2xl3 - Revision history

OCA at 10:33, 20 December 2023

OCA — Wed, 20 Dec 2023 10:33:37 GMT

←Older revision		Revision as of 10:33, 20 December 2023
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	<StructureSection load='2xl3' size='340' side='right'caption='[[2xl3]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2xl3' size='340' side='right'caption='[[2xl3]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xl3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XL3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xl3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XL3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1u35\|1u35]], [[2wp1\|2wp1]], [[1guw\|1guw]], [[2xl2\|2xl2]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xl3 OCA], [https://pdbe.org/2xl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xl3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xl3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xl3 OCA], [https://pdbe.org/2xl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xl3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xl3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/WDR5_MOUSE WDR5_MOUSE]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). [[https://www.uniprot.org/uniprot/RBBP5_MOUSE RBBP5_MOUSE]] As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal.	+	[https://www.uniprot.org/uniprot/WDR5_MOUSE WDR5_MOUSE] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Odho, Z]]	+	[[Category: Odho Z]]
-	[[Category: Southall~~, S M~~]]	+	[[Category: Southall SM]]
-	[[Category: Wilson~~, J R]]~~	+	[[Category: Wilson JR]]
-	~~[[Category: H3k4 methylation]]~~	+
-	~~[[Category: Mll complex]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Wd-40 beta-propeller~~]]	+

OCA at 10:55, 13 April 2022

OCA — Wed, 13 Apr 2022 10:55:07 GMT

←Older revision		Revision as of 10:55, 13 April 2022
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	<StructureSection load='2xl3' size='340' side='right'caption='[[2xl3]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2xl3' size='340' side='right'caption='[[2xl3]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xl3]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XL3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xl3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XL3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u35\|1u35]], [[2wp1\|2wp1]], [[1guw\|1guw]], [[2xl2\|2xl2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u35\|1u35]], [[2wp1\|2wp1]], [[1guw\|1guw]], [[2xl2\|2xl2]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xl3 OCA], [~~http~~://pdbe.org/2xl3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xl3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xl3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xl3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xl3 OCA], [https://pdbe.org/2xl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xl3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xl3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/WDR5_MOUSE WDR5_MOUSE]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). [[~~http~~://www.uniprot.org/uniprot/RBBP5_MOUSE RBBP5_MOUSE]] As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal.	+	[[https://www.uniprot.org/uniprot/WDR5_MOUSE WDR5_MOUSE]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). [[https://www.uniprot.org/uniprot/RBBP5_MOUSE RBBP5_MOUSE]] As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:17, 8 July 2020

OCA — Wed, 08 Jul 2020 15:17:30 GMT

←Older revision		Revision as of 15:17, 8 July 2020
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	==WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE==		==WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE==
-	<StructureSection load='2xl3' size='340' side='right' caption='[[2xl3]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='2xl3' size='340' side='right'caption='[[2xl3]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xl3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XL3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xl3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XL3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u35\|1u35]], [[2wp1\|2wp1]], [[1guw\|1guw]], [[2xl2\|2xl2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u35\|1u35]], [[2wp1\|2wp1]], [[1guw\|1guw]], [[2xl2\|2xl2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xl3 OCA], [http://pdbe.org/2xl3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xl3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xl3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xl3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xl3 OCA], [http://pdbe.org/2xl3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xl3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xl3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xl3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[WD ~~repeat~~-~~containing~~ protein\|WD ~~repeat~~-~~containing~~ protein]]	+	*[[WD-repeat protein 3D structures\|WD-repeat protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Odho, Z]]		[[Category: Odho, Z]]

OCA at 09:09, 3 October 2018

OCA — Wed, 03 Oct 2018 09:09:42 GMT

←Older revision		Revision as of 09:09, 3 October 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xl/2xl3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xl/2xl3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[WD-repeat protein 5\|WD-repeat protein 5]]	+	*[[WD repeat-containing protein\|WD repeat-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:44, 4 August 2016

OCA — Thu, 04 Aug 2016 15:44:14 GMT

←Older revision		Revision as of 15:44, 4 August 2016
Line 1:		Line 1:
		+
	==WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE==		==WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE==
	<StructureSection load='2xl3' size='340' side='right' caption='[[2xl3]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='2xl3' size='340' side='right' caption='[[2xl3]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xl3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XL3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xl3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XL3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u35\|1u35]], [[2wp1\|2wp1]], [[1guw\|1guw]], [[2xl2\|2xl2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u35\|1u35]], [[2wp1\|2wp1]], [[1guw\|1guw]], [[2xl2\|2xl2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xl3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xl3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xl3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xl3 OCA], [http://pdbe.org/2xl3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xl3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xl3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xl3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/RBBP5_MOUSE RBBP5_MOUSE]] As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal.	+	[[http://www.uniprot.org/uniprot/WDR5_MOUSE WDR5_MOUSE]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). [[http://www.uniprot.org/uniprot/RBBP5_MOUSE RBBP5_MOUSE]] As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xl3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xl3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[WD-repeat protein 5\|WD-repeat protein 5]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Odho, Z]]		[[Category: Odho, Z]]
	[[Category: Southall, S M]]		[[Category: Southall, S M]]

