2xfi - Revision history

OCA at 08:39, 10 November 2021

OCA — Wed, 10 Nov 2021 08:39:28 GMT

←Older revision		Revision as of 08:39, 10 November 2021
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	<StructureSection load='2xfi' size='340' side='right'caption='[[2xfi]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='2xfi' size='340' side='right'caption='[[2xfi]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xfi]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XFI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xfi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XFI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XFI:N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(+PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO)+BENZAMIDE'>XFI</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XFI:N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(+PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO)+BENZAMIDE'>XFI</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xn3\|1xn3]], [[2wf3\|2wf3]], [[2wf1\|2wf1]], [[2vnm\|2vnm]], [[2wf4\|2wf4]], [[2fdp\|2fdp]], [[2vj6\|2vj6]], [[1ym4\|1ym4]], [[2wf2\|2wf2]], [[1sgz\|1sgz]], [[1ujk\|1ujk]], [[2va7\|2va7]], [[2wjo\|2wjo]], [[2wez\|2wez]], [[1ym2\|1ym2]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[2wf0\|2wf0]], [[1w51\|1w51]], [[1tqf\|1tqf]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2va6\|2va6]], [[2vie\|2vie]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[2va5\|2va5]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1ujj\|1ujj]], [[2xfj\|2xfj]], [[2xfk\|2xfk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xn3\|1xn3]], [[2wf3\|2wf3]], [[2wf1\|2wf1]], [[2vnm\|2vnm]], [[2wf4\|2wf4]], [[2fdp\|2fdp]], [[2vj6\|2vj6]], [[1ym4\|1ym4]], [[2wf2\|2wf2]], [[1sgz\|1sgz]], [[1ujk\|1ujk]], [[2va7\|2va7]], [[2wjo\|2wjo]], [[2wez\|2wez]], [[1ym2\|1ym2]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[2wf0\|2wf0]], [[1w51\|1w51]], [[1tqf\|1tqf]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2va6\|2va6]], [[2vie\|2vie]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[2va5\|2va5]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1ujj\|1ujj]], [[2xfj\|2xfj]], [[2xfk\|2xfk]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfi OCA], [~~http~~://pdbe.org/2xfi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xfi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xfi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfi OCA], [https://pdbe.org/2xfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xfi RCSB], [https://www.ebi.ac.uk/pdbsum/2xfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>	+	[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:50, 21 May 2019

OCA — Tue, 21 May 2019 07:50:47 GMT

←Older revision		Revision as of 07:50, 21 May 2019
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	==Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino)benzamide==		==Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino)benzamide==
-	<StructureSection load='2xfi' size='340' side='right' caption='[[2xfi]], [[Resolution\|resolution]] 1.73Å' scene=''>	+	<StructureSection load='2xfi' size='340' side='right'caption='[[2xfi]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XFI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XFI FirstGlance]. <br>
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	==See Also==		==See Also==
-	*[[Beta secretase\|Beta secretase]]	+	*[[Beta secretase 3D structures\|Beta secretase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brien, A O]]		[[Category: Brien, A O]]

OCA at 07:57, 6 March 2019

OCA — Wed, 06 Mar 2019 07:57:22 GMT

←Older revision		Revision as of 07:57, 6 March 2019
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	==Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino)benzamide==		==Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino)benzamide==
-	<StructureSection load='2xfi' size='340' side='right' caption='[[2xfi]], [[Resolution\|resolution]] 1.73Å' scene=''>	+	<StructureSection load='2xfi' size='340' side='right' caption='[[2xfi]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XFI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XFI FirstGlance]. <br>

OCA at 09:21, 3 October 2018

OCA — Wed, 03 Oct 2018 09:21:12 GMT

←Older revision		Revision as of 09:21, 3 October 2018
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-	==~~HUMAN~~ BACE-1 ~~IN COMPLEX WITH~~ N-((1S,2R)-3-(((1S)-2-(~~CYCLOHEXYLAMINO~~)-1-~~METHYL~~-2-~~OXOETHYL~~)~~AMINO~~)-2-~~HYDROXY~~-1-(~~PHENYLMETHYL~~)~~PROPYL~~)-3-((~~METHYLSULFONYL~~)(~~PHENYL~~)~~AMINO~~) ~~BENZAMIDE~~==	+	==Human BACE-1 in complex with N-((1S,2R)-3-(((1S)-2-(cyclohexylamino)- 1-methyl-2-oxoethyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino)benzamide==
	<StructureSection load='2xfi' size='340' side='right' caption='[[2xfi]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='2xfi' size='340' side='right' caption='[[2xfi]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/2xfi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/2xfi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 12:09, 5 August 2016

