2xhh - Revision history

OCA at 10:31, 20 December 2023

OCA — Wed, 20 Dec 2023 10:31:44 GMT

←Older revision		Revision as of 10:31, 20 December 2023
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	<StructureSection load='2xhh' size='340' side='right'caption='[[2xhh]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2xhh' size='340' side='right'caption='[[2xhh]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xhh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"cellvibrio_cellulosa"_nagy_et_al._2002 "cellvibrio cellulosa" nagy et al. 2002~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XHH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xhh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XHH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[2xhj\|2xhj]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhh OCA], [https://pdbe.org/2xhh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xhh RCSB], [https://www.ebi.ac.uk/pdbsum/2xhh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhh OCA], [https://pdbe.org/2xhh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xhh RCSB], [https://www.ebi.ac.uk/pdbsum/2xhh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhh ProSAT]</span></td></tr>
	</table>		</table>
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cellvibrio ~~cellulosa nagy et al. 2002~~]]	+	[[Category: Cellvibrio japonicus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bolam~~, D N~~]]	+	[[Category: Bolam DN]]
-	[[Category: Davies~~, G J~~]]	+	[[Category: Davies GJ]]
-	[[Category: Flint~~, J E~~]]	+	[[Category: Flint JE]]
-	[[Category: Gilbert~~, H J~~]]	+	[[Category: Gilbert HJ]]
-	[[Category: Liu, Z]]	+	[[Category: Liu Z]]
-	[[Category: Montanier, C]]	+	[[Category: Montanier C]]
-	[[Category: Nurizzo, D]]	+	[[Category: Nurizzo D]]
-	[[Category: Ratnaparkhe, S]]	+	[[Category: Ratnaparkhe S]]
-	[[Category: Roberts~~, S M~~]]	+	[[Category: Roberts SM]]
-	[[Category: Rogowski, A]]	+	[[Category: Rogowski A]]
-	[[Category: Turkenburg~~, J P~~]]	+	[[Category: Turkenburg JP]]
-	[[Category: Weiner, D]]	+	[[Category: Weiner D]]
-	[[Category: Xie, H]]	+	[[Category: Xie H]]
-	~~[[Category: Beta glucan]]~~	+
-	~~[[Category: Cellulose]]~~	+
-	~~[[Category: Galactan]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Sugar binding protein]]~~	+
-	~~[[Category: Xylan~~]]	+

OCA at 08:40, 10 November 2021

OCA — Wed, 10 Nov 2021 08:40:18 GMT

←Older revision		Revision as of 08:40, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='2xhh' size='340' side='right'caption='[[2xhh]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2xhh' size='340' side='right'caption='[[2xhh]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xhh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"cellvibrio_cellulosa"_nagy_et_al._2002 "cellvibrio cellulosa" nagy et al. 2002]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XHH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xhh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"cellvibrio_cellulosa"_nagy_et_al._2002 "cellvibrio cellulosa" nagy et al. 2002]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XHH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xhj\|2xhj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xhj\|2xhj]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhh OCA], [~~http~~://pdbe.org/2xhh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xhh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xhh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhh OCA], [https://pdbe.org/2xhh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xhh RCSB], [https://www.ebi.ac.uk/pdbsum/2xhh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 12:24, 10 May 2019

OCA — Fri, 10 May 2019 12:24:00 GMT

←Older revision		Revision as of 12:24, 10 May 2019
Line 1:		Line 1:

	==Circular permutation provides an evolutionary link between two families of calcium-dependent carbohydrate binding modules==		==Circular permutation provides an evolutionary link between two families of calcium-dependent carbohydrate binding modules==
-	<StructureSection load='2xhh' size='340' side='right' caption='[[2xhh]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='2xhh' size='340' side='right'caption='[[2xhh]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xhh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"cellvibrio_cellulosa"_nagy_et_al._2002 "cellvibrio cellulosa" nagy et al. 2002]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xhh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"cellvibrio_cellulosa"_nagy_et_al._2002 "cellvibrio cellulosa" nagy et al. 2002]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHH FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Cellvibrio cellulosa nagy et al. 2002]]		[[Category: Cellvibrio cellulosa nagy et al. 2002]]
		+	[[Category: Large Structures]]
	[[Category: Bolam, D N]]		[[Category: Bolam, D N]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]

OCA at 09:24, 3 October 2018

OCA — Wed, 03 Oct 2018 09:24:07 GMT

←Older revision		Revision as of 09:24, 3 October 2018
Line 1:		Line 1:

-	==~~CIRCULAR PERMUTATION PROVIDES AN EVOLUTIONARY LINK BETWEEN TWO FAMILIES OF CALCIUM~~-~~DEPENDENT CARBOHYDRATE BINDING MODULES~~==	+	==Circular permutation provides an evolutionary link between two families of calcium-dependent carbohydrate binding modules==
	<StructureSection load='2xhh' size='340' side='right' caption='[[2xhh]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2xhh' size='340' side='right' caption='[[2xhh]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/2xhh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/2xhh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:22, 11 August 2016

OCA — Thu, 11 Aug 2016 15:22:35 GMT

←Older revision		Revision as of 15:22, 11 August 2016
Line 1:		Line 1:
		+
	==CIRCULAR PERMUTATION PROVIDES AN EVOLUTIONARY LINK BETWEEN TWO FAMILIES OF CALCIUM-DEPENDENT CARBOHYDRATE BINDING MODULES==		==CIRCULAR PERMUTATION PROVIDES AN EVOLUTIONARY LINK BETWEEN TWO FAMILIES OF CALCIUM-DEPENDENT CARBOHYDRATE BINDING MODULES==
	<StructureSection load='2xhh' size='340' side='right' caption='[[2xhh]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2xhh' size='340' side='right' caption='[[2xhh]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xhh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cellvibrio_japonicus Cellvibrio japonicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xhh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"cellvibrio_cellulosa"_nagy_et_al._2002 "cellvibrio cellulosa" nagy et al. 2002]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xhj\|2xhj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xhj\|2xhj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xhh RCSB], [http://www.ebi.ac.uk/pdbsum/2xhh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhh OCA], [http://pdbe.org/2xhh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xhh RCSB], [http://www.ebi.ac.uk/pdbsum/2xhh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xhh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xhh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cellvibrio ~~japonicus~~]]	+	[[Category: Cellvibrio cellulosa nagy et al. 2002]]
	[[Category: Bolam, D N]]		[[Category: Bolam, D N]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]

OCA at 08:19, 25 January 2015

OCA — Sun, 25 Jan 2015 08:19:57 GMT

←Older revision		Revision as of 08:19, 25 January 2015
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Cellvibrio japonicus]]		[[Category: Cellvibrio japonicus]]
-	[[Category: Bolam, D N.]]	+	[[Category: Bolam, D N]]
-	[[Category: Davies, G J.]]	+	[[Category: Davies, G J]]
-	[[Category: Flint, J E.]]	+	[[Category: Flint, J E]]
-	[[Category: Gilbert, H J.]]	+	[[Category: Gilbert, H J]]
-	[[Category: Liu, Z.]]	+	[[Category: Liu, Z]]
-	[[Category: Montanier, C.]]	+	[[Category: Montanier, C]]
-	[[Category: Nurizzo, D.]]	+	[[Category: Nurizzo, D]]
-	[[Category: Ratnaparkhe, S.]]	+	[[Category: Ratnaparkhe, S]]
-	[[Category: Roberts, S M.]]	+	[[Category: Roberts, S M]]
-	[[Category: Rogowski, A.]]	+	[[Category: Rogowski, A]]
-	[[Category: Turkenburg, J P.]]	+	[[Category: Turkenburg, J P]]
-	[[Category: Weiner, D.]]	+	[[Category: Weiner, D]]
-	[[Category: Xie, H.]]	+	[[Category: Xie, H]]
	[[Category: Beta glucan]]		[[Category: Beta glucan]]
	[[Category: Cellulose]]		[[Category: Cellulose]]

OCA at 13:22, 22 October 2014

OCA — Wed, 22 Oct 2014 13:22:21 GMT

←Older revision		Revision as of 13:22, 22 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xhh.~~png~~\|~~left~~\|200px]]	+	==CIRCULAR PERMUTATION PROVIDES AN EVOLUTIONARY LINK BETWEEN TWO FAMILIES OF CALCIUM-DEPENDENT CARBOHYDRATE BINDING MODULES==
		+	<StructureSection load='2xhh' size='340' side='right' caption='[[2xhh]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xhh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xhj\|2xhj]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xhh RCSB], [http://www.ebi.ac.uk/pdbsum/2xhh PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/2xhh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The microbial deconstruction of the plant cell wall is a critical biological process, which also provides important substrates for environmentally sustainable industries. Enzymes that hydrolyze the plant cell wall generally contain non-catalytic carbohydrate binding modules (CBMs). Here we report the biochemical properties and crystal structure of a family of CBMs (CBM60) that are located in xylanases that contribute to plant cell wall degradation. Uniquely, the proteins display broad ligand specificity, targeting xylans, galactans and cellulose. Some of the CBM60s display enhanced affinity for their ligands through avidity effects mediated by protein dimerization. The crystal structure of vCBM60, a member of the CBM60 family, displays a beta-sandwich with the ligand binding site comprising a broad cleft formed by the loops connecting the two beta-sheets. Ligand recognition at site 1 is, exclusively, through hydrophobic interactions, while binding at site 2 is conferred by polar interactions between a protein-bound calcium and the O2 and O3 of the sugar. The observation that ligand recognition at site 2 requires only a beta-linked sugar that contains equatorial hydroxyls at C2 and C3, explains the broad ligand specificity displayed by vCBM60. The ligand binding apparatus of vCBM60 displays remarkable structural conservation with a family 36 CBM (CBM36), however, the residues that contribute to carbohydrate recognition are derived from different regions of the two proteins. 3-D-structure based sequence alignments reveal that CBM36 and CBM60 are related by circular permutation. The biological and evolutionary significance of the mechanism of ligand recognition displayed by family 60 CBMs is discussed.