OCA at 16:36, 24 December 2014

OCA — Wed, 24 Dec 2014 16:36:17 GMT

←Older revision		Revision as of 16:36, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xl3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xl3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xl3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xl3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xl3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xl3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RBBP5_MOUSE RBBP5_MOUSE]] As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:34, 18 December 2014

OCA — Thu, 18 Dec 2014 11:34:09 GMT

←Older revision		Revision as of 11:34, 18 December 2014
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-	~~{{STRUCTURE_2xl3\| PDB=2xl3 \| SCENE= }}~~	+	==WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE==
-	===WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE===	+	<StructureSection load='2xl3' size='340' side='right' caption='[[2xl3]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20716525}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xl3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XL3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1u35\|1u35]], [[2wp1\|2wp1]], [[1guw\|1guw]], [[2xl2\|2xl2]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xl3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xl3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xl3 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xl/2xl3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Histone modification is well established as a fundamental mechanism driving the regulation of transcription, replication and DNA repair through the control of chromatin structure. Likewise, it is apparent that incorrect targeting of histone modifications contributes to misregulated gene expression and hence to developmental disorders and diseases of genomic instability such as cancer. The KMT2 family of SET domain methyltransferases, typified by MLL1, are responsible for histone H3 lysine-4 methylation, a marker of active genes. To ensure that this modification is correctly targeted, a multi-protein complex associates with the methyltransferase and directs activity. We have identified a novel interaction site on the core complex protein WDR5, and mapped the complementary site on its partner RbBP5. We have characterised this interaction by X-ray crystallography and show how it is fundamental to the assembly of the complex and to the regulation of methyltransferase activity. We show which region of RbBP5 contributes directly to MLL activation and combine our structural and biochemical data to produce a model to show how WDR5 and RbBP5 act cooperatively to stimulate activity.

-	~~==Function==~~	+	Characterisation of a novel WDR5 binding site that recruits RbBP5 through a conserved motif and enhances methylation of H3K4 by MLL1.,Odho Z, Southall SM, Wilson JR J Biol Chem. 2010 Aug 17. PMID:20716525<ref>PMID:20716525</ref>
-	~~[[http://www.uniprot.org/uniprot/RBBP5_MOUSE RBBP5_MOUSE]] As part~~ of ~~the MLL1/MLL complex, involved in mono-, di-~~ and ~~trimethylation at 'Lys-4'~~ of ~~histone H3~~. ~~Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells~~, ~~plays a crucial role in the differentiation potential~~, ~~particularly along the neural lineage~~, ~~regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid~~. ~~Does not affect ES cell self-renewal~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2xl3]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020716525</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Odho, Z.]]	+	[[Category: Odho, Z]]
-	[[Category: Southall, S M.]]	+	[[Category: Southall, S M]]
-	[[Category: Wilson, J R.]]	+	[[Category: Wilson, J R]]
	[[Category: H3k4 methylation]]		[[Category: H3k4 methylation]]
	[[Category: Mll complex]]		[[Category: Mll complex]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Wd-40 beta-propeller]]		[[Category: Wd-40 beta-propeller]]

OCA at 08:17, 2 May 2013

OCA — Thu, 02 May 2013 08:17:00 GMT

←Older revision		Revision as of 08:17, 2 May 2013
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-	[[Image:2xl3.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xl3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xl3\| PDB=2xl3 \| SCENE= }}		{{STRUCTURE_2xl3\| PDB=2xl3 \| SCENE= }}
-
	===WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE===		===WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE===
		+	{{ABSTRACT_PUBMED_20716525}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/RBBP5_MOUSE RBBP5_MOUSE]] As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20716525}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 20716525 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20716525}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020716525</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020716525</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Odho, Z.]]		[[Category: Odho, Z.]]

OCA: Protected "2xl3" [edit=sysop:move=sysop]

OCA — Wed, 29 Jun 2011 05:26:08 GMT

Protected "2xl3" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:26, 29 June 2011

OCA at 05:26, 29 June 2011

OCA — Wed, 29 Jun 2011 05:26:07 GMT

←Older revision		Revision as of 05:26, 29 June 2011
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-	{{Seed}}
	[[Image:2xl3.png\|left\|200px]]		[[Image:2xl3.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~2XL3~~ is a 6 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA].	+	[[2xl3]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XL3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20716525~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020716525</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Odho, Z.]]		[[Category: Odho, Z.]]
Line 32:		Line 31:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Wd-40 beta-propeller]]		[[Category: Wd-40 beta-propeller]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:19:53 2010''