2xnt - Revision history

OCA at 08:01, 23 August 2023

OCA — Wed, 23 Aug 2023 08:01:45 GMT

←Older revision		Revision as of 08:01, 23 August 2023
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	<StructureSection load='2xnt' size='340' side='right'caption='[[2xnt]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='2xnt' size='340' side='right'caption='[[2xnt]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xnt]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aplca Aplca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XNT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xnt]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XNT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>~~, ~~<scene name='pdbligand=VU2:(2S)-2-~~[~~(4-CHLOROBENZYL)OXY~~]~~-2-PHENYLETHANAMINE'>VU2</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.21Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2wn9\|2wn9]]~~, [[2w8f\|2w8f]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2byr\|2byr]], [[2byn\|2byn]], [[2bys\|2bys]], [[2wnj\|2wnj]], [[2w8e\|2w8e]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnv\|2xnv]], [[2xnu\|2xnu]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=VU2:(2S)-2-[(4-CHLOROBENZYL)OXY]-2-PHENYLETHANAMINE'>VU2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xnt OCA], [https://pdbe.org/2xnt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xnt RCSB], [https://www.ebi.ac.uk/pdbsum/2xnt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xnt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xnt OCA], [https://pdbe.org/2xnt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xnt RCSB], [https://www.ebi.ac.uk/pdbsum/2xnt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xnt ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplca~~]]	+	[[Category: Aplysia californica]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Akdemir, A]]	+	[[Category: Akdemir A]]
-	[[Category: Rucktooa, P]]	+	[[Category: Rucktooa P]]
-	[[Category: Sixma~~, T K~~]]	+	[[Category: Sixma TK]]
-	[[Category: DeEsch, I]]	+	[[Category: DeEsch I]]
-	~~[[Category: Choline-binding protein]]~~	+
-	~~[[Category: Cys-loop receptor]]~~	+
-	~~[[Category: Electrophysiology]]~~	+
-	~~[[Category: In-silico screening]]~~	+
-	~~[[Category: Ligand-gated ion channel]]~~	+
-	~~[[Category: Receptor~~]]	+

OCA at 14:51, 17 November 2021

OCA — Wed, 17 Nov 2021 14:51:54 GMT

←Older revision		Revision as of 14:51, 17 November 2021
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	<StructureSection load='2xnt' size='340' side='right'caption='[[2xnt]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='2xnt' size='340' side='right'caption='[[2xnt]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xnt]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XNT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xnt]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XNT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=VU2:(2S)-2-[(4-CHLOROBENZYL)OXY]-2-PHENYLETHANAMINE'>VU2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=VU2:(2S)-2-[(4-CHLOROBENZYL)OXY]-2-PHENYLETHANAMINE'>VU2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2byr\|2byr]], [[2byn\|2byn]], [[2bys\|2bys]], [[2wnj\|2wnj]], [[2w8e\|2w8e]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnv\|2xnv]], [[2xnu\|2xnu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2byr\|2byr]], [[2byn\|2byn]], [[2bys\|2bys]], [[2wnj\|2wnj]], [[2w8e\|2w8e]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnv\|2xnv]], [[2xnu\|2xnu]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xnt OCA], [~~http~~://pdbe.org/2xnt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xnt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xnt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xnt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xnt OCA], [https://pdbe.org/2xnt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xnt RCSB], [https://www.ebi.ac.uk/pdbsum/2xnt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xnt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:23, 24 April 2019

OCA — Wed, 24 Apr 2019 07:23:02 GMT

←Older revision		Revision as of 07:23, 24 April 2019
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	==Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors==		==Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors==
-	<StructureSection load='2xnt' size='340' side='right' caption='[[2xnt]], [[Resolution\|resolution]] 3.21Å' scene=''>	+	<StructureSection load='2xnt' size='340' side='right'caption='[[2xnt]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xnt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XNT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xnt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XNT FirstGlance]. <br>
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]	+	*[[Acetylcholine binding protein 3D structures\|Acetylcholine binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Aplca]]		[[Category: Aplca]]
		+	[[Category: Large Structures]]
	[[Category: Akdemir, A]]		[[Category: Akdemir, A]]
	[[Category: Rucktooa, P]]		[[Category: Rucktooa, P]]