-	~~{{STRUCTURE_2xhh\| PDB=2xhh \| SCENE= }}~~	+	Circular permutation provides an evolutionary link between two families of calcium-dependent carbohydrate binding modules.,Montanier C, Flint JE, Bolam DN, Xie H, Liu Z, Rogowski A, Weiner D, Ratnaparkhe S, Nurizzo D, Roberts SM, Turkenburg JP, Davies GJ, Gilbert HJ J Biol Chem. 2010 Jul 21. PMID:20659893<ref>PMID:20659893</ref>

-	~~===CIRCULAR PERMUTATION PROVIDES AN EVOLUTIONARY LINK BETWEEN TWO FAMILIES OF CALCIUM-DEPENDENT CARBOHYDRATE BINDING MODULES===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20659893}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2xhh]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020659893<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cellvibrio japonicus]]		[[Category: Cellvibrio japonicus]]
	[[Category: Bolam, D N.]]		[[Category: Bolam, D N.]]

OCA: Protected "2xhh" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 18:44:26 GMT

Protected "2xhh" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:44, 7 January 2013

OCA at 18:44, 7 January 2013

OCA — Mon, 07 Jan 2013 18:44:22 GMT

←Older revision		Revision as of 18:44, 7 January 2013
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-	{{Seed}}
	[[Image:2xhh.png\|left\|200px]]		[[Image:2xhh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xhh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xhh\| PDB=2xhh \| SCENE= }}		{{STRUCTURE_2xhh\| PDB=2xhh \| SCENE= }}

	===CIRCULAR PERMUTATION PROVIDES AN EVOLUTIONARY LINK BETWEEN TWO FAMILIES OF CALCIUM-DEPENDENT CARBOHYDRATE BINDING MODULES===		===CIRCULAR PERMUTATION PROVIDES AN EVOLUTIONARY LINK BETWEEN TWO FAMILIES OF CALCIUM-DEPENDENT CARBOHYDRATE BINDING MODULES===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20659893}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20659893 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20659893}}		{{ABSTRACT_PUBMED_20659893}}

	==About this Structure==		==About this Structure==
-	~~2XHH~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA].	+	[[2xhh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20659893~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020659893</ref><references group="xtra"/>
	[[Category: Cellvibrio japonicus]]		[[Category: Cellvibrio japonicus]]
	[[Category: Bolam, D N.]]		[[Category: Bolam, D N.]]
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	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]
	[[Category: Xylan]]		[[Category: Xylan]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:04:00 2010''

OCA at 19:56, 11 August 2010

OCA — Wed, 11 Aug 2010 19:56:44 GMT

←Older revision		Revision as of 19:56, 11 August 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2xhh.~~jpg~~\|left\|200px]]	+	[[Image:2xhh.png\|left\|200px]]

	<!--		<!--
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	===CIRCULAR PERMUTATION PROVIDES AN EVOLUTIONARY LINK BETWEEN TWO FAMILIES OF CALCIUM-DEPENDENT CARBOHYDRATE BINDING MODULES===		===CIRCULAR PERMUTATION PROVIDES AN EVOLUTIONARY LINK BETWEEN TWO FAMILIES OF CALCIUM-DEPENDENT CARBOHYDRATE BINDING MODULES===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20659893}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20659893 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20659893}}

	==About this Structure==		==About this Structure==
	2XHH is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA].		2XHH is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHH OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20659893</ref><references group="xtra"/>
	[[Category: Cellvibrio japonicus]]		[[Category: Cellvibrio japonicus]]
	[[Category: Bolam, D N.]]		[[Category: Bolam, D N.]]
Line 36:		Line 45:
	[[Category: Xylan]]		[[Category: Xylan]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 21 10~~:14:56 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:04:00 2010''