2x99 - Revision history

OCA at 10:47, 13 April 2022

OCA — Wed, 13 Apr 2022 10:47:57 GMT

←Older revision		Revision as of 10:47, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='2x99' size='340' side='right'caption='[[2x99]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2x99' size='340' side='right'caption='[[2x99]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x99]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2X99 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x99]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X99 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x8h\|2x8h]], [[2x8g\|2x8g]], [[2v6o\|2v6o]], [[2x8c\|2x8c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2x8h\|2x8h]], [[2x8g\|2x8g]], [[2v6o\|2v6o]], [[2x8c\|2x8c]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2x99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x99 OCA], [~~http~~://pdbe.org/2x99 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x99 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x99 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x99 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x99 OCA], [https://pdbe.org/2x99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x99 RCSB], [https://www.ebi.ac.uk/pdbsum/2x99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x99 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 15:07, 8 July 2020

OCA — Wed, 08 Jul 2020 15:07:55 GMT

←Older revision		Revision as of 15:07, 8 July 2020
Line 1:		Line 1:

	==Thioredoxin glutathione reductase from Schistosoma mansoni in complex with NADPH==		==Thioredoxin glutathione reductase from Schistosoma mansoni in complex with NADPH==
-	<StructureSection load='2x99' size='340' side='right' caption='[[2x99]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2x99' size='340' side='right'caption='[[2x99]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X99 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X99 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x8h\|2x8h]], [[2x8g\|2x8g]], [[2v6o\|2v6o]], [[2x8c\|2x8c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x8h\|2x8h]], [[2x8g\|2x8g]], [[2v6o\|2v6o]], [[2x8c\|2x8c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x99 OCA], [http://pdbe.org/2x99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x99 RCSB], [http://www.ebi.ac.uk/pdbsum/2x99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x99 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x99 OCA], [http://pdbe.org/2x99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x99 RCSB], [http://www.ebi.ac.uk/pdbsum/2x99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x99 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Blood fluke]]		[[Category: Blood fluke]]
		+	[[Category: Large Structures]]
	[[Category: Thioredoxin-disulfide reductase]]		[[Category: Thioredoxin-disulfide reductase]]
	[[Category: Angelucci, F]]		[[Category: Angelucci, F]]

OCA at 09:36, 3 October 2018

OCA — Wed, 03 Oct 2018 09:36:48 GMT

←Older revision		Revision as of 09:36, 3 October 2018
Line 1:		Line 1:

-	==~~THIOREDOXIN GLUTATHIONE REDUCTASE FROM SCHISTOSOMA MANSONI IN COMPLEX WITH~~ NADPH==	+	==Thioredoxin glutathione reductase from Schistosoma mansoni in complex with NADPH==
	<StructureSection load='2x99' size='340' side='right' caption='[[2x99]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2x99' size='340' side='right' caption='[[2x99]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x9/2x99_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x9/2x99_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:01, 11 August 2016

OCA — Thu, 11 Aug 2016 12:01:30 GMT

←Older revision		Revision as of 12:01, 11 August 2016
Line 1:		Line 1:
		+
	==THIOREDOXIN GLUTATHIONE REDUCTASE FROM SCHISTOSOMA MANSONI IN COMPLEX WITH NADPH==		==THIOREDOXIN GLUTATHIONE REDUCTASE FROM SCHISTOSOMA MANSONI IN COMPLEX WITH NADPH==
	<StructureSection load='2x99' size='340' side='right' caption='[[2x99]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2x99' size='340' side='right' caption='[[2x99]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schistosoma_mansoni Schistosoma mansoni~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X99 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X99 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x8h\|2x8h]], [[2x8g\|2x8g]], [[2v6o\|2v6o]], [[2x8c\|2x8c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x8h\|2x8h]], [[2x8g\|2x8g]], [[2v6o\|2v6o]], [[2x8c\|2x8c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x99 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x99 RCSB], [http://www.ebi.ac.uk/pdbsum/2x99 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x99 OCA], [http://pdbe.org/2x99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x99 RCSB], [http://www.ebi.ac.uk/pdbsum/2x99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x99 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x99 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x99" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Schistosoma mansoni~~]]	+	[[Category: Blood fluke]]
	[[Category: Thioredoxin-disulfide reductase]]		[[Category: Thioredoxin-disulfide reductase]]
	[[Category: Angelucci, F]]		[[Category: Angelucci, F]]

