2xel - Revision history

OCA at 12:45, 17 January 2024

OCA — Wed, 17 Jan 2024 12:45:15 GMT

←Older revision		Revision as of 12:45, 17 January 2024
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	<StructureSection load='2xel' size='340' side='right'caption='[[2xel]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xel' size='340' side='right'caption='[[2xel]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xel]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_11735 Atcc 11735~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xel]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=IA2:2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL'>IA2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mne\|1mne]], [[1d1c\|1d1c]], [[1jx2\|1jx2]], [[1q5g\|1q5g]], [[1w9l\|1w9l]], [[1mmn\|1mmn]], [[1d0y\|1d0y]], [[1vom\|1vom]], [[2aka\|2aka]], [[2jhr\|2jhr]], [[2jj9\|2jj9]], [[1lvk\|1lvk]], [[1w9j\|1w9j]], [[1jwy\|1jwy]], [[2x9h\|2x9h]], [[1yv3\|1yv3]], [[1fmv\|1fmv]], [[1d0x\|1d0x]], [[1fmw\|1fmw]], [[1d1b\|1d1b]], [[1g8x\|1g8x]], [[1mma\|1mma]], [[1d1a\|1d1a]], [[1mmg\|1mmg]], [[1w9i\|1w9i]], [[1d0z\|1d0z]], [[1mnd\|1mnd]], [[1w9k\|1w9k]], [[1mmd\|1mmd]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=IA2:2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL'>IA2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xel OCA], [https://pdbe.org/2xel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xel RCSB], [https://www.ebi.ac.uk/pdbsum/2xel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xel ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xel OCA], [https://pdbe.org/2xel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xel RCSB], [https://www.ebi.ac.uk/pdbsum/2xel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xel ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MYS2_DICDI MYS2_DICDI]] Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.	+	[https://www.uniprot.org/uniprot/MYS2_DICDI MYS2_DICDI] Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 11735~~]]	+	[[Category: Dictyostelium discoideum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chinthalapudi, K]]	+	[[Category: Chinthalapudi K]]
-	[[Category: Coluccio~~, L M~~]]	+	[[Category: Coluccio LM]]
-	[[Category: Fedorov, R]]	+	[[Category: Fedorov R]]
-	[[Category: Gutzeit~~, H O~~]]	+	[[Category: Gutzeit HO]]
-	[[Category: Hartmann~~, F K~~]]	+	[[Category: Hartmann FK]]
-	[[Category: Heissler~~, S M~~]]	+	[[Category: Heissler SM]]
-	[[Category: Knoelker~~, H J~~]]	+	[[Category: Knoelker HJ]]
-	[[Category: Manstein~~, D J~~]]	+	[[Category: Manstein DJ]]
-	[[Category: Martin, R]]	+	[[Category: Martin R]]
-	[[Category: Taft~~, M H~~]]	+	[[Category: Taft MH]]
-	[[Category: Tsiavaliaris, G]]	+	[[Category: Tsiavaliaris G]]
-	~~[[Category: Allosteric inhibitor]]~~	+
-	~~[[Category: Contractile protein]]~~	+
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Non-hydroylsable atp analogue~~]]	+

