2x4q - Revision history

OCA at 08:46, 15 November 2023

OCA — Wed, 15 Nov 2023 08:46:20 GMT

←Older revision		Revision as of 08:46, 15 November 2023
Line 3:		Line 3:
	<StructureSection load='2x4q' size='340' side='right'caption='[[2x4q]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x4q' size='340' side='right'caption='[[2x4q]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x4q]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2X4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x4q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRQ:(3S)-3-AMINO-3-(2-NITROPHENYL)PROPANOIC+ACID'>PRQ</scene>, <scene name='pdbligand=PRV:(2R)-AMINO(2-NITROPHENYL)ETHANOIC+ACID'>PRV</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRQ:(3S)-3-AMINO-3-(2-NITROPHENYL)PROPANOIC+ACID'>PRQ</scene>, <scene name='pdbligand=PRV:(2R)-AMINO(2-NITROPHENYL)ETHANOIC+ACID'>PRV</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1zt4\|1zt4]], [[1hsb\|1hsb]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[1tmc\|1tmc]], [[2av1\|2av1]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[2vlj\|2vlj]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[1a9b\|1a9b]], [[2axg\|2axg]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4r\|2x4r]]</div></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4q OCA], [https://pdbe.org/2x4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4q RCSB], [https://www.ebi.ac.uk/pdbsum/2x4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4q ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4q OCA], [~~http~~://pdbe.org/2x4q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x4q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x4q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4q ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/HLAA_HUMAN HLAA_HUMAN] Selection of immunotherapy in solid cancer;Birdshot chorioretinopathy;Prediction of phenytoin or carbamazepine toxicity. Alleles A02:01 and A24:02 are associated with increased susceptibility to diabetes mellitus, insulin-dependent (IDDM) (PubMed:22245737, PubMed:18802479, PubMed:16731854, PubMed:22522618). In a glucose-dependent way, allele A02:01 may aberrantly present the signal peptide of preproinsulin (ALWGPDPAAA) on the surface of pancreatic beta cells to autoreactive CD8-positive T cells, potentially driving T-cell mediated cytotoxicity in pancreatic islets (PubMed:22245737, PubMed:18802479). Allele A24:02 may present the signal peptide of preproinsulin (LWMRLLPLL) and contribute to acute pancreatic beta-cell destruction and early onset of IDDM (PubMed:16731854, PubMed:22522618).<ref>PMID:16731854</ref> <ref>PMID:18802479</ref> <ref>PMID:22245737</ref> <ref>PMID:22522618</ref> Allele A03:01 is associated with increased susceptibility to multiple sclerosis (MS), an autoimmune disease of the central nervous system (PubMed:10746785). May contribute to the initiation phase of the disease by presenting myelin PLP1 self-peptide (KLIETYFSK) to autoreactive CD8-positive T cells capable of initiating the first autoimmune attacks (PubMed:18953350).<ref>PMID:10746785</ref> <ref>PMID:18953350</ref> Allele A26:01 is associated with increased susceptibility to Behcet disease (BD) in the Northeast Asian population. Especially in the HLA-B51-negative BD populations, HLA-A26 is significantly associated with the onset of BD.<ref>PMID:30872678</ref> Allele A*29:02 is associated with increased susceptibility to birdshot chorioretinopathy (BSCR). May aberrantly present retinal autoantigens and induce autoimmune uveitis.<ref>PMID:1728143</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~1A02_HUMAN 1A02_HUMAN~~]~~] Involved~~ in the ~~presentation~~ of ~~foreign~~ antigens to the immune ~~system~~.	+	[https://www.uniprot.org/uniprot/HLAA_HUMAN HLAA_HUMAN] Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:2456340, PubMed:2784196, PubMed:1402688, PubMed:7504010, PubMed:9862734, PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:15893615, PubMed:17189421, PubMed:19543285, PubMed:21498667, PubMed:24192765, PubMed:7694806, PubMed:24395804, PubMed:28250417). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728, PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17189421, PubMed:20364150, PubMed:17079320, PubMed:26929325, PubMed:27049119). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734).<ref>PMID:10449296</ref> <ref>PMID:12138174</ref> <ref>PMID:12393434</ref> <ref>PMID:12796775</ref> <ref>PMID:1402688</ref> <ref>PMID:15893615</ref> <ref>PMID:17079320</ref> <ref>PMID:17189421</ref> <ref>PMID:18275829</ref> <ref>PMID:19542454</ref> <ref>PMID:19543285</ref> <ref>PMID:20364150</ref> <ref>PMID:21498667</ref> <ref>PMID:24192765</ref> <ref>PMID:24395804</ref> <ref>PMID:2456340</ref> <ref>PMID:25880248</ref> <ref>PMID:26929325</ref> <ref>PMID:27049119</ref> <ref>PMID:2784196</ref> <ref>PMID:28250417</ref> <ref>PMID:7504010</ref> <ref>PMID:7506728</ref> <ref>PMID:7679507</ref> <ref>PMID:7694806</ref> <ref>PMID:9862734</ref> Allele A01:01: Presents a restricted peptide repertoire including viral epitopes derived from IAV NP/nucleoprotein (CTELKLSDY), IAV PB1/polymerase basic protein 1 (VSDGGPNLY), HAdV-11 capsid L3/hexon protein (LTDLGQNLLY), SARS-CoV-2 3a/ORF3a (FTSDYYQLY) as well as tumor peptide antigens including MAGE1 (EADPTGHSY), MAGEA3 (EVDPIGHLY) and WT1 (TSEKRPFMCAY), all having in common a canonical motif with a negatively charged Asp or Glu residue at position 3 and a Tyr anchor residue at the C-terminus (PubMed:1402688, PubMed:7504010, PubMed:17189421, PubMed:20364150, PubMed:25880248, PubMed:30530481, PubMed:19177349, PubMed:24395804, PubMed:26758806, PubMed:32887977). A number of HLA-A01:01-restricted peptides carry a post-translational modification with oxidation and N-terminal acetylation being the most frequent (PubMed:25880248). Fails to present highly immunogenic peptides from the EBV latent antigens (PubMed:18779413).