OCA at 09:33, 20 January 2015

OCA — Tue, 20 Jan 2015 09:33:51 GMT

←Older revision		Revision as of 09:33, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X99 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X99 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x8h\|2x8h]], [[2x8g\|2x8g]], [[2v6o\|2v6o]], [[2x8c\|2x8c]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x8h\|2x8h]], [[2x8g\|2x8g]], [[2v6o\|2v6o]], [[2x8c\|2x8c]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x99 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x99 RCSB], [http://www.ebi.ac.uk/pdbsum/2x99 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x99 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x99 RCSB], [http://www.ebi.ac.uk/pdbsum/2x99 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Schistosoma mansoni]]		[[Category: Schistosoma mansoni]]
	[[Category: Thioredoxin-disulfide reductase]]		[[Category: Thioredoxin-disulfide reductase]]
-	[[Category: Angelucci, F.]]	+	[[Category: Angelucci, F]]
-	[[Category: Bellelli, A.]]	+	[[Category: Bellelli, A]]
-	[[Category: Boumis, G.]]	+	[[Category: Boumis, G]]
-	[[Category: Brunori, M.]]	+	[[Category: Brunori, M]]
-	[[Category: Dimastrogiovanni, D.]]	+	[[Category: Dimastrogiovanni, D]]
-	[[Category: Miele, A E.]]	+	[[Category: Miele, A E]]
-	[[Category: Saccoccia, F.]]	+	[[Category: Saccoccia, F]]
	[[Category: Detoxification pathway]]		[[Category: Detoxification pathway]]
	[[Category: Flavoprotein]]		[[Category: Flavoprotein]]

OCA at 00:56, 2 October 2014

OCA — Thu, 02 Oct 2014 00:56:41 GMT

←Older revision		Revision as of 00:56, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2x99.~~png~~\|~~left~~\|200px]]	+	==THIOREDOXIN GLUTATHIONE REDUCTASE FROM SCHISTOSOMA MANSONI IN COMPLEX WITH NADPH==
		+	<StructureSection load='2x99' size='340' side='right' caption='[[2x99]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X99 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x8h\|2x8h]], [[2x8g\|2x8g]], [[2v6o\|2v6o]], [[2x8c\|2x8c]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x99 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x99 RCSB], [http://www.ebi.ac.uk/pdbsum/2x99 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x9/2x99_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Schistosomiasis is the second most widespread human parasitic disease. It is principally treated with one drug, praziquantel that is administered to 100 million people each year; less sensitive strains of schistosomes are emerging. One of the most appealing drug targets against schistosomiasis is thioredoxin glutathione reductase (TGR). This natural chimeric enzyme is a peculiar fusion of a glutaredoxin domain with a thioredoxin Selenocysteine (Sec)-containing reductase domain. Sec is located on a flexible C-terminal arm that is usually disordered in the available structures of the protein and is essential for the full catalytic activity of TGR. In this study, we dissect the catalytic cycle of Schistosoma mansoni TGR (SmTGR) by structural and functional analysis of Sec597Cys mutant. The crystallographic data presented herein include: the oxidized form (at 1.9 A resolution); the NADPH- and GSH-bound forms (2.3 A and 1.9 A , respectively); and a different crystal form of the (partially) reduced enzyme (3.1 A ), showing the physiological dimer and the entire C-terminus of one subunit. Whenever possible, we determined the rate constants for the interconversion between the different oxidation states of TGR by kinetic methods. By combining the crystallographic analysis with computer modelling, we were able to throw further light on the mechanism of action of S. mansoni TGR. In particular, we propose hereby the putative functionally relevant conformational change of the C-terminus after the transfer of reducing equivalents from NADPH to the redox sites of the enzyme.