OCA at 10:51, 13 April 2022

OCA — Wed, 13 Apr 2022 10:51:25 GMT

←Older revision		Revision as of 10:51, 13 April 2022
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	<StructureSection load='2xel' size='340' side='right'caption='[[2xel]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xel' size='340' side='right'caption='[[2xel]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xel]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xel]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XEL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=IA2:2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL'>IA2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=IA2:2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL'>IA2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mne\|1mne]], [[1d1c\|1d1c]], [[1jx2\|1jx2]], [[1q5g\|1q5g]], [[1w9l\|1w9l]], [[1mmn\|1mmn]], [[1d0y\|1d0y]], [[1vom\|1vom]], [[2aka\|2aka]], [[2jhr\|2jhr]], [[2jj9\|2jj9]], [[1lvk\|1lvk]], [[1w9j\|1w9j]], [[1jwy\|1jwy]], [[2x9h\|2x9h]], [[1yv3\|1yv3]], [[1fmv\|1fmv]], [[1d0x\|1d0x]], [[1fmw\|1fmw]], [[1d1b\|1d1b]], [[1g8x\|1g8x]], [[1mma\|1mma]], [[1d1a\|1d1a]], [[1mmg\|1mmg]], [[1w9i\|1w9i]], [[1d0z\|1d0z]], [[1mnd\|1mnd]], [[1w9k\|1w9k]], [[1mmd\|1mmd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mne\|1mne]], [[1d1c\|1d1c]], [[1jx2\|1jx2]], [[1q5g\|1q5g]], [[1w9l\|1w9l]], [[1mmn\|1mmn]], [[1d0y\|1d0y]], [[1vom\|1vom]], [[2aka\|2aka]], [[2jhr\|2jhr]], [[2jj9\|2jj9]], [[1lvk\|1lvk]], [[1w9j\|1w9j]], [[1jwy\|1jwy]], [[2x9h\|2x9h]], [[1yv3\|1yv3]], [[1fmv\|1fmv]], [[1d0x\|1d0x]], [[1fmw\|1fmw]], [[1d1b\|1d1b]], [[1g8x\|1g8x]], [[1mma\|1mma]], [[1d1a\|1d1a]], [[1mmg\|1mmg]], [[1w9i\|1w9i]], [[1d0z\|1d0z]], [[1mnd\|1mnd]], [[1w9k\|1w9k]], [[1mmd\|1mmd]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xel OCA], [~~http~~://pdbe.org/2xel PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xel RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xel PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xel ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xel OCA], [https://pdbe.org/2xel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xel RCSB], [https://www.ebi.ac.uk/pdbsum/2xel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xel ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MYS2_DICDI MYS2_DICDI]] Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.	+	[[https://www.uniprot.org/uniprot/MYS2_DICDI MYS2_DICDI]] Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:12, 8 July 2020

OCA — Wed, 08 Jul 2020 15:12:34 GMT

←Older revision		Revision as of 15:12, 8 July 2020
Line 1:		Line 1:

	==Molecular Mechanism of Pentachloropseudilin Mediated Inhibition of Myosin Motor Activity==		==Molecular Mechanism of Pentachloropseudilin Mediated Inhibition of Myosin Motor Activity==
-	<StructureSection load='2xel' size='340' side='right' caption='[[2xel]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2xel' size='340' side='right'caption='[[2xel]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=IA2:2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL'>IA2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=IA2:2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL'>IA2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mne\|1mne]], [[1d1c\|1d1c]], [[1jx2\|1jx2]], [[1q5g\|1q5g]], [[1w9l\|1w9l]], [[1mmn\|1mmn]], [[1d0y\|1d0y]], [[1vom\|1vom]], [[2aka\|2aka]], [[2jhr\|2jhr]], [[2jj9\|2jj9]], [[1lvk\|1lvk]], [[1w9j\|1w9j]], [[1jwy\|1jwy]], [[2x9h\|2x9h]], [[1yv3\|1yv3]], [[1fmv\|1fmv]], [[1d0x\|1d0x]], [[1fmw\|1fmw]], [[1d1b\|1d1b]], [[1g8x\|1g8x]], [[1mma\|1mma]], [[1d1a\|1d1a]], [[1mmg\|1mmg]], [[1w9i\|1w9i]], [[1d0z\|1d0z]], [[1mnd\|1mnd]], [[1w9k\|1w9k]], [[1mmd\|1mmd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mne\|1mne]], [[1d1c\|1d1c]], [[1jx2\|1jx2]], [[1q5g\|1q5g]], [[1w9l\|1w9l]], [[1mmn\|1mmn]], [[1d0y\|1d0y]], [[1vom\|1vom]], [[2aka\|2aka]], [[2jhr\|2jhr]], [[2jj9\|2jj9]], [[1lvk\|1lvk]], [[1w9j\|1w9j]], [[1jwy\|1jwy]], [[2x9h\|2x9h]], [[1yv3\|1yv3]], [[1fmv\|1fmv]], [[1d0x\|1d0x]], [[1fmw\|1fmw]], [[1d1b\|1d1b]], [[1g8x\|1g8x]], [[1mma\|1mma]], [[1d1a\|1d1a]], [[1mmg\|1mmg]], [[1w9i\|1w9i]], [[1d0z\|1d0z]], [[1mnd\|1mnd]], [[1w9k\|1w9k]], [[1mmd\|1mmd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xel OCA], [http://pdbe.org/2xel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xel RCSB], [http://www.ebi.ac.uk/pdbsum/2xel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xel ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xel OCA], [http://pdbe.org/2xel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xel RCSB], [http://www.ebi.ac.uk/pdbsum/2xel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xel ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Myosin\|Myosin]]	+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 11735]]		[[Category: Atcc 11735]]
		+	[[Category: Large Structures]]
	[[Category: Chinthalapudi, K]]		[[Category: Chinthalapudi, K]]
	[[Category: Coluccio, L M]]		[[Category: Coluccio, L M]]

