2xqy - Revision history

OCA at 10:37, 20 December 2023

OCA — Wed, 20 Dec 2023 10:37:31 GMT

←Older revision		Revision as of 10:37, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xqy' size='340' side='right'caption='[[2xqy]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2xqy' size='340' side='right'caption='[[2xqy]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Alphaherpesvirus_pseudorabies_virus_prv Alphaherpesvirus pseudorabies virus prv~~] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Suid_alphaherpesvirus_1 Suid alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqy OCA], [https://pdbe.org/2xqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqy RCSB], [https://www.ebi.ac.uk/pdbsum/2xqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqy OCA], [https://pdbe.org/2xqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqy RCSB], [https://www.ebi.ac.uk/pdbsum/2xqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GH_SUHVK GH_SUHVK]] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL (By similarity).	+	[https://www.uniprot.org/uniprot/GH_SUHVK GH_SUHVK] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alphaherpesvirus pseudorabies virus prv]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Backovic, M]]	+	[[Category: Suid alphaherpesvirus 1]]
-	[[Category: Bricogne, G]]	+	[[Category: Backovic M]]
-	[[Category: Cockburn, J]]	+	[[Category: Bricogne G]]
-	[[Category: Dubois, R]]	+	[[Category: Cockburn J]]
-	[[Category: Granzow, H]]	+	[[Category: Dubois R]]
-	[[Category: Klupp, B]]	+	[[Category: Granzow H]]
-	[[Category: Mettenleiter, T]]	+	[[Category: Klupp B]]
-	[[Category: Rey, F]]	+	[[Category: Mettenleiter T]]
-	[[Category: Sharff, A]]	+	[[Category: Rey F]]
-	[[Category: Vaney, M]]	+	[[Category: Sharff A]]
-	~~[[Category: Envelope protein]]~~	+	[[Category: Vaney M]]
-	~~[[Category: Immune system-viral protein complex~~]]	+

OCA at 12:15, 27 April 2022

OCA — Wed, 27 Apr 2022 12:15:40 GMT

←Older revision		Revision as of 12:15, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xqy' size='340' side='right'caption='[[2xqy]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2xqy' size='340' side='right'caption='[[2xqy]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqy]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Alphaherpesvirus_pseudorabies_virus_prv Alphaherpesvirus pseudorabies virus prv] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XQY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Alphaherpesvirus_pseudorabies_virus_prv Alphaherpesvirus pseudorabies virus prv] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqy OCA], [~~http~~://pdbe.org/2xqy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xqy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xqy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqy OCA], [https://pdbe.org/2xqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqy RCSB], [https://www.ebi.ac.uk/pdbsum/2xqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GH_SUHVK GH_SUHVK]] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL (By similarity).	+	[[https://www.uniprot.org/uniprot/GH_SUHVK GH_SUHVK]] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:16, 22 July 2020

OCA — Wed, 22 Jul 2020 12:16:43 GMT

←Older revision		Revision as of 12:16, 22 July 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3==		==CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3==
-	<StructureSection load='2xqy' size='340' side='right' caption='[[2xqy]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='2xqy' size='340' side='right'caption='[[2xqy]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqy]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Alphaherpesvirus_pseudorabies_virus_prv Alphaherpesvirus pseudorabies virus prv] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XQY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqy]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Alphaherpesvirus_pseudorabies_virus_prv Alphaherpesvirus pseudorabies virus prv] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XQY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqy OCA], [http://pdbe.org/2xqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xqy RCSB], [http://www.ebi.ac.uk/pdbsum/2xqy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqy OCA], [http://pdbe.org/2xqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xqy RCSB], [http://www.ebi.ac.uk/pdbsum/2xqy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Alphaherpesvirus pseudorabies virus prv]]		[[Category: Alphaherpesvirus pseudorabies virus prv]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Backovic, M]]		[[Category: Backovic, M]]

OCA at 09:33, 10 October 2018

OCA — Wed, 10 Oct 2018 09:33:44 GMT

←Older revision		Revision as of 09:33, 10 October 2018
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:30, 4 August 2016

OCA — Thu, 04 Aug 2016 09:30:04 GMT

←Older revision		Revision as of 09:30, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3==		==CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3==
	<StructureSection load='2xqy' size='340' side='right' caption='[[2xqy]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2xqy' size='340' side='right' caption='[[2xqy]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqy]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~] and [http://en.wikipedia.org/wiki/~~Suid_herpesvirus_1 Suid herpesvirus 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqy]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Alphaherpesvirus_pseudorabies_virus_prv Alphaherpesvirus pseudorabies virus prv] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqy RCSB], [http://www.ebi.ac.uk/pdbsum/2xqy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqy OCA], [http://pdbe.org/2xqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xqy RCSB], [http://www.ebi.ac.uk/pdbsum/2xqy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xqy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Alphaherpesvirus pseudorabies virus prv]]
-	[[Category: ~~Suid herpesvirus 1~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Backovic, M]]		[[Category: Backovic, M]]
	[[Category: Bricogne, G]]		[[Category: Bricogne, G]]

OCA at 08:16, 24 December 2014

OCA — Wed, 24 Dec 2014 08:16:46 GMT

←Older revision		Revision as of 08:16, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqy RCSB], [http://www.ebi.ac.uk/pdbsum/2xqy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqy RCSB], [http://www.ebi.ac.uk/pdbsum/2xqy PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GH_SUHVK GH_SUHVK]] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:31, 19 November 2014