OCA — Fri, 05 Aug 2016 12:09:55 GMT

←Older revision		Revision as of 12:09, 5 August 2016
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		+
	==HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO) BENZAMIDE==		==HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO) BENZAMIDE==
	<StructureSection load='2xfi' size='340' side='right' caption='[[2xfi]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='2xfi' size='340' side='right' caption='[[2xfi]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XFI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XFI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XFI:N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(+PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO)+BENZAMIDE'>XFI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XFI:N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(+PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO)+BENZAMIDE'>XFI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xn3\|1xn3]], [[2wf3\|2wf3]], [[2wf1\|2wf1]], [[2vnm\|2vnm]], [[2wf4\|2wf4]], [[2fdp\|2fdp]], [[2vj6\|2vj6]], [[1ym4\|1ym4]], [[2wf2\|2wf2]], [[1sgz\|1sgz]], [[1ujk\|1ujk]], [[2va7\|2va7]], [[2wjo\|2wjo]], [[2wez\|2wez]], [[1ym2\|1ym2]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[2wf0\|2wf0]], [[1w51\|1w51]], [[1tqf\|1tqf]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2va6\|2va6]], [[2vie\|2vie]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[2va5\|2va5]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1ujj\|1ujj]], [[2xfj\|2xfj]], [[2xfk\|2xfk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xn3\|1xn3]], [[2wf3\|2wf3]], [[2wf1\|2wf1]], [[2vnm\|2vnm]], [[2wf4\|2wf4]], [[2fdp\|2fdp]], [[2vj6\|2vj6]], [[1ym4\|1ym4]], [[2wf2\|2wf2]], [[1sgz\|1sgz]], [[1ujk\|1ujk]], [[2va7\|2va7]], [[2wjo\|2wjo]], [[2wez\|2wez]], [[1ym2\|1ym2]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[2wf0\|2wf0]], [[1w51\|1w51]], [[1tqf\|1tqf]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2va6\|2va6]], [[2vie\|2vie]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[2va5\|2va5]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1ujj\|1ujj]], [[2xfj\|2xfj]], [[2xfk\|2xfk]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xfi RCSB], [http://www.ebi.ac.uk/pdbsum/2xfi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfi OCA], [http://pdbe.org/2xfi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xfi RCSB], [http://www.ebi.ac.uk/pdbsum/2xfi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xfi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xfi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
	[[Category: Brien, A O]]		[[Category: Brien, A O]]

OCA at 18:43, 25 December 2014

OCA — Thu, 25 Dec 2014 18:43:21 GMT

←Older revision		Revision as of 18:43, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XFI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XFI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XFI:N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(+PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO)+BENZAMIDE'>XFI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XFI:N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(+PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO)+BENZAMIDE'>XFI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xn3\|1xn3]], [[2wf3\|2wf3]], [[2wf1\|2wf1]], [[2vnm\|2vnm]], [[2wf4\|2wf4]], [[2fdp\|2fdp]], [[2vj6\|2vj6]], [[1ym4\|1ym4]], [[2wf2\|2wf2]], [[1sgz\|1sgz]], [[1ujk\|1ujk]], [[2va7\|2va7]], [[2wjo\|2wjo]], [[2wez\|2wez]], [[1ym2\|1ym2]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[2wf0\|2wf0]], [[1w51\|1w51]], [[1tqf\|1tqf]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2va6\|2va6]], [[2vie\|2vie]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[2va5\|2va5]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1ujj\|1ujj]], [[2xfj\|2xfj]], [[2xfk\|2xfk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xn3\|1xn3]], [[2wf3\|2wf3]], [[2wf1\|2wf1]], [[2vnm\|2vnm]], [[2wf4\|2wf4]], [[2fdp\|2fdp]], [[2vj6\|2vj6]], [[1ym4\|1ym4]], [[2wf2\|2wf2]], [[1sgz\|1sgz]], [[1ujk\|1ujk]], [[2va7\|2va7]], [[2wjo\|2wjo]], [[2wez\|2wez]], [[1ym2\|1ym2]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[2wf0\|2wf0]], [[1w51\|1w51]], [[1tqf\|1tqf]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2va6\|2va6]], [[2vie\|2vie]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[2va5\|2va5]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1ujj\|1ujj]], [[2xfj\|2xfj]], [[2xfk\|2xfk]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xfi RCSB], [http://www.ebi.ac.uk/pdbsum/2xfi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xfi RCSB], [http://www.ebi.ac.uk/pdbsum/2xfi PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
-	[[Category: Brien, A O.]]	+	[[Category: Brien, A O]]
-	[[Category: Clarke, B.]]	+	[[Category: Clarke, B]]
-	[[Category: Cutler, L.]]	+	[[Category: Cutler, L]]
-	[[Category: Demont, E.]]	+	[[Category: Demont, E]]
-	[[Category: Dingwall, C.]]	+	[[Category: Dingwall, C]]
-	[[Category: Dunsdon, R.]]	+	[[Category: Dunsdon, R]]
-	[[Category: Hawkins, J.]]	+	[[Category: Hawkins, J]]
-	[[Category: Howes, C.]]	+	[[Category: Howes, C]]
-	[[Category: Hussain, I.]]	+	[[Category: Hussain, I]]
-	[[Category: Maile, G.]]	+	[[Category: Maile, G]]
-	[[Category: Matico, R.]]	+	[[Category: Matico, R]]
-	[[Category: Mosley, J.]]	+	[[Category: Mosley, J]]
-	[[Category: Naylor, A.]]	+	[[Category: Naylor, A]]
-	[[Category: Redshaw, S.]]	+	[[Category: Redshaw, S]]
-	[[Category: Rowland, P.]]	+	[[Category: Rowland, P]]
-	[[Category: Smith, K J.]]	+	[[Category: Smith, K J]]
-	[[Category: Soleil, V.]]	+	[[Category: Soleil, V]]
-	[[Category: Sweitzer, S.]]	+	[[Category: Sweitzer, S]]
-	[[Category: Theobald, P.]]	+	[[Category: Theobald, P]]
-	[[Category: Vesey, D.]]	+	[[Category: Vesey, D]]
-	[[Category: Walter, D S.]]	+	[[Category: Walter, D S]]
-	[[Category: Wayne, G.]]	+	[[Category: Wayne, G]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Zymogen]]		[[Category: Zymogen]]

