2xer - Revision history

OCA at 10:30, 20 December 2023

OCA — Wed, 20 Dec 2023 10:30:07 GMT

←Older revision		Revision as of 10:30, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xer' size='340' side='right'caption='[[2xer]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2xer' size='340' side='right'caption='[[2xer]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xer]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XER FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xer]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XER FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2xeq\|2xeq]], [[2xes\|2xes]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xer OCA], [https://pdbe.org/2xer PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xer RCSB], [https://www.ebi.ac.uk/pdbsum/2xer PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xer ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xer OCA], [https://pdbe.org/2xer PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xer RCSB], [https://www.ebi.ac.uk/pdbsum/2xer PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xer ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref> <ref>PMID:19628699</ref> <ref>PMID:20584987</ref> <ref>PMID:20852261</ref> <ref>PMID:20543818</ref>	+	[https://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref> <ref>PMID:19628699</ref> <ref>PMID:20584987</ref> <ref>PMID:20852261</ref> <ref>PMID:20543818</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Tritschler, F]]	+	[[Category: Tritschler F]]
-	[[Category: Weichenrieder, O]]	+	[[Category: Weichenrieder O]]
-	~~[[Category: Mrna decapping]]~~	+
-	~~[[Category: P-body]]~~	+
-	~~[[Category: Rna binding protein~~]]	+

OCA at 10:51, 13 April 2022

OCA — Wed, 13 Apr 2022 10:51:33 GMT

←Older revision		Revision as of 10:51, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='2xer' size='340' side='right'caption='[[2xer]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2xer' size='340' side='right'caption='[[2xer]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xer]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XER FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xer]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XER FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xes\|2xes]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xeq\|2xeq]], [[2xes\|2xes]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xer OCA], [~~http~~://pdbe.org/2xer PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xer RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xer PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xer ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xer OCA], [https://pdbe.org/2xer PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xer RCSB], [https://www.ebi.ac.uk/pdbsum/2xer PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xer ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref> <ref>PMID:19628699</ref> <ref>PMID:20584987</ref> <ref>PMID:20852261</ref> <ref>PMID:20543818</ref>	+	[[https://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref> <ref>PMID:19628699</ref> <ref>PMID:20584987</ref> <ref>PMID:20852261</ref> <ref>PMID:20543818</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:12, 8 July 2020

OCA — Wed, 08 Jul 2020 15:12:46 GMT

←Older revision		Revision as of 15:12, 8 July 2020
Line 1:		Line 1:

	==Human PatL1 C-terminal domain (loop variant with sulfates)==		==Human PatL1 C-terminal domain (loop variant with sulfates)==
-	<StructureSection load='2xer' size='340' side='right' caption='[[2xer]], [[Resolution\|resolution]] 2.95Å' scene=''>	+	<StructureSection load='2xer' size='340' side='right'caption='[[2xer]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xer]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XER FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xer]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XER FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xes\|2xes]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xes\|2xes]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xer OCA], [http://pdbe.org/2xer PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xer RCSB], [http://www.ebi.ac.uk/pdbsum/2xer PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xer ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xer OCA], [http://pdbe.org/2xer PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xer RCSB], [http://www.ebi.ac.uk/pdbsum/2xer PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xer ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Tritschler, F]]		[[Category: Tritschler, F]]
	[[Category: Weichenrieder, O]]		[[Category: Weichenrieder, O]]

OCA at 09:39, 3 October 2018

OCA — Wed, 03 Oct 2018 09:39:48 GMT

←Older revision		Revision as of 09:39, 3 October 2018
Line 1:		Line 1:

-	==~~HUMAN PATL1~~ C-~~TERMINAL DOMAIN~~ (~~LOOP VARIANT WITH SULFATES~~)==	+	==Human PatL1 C-terminal domain (loop variant with sulfates)==
	<StructureSection load='2xer' size='340' side='right' caption='[[2xer]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2xer' size='340' side='right' caption='[[2xer]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xer_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xer_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:08, 4 August 2016

OCA — Thu, 04 Aug 2016 14:08:38 GMT

←Older revision		Revision as of 14:08, 4 August 2016
Line 1:		Line 1:
		+
	==HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT WITH SULFATES)==		==HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT WITH SULFATES)==
	<StructureSection load='2xer' size='340' side='right' caption='[[2xer]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2xer' size='340' side='right' caption='[[2xer]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xer]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XER FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xer]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XER FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xes\|2xes]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xes\|2xes]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xer OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xer RCSB], [http://www.ebi.ac.uk/pdbsum/2xer PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xer OCA], [http://pdbe.org/2xer PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xer RCSB], [http://www.ebi.ac.uk/pdbsum/2xer PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xer ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xer ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xer" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Tritschler, F]]		[[Category: Tritschler, F]]
	[[Category: Weichenrieder, O]]		[[Category: Weichenrieder, O]]