OCA at 09:23, 10 October 2018

OCA — Wed, 10 Oct 2018 09:23:18 GMT

←Older revision		Revision as of 09:23, 10 October 2018
Line 1:		Line 1:

-	==~~ACETYLCHOLINE BINDING PROTEIN~~ (~~ACHBP~~) ~~AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS~~==	+	==Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors==
	<StructureSection load='2xnt' size='340' side='right' caption='[[2xnt]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='2xnt' size='340' side='right' caption='[[2xnt]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 26:		Line 26:
	[[Category: Aplca]]		[[Category: Aplca]]
	[[Category: Akdemir, A]]		[[Category: Akdemir, A]]
-	[[Category: Deesch, I]]
	[[Category: Rucktooa, P]]		[[Category: Rucktooa, P]]
	[[Category: Sixma, T K]]		[[Category: Sixma, T K]]
		+	[[Category: DeEsch, I]]
	[[Category: Choline-binding protein]]		[[Category: Choline-binding protein]]
	[[Category: Cys-loop receptor]]		[[Category: Cys-loop receptor]]

OCA at 21:07, 11 August 2016

OCA — Thu, 11 Aug 2016 21:07:00 GMT

←Older revision		Revision as of 21:07, 11 August 2016
Line 1:		Line 1:
		+
	==ACETYLCHOLINE BINDING PROTEIN (ACHBP) AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS==		==ACETYLCHOLINE BINDING PROTEIN (ACHBP) AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS==
	<StructureSection load='2xnt' size='340' side='right' caption='[[2xnt]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='2xnt' size='340' side='right' caption='[[2xnt]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xnt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aplysia_californica Aplysia californica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XNT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xnt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XNT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=VU2:(2S)-2-[(4-CHLOROBENZYL)OXY]-2-PHENYLETHANAMINE'>VU2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=VU2:(2S)-2-[(4-CHLOROBENZYL)OXY]-2-PHENYLETHANAMINE'>VU2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2byr\|2byr]], [[2byn\|2byn]], [[2bys\|2bys]], [[2wnj\|2wnj]], [[2w8e\|2w8e]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnv\|2xnv]], [[2xnu\|2xnu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2byr\|2byr]], [[2byn\|2byn]], [[2bys\|2bys]], [[2wnj\|2wnj]], [[2w8e\|2w8e]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnv\|2xnv]], [[2xnu\|2xnu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xnt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xnt RCSB], [http://www.ebi.ac.uk/pdbsum/2xnt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xnt OCA], [http://pdbe.org/2xnt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xnt RCSB], [http://www.ebi.ac.uk/pdbsum/2xnt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xnt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xnt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplysia californica~~]]	+	[[Category: Aplca]]
	[[Category: Akdemir, A]]		[[Category: Akdemir, A]]
	[[Category: Deesch, I]]		[[Category: Deesch, I]]

OCA at 08:01, 25 January 2015

OCA — Sun, 25 Jan 2015 08:01:30 GMT

←Older revision		Revision as of 08:01, 25 January 2015
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Aplysia californica]]		[[Category: Aplysia californica]]
-	[[Category: Akdemir, A.]]	+	[[Category: Akdemir, A]]
-	[[Category: Deesch, I.]]	+	[[Category: Deesch, I]]
-	[[Category: Rucktooa, P.]]	+	[[Category: Rucktooa, P]]
-	[[Category: Sixma, T K.]]	+	[[Category: Sixma, T K]]
	[[Category: Choline-binding protein]]		[[Category: Choline-binding protein]]
	[[Category: Cys-loop receptor]]		[[Category: Cys-loop receptor]]

