virions remain infectious over days and it is proposed that they are not degraded, but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the viral infectious potential during DCs' migration from the periphery to the lymphoid tissues. On arrival at lymphoid tissues, intact virions recycle back to DCs' cell surface allowing virus transmission to CD4+ T-cells. Virion capture also seems to lead to MHC-II-restricted viral antigen presentation, and probably to the activation of HIV-specific CD4+ cells (By similarity). The transmembrane protein gp41 (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane. The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity). The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity). The gp120-gp41 heterodimer seems to contribute to T-cell depletion during HIV-1 infection. The envelope glycoproteins expressed on the surface of infected cells induce apoptosis through an interaction with uninfected cells expressing the receptor (CD4) and the coreceptors CXCR4 or CCR5. This type of bystander killing may be obtained by at least three distinct mechanisms. First, the interaction between the 2 cells can induce cellular fusion followed by nuclear fusion within the syncytium. Syncytia are condemned to die from apoptosis. Second, the 2 interacting cells may not fuse entirely and simply exchange plasma membrane lipids, after a sort of hemifusion process, followed by rapid death. Third, it is possible that virus-infected cells, on the point of undergoing apoptosis, fuse with CD4-expressing cells, in which case apoptosis is rapidly transmitted from one cell to the other and thus occurs in a sort of contagious fashion (By similarity). The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).

	==About this Structure==		==About this Structure==
Line 15:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019655750</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019655750</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Celie, P H.N.]]		[[Category: Celie, P H.N.]]

OCA at 05:29, 20 October 2012

OCA — Sat, 20 Oct 2012 05:29:22 GMT

←Older revision		Revision as of 05:29, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x4o]] is a 6 chain structure ~~of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA].	+	[[2x4o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4O OCA].

	==See Also==		==See Also==

OCA: Protected "2x4o" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 10:13:36 GMT

Protected "2x4o" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:13, 25 July 2012