<ref>PMID:1402688</ref> <ref>PMID:17189421</ref> <ref>PMID:18779413</ref> <ref>PMID:19177349</ref> <ref>PMID:20364150</ref> <ref>PMID:24395804</ref> <ref>PMID:25880248</ref> <ref>PMID:26758806</ref> <ref>PMID:30530481</ref> <ref>PMID:7504010</ref> Allele A02:01: A major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at the C-terminal anchors.<ref>PMID:11502003</ref> <ref>PMID:12138174</ref> <ref>PMID:12796775</ref> <ref>PMID:17079320</ref> <ref>PMID:18275829</ref> <ref>PMID:19542454</ref> <ref>PMID:20619457</ref> <ref>PMID:22245737</ref> <ref>PMID:26929325</ref> <ref>PMID:2784196</ref> <ref>PMID:28250417</ref> <ref>PMID:7694806</ref> <ref>PMID:7935798</ref> <ref>PMID:8630735</ref> <ref>PMID:8805302</ref> <ref>PMID:8906788</ref> <ref>PMID:9177355</ref> Allele A03:01: Presents viral epitopes derived from IAV NP (ILRGSVAHK), HIV-1 nef (QVPLRPMTYK), HIV-1 gag-pol (AIFQSSMTK), SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) as well as tumor peptide antigens including PMEL (LIYRRRLMK), NODAL (HAYIQSLLK), TRP-2 (RMYNMVPFF), all having in common hydrophobic amino acids at position 2 and Lys or Arg anchor residues at the C-terminus (PubMed:7504010, PubMed:7679507, PubMed:9862734, PubMed:19543285, PubMed:21943705, PubMed:2456340, PubMed:32887977). May also display spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119).<ref>PMID:19543285</ref> <ref>PMID:21943705</ref> <ref>PMID:2456340</ref> <ref>PMID:27049119</ref> <ref>PMID:7504010</ref> <ref>PMID:7679507</ref> <ref>PMID:9862734</ref> Allele A11:01: Presents several immunodominant epitopes derived from HIV-1 gag-pol and HHV-4 EBNA4, containing the peptide motif with Val, Ile, Thr, Leu, Tyr or Phe at position 2 and Lys anchor residue at the C-terminus. Important in the control of HIV-1, EBV and HBV infections (PubMed:10449296). Presents an immunodominant epitope derived from SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) (PubMed:32887977).<ref>PMID:10449296</ref> <ref>PMID:32887977</ref> Allele A23:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response.<ref>PMID:17182537</ref> Allele A24:02: Presents viral epitopes derived from HIV-1 nef (RYPLTFGWCF), EBV lytic- and latent-cycle antigens BRLF1 (TYPVLEEMF), BMLF1 (DYNFVKQLF) and LMP2 (IYVLVMLVL), SARS-CoV nucleocapsid/N (QFKDNVILL), as well as tumor peptide antigens including PRAME (LYVDSLFFL), all sharing a common signature motif, namely an aromatic residue Tyr or Phe at position 2 and a nonhydrophobic anchor residue Phe, Leu or Iso at the C-terminus (PubMed:9047241, PubMed:12393434, PubMed:24192765, PubMed:20844028). Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response (PubMed:17182537, PubMed:18502829).<ref>PMID:12393434</ref> <ref>PMID:17182537</ref> <ref>PMID:18502829</ref> <ref>PMID:20844028</ref> <ref>PMID:24192765</ref> <ref>PMID:9047241</ref> Allele A26:01: Presents several epitopes derived from HIV-1 gag-pol (EVIPMFSAL, ETKLGKAGY) and env (LVSDGGPNLY), carrying as anchor residues preferentially Glu at position 1, Val or Thr at position 2 and Tyr at the C-terminus.<ref>PMID:15893615</ref> Allele A29:02: Presents peptides having a common motif, namely a Glu residue at position 2 and Tyr or Leu anchor residues at the C-terminus.<ref>PMID:8622959</ref> Allele A32:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response.<ref>PMID:17182537</ref> Allele A68:01: Presents viral epitopes derived from IAV NP (KTGGPIYKR) and HIV-1 tat (ITKGLGISYGR), having a common signature motif namely, Val or Thr at position 2 and positively charged residues Arg or Lys at the C-terminal anchor.<ref>PMID:1448153</ref> <ref>PMID:1448154</ref> <ref>PMID:2784196</ref> Allele A74:01: Presents immunodominant HIV-1 epitopes derived from gag-pol (GQMVHQAISPR, QIYPGIKVR) and rev (RQIHSISER), carrying an aliphatic residue at position 2 and Arg anchor residue at the C-terminus. May contribute to viral load control in chronic HIV-1 infection.<ref>PMID:21498667</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 35:
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	*[[MHC 3D structures\|MHC 3D structures]]		*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
		+	[[Category: Influenza A virus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Celie~~, P H.N~~]]	+	[[Category: Celie PHN]]
-	[[Category: Ovaa, H]]	+	[[Category: Ovaa H]]
-	[[Category: Perrakis, A]]	+	[[Category: Perrakis A]]
-	[[Category: Rodenko, B]]	+	[[Category: Rodenko B]]
-	[[Category: Schumacher~~, T N.M~~]]	+	[[Category: Schumacher TNM]]
-	[[Category: Toebes, M]]	+	[[Category: Toebes M]]
-	~~[[Category: Amyloid]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Photocleavable peptide~~]]	+

