2xq7 - Revision history

OCA at 10:28, 9 May 2024

OCA — Thu, 09 May 2024 10:28:48 GMT

←Older revision		Revision as of 10:28, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2xq7' size='340' side='right'caption='[[2xq7]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='2xq7' size='340' side='right'caption='[[2xq7]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xq7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Glovi Glovi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xq7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQ7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2xqa\|2xqa]], [[2xq9\|2xq9]], [[2xq5\|2xq5]], [[2xq3\|2xq3]], [[2xq8\|2xq8]], [[2xq4\|2xq4]], [[2xq6\|2xq6]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [https://pdbe.org/2xq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [https://www.ebi.ac.uk/pdbsum/2xq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [https://pdbe.org/2xq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [https://www.ebi.ac.uk/pdbsum/2xq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>	+	[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glovi~~]]	+	[[Category: Gloeobacter violaceus PCC 7421]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bertozzi, C]]	+	[[Category: Bertozzi C]]
-	[[Category: Dutzler, R]]	+	[[Category: Dutzler R]]
-	[[Category: Hilf~~, R J.C~~]]	+	[[Category: Hilf RJC]]
-	[[Category: Reiter, A]]	+	[[Category: Reiter A]]
-	[[Category: Trauner, D]]	+	[[Category: Trauner D]]
-	[[Category: Zimmermann, I]]	+	[[Category: Zimmermann I]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Open channel block~~]]	+

OCA at 05:25, 10 August 2022

OCA — Wed, 10 Aug 2022 05:25:12 GMT

←Older revision		Revision as of 05:25, 10 August 2022
Line 3:		Line 3:
	<StructureSection load='2xq7' size='340' side='right'caption='[[2xq7]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='2xq7' size='340' side='right'caption='[[2xq7]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xq7]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XQ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xq7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQ7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xqa\|2xqa]], [[2xq9\|2xq9]], [[2xq5\|2xq5]], [[2xq3\|2xq3]], [[2xq8\|2xq8]], [[2xq4\|2xq4]], [[2xq6\|2xq6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xqa\|2xqa]], [[2xq9\|2xq9]], [[2xq5\|2xq5]], [[2xq3\|2xq3]], [[2xq8\|2xq8]], [[2xq4\|2xq4]], [[2xq6\|2xq6]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [~~http~~://pdbe.org/2xq7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xq7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [https://pdbe.org/2xq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [https://www.ebi.ac.uk/pdbsum/2xq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>	+	[[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:02, 4 November 2020

OCA — Wed, 04 Nov 2020 08:02:51 GMT

←Older revision		Revision as of 08:02, 4 November 2020
Line 1:		Line 1:

	==Pentameric ligand gated ion channel GLIC in complex with cadmium ion (Cd2+)==		==Pentameric ligand gated ion channel GLIC in complex with cadmium ion (Cd2+)==
-	<StructureSection load='2xq7' size='340' side='right' caption='[[2xq7]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<StructureSection load='2xq7' size='340' side='right'caption='[[2xq7]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xq7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XQ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xq7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XQ7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xqa\|2xqa]], [[2xq9\|2xq9]], [[2xq5\|2xq5]], [[2xq3\|2xq3]], [[2xq8\|2xq8]], [[2xq4\|2xq4]], [[2xq6\|2xq6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xqa\|2xqa]], [[2xq9\|2xq9]], [[2xq5\|2xq5]], [[2xq3\|2xq3]], [[2xq8\|2xq8]], [[2xq4\|2xq4]], [[2xq6\|2xq6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [http://pdbe.org/2xq7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [http://pdbe.org/2xq7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Ion channels\|Ion channels]]	+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Glovi]]		[[Category: Glovi]]
		+	[[Category: Large Structures]]
	[[Category: Bertozzi, C]]		[[Category: Bertozzi, C]]
	[[Category: Dutzler, R]]		[[Category: Dutzler, R]]

OCA at 09:19, 10 October 2018

OCA — Wed, 10 Oct 2018 09:19:40 GMT

←Older revision		Revision as of 09:19, 10 October 2018
Line 1:		Line 1:

-	==~~PENTAMERIC LIGAND GATED ION CHANNEL~~ GLIC ~~IN COMPLEX WITH CADMIUM ION~~ (~~CD2~~+)==	+	==Pentameric ligand gated ion channel GLIC in complex with cadmium ion (Cd2+)==
	<StructureSection load='2xq7' size='340' side='right' caption='[[2xq7]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='2xq7' size='340' side='right' caption='[[2xq7]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 23:21, 4 August 2016

OCA — Thu, 04 Aug 2016 23:21:10 GMT

←Older revision		Revision as of 23:21, 4 August 2016
Line 1:		Line 1:
		+
	==PENTAMERIC LIGAND GATED ION CHANNEL GLIC IN COMPLEX WITH CADMIUM ION (CD2+)==		==PENTAMERIC LIGAND GATED ION CHANNEL GLIC IN COMPLEX WITH CADMIUM ION (CD2+)==
	<StructureSection load='2xq7' size='340' side='right' caption='[[2xq7]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='2xq7' size='340' side='right' caption='[[2xq7]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xq7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xq7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQ7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xqa\|2xqa]], [[2xq9\|2xq9]], [[2xq5\|2xq5]], [[2xq3\|2xq3]], [[2xq8\|2xq8]], [[2xq4\|2xq4]], [[2xq6\|2xq6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xqa\|2xqa]], [[2xq9\|2xq9]], [[2xq5\|2xq5]], [[2xq3\|2xq3]], [[2xq8\|2xq8]], [[2xq4\|2xq4]], [[2xq6\|2xq6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [http://pdbe.org/2xq7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q7NDN8_GLOVI Q7NDN8_GLOVI~~]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>	+	[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xq7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gloeobacter violaceus pcc 7421~~]]	+	[[Category: Glovi]]
	[[Category: Bertozzi, C]]		[[Category: Bertozzi, C]]
	[[Category: Dutzler, R]]		[[Category: Dutzler, R]]

