2xqk - Revision history

OCA at 10:37, 20 December 2023

OCA — Wed, 20 Dec 2023 10:37:19 GMT

←Older revision		Revision as of 10:37, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xqk' size='340' side='right'caption='[[2xqk]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2xqk' size='340' side='right'caption='[[2xqk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wsl\|2wsl]], [[2j4c\|2j4c]], [[2xmg\|2xmg]], [[2xmb\|2xmb]], [[1kcj\|1kcj]], [[2wik\|2wik]], [[1p0p\|1p0p]], [[1xlu\|1xlu]], [[2wij\|2wij]], [[2xmd\|2xmd]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1xlw\|1xlw]], [[1ehq\|1ehq]], [[1p0q\|1p0q]], [[2wid\|2wid]], [[2xmc\|2xmc]], [[2wil\|2wil]], [[2wif\|2wif]], [[1p0i\|1p0i]], [[2wig\|2wig]], [[2xqi\|2xqi]], [[2xqg\|2xqg]], [[2xqj\|2xqj]], [[2xqf\|2xqf]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqk OCA], [https://pdbe.org/2xqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqk RCSB], [https://www.ebi.ac.uk/pdbsum/2xqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqk OCA], [https://pdbe.org/2xqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqk RCSB], [https://www.ebi.ac.uk/pdbsum/2xqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.	+	[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>	+	[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cholinesterase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Carletti, E]]	+	[[Category: Carletti E]]
-	[[Category: Gillon, E]]	+	[[Category: Gillon E]]
-	[[Category: Goeldner, M]]	+	[[Category: Goeldner M]]
-	[[Category: Masson, P]]	+	[[Category: Masson P]]
-	[[Category: Nachon, F]]	+	[[Category: Nachon F]]
-	[[Category: Noort, D]]	+	[[Category: Noort D]]
-	[[Category: Wandhammer, M]]	+	[[Category: Wandhammer M]]
-	~~[[Category: Bioscavenger]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Nerve agent~~]]	+

OCA at 05:25, 10 August 2022

OCA — Wed, 10 Aug 2022 05:25:25 GMT

OCA at 08:03, 4 November 2020

OCA — Wed, 04 Nov 2020 08:03:16 GMT

←Older revision		Revision as of 08:03, 4 November 2020
Line 1:		Line 1:

	==X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(S)==		==X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(S)==
-	<StructureSection load='2xqk' size='340' side='right' caption='[[2xqk]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2xqk' size='340' side='right'caption='[[2xqk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XQK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsl\|2wsl]], [[2j4c\|2j4c]], [[2xmg\|2xmg]], [[2xmb\|2xmb]], [[1kcj\|1kcj]], [[2wik\|2wik]], [[1p0p\|1p0p]], [[1xlu\|1xlu]], [[2wij\|2wij]], [[2xmd\|2xmd]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1xlw\|1xlw]], [[1ehq\|1ehq]], [[1p0q\|1p0q]], [[2wid\|2wid]], [[2xmc\|2xmc]], [[2wil\|2wil]], [[2wif\|2wif]], [[1p0i\|1p0i]], [[2wig\|2wig]], [[2xqi\|2xqi]], [[2xqg\|2xqg]], [[2xqj\|2xqj]], [[2xqf\|2xqf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsl\|2wsl]], [[2j4c\|2j4c]], [[2xmg\|2xmg]], [[2xmb\|2xmb]], [[1kcj\|1kcj]], [[2wik\|2wik]], [[1p0p\|1p0p]], [[1xlu\|1xlu]], [[2wij\|2wij]], [[2xmd\|2xmd]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1xlw\|1xlw]], [[1ehq\|1ehq]], [[1p0q\|1p0q]], [[2wid\|2wid]], [[2xmc\|2xmc]], [[2wil\|2wil]], [[2wif\|2wif]], [[1p0i\|1p0i]], [[2wig\|2wig]], [[2xqi\|2xqi]], [[2xqg\|2xqg]], [[2xqj\|2xqj]], [[2xqf\|2xqf]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqk OCA], [http://pdbe.org/2xqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xqk RCSB], [http://www.ebi.ac.uk/pdbsum/2xqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqk OCA], [http://pdbe.org/2xqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xqk RCSB], [http://www.ebi.ac.uk/pdbsum/2xqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Carletti, E]]		[[Category: Carletti, E]]
	[[Category: Gillon, E]]		[[Category: Gillon, E]]