OCA at 09:12, 3 October 2018

OCA — Wed, 03 Oct 2018 09:12:09 GMT

←Older revision		Revision as of 09:12, 3 October 2018
Line 1:		Line 1:

-	==~~MOLECULAR MECHANISM OF PENTACHLOROPSEUDILIN MEDIATED INHIBITION OF MYOSIN MOTOR ACTIVITY~~==	+	==Molecular Mechanism of Pentachloropseudilin Mediated Inhibition of Myosin Motor Activity==
	<StructureSection load='2xel' size='340' side='right' caption='[[2xel]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xel' size='340' side='right' caption='[[2xel]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 02:46, 5 August 2016

OCA — Fri, 05 Aug 2016 02:46:24 GMT

←Older revision		Revision as of 02:46, 5 August 2016
Line 1:		Line 1:
		+
	==MOLECULAR MECHANISM OF PENTACHLOROPSEUDILIN MEDIATED INHIBITION OF MYOSIN MOTOR ACTIVITY==		==MOLECULAR MECHANISM OF PENTACHLOROPSEUDILIN MEDIATED INHIBITION OF MYOSIN MOTOR ACTIVITY==
	<StructureSection load='2xel' size='340' side='right' caption='[[2xel]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xel' size='340' side='right' caption='[[2xel]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Dictyostelium_discoideum Dictyostelium discoideum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XEL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=IA2:2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL'>IA2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=IA2:2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL'>IA2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mne\|1mne]], [[1d1c\|1d1c]], [[1jx2\|1jx2]], [[1q5g\|1q5g]], [[1w9l\|1w9l]], [[1mmn\|1mmn]], [[1d0y\|1d0y]], [[1vom\|1vom]], [[2aka\|2aka]], [[2jhr\|2jhr]], [[2jj9\|2jj9]], [[1lvk\|1lvk]], [[1w9j\|1w9j]], [[1jwy\|1jwy]], [[2x9h\|2x9h]], [[1yv3\|1yv3]], [[1fmv\|1fmv]], [[1d0x\|1d0x]], [[1fmw\|1fmw]], [[1d1b\|1d1b]], [[1g8x\|1g8x]], [[1mma\|1mma]], [[1d1a\|1d1a]], [[1mmg\|1mmg]], [[1w9i\|1w9i]], [[1d0z\|1d0z]], [[1mnd\|1mnd]], [[1w9k\|1w9k]], [[1mmd\|1mmd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mne\|1mne]], [[1d1c\|1d1c]], [[1jx2\|1jx2]], [[1q5g\|1q5g]], [[1w9l\|1w9l]], [[1mmn\|1mmn]], [[1d0y\|1d0y]], [[1vom\|1vom]], [[2aka\|2aka]], [[2jhr\|2jhr]], [[2jj9\|2jj9]], [[1lvk\|1lvk]], [[1w9j\|1w9j]], [[1jwy\|1jwy]], [[2x9h\|2x9h]], [[1yv3\|1yv3]], [[1fmv\|1fmv]], [[1d0x\|1d0x]], [[1fmw\|1fmw]], [[1d1b\|1d1b]], [[1g8x\|1g8x]], [[1mma\|1mma]], [[1d1a\|1d1a]], [[1mmg\|1mmg]], [[1w9i\|1w9i]], [[1d0z\|1d0z]], [[1mnd\|1mnd]], [[1w9k\|1w9k]], [[1mmd\|1mmd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xel RCSB], [http://www.ebi.ac.uk/pdbsum/2xel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xel OCA], [http://pdbe.org/2xel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xel RCSB], [http://www.ebi.ac.uk/pdbsum/2xel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xel ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xel" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dictyostelium discoideum~~]]	+	[[Category: Atcc 11735]]
	[[Category: Chinthalapudi, K]]		[[Category: Chinthalapudi, K]]
	[[Category: Coluccio, L M]]		[[Category: Coluccio, L M]]