-	~~{{STRUCTURE_2x99\| PDB=2x99 \| SCENE= }}~~	+	Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by x-ray crystallography.,Angelucci F, Dimastrogiovanni D, Boumis G, Brunori M, Miele AE, Saccoccia F, Bellelli A J Biol Chem. 2010 Jul 21. PMID:20659890<ref>PMID:20659890</ref>

-	~~===THIOREDOXIN GLUTATHIONE REDUCTASE FROM SCHISTOSOMA MANSONI IN COMPLEX WITH NADPH===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20659890}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2x99]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Schistosoma_mansoni Schistosoma mansoni]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA].~~	+

	==See Also==		==See Also==
	*[[Thioredoxin Glutathione Reductase\|Thioredoxin Glutathione Reductase]]		*[[Thioredoxin Glutathione Reductase\|Thioredoxin Glutathione Reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020659890<~~/~~ref~~><~~ref group="xtra">PMID:018300227</ref><ref group="xtra">PMID:019710012</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Schistosoma mansoni]]		[[Category: Schistosoma mansoni]]
	[[Category: Thioredoxin-disulfide reductase]]		[[Category: Thioredoxin-disulfide reductase]]

OCA at 15:22, 20 October 2012

OCA — Sat, 20 Oct 2012 15:22:17 GMT

←Older revision		Revision as of 15:22, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x99]] is a 1 chain structure ~~of [[Thioredoxin Glutathione Reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA].	+	[[2x99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA].

	==See Also==		==See Also==

OCA at 18:10, 26 July 2012

OCA — Thu, 26 Jul 2012 18:10:35 GMT

←Older revision		Revision as of 18:10, 26 July 2012
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	[[Image:2x99.png\|left\|200px]]		[[Image:2x99.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2x99", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2x99\| PDB=2x99 \| SCENE= }}		{{STRUCTURE_2x99\| PDB=2x99 \| SCENE= }}

	===THIOREDOXIN GLUTATHIONE REDUCTASE FROM SCHISTOSOMA MANSONI IN COMPLEX WITH NADPH===		===THIOREDOXIN GLUTATHIONE REDUCTASE FROM SCHISTOSOMA MANSONI IN COMPLEX WITH NADPH===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20659890}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20659890 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20659890}}		{{ABSTRACT_PUBMED_20659890}}

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	==See Also==		==See Also==
-	*[[Thioredoxin Glutathione Reductase]]	+	*[[Thioredoxin Glutathione Reductase\|Thioredoxin Glutathione Reductase]]

	==Reference==		==Reference==

OCA at 07:14, 7 December 2011

OCA — Wed, 07 Dec 2011 07:14:17 GMT

←Older revision		Revision as of 07:14, 7 December 2011
Line 19:		Line 19:

	==About this Structure==		==About this Structure==
-	[[2x99]] is a 1 chain structure of [[Thioredoxin ~~Glutathion~~ Reductase]] with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA].	+	[[2x99]] is a 1 chain structure of [[Thioredoxin Glutathione Reductase]] with sequence from [http://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X99 OCA].

	==See Also==		==See Also==
-	*[[Thioredoxin ~~Glutathion~~ Reductase]]	+	*[[Thioredoxin Glutathione Reductase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20659890~~</ref><ref group="xtra">PMID:~~18300227~~</ref><ref group="xtra">PMID:~~19710012~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020659890</ref><ref group="xtra">PMID:018300227</ref><ref group="xtra">PMID:019710012</ref><references group="xtra"/>
	[[Category: Schistosoma mansoni]]		[[Category: Schistosoma mansoni]]
	[[Category: Thioredoxin-disulfide reductase]]		[[Category: Thioredoxin-disulfide reductase]]

OCA: Protected "2x99" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 20:37:39 GMT

Protected "2x99" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:37, 14 March 2011