2xjj - Revision history

OCA at 10:27, 9 May 2024

OCA — Thu, 09 May 2024 10:27:23 GMT

←Older revision		Revision as of 10:27, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2xjj' size='340' side='right'caption='[[2xjj]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xjj' size='340' side='right'caption='[[2xjj]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xjj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XJJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xjj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XJJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L81:1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE'>L81</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cdd\|2cdd]], [[1yes\|1yes]], [[1uy9\|1uy9]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2bug\|2bug]], [[2wi4\|2wi4]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2bz5\|2bz5]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[1uyf\|1uyf]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[2vci\|2vci]], [[1uy6\|1uy6]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[1uyk\|1uyk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[1uyc\|1uyc]], [[2xht\|2xht]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2xjk\|2xjk]], [[2xjl\|2xjl]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L81:1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE'>L81</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xjj OCA], [https://pdbe.org/2xjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xjj RCSB], [https://www.ebi.ac.uk/pdbsum/2xjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xjj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xjj OCA], [https://pdbe.org/2xjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xjj RCSB], [https://www.ebi.ac.uk/pdbsum/2xjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xjj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Callaghan, O]]	+	[[Category: Callaghan O]]
-	[[Category: Carr~~, M G~~]]	+	[[Category: Carr MG]]
-	[[Category: Chessari, G]]	+	[[Category: Chessari G]]
-	[[Category: Congreve, M]]	+	[[Category: Congreve M]]
-	[[Category: Cowan, S]]	+	[[Category: Cowan S]]
-	[[Category: Coyle~~, J E~~]]	+	[[Category: Coyle JE]]
-	[[Category: Downham, R]]	+	[[Category: Downham R]]
-	[[Category: Figueroa, E]]	+	[[Category: Figueroa E]]
-	[[Category: Frederickson, M]]	+	[[Category: Frederickson M]]
-	[[Category: Graham, B]]	+	[[Category: Graham B]]
-	[[Category: McMenamin, R]]	+	[[Category: McMenamin R]]
-	[[Category: Murray~~, C W~~]]	+	[[Category: Murray CW]]
-	[[Category: OBrien~~, M A~~]]	+	[[Category: OBrien MA]]
-	[[Category: Patel, S]]	+	[[Category: Patel S]]
-	[[Category: Phillips~~, T R~~]]	+	[[Category: Phillips TR]]
-	[[Category: Williams, G]]	+	[[Category: Williams G]]
-	[[Category: Woodhead~~, A J~~]]	+	[[Category: Woodhead AJ]]
-	[[Category: Woolford~~, A J.A]]~~	+	[[Category: Woolford AJA]]
-	~~[[Category: Chaperone~~]]	+

OCA at 10:54, 13 April 2022

OCA — Wed, 13 Apr 2022 10:54:13 GMT

←Older revision		Revision as of 10:54, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='2xjj' size='340' side='right'caption='[[2xjj]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xjj' size='340' side='right'caption='[[2xjj]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xjj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XJJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xjj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XJJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L81:1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE'>L81</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L81:1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE'>L81</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cdd\|2cdd]], [[1yes\|1yes]], [[1uy9\|1uy9]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2bug\|2bug]], [[2wi4\|2wi4]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2bz5\|2bz5]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[1uyf\|1uyf]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[2vci\|2vci]], [[1uy6\|1uy6]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[1uyk\|1uyk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[1uyc\|1uyc]], [[2xht\|2xht]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2xjk\|2xjk]], [[2xjl\|2xjl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cdd\|2cdd]], [[1yes\|1yes]], [[1uy9\|1uy9]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2bug\|2bug]], [[2wi4\|2wi4]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2bz5\|2bz5]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[1uyf\|1uyf]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[2vci\|2vci]], [[1uy6\|1uy6]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[1uyk\|1uyk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[1uyc\|1uyc]], [[2xht\|2xht]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2xjk\|2xjk]], [[2xjl\|2xjl]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xjj OCA], [~~http~~://pdbe.org/2xjj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xjj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xjj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xjj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xjj OCA], [https://pdbe.org/2xjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xjj RCSB], [https://www.ebi.ac.uk/pdbsum/2xjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xjj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:16, 8 July 2020