OCA at 15:13, 25 December 2014

OCA — Thu, 25 Dec 2014 15:13:29 GMT

←Older revision		Revision as of 15:13, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XEL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XEL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=IA2:2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL'>IA2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=IA2:2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL'>IA2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mne\|1mne]], [[1d1c\|1d1c]], [[1jx2\|1jx2]], [[1q5g\|1q5g]], [[1w9l\|1w9l]], [[1mmn\|1mmn]], [[1d0y\|1d0y]], [[1vom\|1vom]], [[2aka\|2aka]], [[2jhr\|2jhr]], [[2jj9\|2jj9]], [[1lvk\|1lvk]], [[1w9j\|1w9j]], [[1jwy\|1jwy]], [[2x9h\|2x9h]], [[1yv3\|1yv3]], [[1fmv\|1fmv]], [[1d0x\|1d0x]], [[1fmw\|1fmw]], [[1d1b\|1d1b]], [[1g8x\|1g8x]], [[1mma\|1mma]], [[1d1a\|1d1a]], [[1mmg\|1mmg]], [[1w9i\|1w9i]], [[1d0z\|1d0z]], [[1mnd\|1mnd]], [[1w9k\|1w9k]], [[1mmd\|1mmd]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mne\|1mne]], [[1d1c\|1d1c]], [[1jx2\|1jx2]], [[1q5g\|1q5g]], [[1w9l\|1w9l]], [[1mmn\|1mmn]], [[1d0y\|1d0y]], [[1vom\|1vom]], [[2aka\|2aka]], [[2jhr\|2jhr]], [[2jj9\|2jj9]], [[1lvk\|1lvk]], [[1w9j\|1w9j]], [[1jwy\|1jwy]], [[2x9h\|2x9h]], [[1yv3\|1yv3]], [[1fmv\|1fmv]], [[1d0x\|1d0x]], [[1fmw\|1fmw]], [[1d1b\|1d1b]], [[1g8x\|1g8x]], [[1mma\|1mma]], [[1d1a\|1d1a]], [[1mmg\|1mmg]], [[1w9i\|1w9i]], [[1d0z\|1d0z]], [[1mnd\|1mnd]], [[1w9k\|1w9k]], [[1mmd\|1mmd]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xel RCSB], [http://www.ebi.ac.uk/pdbsum/2xel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xel RCSB], [http://www.ebi.ac.uk/pdbsum/2xel PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYS2_DICDI MYS2_DICDI]] Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Dictyostelium discoideum]]		[[Category: Dictyostelium discoideum]]
-	[[Category: Chinthalapudi, K.]]	+	[[Category: Chinthalapudi, K]]
-	[[Category: Coluccio, L M.]]	+	[[Category: Coluccio, L M]]
-	[[Category: Fedorov, R.]]	+	[[Category: Fedorov, R]]
-	[[Category: Gutzeit, H O.]]	+	[[Category: Gutzeit, H O]]
-	[[Category: Hartmann, F K.]]	+	[[Category: Hartmann, F K]]
-	[[Category: Heissler, S M.]]	+	[[Category: Heissler, S M]]
-	[[Category: Knoelker, H J.]]	+	[[Category: Knoelker, H J]]
-	[[Category: Manstein, D J.]]	+	[[Category: Manstein, D J]]
-	[[Category: Martin, R.]]	+	[[Category: Martin, R]]
-	[[Category: Taft, M H.]]	+	[[Category: Taft, M H]]
-	[[Category: Tsiavaliaris, G.]]	+	[[Category: Tsiavaliaris, G]]
	[[Category: Allosteric inhibitor]]		[[Category: Allosteric inhibitor]]
	[[Category: Contractile protein]]		[[Category: Contractile protein]]
	[[Category: Motor protein]]		[[Category: Motor protein]]
	[[Category: Non-hydroylsable atp analogue]]		[[Category: Non-hydroylsable atp analogue]]