OCA at 13:02, 22 October 2014

OCA — Wed, 22 Oct 2014 13:02:32 GMT

←Older revision		Revision as of 13:02, 22 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xnt.~~png~~\|~~left~~\|~~200px~~]]	+	==ACETYLCHOLINE BINDING PROTEIN (ACHBP) AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS==
		+	<StructureSection load='2xnt' size='340' side='right' caption='[[2xnt]], [[Resolution\|resolution]] 3.21Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xnt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XNT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=VU2:(2S)-2-[(4-CHLOROBENZYL)OXY]-2-PHENYLETHANAMINE'>VU2</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2byr\|2byr]], [[2byn\|2byn]], [[2bys\|2bys]], [[2wnj\|2wnj]], [[2w8e\|2w8e]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnv\|2xnv]], [[2xnu\|2xnu]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xnt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xnt RCSB], [http://www.ebi.ac.uk/pdbsum/2xnt PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hierarchical in silico screening protocols against the agonist bound acetylcholine binding protein (AChBP) crystal structure were efficient in identifying novel chemotypes for AChBP and the human alpha7 receptor. Two hit structures were cocrystallized with AChBP revealing intermolecular cation-pi interactions with loop C but lacking intermolecular hydrogen bonding. The compounds act as competitive alpha7 receptor antagonists and as non-competitive alpha4beta2 receptor inhibitors. These results underline the usability of AChBP in structure-based in silico screening strategies in finding novel scaffolds for the alpha7 receptor, but also illustrates some limitations of using AChBP as bait to find competitive alpha4beta2 receptor ligands and alpha7 receptor agonists.

-	~~{{STRUCTURE_2xnt\| PDB=2xnt \| SCENE= }}~~	+	Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.,Akdemir A, Rucktooa P, Jongejan A, Elk R, Bertrand S, Sixma TK, Bertrand D, Smit AB, Leurs R, de Graaf C, de Esch IJ Bioorg Med Chem. 2011 Oct 15;19(20):6107-19. Epub 2011 Aug 27. PMID:21920761<ref>PMID:21920761</ref>

-	~~===ACETYLCHOLINE BINDING PROTEIN (ACHBP) AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21920761}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xnt]] is~~ a ~~10 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aplysia_californica Aplysia californica]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA].~~	+

	==See Also==		==See Also==
	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]		*[[Acetylcholine binding protein\|Acetylcholine binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021920761<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aplysia californica]]		[[Category: Aplysia californica]]
	[[Category: Akdemir, A.]]		[[Category: Akdemir, A.]]

OCA at 18:03, 20 October 2012

OCA — Sat, 20 Oct 2012 18:03:08 GMT

←Older revision		Revision as of 18:03, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2xnt]] is a 10 chain structure ~~of [[Acetylcholine binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA].	+	[[2xnt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA].

	==See Also==		==See Also==

OCA at 02:49, 27 July 2012

OCA — Fri, 27 Jul 2012 02:49:10 GMT

←Older revision		Revision as of 02:49, 27 July 2012
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	[[Image:2xnt.png\|left\|200px]]		[[Image:2xnt.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2xnt\| PDB=2xnt \| SCENE= }}		{{STRUCTURE_2xnt\| PDB=2xnt \| SCENE= }}

	===ACETYLCHOLINE BINDING PROTEIN (ACHBP) AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS===		===ACETYLCHOLINE BINDING PROTEIN (ACHBP) AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS===

-
-	<!--
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	{{ABSTRACT_PUBMED_21920761}}		{{ABSTRACT_PUBMED_21920761}}

	==About this Structure==		==About this Structure==
-	[[2xnt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA].	+	[[2xnt]] is a 10 chain structure of [[Acetylcholine binding protein]] with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA].
		+
		+	==See Also==
		+	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]

	==Reference==		==Reference==

OCA at 07:29, 30 October 2011

OCA — Sun, 30 Oct 2011 07:29:38 GMT

←Older revision		Revision as of 07:29, 30 October 2011
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-	[[Image:2xnt.~~jpg~~\|left\|200px]]	+	[[Image:2xnt.png\|left\|200px]]

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	===ACETYLCHOLINE BINDING PROTEIN (ACHBP) AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS===		===ACETYLCHOLINE BINDING PROTEIN (ACHBP) AS TEMPLATE FOR HIERARCHICAL IN SILICO SCREENING PROCEDURES TO IDENTIFY STRUCTURALLY NOVEL LIGANDS FOR THE NICOTINIC RECEPTORS===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21920761}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21920761 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21920761}}

	==About this Structure==		==About this Structure==
	[[2xnt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA].		[[2xnt]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XNT OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021920761</ref><references group="xtra"/>
	[[Category: Aplysia californica]]		[[Category: Aplysia californica]]
	[[Category: Akdemir, A.]]		[[Category: Akdemir, A.]]