OCA at 15:27, 24 December 2014

OCA — Wed, 24 Dec 2014 15:27:15 GMT

←Older revision		Revision as of 15:27, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xer OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xer RCSB], [http://www.ebi.ac.uk/pdbsum/2xer PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xer OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xer RCSB], [http://www.ebi.ac.uk/pdbsum/2xer PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref> <ref>PMID:19628699</ref> <ref>PMID:20584987</ref> <ref>PMID:20852261</ref> <ref>PMID:20543818</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:33, 18 December 2014

OCA — Thu, 18 Dec 2014 12:33:30 GMT

←Older revision		Revision as of 12:33, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2xer\| PDB=2xer \| SCENE= }}~~	+	==HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT WITH SULFATES)==
-	===HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT WITH SULFATES)===	+	<StructureSection load='2xer' size='340' side='right' caption='[[2xer]], [[Resolution\|resolution]] 2.95Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20543818}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xer]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XER FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xeq\|2xeq]], [[2xes\|2xes]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xer FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xer OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xer RCSB], [http://www.ebi.ac.uk/pdbsum/2xer PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xer_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pat proteins regulate the transition of mRNAs from a state that is translationally active to one that is repressed, committing targeted mRNAs to degradation. Pat proteins contain a conserved N-terminal sequence, a proline-rich region, a Mid domain and a C-terminal domain (Pat-C). We show that Pat-C is essential for the interaction with mRNA decapping factors (i.e. DCP2, EDC4 and LSm1-7), whereas the P-rich region and Mid domain have distinct functions in modulating these interactions. DCP2 and EDC4 binding is enhanced by the P-rich region and does not require LSm1-7. LSm1-7 binding is assisted by the Mid domain and is reduced by the P-rich region. Structural analysis revealed that Pat-C folds into an alpha-alpha superhelix, exposing conserved and basic residues on one side of the domain. This conserved and basic surface is required for RNA, DCP2, EDC4 and LSm1-7 binding. The multiplicity of interactions mediated by Pat-C suggests that certain of these interactions are mutually exclusive and, therefore, that Pat proteins switch decapping partners allowing transitions between sequential steps in the mRNA decapping pathway.

-	~~==Function==~~	+	The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.,Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O, Izaurralde E EMBO J. 2010 Jul 21;29(14):2368-80. Epub 2010 Jun 11. PMID:20543818<ref>PMID:20543818</ref>
-	~~[[http://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA~~-~~binding protein involved in deadenylation~~-~~dependent decapping~~ of ~~mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required~~ for ~~cytoplasmic~~ mRNA ~~processing body (P-body) assembly~~. ~~In case of infection~~, ~~required for translation and replication of hepatitis~~ C ~~virus~~ (~~HCV~~).~~<ref>PMID:17936923</ref><ref>PMID:19628699</ref><ref>PMID:20584987</ref><ref>~~PMID:~~20852261</ref>~~<ref>PMID:20543818</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2xer]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020543818</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Tritschler, F.]]	+	[[Category: Tritschler, F]]
-	[[Category: Weichenrieder, O.]]	+	[[Category: Weichenrieder, O]]
	[[Category: Mrna decapping]]		[[Category: Mrna decapping]]
	[[Category: P-body]]		[[Category: P-body]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 09:24, 27 March 2013

OCA — Wed, 27 Mar 2013 09:24:00 GMT

←Older revision		Revision as of 09:24, 27 March 2013
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-	[[Image:2xer.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xer", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xer\| PDB=2xer \| SCENE= }}		{{STRUCTURE_2xer\| PDB=2xer \| SCENE= }}
-
	===HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT WITH SULFATES)===		===HUMAN PATL1 C-TERMINAL DOMAIN (LOOP VARIANT WITH SULFATES)===
		+	{{ABSTRACT_PUBMED_20543818}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/PATL1_HUMAN PATL1_HUMAN]] RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).<ref>PMID:17936923</ref><ref>PMID:19628699</ref><ref>PMID:20584987</ref><ref>PMID:20852261</ref><ref>PMID:20543818</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20543818}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 20543818 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20543818}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020543818</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020543818</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Tritschler, F.]]		[[Category: Tritschler, F.]]
	[[Category: Weichenrieder, O.]]		[[Category: Weichenrieder, O.]]
		+	[[Category: Mrna decapping]]
		+	[[Category: P-body]]
		+	[[Category: Rna binding protein]]

OCA: Protected "2xer" [edit=sysop:move=sysop]

OCA — Wed, 18 May 2011 06:00:03 GMT

Protected "2xer" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 18 May 2011

OCA at 05:59, 18 May 2011

OCA — Wed, 18 May 2011 05:59:57 GMT

←Older revision		Revision as of 05:59, 18 May 2011
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-	{{Seed}}
	[[Image:2xer.png\|left\|200px]]		[[Image:2xer.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~2XER~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA].	+	[[2xer]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XER OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20543818~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020543818</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Tritschler, F.]]		[[Category: Tritschler, F.]]
	[[Category: Weichenrieder, O.]]		[[Category: Weichenrieder, O.]]
-	[[Category: Mrna decapping]]
-	[[Category: P-body]]
-	[[Category: Rna binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:36:42 2010''