OCA at 00:57, 2 October 2014

OCA — Thu, 02 Oct 2014 00:57:22 GMT

←Older revision		Revision as of 00:57, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xel.~~png~~\|~~left~~\|~~200px~~]]	+	==MOLECULAR MECHANISM OF PENTACHLOROPSEUDILIN MEDIATED INHIBITION OF MYOSIN MOTOR ACTIVITY==
		+	<StructureSection load='2xel' size='340' side='right' caption='[[2xel]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XEL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AD9:ADP+METAVANADATE'>AD9</scene>, <scene name='pdbligand=IA2:2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL'>IA2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mne\|1mne]], [[1d1c\|1d1c]], [[1jx2\|1jx2]], [[1q5g\|1q5g]], [[1w9l\|1w9l]], [[1mmn\|1mmn]], [[1d0y\|1d0y]], [[1vom\|1vom]], [[2aka\|2aka]], [[2jhr\|2jhr]], [[2jj9\|2jj9]], [[1lvk\|1lvk]], [[1w9j\|1w9j]], [[1jwy\|1jwy]], [[2x9h\|2x9h]], [[1yv3\|1yv3]], [[1fmv\|1fmv]], [[1d0x\|1d0x]], [[1fmw\|1fmw]], [[1d1b\|1d1b]], [[1g8x\|1g8x]], [[1mma\|1mma]], [[1d1a\|1d1a]], [[1mmg\|1mmg]], [[1w9i\|1w9i]], [[1d0z\|1d0z]], [[1mnd\|1mnd]], [[1w9k\|1w9k]], [[1mmd\|1mmd]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xel RCSB], [http://www.ebi.ac.uk/pdbsum/2xel PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Here, we report that the natural compound pentachloropseudilin (PClP) acts as a reversible and allosteric inhibitor of myosin ATPase and motor activity. IC(50) values are in the range from 1 to 5 mum for mammalian class-1 myosins and greater than 90 mum for class-2 and class-5 myosins, and no inhibition was observed with class-6 and class-7 myosins. We show that in mammalian cells, PClP selectively inhibits myosin-1c function. To elucidate the structural basis for PClP-induced allosteric coupling and isoform-specific differences in the inhibitory potency of the compound, we used a multifaceted approach combining direct functional, crystallographic, and in silico modeling studies. Our results indicate that allosteric inhibition by PClP is mediated by the combined effects of global changes in protein dynamics and direct communication between the catalytic and allosteric sites via a cascade of small conformational changes along a conserved communication pathway.

-	~~{{STRUCTURE_2xel\| PDB=2xel \| SCENE= }}~~	+	Mechanism and Specificity of Pentachloropseudilin-mediated Inhibition of Myosin Motor Activity.,Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knolker HJ, Coluccio LM, Manstein DJ J Biol Chem. 2011 Aug 26;286(34):29700-8. Epub 2011 Jun 16. PMID:21680745<ref>PMID:21680745</ref>

-	~~===MOLECULAR MECHANISM OF PENTACHLOROPSEUDILIN MEDIATED INHIBITION OF MYOSIN MOTOR ACTIVITY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21680745}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xel]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA].~~	+

	==See Also==		==See Also==
	*[[Myosin\|Myosin]]		*[[Myosin\|Myosin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021680745<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Dictyostelium discoideum]]		[[Category: Dictyostelium discoideum]]
	[[Category: Chinthalapudi, K.]]		[[Category: Chinthalapudi, K.]]

OCA at 18:11, 20 October 2012

OCA — Sat, 20 Oct 2012 18:11:53 GMT

←Older revision		Revision as of 18:11, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xel]] is a 1 chain structure ~~of [[Myosin]]~~ with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA].	+	[[2xel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA].

	==See Also==		==See Also==

OCA at 03:19, 27 July 2012

OCA — Fri, 27 Jul 2012 03:19:30 GMT

←Older revision		Revision as of 03:19, 27 July 2012
Line 1:		Line 1:
	[[Image:2xel.png\|left\|200px]]		[[Image:2xel.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xel", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xel\| PDB=2xel \| SCENE= }}		{{STRUCTURE_2xel\| PDB=2xel \| SCENE= }}

	===MOLECULAR MECHANISM OF PENTACHLOROPSEUDILIN MEDIATED INHIBITION OF MYOSIN MOTOR ACTIVITY===		===MOLECULAR MECHANISM OF PENTACHLOROPSEUDILIN MEDIATED INHIBITION OF MYOSIN MOTOR ACTIVITY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21680745}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21680745 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21680745}}		{{ABSTRACT_PUBMED_21680745}}

	==About this Structure==		==About this Structure==
-	[[2xel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA].	+	[[2xel]] is a 1 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA].
		+
		+	==See Also==
		+	*[[Myosin\|Myosin]]

	==Reference==		==Reference==

OCA at 06:02, 31 August 2011

OCA — Wed, 31 Aug 2011 06:02:18 GMT

←Older revision		Revision as of 06:02, 31 August 2011
Line 1:		Line 1:
-	[[Image:2xel.~~jpg~~\|left\|200px]]	+	[[Image:2xel.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===MOLECULAR MECHANISM OF PENTACHLOROPSEUDILIN MEDIATED INHIBITION OF MYOSIN MOTOR ACTIVITY===		===MOLECULAR MECHANISM OF PENTACHLOROPSEUDILIN MEDIATED INHIBITION OF MYOSIN MOTOR ACTIVITY===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21680745}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21680745 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21680745}}

	==About this Structure==		==About this Structure==
	[[2xel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA].		[[2xel]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021680745</ref><references group="xtra"/>
	[[Category: Dictyostelium discoideum]]		[[Category: Dictyostelium discoideum]]
	[[Category: Chinthalapudi, K.]]		[[Category: Chinthalapudi, K.]]