2xci - Revision history

OCA at 10:37, 16 August 2023

OCA — Wed, 16 Aug 2023 10:37:52 GMT

←Older revision		Revision as of 10:37, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='2xci' size='340' side='right'caption='[[2xci]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2xci' size='340' side='right'caption='[[2xci]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xci]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex~~ aeolicus~~" huber and stetter 2001~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xci]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xcu\|2xcu]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xci OCA], [https://pdbe.org/2xci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xci RCSB], [https://www.ebi.ac.uk/pdbsum/2xci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xci ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xci OCA], [https://pdbe.org/2xci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xci RCSB], [https://www.ebi.ac.uk/pdbsum/2xci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xci ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/KDTA_AQUAE KDTA_AQUAE]] Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid.<ref>PMID:19546212</ref>	+	[https://www.uniprot.org/uniprot/KDTA_AQUAE KDTA_AQUAE] Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid.<ref>PMID:19546212</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aquifex aeolicus ~~huber and stetter 2001~~]]	+	[[Category: Aquifex aeolicus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hansen, G]]	+	[[Category: Hansen G]]
-	[[Category: Hilgenfeld, R]]	+	[[Category: Hilgenfeld R]]
-	[[Category: Mamat, U]]	+	[[Category: Mamat U]]
-	[[Category: Mesters~~, J R~~]]	+	[[Category: Mesters JR]]
-	[[Category: Schmidt, H]]	+	[[Category: Schmidt H]]
-	~~[[Category: Glycosyltransferase superfamily b]]~~	+
-	~~[[Category: Gsea]]~~	+
-	~~[[Category: Gt-b]]~~	+
-	~~[[Category: Kdta]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:38, 10 November 2021

OCA — Wed, 10 Nov 2021 08:38:27 GMT

←Older revision		Revision as of 08:38, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='2xci' size='340' side='right'caption='[[2xci]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2xci' size='340' side='right'caption='[[2xci]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xci]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XCI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xci]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XCI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xcu\|2xcu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xcu\|2xcu]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xci OCA], [~~http~~://pdbe.org/2xci PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xci RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xci PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xci ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xci OCA], [https://pdbe.org/2xci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xci RCSB], [https://www.ebi.ac.uk/pdbsum/2xci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xci ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KDTA_AQUAE KDTA_AQUAE]] Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid.<ref>PMID:19546212</ref>	+	[[https://www.uniprot.org/uniprot/KDTA_AQUAE KDTA_AQUAE]] Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid.<ref>PMID:19546212</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Glycosyltransferase\|Glycosyltransferase]]	+	*[[Glycosyltransferase 3D structures\|Glycosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:50, 21 May 2019

OCA — Tue, 21 May 2019 07:50:40 GMT

←Older revision		Revision as of 07:50, 21 May 2019
Line 1:		Line 1:

	==Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form==		==Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form==
-	<StructureSection load='2xci' size='340' side='right' caption='[[2xci]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2xci' size='340' side='right'caption='[[2xci]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xci]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xci]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCI FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 2xci" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2xci" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glycosyltransferase\|Glycosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Aquifex aeolicus huber and stetter 2001]]		[[Category: Aquifex aeolicus huber and stetter 2001]]
		+	[[Category: Large Structures]]
	[[Category: Hansen, G]]		[[Category: Hansen, G]]
	[[Category: Hilgenfeld, R]]		[[Category: Hilgenfeld, R]]

OCA at 07:31, 17 January 2018

OCA — Wed, 17 Jan 2018 07:31:30 GMT

←Older revision		Revision as of 07:31, 17 January 2018
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 2xci" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2xci" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Glycosyltransferase\|Glycosyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:16, 11 August 2016

OCA — Thu, 11 Aug 2016 16:16:16 GMT

←Older revision		Revision as of 16:16, 11 August 2016
Line 1:		Line 1:
		+
	==Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form==		==Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form==
	<StructureSection load='2xci' size='340' side='right' caption='[[2xci]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2xci' size='340' side='right' caption='[[2xci]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xci]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aquifex_aeolicus Aquifex~~ aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xci]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"aquifex_aeolicus"_huber_and_stetter_2001 "aquifex aeolicus" huber and stetter 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xcu\|2xcu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xcu\|2xcu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xci RCSB], [http://www.ebi.ac.uk/pdbsum/2xci PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xci OCA], [http://pdbe.org/2xci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xci RCSB], [http://www.ebi.ac.uk/pdbsum/2xci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xci ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KDTA_AQUAE KDTA_AQUAE]] Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid.<ref>PMID:19546212</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xci" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aquifex aeolicus]]	+	[[Category: Aquifex aeolicus huber and stetter 2001]]
	[[Category: Hansen, G]]		[[Category: Hansen, G]]
	[[Category: Hilgenfeld, R]]		[[Category: Hilgenfeld, R]]

OCA at 10:24, 20 January 2015

OCA — Tue, 20 Jan 2015 10:24:35 GMT

←Older revision		Revision as of 10:24, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xci]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xci]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xcu\|2xcu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xcu\|2xcu]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xci RCSB], [http://www.ebi.ac.uk/pdbsum/2xci PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xci RCSB], [http://www.ebi.ac.uk/pdbsum/2xci PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
-	[[Category: Hansen, G.]]	+	[[Category: Hansen, G]]
-	[[Category: Hilgenfeld, R.]]	+	[[Category: Hilgenfeld, R]]
-	[[Category: Mamat, U.]]	+	[[Category: Mamat, U]]
-	[[Category: Mesters, J R.]]	+	[[Category: Mesters, J R]]
-	[[Category: Schmidt, H.]]	+	[[Category: Schmidt, H]]
	[[Category: Glycosyltransferase superfamily b]]		[[Category: Glycosyltransferase superfamily b]]
	[[Category: Gsea]]		[[Category: Gsea]]