OCA — Wed, 08 Jul 2020 15:16:16 GMT

←Older revision		Revision as of 15:16, 8 July 2020
Line 1:		Line 1:

	==Structure of HSP90 with small molecule inhibitor bound==		==Structure of HSP90 with small molecule inhibitor bound==
-	<StructureSection load='2xjj' size='340' side='right' caption='[[2xjj]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2xjj' size='340' side='right'caption='[[2xjj]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xjj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XJJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xjj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XJJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L81:1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE'>L81</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L81:1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE'>L81</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cdd\|2cdd]], [[1yes\|1yes]], [[1uy9\|1uy9]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2bug\|2bug]], [[2wi4\|2wi4]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2bz5\|2bz5]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[1uyf\|1uyf]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[2vci\|2vci]], [[1uy6\|1uy6]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[1uyk\|1uyk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[1uyc\|1uyc]], [[2xht\|2xht]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2xjk\|2xjk]], [[2xjl\|2xjl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cdd\|2cdd]], [[1yes\|1yes]], [[1uy9\|1uy9]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2bug\|2bug]], [[2wi4\|2wi4]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2bz5\|2bz5]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[1uyf\|1uyf]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[2vci\|2vci]], [[1uy6\|1uy6]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[1uyk\|1uyk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[1uyc\|1uyc]], [[2xht\|2xht]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2xjk\|2xjk]], [[2xjl\|2xjl]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xjj OCA], [http://pdbe.org/2xjj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xjj RCSB], [http://www.ebi.ac.uk/pdbsum/2xjj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xjj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xjj OCA], [http://pdbe.org/2xjj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xjj RCSB], [http://www.ebi.ac.uk/pdbsum/2xjj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xjj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Callaghan, O]]		[[Category: Callaghan, O]]
	[[Category: Carr, M G]]		[[Category: Carr, M G]]

OCA at 09:03, 3 October 2018

OCA — Wed, 03 Oct 2018 09:03:10 GMT

←Older revision		Revision as of 09:03, 3 October 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xj/2xjj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xj/2xjj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:48, 2 January 2017

OCA — Mon, 02 Jan 2017 16:48:36 GMT

←Older revision		Revision as of 16:48, 2 January 2017
Line 1:		Line 1:
		+
	==Structure of HSP90 with small molecule inhibitor bound==		==Structure of HSP90 with small molecule inhibitor bound==
	<StructureSection load='2xjj' size='340' side='right' caption='[[2xjj]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xjj' size='340' side='right' caption='[[2xjj]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L81:1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE'>L81</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L81:1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE'>L81</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cdd\|2cdd]], [[1yes\|1yes]], [[1uy9\|1uy9]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2bug\|2bug]], [[2wi4\|2wi4]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2bz5\|2bz5]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[1uyf\|1uyf]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[2vci\|2vci]], [[1uy6\|1uy6]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[1uyk\|1uyk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[1uyc\|1uyc]], [[2xht\|2xht]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2xjk\|2xjk]], [[2xjl\|2xjl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cdd\|2cdd]], [[1yes\|1yes]], [[1uy9\|1uy9]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2bug\|2bug]], [[2wi4\|2wi4]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2bz5\|2bz5]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[1uyf\|1uyf]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[2vci\|2vci]], [[1uy6\|1uy6]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[1uyk\|1uyk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[1uyc\|1uyc]], [[2xht\|2xht]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2xjk\|2xjk]], [[2xjl\|2xjl]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xjj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xjj RCSB], [http://www.ebi.ac.uk/pdbsum/2xjj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xjj OCA], [http://pdbe.org/2xjj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xjj RCSB], [http://www.ebi.ac.uk/pdbsum/2xjj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xjj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xjj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xjj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:49, 1 April 2015