OCA at 13:57, 25 December 2014

OCA — Thu, 25 Dec 2014 13:57:14 GMT

←Older revision		Revision as of 13:57, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q7NDN8_GLOVI Q7NDN8_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Gloeobacter violaceus pcc 7421]]		[[Category: Gloeobacter violaceus pcc 7421]]
-	[[Category: Bertozzi, C.]]	+	[[Category: Bertozzi, C]]
-	[[Category: Dutzler, R.]]	+	[[Category: Dutzler, R]]
-	[[Category: Hilf, R J.C.]]	+	[[Category: Hilf, R J.C]]
-	[[Category: Reiter, A.]]	+	[[Category: Reiter, A]]
-	[[Category: Trauner, D.]]	+	[[Category: Trauner, D]]
-	[[Category: Zimmermann, I.]]	+	[[Category: Zimmermann, I]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Open channel block]]		[[Category: Open channel block]]

OCA at 12:54, 22 October 2014

OCA — Wed, 22 Oct 2014 12:54:17 GMT

←Older revision		Revision as of 12:54, 22 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xq7.~~png~~\|~~left~~\|~~200px~~]]	+	==PENTAMERIC LIGAND GATED ION CHANNEL GLIC IN COMPLEX WITH CADMIUM ION (CD2+)==
		+	<StructureSection load='2xq7' size='340' side='right' caption='[[2xq7]], [[Resolution\|resolution]] 3.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xq7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQ7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xqa\|2xqa]], [[2xq9\|2xq9]], [[2xq5\|2xq5]], [[2xq3\|2xq3]], [[2xq8\|2xq8]], [[2xq4\|2xq4]], [[2xq6\|2xq6]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xq7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq7 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The flow of ions through cation-selective members of the pentameric ligand-gated ion channel family is inhibited by a structurally diverse class of molecules that bind to the transmembrane pore in the open state of the protein. To obtain insight into the mechanism of channel block, we have investigated the binding of positively charged inhibitors to the open channel of the bacterial homolog GLIC by using X-ray crystallography and electrophysiology. Our studies reveal the location of two regions for interactions, with larger blockers binding in the center of the membrane and divalent transition metal ions binding to the narrow intracellular pore entry. The results provide a structural foundation for understanding the interactions of the channel with inhibitors that is relevant for the entire family.

-	~~{{STRUCTURE_2xq7\| PDB=2xq7 \| SCENE= }}~~	+	Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel.,Hilf RJ, Bertozzi C, Zimmermann I, Reiter A, Trauner D, Dutzler R Nat Struct Mol Biol. 2010 Nov;17(11):1330-1336. Epub 2010 Oct 31. PMID:21037567<ref>PMID:21037567</ref>

-	~~===PENTAMERIC LIGAND GATED ION CHANNEL GLIC IN COMPLEX WITH CADMIUM ION (CD2+)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21037567}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xq7]] is~~ a ~~5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA].~~	+

	==See Also==		==See Also==
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021037567<~~/~~ref~~><~~ref group="xtra">PMID:018987630</ref><references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Gloeobacter violaceus pcc 7421]]		[[Category: Gloeobacter violaceus pcc 7421]]
	[[Category: Bertozzi, C.]]		[[Category: Bertozzi, C.]]

OCA at 17:31, 20 October 2012

OCA — Sat, 20 Oct 2012 17:31:32 GMT

←Older revision		Revision as of 17:31, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xq7]] is a 5 chain structure ~~of [[Ion channels]]~~ with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA].	+	[[2xq7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA].

	==See Also==		==See Also==

OCA at 18:59, 6 August 2012

OCA — Mon, 06 Aug 2012 18:59:18 GMT

←Older revision		Revision as of 18:59, 6 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xq7]] is a 5 chain structure of ~~[[]] and~~ [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA].	+	[[2xq7]] is a 5 chain structure of [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA].

	==See Also==		==See Also==
-	*[[\|]]
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]

OCA at 18:54, 6 August 2012

OCA — Mon, 06 Aug 2012 18:54:13 GMT

←Older revision		Revision as of 18:54, 6 August 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xq7]] is a 5 chain structure of [[~~Ion channels~~]] and [[Ion channels ~~(Part II)~~]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA].	+	[[2xq7]] is a 5 chain structure of [[]] and [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ7 OCA].

	==See Also==		==See Also==
		+	*[[\|]]
	*[[Ion channels\|Ion channels]]		*[[Ion channels\|Ion channels]]
-	*[[Ion channels (Part II)\|Ion channels (Part II)]]

	==Reference==		==Reference==