OCA at 14:51, 4 August 2016

OCA — Thu, 04 Aug 2016 14:51:24 GMT

←Older revision		Revision as of 14:51, 4 August 2016
Line 1:		Line 1:
		+
	==X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(S)==		==X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(S)==
	<StructureSection load='2xqk' size='340' side='right' caption='[[2xqk]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2xqk' size='340' side='right' caption='[[2xqk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsl\|2wsl]], [[2j4c\|2j4c]], [[2xmg\|2xmg]], [[2xmb\|2xmb]], [[1kcj\|1kcj]], [[2wik\|2wik]], [[1p0p\|1p0p]], [[1xlu\|1xlu]], [[2wij\|2wij]], [[2xmd\|2xmd]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1xlw\|1xlw]], [[1ehq\|1ehq]], [[1p0q\|1p0q]], [[2wid\|2wid]], [[2xmc\|2xmc]], [[2wil\|2wil]], [[2wif\|2wif]], [[1p0i\|1p0i]], [[2wig\|2wig]], [[2xqi\|2xqi]], [[2xqg\|2xqg]], [[2xqj\|2xqj]], [[2xqf\|2xqf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsl\|2wsl]], [[2j4c\|2j4c]], [[2xmg\|2xmg]], [[2xmb\|2xmb]], [[1kcj\|1kcj]], [[2wik\|2wik]], [[1p0p\|1p0p]], [[1xlu\|1xlu]], [[2wij\|2wij]], [[2xmd\|2xmd]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1xlw\|1xlw]], [[1ehq\|1ehq]], [[1p0q\|1p0q]], [[2wid\|2wid]], [[2xmc\|2xmc]], [[2wil\|2wil]], [[2wif\|2wif]], [[1p0i\|1p0i]], [[2wig\|2wig]], [[2xqi\|2xqi]], [[2xqg\|2xqg]], [[2xqj\|2xqj]], [[2xqf\|2xqf]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqk RCSB], [http://www.ebi.ac.uk/pdbsum/2xqk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqk OCA], [http://pdbe.org/2xqk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xqk RCSB], [http://www.ebi.ac.uk/pdbsum/2xqk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xqk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Carletti, E]]		[[Category: Carletti, E]]
	[[Category: Gillon, E]]		[[Category: Gillon, E]]

OCA at 11:55, 18 December 2014

OCA — Thu, 18 Dec 2014 11:55:27 GMT

←Older revision		Revision as of 11:55, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2xqk\| PDB=2xqk \| SCENE= }}~~	+	==X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(S)==
-	===X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(S)===	+	<StructureSection load='2xqk' size='340' side='right' caption='[[2xqk]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21454498}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2xqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQK FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsl\|2wsl]], [[2j4c\|2j4c]], [[2xmg\|2xmg]], [[2xmb\|2xmb]], [[1kcj\|1kcj]], [[2wik\|2wik]], [[1p0p\|1p0p]], [[1xlu\|1xlu]], [[2wij\|2wij]], [[2xmd\|2xmd]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1xlw\|1xlw]], [[1ehq\|1ehq]], [[1p0q\|1p0q]], [[2wid\|2wid]], [[2xmc\|2xmc]], [[2wil\|2wil]], [[2wif\|2wif]], [[1p0i\|1p0i]], [[2wig\|2wig]], [[2xqi\|2xqi]], [[2xqg\|2xqg]], [[2xqj\|2xqj]], [[2xqf\|2xqf]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqk RCSB], [http://www.ebi.ac.uk/pdbsum/2xqk PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.		[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nerve agents are chiral organophosphate compounds (OPs) that exert their acute toxicity by phosphorylating the catalytic serine of acetylcholinesterase (AChE). The inhibited cholinesterases can be reactivated using oximes, but a spontaneous time-dependent process called aging alters the adduct, leading to resistance toward oxime reactivation. Human butyrylcholinesterase (BChE) functions as a bioscavenger, protecting the cholinergic system against OPs. The stereoselectivity of BChE is an important parameter for its efficiency at scavenging the most toxic OPs enantiomer for AChE. Crystals of BChE inhibited in solution or in cristallo with racemic V-agents (VX, Russian VX, and Chinese VX) systematically show the formation of the P(S) adduct. In this configuration, no catalysis of aging seems possible as confirmed by the three-dimensional structures of the three conjugates incubated over a period exceeding a week. Crystals of BChE soaked in optically pure VX(R)-(+) and VX(S)-(-) solutions lead to the formation of the P(S) and P(R) adduct, respectively. These structural data support an in-line phosphonylation mechanism. Additionally, they show that BChE reacts with VX(R)-(+) in the presence of racemic mixture of V-agents, at odds with earlier kinetic results showing a moderate higher inhibition rate for VX(S)-(-). These combined results suggest that the simultaneous presence of both enantiomers alters the enzyme stereoselectivity. In summary, the three-dimensional data show that BChE reacts preferentially with P(R) enantiomer of V-agents and does not age, in complete contrast to AChE, which is selectively inhibited by the P(S) enantiomer and ages.