OCA — Wed, 01 Apr 2015 06:49:14 GMT

←Older revision		Revision as of 06:49, 1 April 2015
Line 2:		Line 2:
	<StructureSection load='2xjj' size='340' side='right' caption='[[2xjj]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xjj' size='340' side='right' caption='[[2xjj]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xjj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XJJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xjj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XJJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L81:1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE'>L81</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L81:1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE'>L81</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cdd\|2cdd]], [[1yes\|1yes]], [[1uy9\|1uy9]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2bug\|2bug]], [[2wi4\|2wi4]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2bz5\|2bz5]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[1uyf\|1uyf]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[2vci\|2vci]], [[1uy6\|1uy6]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[1uyk\|1uyk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[1uyc\|1uyc]], [[2xht\|2xht]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2xjk\|2xjk]], [[2xjl\|2xjl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cdd\|2cdd]], [[1yes\|1yes]], [[1uy9\|1uy9]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2bug\|2bug]], [[2wi4\|2wi4]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2bz5\|2bz5]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[1uyf\|1uyf]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[2vci\|2vci]], [[1uy6\|1uy6]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[1uyk\|1uyk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[1uyc\|1uyc]], [[2xht\|2xht]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2xjk\|2xjk]], [[2xjl\|2xjl]]</td></tr>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Callaghan, O]]		[[Category: Callaghan, O]]
	[[Category: Carr, M G]]		[[Category: Carr, M G]]

OCA at 15:47, 24 December 2014

OCA — Wed, 24 Dec 2014 15:47:58 GMT

←Older revision		Revision as of 15:47, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2xjj\| PDB=2xjj \| SCENE= }}~~	+	==Structure of HSP90 with small molecule inhibitor bound==
-	===Structure of HSP90 with small molecule inhibitor bound===	+	<StructureSection load='2xjj' size='340' side='right' caption='[[2xjj]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20662534}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2xjj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XJJ FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L81:1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE'>L81</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cdd\|2cdd]], [[1yes\|1yes]], [[1uy9\|1uy9]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2bug\|2bug]], [[2wi4\|2wi4]], [[2uwd\|2uwd]], [[2xhx\|2xhx]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2ccu\|2ccu]], [[2bz5\|2bz5]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyi\|1uyi]], [[1uyf\|1uyf]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[2vci\|2vci]], [[1uy6\|1uy6]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2c2l\|2c2l]], [[2fwz\|2fwz]], [[2xdk\|2xdk]], [[1uyk\|1uyk]], [[2xjg\|2xjg]], [[1uyh\|1uyh]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uye\|1uye]], [[1uyl\|1uyl]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[2xhr\|2xhr]], [[1uy7\|1uy7]], [[1uyc\|1uyc]], [[2xht\|2xht]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]], [[2xjk\|2xjk]], [[2xjl\|2xjl]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xjj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xjj RCSB], [http://www.ebi.ac.uk/pdbsum/2xjj PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>		[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xj/2xjj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibitors of the molecular chaperone heat shock protein 90 (Hsp90) are currently generating significant interest in clinical development as potential treatments for cancer. In a preceding publication (DOI: 10.1021/jm100059d ) we describe Astex's approach to screening fragments against Hsp90 and the subsequent optimization of two hits into leads with inhibitory activities in the low nanomolar range. This paper describes the structure guided optimization of the 2,4-dihydroxybenzamide lead molecule 1 and details some of the drug discovery strategies employed in the identification of AT13387 (35), which has progressed through preclinical development and is currently being tested in man.