OCA at 05:04, 19 November 2020

OCA — Thu, 19 Nov 2020 05:04:23 GMT

←Older revision		Revision as of 05:04, 19 November 2020
Line 3:		Line 3:
	<StructureSection load='2x4q' size='340' side='right'caption='[[2x4q]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x4q' size='340' side='right'caption='[[2x4q]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x4q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x4q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X4Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRQ:(3S)-3-AMINO-3-(2-NITROPHENYL)PROPANOIC+ACID'>PRQ</scene>, <scene name='pdbligand=PRV:(2R)-AMINO(2-NITROPHENYL)ETHANOIC+ACID'>PRV</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRQ:(3S)-3-AMINO-3-(2-NITROPHENYL)PROPANOIC+ACID'>PRQ</scene>, <scene name='pdbligand=PRV:(2R)-AMINO(2-NITROPHENYL)ETHANOIC+ACID'>PRV</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1zt4\|1zt4]], [[1hsb\|1hsb]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[1tmc\|1tmc]], [[2av1\|2av1]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[2vlj\|2vlj]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[1a9b\|1a9b]], [[2axg\|2axg]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4r\|2x4r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1zt4\|1zt4]], [[1hsb\|1hsb]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[1tmc\|1tmc]], [[2av1\|2av1]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[2vlj\|2vlj]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[1a9b\|1a9b]], [[2axg\|2axg]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4r\|2x4r]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4q OCA], [http://pdbe.org/2x4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4q RCSB], [http://www.ebi.ac.uk/pdbsum/2x4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4q OCA], [http://pdbe.org/2x4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4q RCSB], [http://www.ebi.ac.uk/pdbsum/2x4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	==See Also==		==See Also==
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[~~Major histocompatibility complex~~\|~~Major histocompatibility complex~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:22, 24 April 2019

