2xkk - Revision history

OCA at 10:33, 20 December 2023

OCA — Wed, 20 Dec 2023 10:33:20 GMT

←Older revision		Revision as of 10:33, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xkk' size='340' side='right'caption='[[2xkk]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='2xkk' size='340' side='right'caption='[[2xkk]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xkk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Acibs Acibs~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xkk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XKK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.25Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xkj\|2xkj]]</div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkk OCA], [https://pdbe.org/2xkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xkk RCSB], [https://www.ebi.ac.uk/pdbsum/2xkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkk OCA], [https://pdbe.org/2xkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xkk RCSB], [https://www.ebi.ac.uk/pdbsum/2xkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B0V9T6_ACIBY B0V9T6_ACIBY] [https://www.uniprot.org/uniprot/B0VP98_ACIBS B0VP98_ACIBS] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00936]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acibs~~]]	+	[[Category: Acinetobacter baumannii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bax~~, B D~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Chan~~, P F~~]]	+	[[Category: Bax BD]]
-	[[Category: Fosberry~~, A P~~]]	+	[[Category: Chan PF]]
-	[[Category: Gwynn~~, M N~~]]	+	[[Category: Fosberry AP]]
-	[[Category: Homes, P]]	+	[[Category: Gwynn MN]]
-	[[Category: Huang, J]]	+	[[Category: Homes P]]
-	[[Category: Kranz, M]]	+	[[Category: Huang J]]
-	[[Category: Leydon~~, V R~~]]	+	[[Category: Kranz M]]
-	[[Category: Miles~~, T J~~]]	+	[[Category: Leydon VR]]
-	[[Category: Pearson~~, N D~~]]	+	[[Category: Miles TJ]]
-	[[Category: Perera~~, R L~~]]	+	[[Category: Pearson ND]]
-	[[Category: Shillings~~, A J~~]]	+	[[Category: Perera RL]]
-	[[Category: Wohlkonig, A]]	+	[[Category: Shillings AJ]]
-	~~[[Category: Antibacterial agent]]~~	+	[[Category: Wohlkonig A]]
-	~~[[Category: Isomerase-dna-antibiotic complex]]~~	+
-	~~[[Category: Quinolone]]~~	+
-	~~[[Category: Type iia topoisomerase~~]]	+

OCA at 10:54, 13 April 2022

OCA — Wed, 13 Apr 2022 10:54:55 GMT

←Older revision		Revision as of 10:54, 13 April 2022
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	<StructureSection load='2xkk' size='340' side='right'caption='[[2xkk]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='2xkk' size='340' side='right'caption='[[2xkk]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xkk]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Acibs Acibs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xkk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Acibs Acibs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XKK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xkj\|2xkj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xkj\|2xkj]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkk OCA], [~~http~~://pdbe.org/2xkk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xkk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xkk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkk OCA], [https://pdbe.org/2xkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xkk RCSB], [https://www.ebi.ac.uk/pdbsum/2xkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkk ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 15:17, 8 July 2020

OCA — Wed, 08 Jul 2020 15:17:12 GMT

←Older revision		Revision as of 15:17, 8 July 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, and A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)==		==CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, and A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)==
-	<StructureSection load='2xkk' size='340' side='right' caption='[[2xkk]], [[Resolution\|resolution]] 3.25Å' scene=''>	+	<StructureSection load='2xkk' size='340' side='right'caption='[[2xkk]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xkk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Acibs Acibs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xkk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Acibs Acibs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XKK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xkj\|2xkj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xkj\|2xkj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkk OCA], [http://pdbe.org/2xkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xkk RCSB], [http://www.ebi.ac.uk/pdbsum/2xkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkk OCA], [http://pdbe.org/2xkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xkk RCSB], [http://www.ebi.ac.uk/pdbsum/2xkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkk ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Topoisomerase\|Topoisomerase]]	+	*[[Topoisomerase 3D structures\|Topoisomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Acibs]]		[[Category: Acibs]]
		+	[[Category: Large Structures]]
	[[Category: Bax, B D]]		[[Category: Bax, B D]]
	[[Category: Chan, P F]]		[[Category: Chan, P F]]

OCA at 09:26, 3 October 2018

OCA — Wed, 03 Oct 2018 09:26:26 GMT

←Older revision		Revision as of 09:26, 3 October 2018
Line 1:		Line 1:

-	==CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, ~~AND~~ A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)==	+	==CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, and A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)==
	<StructureSection load='2xkk' size='340' side='right' caption='[[2xkk]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='2xkk' size='340' side='right' caption='[[2xkk]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xk/2xkk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xk/2xkk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:22, 11 August 2016

OCA — Thu, 11 Aug 2016 09:22:36 GMT

←Older revision		Revision as of 09:22, 11 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, AND A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)==		==CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, AND A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)==
	<StructureSection load='2xkk' size='340' side='right' caption='[[2xkk]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='2xkk' size='340' side='right' caption='[[2xkk]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xkk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Acinetobacter_baumannii Acinetobacter baumannii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XKK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xkk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Acibs Acibs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XKK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xkj\|2xkj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xkj\|2xkj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xkk RCSB], [http://www.ebi.ac.uk/pdbsum/2xkk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkk OCA], [http://pdbe.org/2xkk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xkk RCSB], [http://www.ebi.ac.uk/pdbsum/2xkk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkk ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xkk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xkk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acinetobacter baumannii~~]]	+	[[Category: Acibs]]
	[[Category: Bax, B D]]		[[Category: Bax, B D]]
	[[Category: Chan, P F]]		[[Category: Chan, P F]]