OCA — Wed, 19 Nov 2014 13:31:20 GMT

←Older revision		Revision as of 13:31, 19 November 2014
Line 1:		Line 1:
-	[[~~Image:~~2xqy.~~png~~\|~~left\|200px~~]]	+	==CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3==
		+	<StructureSection load='2xqy' size='340' side='right' caption='[[2xqy]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xqy]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Suid_herpesvirus_1 Suid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqy RCSB], [http://www.ebi.ac.uk/pdbsum/2xqy PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Compared with many well-studied enveloped viruses, herpesviruses use a more sophisticated molecular machinery to induce fusion of viral and cellular membranes during cell invasion. This essential function is carried out by glycoprotein B (gB), a class III viral fusion protein, together with the heterodimer of glycoproteins H and L (gH/gL). In pseudorabies virus (PrV), a porcine herpesvirus, it was shown that gH/gL can be substituted by a chimeric fusion protein gDgH, containing the receptor binding domain (RBD) of glycoprotein D fused to a truncated version of gH lacking its N-terminal domain. We report here the 2.1-A resolution structure of the core fragment of gH present in this chimera, bound to the Fab fragment of a PrV gH-specific monoclonal antibody. The structure strongly complements the information derived from the recently reported structure of gH/gL from herpes simplex virus type 2 (HSV-2). Together with the structure of Epstein-Barr virus (EBV) gH/gL reported in parallel, it provides insight into potentially functional conserved structural features. One feature is the presence of a syntaxin motif, and the other is an extended "flap" masking a conserved hydrophobic patch in the C-terminal domain, which is closest to the viral membrane. The negative electrostatic surface potential of this domain suggests repulsive interactions with the lipid heads. The structure indicates the possible unmasking of an extended hydrophobic patch by movement of the flap during a receptor-triggered conformational change of gH, exposing a hydrophobic surface to interact with the viral membrane during the fusion process.

-	~~{{STRUCTURE_2xqy\| PDB=2xqy \| SCENE= }}~~	+	Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody.,Backovic M, Dubois RM, Cockburn JJ, Sharff AJ, Vaney MC, Granzow H, Klupp BG, Bricogne G, Mettenleiter TC, Rey FA Proc Natl Acad Sci U S A. 2010 Dec 13. PMID:21149698<ref>PMID:21149698</ref>

-	~~===CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6~~.~~3===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_21149698}}~~	+	==See Also==
-		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2xqy~~]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Suid_herpesvirus_1 Suid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:021149698<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Suid herpesvirus 1]]		[[Category: Suid herpesvirus 1]]
-	[[Category: Backovic, M.]]	+	[[Category: Backovic, M]]
-	[[Category: Bricogne, G.]]	+	[[Category: Bricogne, G]]
-	[[Category: Cockburn, J.]]	+	[[Category: Cockburn, J]]
-	[[Category: Dubois, R.]]	+	[[Category: Dubois, R]]
-	[[Category: Granzow, H.]]	+	[[Category: Granzow, H]]
-	[[Category: Klupp, B.]]	+	[[Category: Klupp, B]]
-	[[Category: Mettenleiter, T.]]	+	[[Category: Mettenleiter, T]]
-	[[Category: Rey, F.]]	+	[[Category: Rey, F]]
-	[[Category: Sharff, A.]]	+	[[Category: Sharff, A]]
-	[[Category: Vaney, M.]]	+	[[Category: Vaney, M]]
	[[Category: Envelope protein]]		[[Category: Envelope protein]]
	[[Category: Immune system-viral protein complex]]		[[Category: Immune system-viral protein complex]]

OCA at 11:13, 13 February 2013

OCA — Wed, 13 Feb 2013 11:13:26 GMT

←Older revision		Revision as of 11:13, 13 February 2013
Line 1:		Line 1:
	[[Image:2xqy.png\|left\|200px]]		[[Image:2xqy.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xqy", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2xqy\| PDB=2xqy \| SCENE= }}		{{STRUCTURE_2xqy\| PDB=2xqy \| SCENE= }}

	===CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3===		===CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21149698}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21149698 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21149698}}		{{ABSTRACT_PUBMED_21149698}}

	==About this Structure==		==About this Structure==
-	[[2xqy]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/~~Suid_herpesvirus~~ Suid herpesvirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA].	+	[[2xqy]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Suid_herpesvirus_1 Suid herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQY OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21149698~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021149698</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Suid herpesvirus]]	+	[[Category: Suid herpesvirus 1]]
	[[Category: Backovic, M.]]		[[Category: Backovic, M.]]
	[[Category: Bricogne, G.]]		[[Category: Bricogne, G.]]
Line 35:		Line 24:
	[[Category: Sharff, A.]]		[[Category: Sharff, A.]]
	[[Category: Vaney, M.]]		[[Category: Vaney, M.]]
		+	[[Category: Envelope protein]]
		+	[[Category: Immune system-viral protein complex]]

OCA at 08:10, 6 April 2011

OCA — Wed, 06 Apr 2011 08:10:12 GMT

←Older revision		Revision as of 08:10, 6 April 2011
Line 35:		Line 35:
	[[Category: Sharff, A.]]		[[Category: Sharff, A.]]
	[[Category: Vaney, M.]]		[[Category: Vaney, M.]]
-	[[Category: Envelope protein]]
-	[[Category: Immune system-viral protein complex]]

OCA: Protected "2xqy" [edit=sysop:move=sysop]

OCA — Wed, 29 Dec 2010 17:57:47 GMT

Protected "2xqy" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:57, 29 December 2010