OCA — Wed, 24 Apr 2019 07:22:39 GMT

←Older revision		Revision as of 07:22, 24 April 2019
Line 1:		Line 1:

	==Crystal structure of MHC CLass I HLA-A2.1 bound to a photocleavable peptide==		==Crystal structure of MHC CLass I HLA-A2.1 bound to a photocleavable peptide==
-	<StructureSection load='2x4q' size='340' side='right' caption='[[2x4q]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2x4q' size='340' side='right'caption='[[2x4q]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x4q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x4q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4Q FirstGlance]. <br>
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
	== References ==		== References ==
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Celie, P H.N]]		[[Category: Celie, P H.N]]
	[[Category: Ovaa, H]]		[[Category: Ovaa, H]]

OCA at 09:38, 3 October 2018

OCA — Wed, 03 Oct 2018 09:38:32 GMT

←Older revision		Revision as of 09:38, 3 October 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF~~ MHC ~~CLASS~~ I HLA-A2.1 ~~BOUND TO A PHOTOCLEAVABLE PEPTIDE~~==	+
		+	==Crystal structure of MHC CLass I HLA-A2.1 bound to a photocleavable peptide==
	<StructureSection load='2x4q' size='340' side='right' caption='[[2x4q]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x4q' size='340' side='right' caption='[[2x4q]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRQ:(3S)-3-AMINO-3-(2-NITROPHENYL)PROPANOIC+ACID'>PRQ</scene>, <scene name='pdbligand=PRV:(2R)-AMINO(2-NITROPHENYL)ETHANOIC+ACID'>PRV</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRQ:(3S)-3-AMINO-3-(2-NITROPHENYL)PROPANOIC+ACID'>PRQ</scene>, <scene name='pdbligand=PRV:(2R)-AMINO(2-NITROPHENYL)ETHANOIC+ACID'>PRV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1zt4\|1zt4]], [[1hsb\|1hsb]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[1tmc\|1tmc]], [[2av1\|2av1]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[2vlj\|2vlj]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[1a9b\|1a9b]], [[2axg\|2axg]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4r\|2x4r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1zt4\|1zt4]], [[1hsb\|1hsb]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[1tmc\|1tmc]], [[2av1\|2av1]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[2vlj\|2vlj]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[1a9b\|1a9b]], [[2axg\|2axg]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4r\|2x4r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4q OCA], [http://pdbe.org/2x4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4q RCSB], [http://www.ebi.ac.uk/pdbsum/2x4q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4q OCA], [http://pdbe.org/2x4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4q RCSB], [http://www.ebi.ac.uk/pdbsum/2x4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:56, 9 February 2016

OCA — Tue, 09 Feb 2016 11:56:21 GMT

←Older revision		Revision as of 11:56, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2x4q' size='340' side='right' caption='[[2x4q]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x4q' size='340' side='right' caption='[[2x4q]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x4q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x4q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRQ:(3S)-3-AMINO-3-(2-NITROPHENYL)PROPANOIC+ACID'>PRQ</scene>, <scene name='pdbligand=PRV:(2R)-AMINO(2-NITROPHENYL)ETHANOIC+ACID'>PRV</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRQ:(3S)-3-AMINO-3-(2-NITROPHENYL)PROPANOIC+ACID'>PRQ</scene>, <scene name='pdbligand=PRV:(2R)-AMINO(2-NITROPHENYL)ETHANOIC+ACID'>PRV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1zt4\|1zt4]], [[1hsb\|1hsb]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[1tmc\|1tmc]], [[2av1\|2av1]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[2vlj\|2vlj]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[1a9b\|1a9b]], [[2axg\|2axg]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4r\|2x4r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1zt4\|1zt4]], [[1hsb\|1hsb]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[1tmc\|1tmc]], [[2av1\|2av1]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[2vlj\|2vlj]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[1a9b\|1a9b]], [[2axg\|2axg]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4r\|2x4r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4q RCSB], [http://www.ebi.ac.uk/pdbsum/2x4q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4q OCA], [http://pdbe.org/2x4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4q RCSB], [http://www.ebi.ac.uk/pdbsum/2x4q PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x4q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x4q" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Celie, P H.N]]		[[Category: Celie, P H.N]]
	[[Category: Ovaa, H]]		[[Category: Ovaa, H]]