OCA at 01:02, 2 October 2014

OCA — Thu, 02 Oct 2014 01:02:06 GMT

←Older revision		Revision as of 01:02, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xfi.~~png~~\|~~left~~\|200px]]	+	==HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO) BENZAMIDE==
		+	<StructureSection load='2xfi' size='340' side='right' caption='[[2xfi]], [[Resolution\|resolution]] 1.73Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XFI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XFI:N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(+PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO)+BENZAMIDE'>XFI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xn3\|1xn3]], [[2wf3\|2wf3]], [[2wf1\|2wf1]], [[2vnm\|2vnm]], [[2wf4\|2wf4]], [[2fdp\|2fdp]], [[2vj6\|2vj6]], [[1ym4\|1ym4]], [[2wf2\|2wf2]], [[1sgz\|1sgz]], [[1ujk\|1ujk]], [[2va7\|2va7]], [[2wjo\|2wjo]], [[2wez\|2wez]], [[1ym2\|1ym2]], [[1py1\|1py1]], [[1w50\|1w50]], [[2vj7\|2vj7]], [[2wf0\|2wf0]], [[1w51\|1w51]], [[1tqf\|1tqf]], [[1m4h\|1m4h]], [[1xn2\|1xn2]], [[2viy\|2viy]], [[2va6\|2va6]], [[2vie\|2vie]], [[2viz\|2viz]], [[2b8l\|2b8l]], [[2va5\|2va5]], [[2b8v\|2b8v]], [[1fkn\|1fkn]], [[1xs7\|1xs7]], [[2vij\|2vij]], [[2vj9\|2vj9]], [[2vkm\|2vkm]], [[2vnn\|2vnn]], [[1ujj\|1ujj]], [[2xfj\|2xfj]], [[2xfk\|2xfk]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xfi RCSB], [http://www.ebi.ac.uk/pdbsum/2xfi PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/2xfi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibition of the aspartyl protease BACE-1 has the potential to deliver a disease-modifying therapy for Alzheimer's disease. Herein, is described a series of potent inhibitors based on an hydroxyethylamine (HEA) transition state mimetic template. These inhibitors interact with the non prime side of the enzyme using a novel edge-to-face interaction with Arg-296.

-	~~{{STRUCTURE_2xfi\| PDB=2xfi \| SCENE= }}~~	+	BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.,Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, Hawkins J, Howes C, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G Bioorg Med Chem Lett. 2010 Aug 1;20(15):4639-44. Epub 2010 Jun 8. PMID:20579874<ref>PMID:20579874</ref>

-	~~===HUMAN BACE-1 IN COMPLEX WITH N-((1S~~,~~2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO) BENZAMIDE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20579874}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xfi]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA].~~	+

	==See Also==		==See Also==
	*[[Beta secretase\|Beta secretase]]		*[[Beta secretase\|Beta secretase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020579874<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]

OCA at 20:07, 20 October 2012

OCA — Sat, 20 Oct 2012 20:07:35 GMT

←Older revision		Revision as of 20:07, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xfi]] is a 1 chain structure ~~of [[Beta secretase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA].	+	[[2xfi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA].

	==See Also==		==See Also==

OCA: Protected "2xfi" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 09:29:19 GMT

Protected "2xfi" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:29, 27 July 2012

OCA at 09:29, 27 July 2012

OCA — Fri, 27 Jul 2012 09:29:17 GMT

←Older revision		Revision as of 09:29, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2xfi.png\|left\|200px]]		[[Image:2xfi.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xfi", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xfi\| PDB=2xfi \| SCENE= }}		{{STRUCTURE_2xfi\| PDB=2xfi \| SCENE= }}

	===HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO) BENZAMIDE===		===HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLAMINO)-1-METHYL-2-OXOETHYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-((METHYLSULFONYL)(PHENYL)AMINO) BENZAMIDE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20579874}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20579874 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20579874}}		{{ABSTRACT_PUBMED_20579874}}

	==About this Structure==		==About this Structure==
-	~~2XFI~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA].	+	[[2xfi]] is a 1 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFI OCA].
		+
		+	==See Also==
		+	*[[Beta secretase\|Beta secretase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20579874~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020579874</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Memapsin 2]]		[[Category: Memapsin 2]]
Line 51:		Line 42:
	[[Category: Protease]]		[[Category: Protease]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:07:33 2010''