2xps - Revision history

OCA: Redirecting to 4d7m

OCA — Wed, 10 Dec 2014 15:16:47 GMT

Redirecting to 4d7m

←Older revision		Revision as of 15:16, 10 December 2014
Line 1:		Line 1:
-	~~==TETR(D) IN COMPLEX WITH ANHYDROTETRACYCLINE AND MAGNESIUM==~~	+	#REDIRECT [[4d7m]] This PDB entry is obsolete and replaced by 4d7m
-	~~<StructureSection load='2xps' size='340' side='right' caption='~~[[~~2xps~~]]~~, [[Resolution\|resolution]] 1.75Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	<table><tr><td colspan='2'>[[2xps]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPS OCA]. <br>	+
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene><br>	+
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[3zqg\|3zqg]], [[2x9d\|2x9d]], [[3zqh\|3zqh]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[1a6i\|1a6i]], [[2x6o\|2x6o]], [[1qpi\|1qpi]], [[2vke\|2vke]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[1bj0\|1bj0]], [[2tct\|2tct]], [[1bjy\|1bjy]]</td></tr>	+
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xps RCSB], [http://www.ebi.ac.uk/pdbsum/2xps PDBsum]</span></td></tr>	+
-	~~<table>~~	+
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	~~The most frequently occurring resistance of Gram-negative bacteria against tetracyclines is triggered by drug recognition of the Tet repressor.~~ This ~~causes dissociation of the repressor-operator DNA complex and enables expression of the resistance protein TetA, which~~ is responsible for active efflux of tetracycline. The 2.5 angstrom resolution crystal structure of the homodimeric Tet repressor complexed with tetracycline-magnesium reveals detailed drug recognition. The orientation of the operator-binding helix-turn-helix motifs of the repressor is inverted in comparison with other DNA binding proteins. The repressor-drug complex is unable to interact with DNA because the separation of the DNA binding motifs is 5 angstroms wider than usually observed.	+
-		+
-	~~Structure of the Tet repressor-tetracycline complex~~ and ~~regulation of antibiotic resistance.,Hinrichs W, Kisker C, Duvel M, Muller A, Tovar K, Hillen W, Saenger W Science. 1994 Apr 15;264(5157):418-20. PMID:8153629<ref>PMID:8153629</ref>~~	+
-		+
-	~~From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Escherichia coli]]~~	+
-	~~[[Category: Dalm, D.]]~~	+
-	~~[[Category: Hinrichs, W.]]~~	+
-	~~[[Category: Matthes, N.]]~~	+
-	~~[[Category: Palm, G J.]]~~	+
-	~~[[Category: Metal coordination]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulator]]~~	+

OCA at 07:53, 14 May 2014

OCA — Wed, 14 May 2014 07:53:04 GMT

←Older revision		Revision as of 07:53, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2xps.~~jpg~~\|~~left~~\|~~200px~~]]	+	==TETR(D) IN COMPLEX WITH ANHYDROTETRACYCLINE AND MAGNESIUM==
		+	<StructureSection load='2xps' size='340' side='right' caption='[[2xps]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xps]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPS OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TDC:5A,6-ANHYDROTETRACYCLINE'>TDC</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xgc\|2xgc]], [[2xpw\|2xpw]], [[1bjz\|1bjz]], [[3zqg\|3zqg]], [[2x9d\|2x9d]], [[3zqh\|3zqh]], [[2trt\|2trt]], [[2xpv\|2xpv]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[2xge\|2xge]], [[1a6i\|1a6i]], [[2x6o\|2x6o]], [[1qpi\|1qpi]], [[2vke\|2vke]], [[2xgd\|2xgd]], [[1du7\|1du7]], [[2xrl\|2xrl]], [[2xpt\|2xpt]], [[2xpu\|2xpu]], [[2xb5\|2xb5]], [[3zqi\|3zqi]], [[3zqf\|3zqf]], [[1bj0\|1bj0]], [[2tct\|2tct]], [[1bjy\|1bjy]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xps RCSB], [http://www.ebi.ac.uk/pdbsum/2xps PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The most frequently occurring resistance of Gram-negative bacteria against tetracyclines is triggered by drug recognition of the Tet repressor. This causes dissociation of the repressor-operator DNA complex and enables expression of the resistance protein TetA, which is responsible for active efflux of tetracycline. The 2.5 angstrom resolution crystal structure of the homodimeric Tet repressor complexed with tetracycline-magnesium reveals detailed drug recognition. The orientation of the operator-binding helix-turn-helix motifs of the repressor is inverted in comparison with other DNA binding proteins. The repressor-drug complex is unable to interact with DNA because the separation of the DNA binding motifs is 5 angstroms wider than usually observed.