-	~~==About this Structure==~~	+	Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-di hydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design.,Woodhead AJ, Angove H, Carr MG, Chessari G, Congreve M, Coyle JE, Cosme J, Graham B, Day PJ, Downham R, Fazal L, Feltell R, Figueroa E, Frederickson M, Lewis J, McMenamin R, Murray CW, O'Brien MA, Parra L, Patel S, Phillips T, Rees DC, Rich S, Smith DM, Trewartha G, Vinkovic M, Williams B, Woolford AJ J Med Chem. 2010 Jul 28. PMID:20662534<ref>PMID:20662534</ref>
-	[~~[2xjj~~]~~] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2XJJ OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020662534</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Callaghan, O.]]	+	[[Category: Callaghan, O]]
-	[[Category: Carr, M G.]]	+	[[Category: Carr, M G]]
-	[[Category: Chessari, G.]]	+	[[Category: Chessari, G]]
-	[[Category: Congreve, M.]]	+	[[Category: Congreve, M]]
-	[[Category: Cowan, S.]]	+	[[Category: Cowan, S]]
-	[[Category: Coyle, J E.]]	+	[[Category: Coyle, J E]]
-	[[Category: Downham, R.]]	+	[[Category: Downham, R]]
-	[[Category: Figueroa, E.]]	+	[[Category: Figueroa, E]]
-	[[Category: Frederickson, M.]]	+	[[Category: Frederickson, M]]
-	[[Category: Graham, B.]]	+	[[Category: Graham, B]]
-	[[Category: McMenamin, R.]]	+	[[Category: McMenamin, R]]
-	[[Category: Murray, C W.]]	+	[[Category: Murray, C W]]
-	[[Category: OBrien, M A.]]	+	[[Category: OBrien, M A]]
-	[[Category: Patel, S.]]	+	[[Category: Patel, S]]
-	[[Category: Phillips, T R.]]	+	[[Category: Phillips, T R]]
-	[[Category: Williams, G.]]	+	[[Category: Williams, G]]
-	[[Category: Woodhead, A J.]]	+	[[Category: Woodhead, A J]]
-	[[Category: Woolford, A J.A.]]	+	[[Category: Woolford, A J.A]]
	[[Category: Chaperone]]		[[Category: Chaperone]]

OCA at 09:21, 24 April 2013

OCA — Wed, 24 Apr 2013 09:21:09 GMT

←Older revision		Revision as of 09:21, 24 April 2013
Line 1:		Line 1:
-	[[Image:2xjj.png\|left\|200px]]
-
	{{STRUCTURE_2xjj\| PDB=2xjj \| SCENE= }}		{{STRUCTURE_2xjj\| PDB=2xjj \| SCENE= }}
		+	===Structure of HSP90 with small molecule inhibitor bound===
		+	{{ABSTRACT_PUBMED_20662534}}

-	===~~STRUCTRE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND~~===	+	==Function==
-		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
-	~~{{ABSTRACT_PUBMED_20662534}}~~	+

	==About this Structure==		==About this Structure==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020662534</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020662534</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Callaghan, O.]]		[[Category: Callaghan, O.]]
Line 26:		Line 25:
	[[Category: Frederickson, M.]]		[[Category: Frederickson, M.]]
	[[Category: Graham, B.]]		[[Category: Graham, B.]]
-	[[Category: ~~Mcmenamin~~, R.]]	+	[[Category: McMenamin, R.]]
	[[Category: Murray, C W.]]		[[Category: Murray, C W.]]
-	[[Category: ~~Obrien~~, M A.]]	+	[[Category: OBrien, M A.]]
	[[Category: Patel, S.]]		[[Category: Patel, S.]]
	[[Category: Phillips, T R.]]		[[Category: Phillips, T R.]]

OCA at 06:52, 20 October 2012

OCA — Sat, 20 Oct 2012 06:52:13 GMT

←Older revision		Revision as of 06:52, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xjj]] is a 2 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJJ OCA].	+	[[2xjj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJJ OCA].

	==See Also==		==See Also==

OCA at 14:35, 25 July 2012

OCA — Wed, 25 Jul 2012 14:35:14 GMT

←Older revision		Revision as of 14:35, 25 July 2012
Line 1:		Line 1:
	[[Image:2xjj.png\|left\|200px]]		[[Image:2xjj.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2xjj\| PDB=2xjj \| SCENE= }}		{{STRUCTURE_2xjj\| PDB=2xjj \| SCENE= }}

	===STRUCTRE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND===		===STRUCTRE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND===

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	{{ABSTRACT_PUBMED_20662534}}		{{ABSTRACT_PUBMED_20662534}}

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	==See Also==		==See Also==
-	*[[Heat Shock Proteins]]	+	*[[Heat Shock Proteins\|Heat Shock Proteins]]

	==Reference==		==Reference==