2xb1 - Revision history

OCA at 10:27, 20 December 2023

OCA — Wed, 20 Dec 2023 10:27:54 GMT

←Older revision		Revision as of 10:27, 20 December 2023
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	<StructureSection load='2xb1' size='340' side='right'caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xb1' size='340' side='right'caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xb1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XB1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xb1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XB1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb1 OCA], [https://pdbe.org/2xb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xb1 RCSB], [https://www.ebi.ac.uk/pdbsum/2xb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb1 OCA], [https://pdbe.org/2xb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xb1 RCSB], [https://www.ebi.ac.uk/pdbsum/2xb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PYGO2_HUMAN PYGO2_HUMAN]] Involved in signal transduction through the Wnt pathway.	+	[https://www.uniprot.org/uniprot/PYGO2_HUMAN PYGO2_HUMAN] Involved in signal transduction through the Wnt pathway.[https://www.uniprot.org/uniprot/BCL9L_HUMAN BCL9L_HUMAN] Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bienz, M]]	+	[[Category: Bienz M]]
-	[[Category: Fiedler, M]]	+	[[Category: Fiedler M]]
-	[[Category: Johnson~~, C M~~]]	+	[[Category: Johnson CM]]
-	[[Category: Miller~~, T C~~]]	+	[[Category: Miller TC]]
-	[[Category: Rutherford~~, T J]]~~	+	[[Category: Rutherford TJ]]
-	~~[[Category: Fusion protein]]~~	+
-	~~[[Category: Metal binding]]~~	+
-	~~[[Category: Signal transduction]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Wnt protein~~]]	+

OCA at 10:48, 13 April 2022

OCA — Wed, 13 Apr 2022 10:48:58 GMT

←Older revision		Revision as of 10:48, 13 April 2022
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	<StructureSection load='2xb1' size='340' side='right'caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xb1' size='340' side='right'caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xb1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XB1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xb1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XB1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb1 OCA], [~~http~~://pdbe.org/2xb1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xb1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xb1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb1 OCA], [https://pdbe.org/2xb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xb1 RCSB], [https://www.ebi.ac.uk/pdbsum/2xb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PYGO2_HUMAN PYGO2_HUMAN]] Involved in signal transduction through the Wnt pathway.	+	[[https://www.uniprot.org/uniprot/PYGO2_HUMAN PYGO2_HUMAN]] Involved in signal transduction through the Wnt pathway.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:09, 8 July 2020

OCA — Wed, 08 Jul 2020 15:09:13 GMT

←Older revision		Revision as of 15:09, 8 July 2020
Line 1:		Line 1:

	==Crystal structure of the human Pygo2 PHD finger in complex with the B9L HD1 domain==		==Crystal structure of the human Pygo2 PHD finger in complex with the B9L HD1 domain==
-	<StructureSection load='2xb1' size='340' side='right' caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2xb1' size='340' side='right'caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xb1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XB1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xb1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XB1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb1 OCA], [http://pdbe.org/2xb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb1 OCA], [http://pdbe.org/2xb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bienz, M]]		[[Category: Bienz, M]]
	[[Category: Fiedler, M]]		[[Category: Fiedler, M]]

OCA at 09:16, 3 October 2018

OCA — Wed, 03 Oct 2018 09:16:47 GMT

←Older revision		Revision as of 09:16, 3 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF THE HUMAN PYGO2~~ PHD ~~FINGER IN COMPLEX WITH THE~~ B9L HD1 ~~DOMAIN~~==	+	==Crystal structure of the human Pygo2 PHD finger in complex with the B9L HD1 domain==
	<StructureSection load='2xb1' size='340' side='right' caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xb1' size='340' side='right' caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/2xb1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/2xb1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:36, 5 August 2016

OCA — Fri, 05 Aug 2016 05:36:49 GMT

←Older revision		Revision as of 05:36, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE HUMAN PYGO2 PHD FINGER IN COMPLEX WITH THE B9L HD1 DOMAIN==		==CRYSTAL STRUCTURE OF THE HUMAN PYGO2 PHD FINGER IN COMPLEX WITH THE B9L HD1 DOMAIN==
	<StructureSection load='2xb1' size='340' side='right' caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xb1' size='340' side='right' caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xb1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XB1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xb1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XB1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb1 OCA], [http://pdbe.org/2xb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYGO2_HUMAN PYGO2_HUMAN]] Involved in signal transduction through the Wnt pathway.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 14:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xb1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xb1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bienz, M]]		[[Category: Bienz, M]]
	[[Category: Fiedler, M]]		[[Category: Fiedler, M]]