-	<!--	+	Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.,Hinrichs W, Kisker C, Duvel M, Muller A, Tovar K, Hillen W, Saenger W Science. 1994 Apr 15;264(5157):418-20. PMID:8153629<ref>PMID:8153629</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2xps"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2xps\| PDB=2xps \| SCENE= }}~~	+

-	~~===TETR(D) IN COMPLEX WITH ANHYDROTETRACYCLINE AND MAGNESIUM===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_8153629}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 8153629 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_8153629}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xps]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPS OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:008153629<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Dalm, D.]]		[[Category: Dalm, D.]]

OCA: Protected "2xps" [edit=sysop:move=sysop]

OCA — Wed, 07 Sep 2011 06:13:09 GMT

Protected "2xps" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:13, 7 September 2011

OCA at 06:13, 7 September 2011

OCA — Wed, 07 Sep 2011 06:13:03 GMT

←Older revision		Revision as of 06:13, 7 September 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2xps.jpg\|left\|200px]]

-	The ~~entry 2xps~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xps", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xps\| PDB=2xps \| SCENE= }}

-	~~Authors: Dalm,~~ D~~., Matthes, N., Palm, G.J., Hinrichs, W.~~	+	===TETR(D) IN COMPLEX WITH ANHYDROTETRACYCLINE AND MAGNESIUM===

-	Description: TetR(D) in complex with anhydrotetracycline and magnesium.

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Sep 22 14~~:26:~~25 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_8153629}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 8153629 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_8153629}}
		+
		+	==About this Structure==
		+	[[2xps]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:008153629</ref><references group="xtra"/>
		+	[[Category: Escherichia coli]]
		+	[[Category: Dalm, D.]]
		+	[[Category: Hinrichs, W.]]
		+	[[Category: Matthes, N.]]
		+	[[Category: Palm, G J.]]
		+	[[Category: Metal coordination]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulator]]

OCA at 11:17, 22 September 2010

OCA — Wed, 22 Sep 2010 11:17:26 GMT

←Older revision		Revision as of 11:17, 22 September 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2xps is ON HOLD	+	The entry 2xps is ON HOLD until Paper Publication

	Authors: Dalm, D., Matthes, N., Palm, G.J., Hinrichs, W.		Authors: Dalm, D., Matthes, N., Palm, G.J., Hinrichs, W.

-	Description: TetR(D) in complex with anhydrotetracycline and Mg.	+	Description: TetR(D) in complex with anhydrotetracycline and magnesium.

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~15 10~~:28:34 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:26:25 2010''

OCA: New page: '''Unreleased structure''' The entry 2xps is ON HOLD Authors: Dalm, D., Matthes, N., Palm, G.J., Hinrichs, W. Description: TetR(D) in complex with anhydrotetracycline and Mg. ''Page s...

OCA — Wed, 15 Sep 2010 07:19:52 GMT

New page: '''Unreleased structure''' The entry 2xps is ON HOLD Authors: Dalm, D., Matthes, N., Palm, G.J., Hinrichs, W. Description: TetR(D) in complex with anhydrotetracycline and Mg. ''Page s...

New page

'''Unreleased structure'''

The entry 2xps is ON HOLD

Authors: Dalm, D., Matthes, N., Palm, G.J., Hinrichs, W.

Description: TetR(D) in complex with anhydrotetracycline and Mg.

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:28:34 2010''