2x8y - Revision history

OCA at 10:26, 20 December 2023

OCA — Wed, 20 Dec 2023 10:26:45 GMT

←Older revision		Revision as of 10:26, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2x8y' size='340' side='right'caption='[[2x8y]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x8y' size='340' side='right'caption='[[2x8y]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=ZN:~~ZINC+ION~~'>ZN</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8y OCA], [https://pdbe.org/2x8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8y RCSB], [https://www.ebi.ac.uk/pdbsum/2x8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8y OCA], [https://pdbe.org/2x8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8y RCSB], [https://www.ebi.ac.uk/pdbsum/2x8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACE_DROME ACE_DROME]] May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.<ref>PMID:12591244</ref>	+	[https://www.uniprot.org/uniprot/ACE_DROME ACE_DROME] May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.<ref>PMID:12591244</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Peptidyl-dipeptidase A]]~~	+	[[Category: Acharya KR]]
-	[[Category: Acharya~~, K R~~]]	+	[[Category: Akif M]]
-	[[Category: Akif, M]]	+	[[Category: Dive V]]
-	[[Category: Dive, V]]	+	[[Category: Georgiadis D]]
-	[[Category: Georgiadis, D]]	+	[[Category: Isaac RE]]
-	[[Category: Isaac~~, R E~~]]	+	[[Category: Mahajan A]]
-	[[Category: Mahajan, A]]	+	[[Category: Sturrock ED]]
-	[[Category: Sturrock~~, E D]]~~	+
-	~~[[Category: Ace inhibitor]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Zinc metallopeptidase~~]]	+

OCA at 10:47, 13 April 2022

OCA — Wed, 13 Apr 2022 10:47:32 GMT

←Older revision		Revision as of 10:47, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='2x8y' size='340' side='right'caption='[[2x8y]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x8y' size='340' side='right'caption='[[2x8y]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=ZN:~~ZINC+ION~~'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2x8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8y OCA], [~~http~~://pdbe.org/2x8y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x8y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x8y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8y OCA], [https://pdbe.org/2x8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8y RCSB], [https://www.ebi.ac.uk/pdbsum/2x8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACE_DROME ACE_DROME]] May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.<ref>PMID:12591244</ref>	+	[[https://www.uniprot.org/uniprot/ACE_DROME ACE_DROME]] May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.<ref>PMID:12591244</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:07, 8 July 2020

OCA — Wed, 08 Jul 2020 15:07:25 GMT

←Older revision		Revision as of 15:07, 8 July 2020
Line 1:		Line 1:

	==Crystal structure of AnCE==		==Crystal structure of AnCE==
-	<StructureSection load='2x8y' size='340' side='right' caption='[[2x8y]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2x8y' size='340' side='right'caption='[[2x8y]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8y OCA], [http://pdbe.org/2x8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x8y RCSB], [http://www.ebi.ac.uk/pdbsum/2x8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8y OCA], [http://pdbe.org/2x8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x8y RCSB], [http://www.ebi.ac.uk/pdbsum/2x8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Angiotensin-Converting Enzyme\|Angiotensin-Converting Enzyme]]	+	*[[Angiotensin-Converting Enzyme 3D structures\|Angiotensin-Converting Enzyme 3D structures]]
-	*[[Carboxypeptidase\|Carboxypeptidase]]	+	*[[Carboxypeptidase 3D structures\|Carboxypeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Peptidyl-dipeptidase A]]		[[Category: Peptidyl-dipeptidase A]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]

OCA at 09:42, 3 October 2018

OCA — Wed, 03 Oct 2018 09:42:55 GMT

←Older revision		Revision as of 09:42, 3 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF ANCE~~==	+	==Crystal structure of AnCE==
	<StructureSection load='2x8y' size='340' side='right' caption='[[2x8y]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x8y' size='340' side='right' caption='[[2x8y]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=ZN:~~ZINC+ION~~'>ZN</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8y_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8y_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:39, 5 August 2016

OCA — Fri, 05 Aug 2016 20:39:40 GMT

←Older revision		Revision as of 20:39, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF ANCE==		==CRYSTAL STRUCTURE OF ANCE==
	<StructureSection load='2x8y' size='340' side='right' caption='[[2x8y]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x8y' size='340' side='right' caption='[[2x8y]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8y RCSB], [http://www.ebi.ac.uk/pdbsum/2x8y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8y OCA], [http://pdbe.org/2x8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x8y RCSB], [http://www.ebi.ac.uk/pdbsum/2x8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x8y ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x8y" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drosophila melanogaster~~]]	+	[[Category: Drome]]
	[[Category: Peptidyl-dipeptidase A]]		[[Category: Peptidyl-dipeptidase A]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]