-	~~==Function==~~	+	Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agents.,Wandhammer M, Carletti E, Van der Schans M, Gillon E, Nicolet Y, Masson P, Goeldner M, Noort D, Nachon F J Biol Chem. 2011 May 13;286(19):16783-9. Epub 2011 Mar 23. PMID:21454498<ref>PMID:21454498</ref>
-	~~[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to~~ the ~~inactivation~~ of the ~~neurotransmitter acetylcholine~~. ~~Can degrade neurotoxic organophosphate esters~~.~~<ref>~~PMID:~~19542320</ref>~~<ref>PMID:~~19452557~~</ref>	+
-		+
-	~~==About this Structure==~~	+
-	[[2xqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA].	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:021454498</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Carletti, E.]]	+	[[Category: Carletti, E]]
-	[[Category: Gillon, E.]]	+	[[Category: Gillon, E]]
-	[[Category: Goeldner, M.]]	+	[[Category: Goeldner, M]]
-	[[Category: Masson, P.]]	+	[[Category: Masson, P]]
-	[[Category: Nachon, F.]]	+	[[Category: Nachon, F]]
-	[[Category: Noort, D.]]	+	[[Category: Noort, D]]
-	[[Category: Wandhammer, M.]]	+	[[Category: Wandhammer, M]]
	[[Category: Bioscavenger]]		[[Category: Bioscavenger]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Nerve agent]]		[[Category: Nerve agent]]

OCA at 20:45, 24 March 2013

OCA — Sun, 24 Mar 2013 20:45:29 GMT

←Older revision		Revision as of 20:45, 24 March 2013
Line 1:		Line 1:
-	[[Image:2xqk.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xqk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xqk\| PDB=2xqk \| SCENE= }}		{{STRUCTURE_2xqk\| PDB=2xqk \| SCENE= }}
		+	===X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(S)===
		+	{{ABSTRACT_PUBMED_21454498}}

-	===~~X-RAY STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY PURE ENANTIOMER VX-~~(S)~~===~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref><ref>PMID:19452557</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21454498}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 21454498 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_21454498}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021454498</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021454498</ref><references group="xtra"/><references/>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 32:		Line 23:
	[[Category: Noort, D.]]		[[Category: Noort, D.]]
	[[Category: Wandhammer, M.]]		[[Category: Wandhammer, M.]]
		+	[[Category: Bioscavenger]]
		+	[[Category: Hydrolase]]
		+	[[Category: Nerve agent]]

OCA at 05:34, 18 May 2011

OCA — Wed, 18 May 2011 05:34:49 GMT

←Older revision		Revision as of 05:34, 18 May 2011
Line 1:		Line 1:
-	[[Image:2xqk.~~jpg~~\|left\|200px]]	+	[[Image:2xqk.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===X-RAY STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY PURE ENANTIOMER VX-(S)===		===X-RAY STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY PURE ENANTIOMER VX-(S)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21454498}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21454498 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21454498}}

	==About this Structure==		==About this Structure==
	[[2xqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA].		[[2xqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021454498</ref><references group="xtra"/>
	[[Category: Cholinesterase]]		[[Category: Cholinesterase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA: Protected "2xqk" [edit=sysop:move=sysop]