OCA at 06:39, 25 December 2014

OCA — Thu, 25 Dec 2014 06:39:17 GMT

←Older revision		Revision as of 06:39, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x4q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x4q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRQ:(3S)-3-AMINO-3-(2-NITROPHENYL)PROPANOIC+ACID'>PRQ</scene>, <scene name='pdbligand=PRV:(2R)-AMINO(2-NITROPHENYL)ETHANOIC+ACID'>PRV</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRQ:(3S)-3-AMINO-3-(2-NITROPHENYL)PROPANOIC+ACID'>PRQ</scene>, <scene name='pdbligand=PRV:(2R)-AMINO(2-NITROPHENYL)ETHANOIC+ACID'>PRV</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1zt4\|1zt4]], [[1hsb\|1hsb]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[1tmc\|1tmc]], [[2av1\|2av1]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[2vlj\|2vlj]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[1a9b\|1a9b]], [[2axg\|2axg]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4r\|2x4r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1zt4\|1zt4]], [[1hsb\|1hsb]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[1tmc\|1tmc]], [[2av1\|2av1]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[2vlj\|2vlj]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[1a9b\|1a9b]], [[2axg\|2axg]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4r\|2x4r]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4q RCSB], [http://www.ebi.ac.uk/pdbsum/2x4q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4q RCSB], [http://www.ebi.ac.uk/pdbsum/2x4q PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Celie, P H.N.]]	+	[[Category: Celie, P H.N]]
-	[[Category: Ovaa, H.]]	+	[[Category: Ovaa, H]]
-	[[Category: Perrakis, A.]]	+	[[Category: Perrakis, A]]
-	[[Category: Rodenko, B.]]	+	[[Category: Rodenko, B]]
-	[[Category: Schumacher, T N.M.]]	+	[[Category: Schumacher, T N.M]]
-	[[Category: Toebes, M.]]	+	[[Category: Toebes, M]]
	[[Category: Amyloid]]		[[Category: Amyloid]]
	[[Category: Host-virus interaction]]		[[Category: Host-virus interaction]]