OCA at 01:04, 2 October 2014

OCA — Thu, 02 Oct 2014 01:04:59 GMT

←Older revision		Revision as of 01:04, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xci.~~png~~\|~~left~~\|~~200px~~]]	+	==Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form==
		+	<StructureSection load='2xci' size='340' side='right' caption='[[2xci]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xci]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XCI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xcu\|2xcu]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xci RCSB], [http://www.ebi.ac.uk/pdbsum/2xci PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	WaaA is a key enzyme in the biosynthesis of LPS, a critical component of the outer envelope of Gram-negative bacteria. Embedded in the cytoplasmic face of the inner membrane, WaaA catalyzes the transfer of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) to the lipid A precursor of LPS. Here we present crystal structures of the free and CMP-bound forms of WaaA from Aquifex aeolicus, an ancient Gram-negative hyperthermophile. These structures reveal details of the CMP-binding site and implicate a unique sequence motif (GGS/TX(5)GXNXLE) in Kdo binding. In addition, a cluster of highly conserved amino acid residues was identified which represents the potential membrane-attachment and acceptor-substrate binding site of WaaA. A series of site-directed mutagenesis experiments revealed critical roles for glycine 30 and glutamate 31 in Kdo transfer. Our results provide the structural basis of a critical reaction in LPS biosynthesis and allowed the development of a detailed model of the catalytic mechanism of WaaA.

-	~~{{STRUCTURE_2xci\| PDB=2xci \| SCENE= }}~~	+	Structural and mechanistic analysis of the membrane-embedded glycosyltransferase WaaA required for lipopolysaccharide synthesis.,Schmidt H, Hansen G, Singh S, Hanuszkiewicz A, Lindner B, Fukase K, Woodard RW, Holst O, Hilgenfeld R, Mamat U, Mesters JR Proc Natl Acad Sci U S A. 2012 Apr 2. PMID:22474366<ref>PMID:22474366</ref>

-	~~===Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus~~, ~~substrate-free form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22474366}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xci]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aquifex_aeolicus Aquifex aeolicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA].~~	+

	==See Also==		==See Also==
	*[[Glycosyltransferase\|Glycosyltransferase]]		*[[Glycosyltransferase\|Glycosyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022474366<~~/~~ref~~><~~ref group="xtra">PMID:019546212</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
	[[Category: Hansen, G.]]		[[Category: Hansen, G.]]

OCA at 12:22, 20 October 2012

OCA — Sat, 20 Oct 2012 12:22:42 GMT

←Older revision		Revision as of 12:22, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2xci]] is a 4 chain structure ~~of [[Glycosyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA].	+	[[2xci]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA].

	==See Also==		==See Also==

OCA at 08:31, 26 July 2012

OCA — Thu, 26 Jul 2012 08:31:55 GMT

←Older revision		Revision as of 08:31, 26 July 2012
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	[[Image:2xci.png\|left\|200px]]		[[Image:2xci.png\|left\|200px]]

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	{{STRUCTURE_2xci\| PDB=2xci \| SCENE= }}		{{STRUCTURE_2xci\| PDB=2xci \| SCENE= }}

	===Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form===		===Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form===

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OCA at 07:07, 18 April 2012

OCA — Wed, 18 Apr 2012 07:07:00 GMT

←Older revision		Revision as of 07:07, 18 April 2012
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-	[[Image:2xci.~~jpg~~\|left\|200px]]	+	[[Image:2xci.png\|left\|200px]]

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	{{STRUCTURE_2xci\| PDB=2xci \| SCENE= }}		{{STRUCTURE_2xci\| PDB=2xci \| SCENE= }}

-	===~~MEMBRANE~~-~~EMBEDDED MONOFUNCTIONAL GLYCOSYLTRANSFERASE WAAA OF AQUIFEX AEOLICUS~~, ~~SUBSTRATE~~-~~FREE FORM~~===	+	===Membrane-embedded monofunctional glycosyltransferase WaaA of Aquifex aeolicus, substrate-free form===


	<!--		<!--
-	The line below this paragraph, {{~~ABSTRACT_PUBMED_19546212~~}}, adds the Publication Abstract to the page	+	The line below this paragraph, {{ABSTRACT_PUBMED_22474366}}, adds the Publication Abstract to the page
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-	{{~~ABSTRACT_PUBMED_19546212~~}}	+	{{ABSTRACT_PUBMED_22474366}}

	==About this Structure==		==About this Structure==
-	[[2xci]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA].	+	[[2xci]] is a 4 chain structure of [[Glycosyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XCI OCA].
		+
		+	==See Also==
		+	*[[Glycosyltransferase\|Glycosyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019546212</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022474366</ref><ref group="xtra">PMID:019546212</ref><references group="xtra"/>
	[[Category: Aquifex aeolicus]]		[[Category: Aquifex aeolicus]]
	[[Category: Hansen, G.]]		[[Category: Hansen, G.]]
Line 29:		Line 32:
	[[Category: Mesters, J R.]]		[[Category: Mesters, J R.]]
	[[Category: Schmidt, H.]]		[[Category: Schmidt, H.]]
		+	[[Category: Glycosyltransferase superfamily b]]
		+	[[Category: Gsea]]
		+	[[Category: Gt-b]]
		+	[[Category: Kdta]]
		+	[[Category: Transferase]]