OCA at 05:41, 25 December 2014

OCA — Thu, 25 Dec 2014 05:41:22 GMT

←Older revision		Revision as of 05:41, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8y RCSB], [http://www.ebi.ac.uk/pdbsum/2x8y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8y RCSB], [http://www.ebi.ac.uk/pdbsum/2x8y PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACE_DROME ACE_DROME]] May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.<ref>PMID:12591244</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Peptidyl-dipeptidase A]]		[[Category: Peptidyl-dipeptidase A]]
-	[[Category: Acharya, K R.]]	+	[[Category: Acharya, K R]]
-	[[Category: Akif, M.]]	+	[[Category: Akif, M]]
-	[[Category: Dive, V.]]	+	[[Category: Dive, V]]
-	[[Category: Georgiadis, D.]]	+	[[Category: Georgiadis, D]]
-	[[Category: Isaac, R E.]]	+	[[Category: Isaac, R E]]
-	[[Category: Mahajan, A.]]	+	[[Category: Mahajan, A]]
-	[[Category: Sturrock, E D.]]	+	[[Category: Sturrock, E D]]
	[[Category: Ace inhibitor]]		[[Category: Ace inhibitor]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Zinc metallopeptidase]]		[[Category: Zinc metallopeptidase]]

OCA at 00:59, 2 October 2014

OCA — Thu, 02 Oct 2014 00:59:27 GMT

←Older revision		Revision as of 00:59, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2x8y.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF ANCE==
		+	<StructureSection load='2x8y' size='340' side='right' caption='[[2x8y]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Y FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j38\|1j38]], [[1j36\|1j36]], [[1j37\|1j37]], [[2x94\|2x94]], [[2x8z\|2x8z]], [[2x91\|2x91]], [[2x95\|2x95]], [[2x92\|2x92]], [[2x96\|2x96]], [[2x97\|2x97]], [[2x93\|2x93]], [[2x90\|2x90]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidyl-dipeptidase_A Peptidyl-dipeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.15.1 3.4.15.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8y RCSB], [http://www.ebi.ac.uk/pdbsum/2x8y PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8y_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Angiotensin I-converting enzyme (ACE), one of the central components of the renin-angiotensin system, is a key therapeutic target for the treatment of hypertension and cardiovascular disorders. Human somatic ACE (sACE) has two homologous domains (N and C). The N- and C-domain catalytic sites have different activities toward various substrates. Moreover, some of the undesirable side effects of the currently available and widely used ACE inhibitors may arise from their targeting both domains leading to defects in other pathways. In addition, structural studies have shown that although both these domains have much in common at the inhibitor binding site, there are significant differences and these are greater at the peptide binding sites than regions distal to the active site. As a model system, we have used an ACE homologue from Drosophila melanogaster (AnCE, a single domain protein with ACE activity) to study ACE inhibitor binding. In an extensive study, we present high-resolution structures for native AnCE and in complex with six known antihypertensive drugs, a novel C-domain sACE specific inhibitor, lisW-S, and two sACE domain-specific phosphinic peptidyl inhibitors, RXPA380 and RXP407 (i.e., nine structures). These structures show detailed binding features of the inhibitors and highlight subtle changes in the orientation of side chains at different binding pockets in the active site in comparison with the active site of N- and C-domains of sACE. This study provides information about the structure-activity relationships that could be utilized for designing new inhibitors with improved domain selectivity for sACE.

-	~~{{STRUCTURE_2x8y\| PDB=2x8y \| SCENE= }}~~	+	High-resolution crystal structures of Drosophila melanogaster angiotensin-converting enzyme in complex with novel inhibitors and antihypertensive drugs.,Akif M, Georgiadis D, Mahajan A, Dive V, Sturrock ED, Isaac RE, Acharya KR J Mol Biol. 2010 Jul 16;400(3):502-17. Epub 2010 May 19. PMID:20488190<ref>PMID:20488190</ref>

-	~~===CRYSTAL STRUCTURE OF ANCE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20488190}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2x8y]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drosophila_melanogaster Drosophila melanogaster]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA].~~	+

	==See Also==		==See Also==
	*[[Angiotensin-Converting Enzyme\|Angiotensin-Converting Enzyme]]		*[[Angiotensin-Converting Enzyme\|Angiotensin-Converting Enzyme]]
	*[[Carboxypeptidase\|Carboxypeptidase]]		*[[Carboxypeptidase\|Carboxypeptidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020488190<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Peptidyl-dipeptidase A]]		[[Category: Peptidyl-dipeptidase A]]

OCA at 13:15, 20 October 2012

OCA — Sat, 20 Oct 2012 13:15:42 GMT

←Older revision		Revision as of 13:15, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x8y]] is a 1 chain structure ~~of [[Angiotensin-Converting Enzyme]] and [[Carboxypeptidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA].	+	[[2x8y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Y OCA].

	==See Also==		==See Also==

OCA at 11:24, 26 July 2012

OCA — Thu, 26 Jul 2012 11:24:26 GMT

←Older revision		Revision as of 11:24, 26 July 2012
Line 1:		Line 1:
	[[Image:2x8y.png\|left\|200px]]		[[Image:2x8y.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2x8y", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2x8y\| PDB=2x8y \| SCENE= }}		{{STRUCTURE_2x8y\| PDB=2x8y \| SCENE= }}

	===CRYSTAL STRUCTURE OF ANCE===		===CRYSTAL STRUCTURE OF ANCE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20488190}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20488190 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20488190}}		{{ABSTRACT_PUBMED_20488190}}

OCA: Protected "2x8y" [edit=sysop:move=sysop]

OCA — Sat, 02 Jun 2012 15:15:37 GMT

Protected "2x8y" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:15, 2 June 2012