OCA at 08:22, 25 January 2015

OCA — Sun, 25 Jan 2015 08:22:47 GMT

←Older revision		Revision as of 08:22, 25 January 2015
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Acinetobacter baumannii]]		[[Category: Acinetobacter baumannii]]
-	[[Category: Bax, B D.]]	+	[[Category: Bax, B D]]
-	[[Category: Chan, P F.]]	+	[[Category: Chan, P F]]
-	[[Category: Fosberry, A P.]]	+	[[Category: Fosberry, A P]]
-	[[Category: Gwynn, M N.]]	+	[[Category: Gwynn, M N]]
-	[[Category: Homes, P.]]	+	[[Category: Homes, P]]
-	[[Category: Huang, J.]]	+	[[Category: Huang, J]]
-	[[Category: Kranz, M.]]	+	[[Category: Kranz, M]]
-	[[Category: Leydon, V R.]]	+	[[Category: Leydon, V R]]
-	[[Category: Miles, T J.]]	+	[[Category: Miles, T J]]
-	[[Category: Pearson, N D.]]	+	[[Category: Pearson, N D]]
-	[[Category: Perera, R L.]]	+	[[Category: Perera, R L]]
-	[[Category: Shillings, A J.]]	+	[[Category: Shillings, A J]]
-	[[Category: Wohlkonig, A.]]	+	[[Category: Wohlkonig, A]]
	[[Category: Antibacterial agent]]		[[Category: Antibacterial agent]]
	[[Category: Isomerase-dna-antibiotic complex]]		[[Category: Isomerase-dna-antibiotic complex]]
	[[Category: Quinolone]]		[[Category: Quinolone]]
	[[Category: Type iia topoisomerase]]		[[Category: Type iia topoisomerase]]

OCA at 13:24, 22 October 2014

OCA — Wed, 22 Oct 2014 13:24:38 GMT

←Older revision		Revision as of 13:24, 22 October 2014
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-	[[~~Image:~~2xkk.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, AND A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)==
		+	<StructureSection load='2xkk' size='340' side='right' caption='[[2xkk]], [[Resolution\|resolution]] 3.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xkk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XKK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xkj\|2xkj]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xkk RCSB], [http://www.ebi.ac.uk/pdbsum/2xkk PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xk/2xkk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Quinolone antibacterials have been used to treat bacterial infections for over 40 years. A crystal structure of moxifloxacin in complex with Acinetobacter baumannii topoisomerase IV now shows the wedge-shaped quinolone stacking between base pairs at the DNA cleavage site and binding conserved residues in the DNA cleavage domain through chelation of a noncatalytic magnesium ion. This provides a molecular basis for the quinolone inhibition mechanism, resistance mutations and invariant quinolone antibacterial structural features.

-	~~{{STRUCTURE_2xkk\| PDB=2xkk \| SCENE= }}~~	+	Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance.,Wohlkonig A, Chan PF, Fosberry AP, Homes P, Huang J, Kranz M, Leydon VR, Miles TJ, Pearson ND, Perera RL, Shillings AJ, Gwynn MN, Bax BD Nat Struct Mol Biol. 2010 Sep;17(9):1152-3. Epub 2010 Aug 29. PMID:20802486<ref>PMID:20802486</ref>

-	~~===CRYSTAL STRUCTURE OF MOXIFLOXACIN~~, ~~DNA, AND A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20802486}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xkk]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA].~~	+

	==See Also==		==See Also==
	*[[Topoisomerase\|Topoisomerase]]		*[[Topoisomerase\|Topoisomerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020802486<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Acinetobacter baumannii]]		[[Category: Acinetobacter baumannii]]
	[[Category: Bax, B D.]]		[[Category: Bax, B D.]]

OCA at 10:15, 20 October 2012

OCA — Sat, 20 Oct 2012 10:15:12 GMT

←Older revision		Revision as of 10:15, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xkk]] is a 4 chain structure ~~of [[Topoisomerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA].	+	[[2xkk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKK OCA].

	==See Also==		==See Also==

OCA at 01:29, 26 July 2012

OCA — Thu, 26 Jul 2012 01:29:06 GMT

←Older revision		Revision as of 01:29, 26 July 2012
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	[[Image:2xkk.png\|left\|200px]]		[[Image:2xkk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xkk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xkk\| PDB=2xkk \| SCENE= }}		{{STRUCTURE_2xkk\| PDB=2xkk \| SCENE= }}

	===CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, AND A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)===		===CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, AND A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20802486}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20802486 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20802486}}		{{ABSTRACT_PUBMED_20802486}}

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	==See Also==		==See Also==
-	*[[Topoisomerase]]	+	*[[Topoisomerase\|Topoisomerase]]

	==Reference==		==Reference==

OCA: Protected "2xkk" [edit=sysop:move=sysop]

OCA — Sun, 30 Oct 2011 08:20:12 GMT

Protected "2xkk" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:20, 30 October 2011