OCA — Wed, 23 Mar 2011 07:13:22 GMT

Protected "2xqk" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:13, 23 March 2011

OCA at 07:13, 23 March 2011

OCA — Wed, 23 Mar 2011 07:13:20 GMT

←Older revision		Revision as of 07:13, 23 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2xqk.jpg\|left\|200px]]

-	The ~~entry 2xqk~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xqk", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xqk\| PDB=2xqk \| SCENE= }}

-	~~Authors: Wandhammer, M., Carletti, E., Gillon, E., Masson, P., Goeldner, M., Noort, D., Nachon, F.~~	+	===X-RAY STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY PURE ENANTIOMER VX-(S)===

-	Description: X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(S)

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Sep 15 10~~:28:~~54 2010''~~	+	==About this Structure==
		+	[[2xqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA].
		+	[[Category: Cholinesterase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Carletti, E.]]
		+	[[Category: Gillon, E.]]
		+	[[Category: Goeldner, M.]]
		+	[[Category: Masson, P.]]
		+	[[Category: Nachon, F.]]
		+	[[Category: Noort, D.]]
		+	[[Category: Wandhammer, M.]]

OCA: New page: '''Unreleased structure''' The entry 2xqk is ON HOLD until Paper Publication Authors: Wandhammer, M., Carletti, E., Gillon, E., Masson, P., Goeldner, M., Noort, D., Nachon, F. Descript...

OCA — Wed, 15 Sep 2010 07:20:12 GMT

New page: '''Unreleased structure''' The entry 2xqk is ON HOLD until Paper Publication Authors: Wandhammer, M., Carletti, E., Gillon, E., Masson, P., Goeldner, M., Noort, D., Nachon, F. Descript...

New page

'''Unreleased structure'''

The entry 2xqk is ON HOLD until Paper Publication

Authors: Wandhammer, M., Carletti, E., Gillon, E., Masson, P., Goeldner, M., Noort, D., Nachon, F.

Description: X-ray Structure of human butyrylcholinesterase inhibited by pure enantiomer VX-(S)

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:28:54 2010''

←Older revision		Revision as of 05:25, 10 August 2022
Line 3:		Line 3:
	<StructureSection load='2xqk' size='340' side='right'caption='[[2xqk]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2xqk' size='340' side='right'caption='[[2xqk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XQK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wsl\|2wsl]], [[2j4c\|2j4c]], [[2xmg\|2xmg]], [[2xmb\|2xmb]], [[1kcj\|1kcj]], [[2wik\|2wik]], [[1p0p\|1p0p]], [[1xlu\|1xlu]], [[2wij\|2wij]], [[2xmd\|2xmd]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1xlw\|1xlw]], [[1ehq\|1ehq]], [[1p0q\|1p0q]], [[2wid\|2wid]], [[2xmc\|2xmc]], [[2wil\|2wil]], [[2wif\|2wif]], [[1p0i\|1p0i]], [[2wig\|2wig]], [[2xqi\|2xqi]], [[2xqg\|2xqg]], [[2xqj\|2xqj]], [[2xqf\|2xqf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wsl\|2wsl]], [[2j4c\|2j4c]], [[2xmg\|2xmg]], [[2xmb\|2xmb]], [[1kcj\|1kcj]], [[2wik\|2wik]], [[1p0p\|1p0p]], [[1xlu\|1xlu]], [[2wij\|2wij]], [[2xmd\|2xmd]], [[1xlv\|1xlv]], [[1eho\|1eho]], [[1p0m\|1p0m]], [[1xlw\|1xlw]], [[1ehq\|1ehq]], [[1p0q\|1p0q]], [[2wid\|2wid]], [[2xmc\|2xmc]], [[2wil\|2wil]], [[2wif\|2wif]], [[1p0i\|1p0i]], [[2wig\|2wig]], [[2xqi\|2xqi]], [[2xqg\|2xqg]], [[2xqj\|2xqj]], [[2xqf\|2xqf]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqk OCA], [~~http~~://pdbe.org/2xqk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xqk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xqk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqk OCA], [https://pdbe.org/2xqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqk RCSB], [https://www.ebi.ac.uk/pdbsum/2xqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqk ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[~~http~~://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.	+	[[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>	+	[[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==