OCA at 21:27, 3 January 2015

OCA — Sat, 03 Jan 2015 21:27:15 GMT

←Older revision		Revision as of 21:27, 3 January 2015
Line 2:		Line 2:
	<StructureSection load='2xb1' size='340' side='right' caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xb1' size='340' side='right' caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xb1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA]. <br>	+	<table><tr><td colspan='2'>[[2xb1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XB1 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~><br>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb1 PDBsum]</span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb1 PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 22:
	Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.,Miller TC, Rutherford TJ, Johnson CM, Fiedler M, Bienz M J Mol Biol. 2010 Sep 3;401(5):969-84. Epub 2010 Jul 14. PMID:20637214<ref>PMID:20637214</ref>		Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.,Miller TC, Rutherford TJ, Johnson CM, Fiedler M, Bienz M J Mol Biol. 2010 Sep 3;401(5):969-84. Epub 2010 Jul 14. PMID:20637214<ref>PMID:20637214</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 30:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bienz, M.]]	+	[[Category: Bienz, M]]
-	[[Category: Fiedler, M.]]	+	[[Category: Fiedler, M]]
-	[[Category: Johnson, C M.]]	+	[[Category: Johnson, C M]]
-	[[Category: Miller, T C.]]	+	[[Category: Miller, T C]]
-	[[Category: Rutherford, T J.]]	+	[[Category: Rutherford, T J]]
	[[Category: Fusion protein]]		[[Category: Fusion protein]]
	[[Category: Metal binding]]		[[Category: Metal binding]]

OCA at 07:47, 14 May 2014

OCA — Wed, 14 May 2014 07:47:39 GMT

←Older revision		Revision as of 07:47, 14 May 2014
Line 1:		Line 1:
-	[[~~Image~~:2xb1.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE HUMAN PYGO2 PHD FINGER IN COMPLEX WITH THE B9L HD1 DOMAIN==
		+	<StructureSection load='2xb1' size='340' side='right' caption='[[2xb1]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xb1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xb1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb1 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/2xb1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Zn-coordinated PHD fingers of Pygopus (Pygo) proteins are critical for beta-catenin-dependent transcriptional switches in normal and malignant tissues. They bind to methylated histone H3 tails, assisted by their BCL9 co-factors whose homology domain 1 (HD1) binds to the rear PHD surface. Although histone-binding residues are identical between the two human Pygo paralogs, we show here that Pygo2 complexes exhibit slightly higher binding affinities for methylated histone H3 tail peptides than Pygo1 complexes. We solved the crystal structure of the Pygo2 PHD-BCL9-2 HD1 complex, which revealed paralog-specific interactions in its PHD-HD1 interface that could contribute indirectly to its elevated affinity for the methylated histone H3 tail. Interestingly, using NMR spectroscopy, we discovered that HD1 binding to PHD triggers an allosteric communication with a conserved isoleucine residue that lines the binding channel for histone H3 threonine 3 (T3), the link between the two adjacent binding pockets accommodating histone H3 alanine 1 and methylated lysine 4, respectively. This modulates the surface of the T3 channel, providing a plausible explanation as to how BCL9 co-factors binding to Pygo PHD fingers impact indirectly on their histone binding affinity. Intriguingly, this allosteric modulation of the T3 channel is propagated through the PHD structural core by a highly conserved tryptophan, the signature residue defining the PHD subclass of Zn fingers, which suggests that other PHD proteins may also be assisted by co-factors in their decoding of modified histone H3 tails.

-	<!--	+	Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.,Miller TC, Rutherford TJ, Johnson CM, Fiedler M, Bienz M J Mol Biol. 2010 Sep 3;401(5):969-84. Epub 2010 Jul 14. PMID:20637214<ref>PMID:20637214</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2xb1"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2xb1\| PDB=2xb1 \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF THE HUMAN PYGO2 PHD FINGER IN COMPLEX WITH THE B9L HD1 DOMAIN===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_20637214}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 20637214 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_20637214}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xb1]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020637214<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bienz, M.]]		[[Category: Bienz, M.]]

OCA: Protected "2xb1" [edit=sysop:move=sysop]

OCA — Wed, 27 Jul 2011 05:06:03 GMT

Protected "2xb1" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:06, 27 July 2011

OCA at 05:06, 27 July 2011

OCA — Wed, 27 Jul 2011 05:06:02 GMT

←Older revision		Revision as of 05:06, 27 July 2011
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-	~~{{Seed}}~~	+	[[Image:2xb1.png\|left\|200px]]
-	[[Image:2xb1.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	~~2XB1~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA].	+	[[2xb1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20637214~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020637214</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bienz, M.]]		[[Category: Bienz, M.]]
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	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Wnt protein]]		[[Category: Wnt protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:34:39 2010''

OCA at 08:27, 28 July 2010

OCA — Wed, 28 Jul 2010 08:27:56 GMT

←Older revision		Revision as of 08:27, 28 July 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2xb1.jpg\|left\|200px]]

-	The ~~entry 2xb1~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xb1", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xb1\| PDB=2xb1 \| SCENE= }}

-	~~Authors: Miller, T., Rutherford, T., Johnson, C., Fiedler, M., Bienz, M.~~	+	===CRYSTAL STRUCTURE OF THE HUMAN PYGO2 PHD FINGER IN COMPLEX WITH THE B9L HD1 DOMAIN===

-	Description: Crystal structure of the human Pygo2 PHD finger in complex with the B9L HD1 domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul ~~14 16~~:00:41 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20637214}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20637214 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20637214}}
		+
		+	==About this Structure==
		+	2XB1 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB1 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20637214</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Bienz, M.]]
		+	[[Category: Fiedler, M.]]
		+	[[Category: Johnson, C M.]]
		+	[[Category: Miller, T C.]]
		+	[[Category: Rutherford, T J.]]
		+	[[Category: Fusion protein]]
		+	[[Category: Metal binding]]
		+	[[Category: Signal transduction]]
		+	[[Category: Transcription]]
		+	[[Category: Wnt protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:34:39 2010''