OCA at 02:09, 1 October 2014

OCA — Wed, 01 Oct 2014 02:09:36 GMT

←Older revision		Revision as of 02:09, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2x4q\| PDB=2x4q \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PHOTOCLEAVABLE PEPTIDE==
-	===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PHOTOCLEAVABLE PEPTIDE===	+	<StructureSection load='2x4q' size='340' side='right' caption='[[2x4q]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19655751}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x4q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4Q FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRQ:(3S)-3-AMINO-3-(2-NITROPHENYL)PROPANOIC+ACID'>PRQ</scene>, <scene name='pdbligand=PRV:(2R)-AMINO(2-NITROPHENYL)ETHANOIC+ACID'>PRV</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[1a1n\|1a1n]], [[2bvo\|2bvo]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1zt4\|1zt4]], [[1hsb\|1hsb]], [[1ce6\|1ce6]], [[1x7q\|1x7q]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1tvh\|1tvh]], [[1hhh\|1hhh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1efx\|1efx]], [[1qlf\|1qlf]], [[1tmc\|1tmc]], [[2av1\|2av1]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[1b0r\|1b0r]], [[2vlj\|2vlj]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[1a9b\|1a9b]], [[2axg\|2axg]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1qvo\|1qvo]], [[1hhj\|1hhj]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4r\|2x4r]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4q RCSB], [http://www.ebi.ac.uk/pdbsum/2x4q PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Class I major histocompatibility complexes (MHCs) present peptide ligands on the cell surface for recognition by appropriate cytotoxic T cells. The unstable nature of unliganded MHC necessitates the production of recombinant class I complexes through in vitro refolding reactions in the presence of an added excess of peptides. This strategy is not amenable to high-throughput production of vast collections of class I complexes. To address this issue, we recently designed photocaged MHC ligands that can be cleaved by a UV light trigger in the MHC bound state under conditions that do not affect the integrity of the MHC structure. The results obtained with photocaged MHC ligands demonstrate that conditional MHC ligands can form a generally applicable concept for the creation of defined peptide-MHCs. However, the use of UV exposure to mediate ligand exchange is unsuited for a number of applications, due to the lack of UV penetration through cell culture systems and due to the transfer of heat upon UV irradiation, which can induce evaporation. To overcome these limitations, here, we provide proof-of-concept for the generation of defined peptide-MHCs by chemical trigger-induced ligand exchange. The crystal structure of the MHC with the novel chemosensitive ligand showcases that the ligand occupies the expected binding site, in a conformation where the hydroxyl groups should be reactive to periodate. We proceed to validate this technology by producing peptide-MHCs that can be used for T cell detection. The methodology that we describe here should allow loading of MHCs with defined peptides in cell culture devices, thereby permitting antigen-specific T cell expansion and purification for cell therapy. In addition, this technology will be useful to develop miniaturized assay systems for performing high-throughput screens for natural and unnatural MHC ligands.

-	~~==Function==~~	+	Class I major histocompatibility complexes loaded by a periodate trigger.,Rodenko B, Toebes M, Celie PH, Perrakis A, Schumacher TN, Ovaa H J Am Chem Soc. 2009 Sep 2;131(34):12305-13. PMID:19655751<ref>PMID:19655751</ref>
-	~~[[http~~:~~//www~~.~~uniprot.org~~/~~uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2x4q]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019655751</ref><ref group="xtra">PMID:019655750</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Celie, P H.N.]]		[[Category: Celie, P H.N.]]

OCA at 07:02, 25 March 2013

OCA — Mon, 25 Mar 2013 07:02:18 GMT

←Older revision		Revision as of 07:02, 25 March 2013
Line 1:		Line 1:
-	[[Image:2x4q.png\|left\|200px]]
-
	{{STRUCTURE_2x4q\| PDB=2x4q \| SCENE= }}		{{STRUCTURE_2x4q\| PDB=2x4q \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PHOTOCLEAVABLE PEPTIDE===		===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PHOTOCLEAVABLE PEPTIDE===
		+	{{ABSTRACT_PUBMED_19655751}}

-	~~{{ABSTRACT_PUBMED_19655751}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system.

	==About this Structure==		==About this Structure==
Line 15:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019655751</ref><ref group="xtra">PMID:019655750</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019655751</ref><ref group="xtra">PMID:019655750</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Celie, P H.N.]]		[[Category: Celie, P H.N.]]

OCA at 13:45, 20 October 2012

OCA — Sat, 20 Oct 2012 13:45:19 GMT

←Older revision		Revision as of 13:45, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x4q]] is a 6 chain structure ~~of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA].	+	[[2x4q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA].

	==See Also==		==See Also==

OCA at 12:59, 26 July 2012

OCA — Thu, 26 Jul 2012 12:59:55 GMT

←Older revision		Revision as of 12:59, 26 July 2012
Line 1:		Line 1:
	[[Image:2x4q.png\|left\|200px]]		[[Image:2x4q.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2x4q", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2x4q\| PDB=2x4q \| SCENE= }}		{{STRUCTURE_2x4q\| PDB=2x4q \| SCENE= }}

	===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PHOTOCLEAVABLE PEPTIDE===		===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PHOTOCLEAVABLE PEPTIDE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19655751}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19655751 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19655751}}		{{ABSTRACT_PUBMED_19655751}}

	==About this Structure==		==About this Structure==
-	[[2x4q]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA].	+	[[2x4q]] is a 6 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4Q OCA].
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
		+	*[[Major histocompatibility complex\|Major histocompatibility complex]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19655751~~</ref><ref group="xtra">PMID:~~19655750~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019655751</ref><ref group="xtra">PMID:019655750</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Celie, P H.N.]]		[[Category: Celie, P H.N.]]