2xqz - Revision history

OCA at 08:02, 23 August 2023

OCA — Wed, 23 Aug 2023 08:02:42 GMT

←Older revision		Revision as of 08:02, 23 August 2023
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	<StructureSection load='2xqz' size='340' side='right'caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xqz' size='340' side='right'caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Neutron Diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[2xr0\|2xr0]], [[1bza\|1bza]], [[1iyq\|1iyq]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqz OCA], [https://pdbe.org/2xqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqz RCSB], [https://www.ebi.ac.uk/pdbsum/2xqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqz OCA], [https://pdbe.org/2xqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqz RCSB], [https://www.ebi.ac.uk/pdbsum/2xqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity.	+	[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX] Has strong cefotaxime-hydrolyzing activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Beta-lactamase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blakeley~~, M P~~]]	+	[[Category: Blakeley MP]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Coates, L]]	+	[[Category: Coates L]]
-	[[Category: Cooper, J]]	+	[[Category: Cooper J]]
-	[[Category: Tomanicek~~, S J~~]]	+	[[Category: Tomanicek SJ]]
-	[[Category: Wang~~, K K~~]]	+	[[Category: Wang KK]]
-	[[Category: Weiss~~, K L]]~~	+	[[Category: Weiss KL]]
-	~~[[Category: Ctx-m-type esbl]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 14:53, 17 November 2021

OCA — Wed, 17 Nov 2021 14:53:10 GMT

←Older revision		Revision as of 14:53, 17 November 2021
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	<StructureSection load='2xqz' size='340' side='right'caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xqz' size='340' side='right'caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[2xr0\|2xr0]], [[1bza\|1bza]], [[1iyq\|1iyq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[2xr0\|2xr0]], [[1bza\|1bza]], [[1iyq\|1iyq]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqz OCA], [~~http~~://pdbe.org/2xqz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xqz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xqz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqz OCA], [https://pdbe.org/2xqz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqz RCSB], [https://www.ebi.ac.uk/pdbsum/2xqz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity.	+	[[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 14:02, 25 December 2019

OCA — Wed, 25 Dec 2019 14:02:49 GMT

←Older revision		Revision as of 14:02, 25 December 2019
Line 1:		Line 1:

	==Neutron structure of the perdeuterated Toho-1 R274N R276N double mutant beta-lactamase==		==Neutron structure of the perdeuterated Toho-1 R274N R276N double mutant beta-lactamase==
-	<StructureSection load='2xqz' size='340' side='right' caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2xqz' size='340' side='right'caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 2xqz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2xqz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Blakeley, M P]]		[[Category: Blakeley, M P]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]

OCA at 08:49, 27 December 2017

OCA — Wed, 27 Dec 2017 08:49:07 GMT

←Older revision		Revision as of 08:49, 27 December 2017
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	<StructureSection load='2xqz' size='340' side='right' caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xqz' size='340' side='right' caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[2xr0\|2xr0]], [[1bza\|1bza]], [[1iyq\|1iyq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[2xr0\|2xr0]], [[1bza\|1bza]], [[1iyq\|1iyq]]</td></tr>
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	</div>		</div>
	<div class="pdbe-citations 2xqz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2xqz" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Blakeley, M P]]		[[Category: Blakeley, M P]]

OCA at 09:51, 22 March 2017

OCA — Wed, 22 Mar 2017 09:51:37 GMT

←Older revision		Revision as of 09:51, 22 March 2017
Line 1:		Line 1:

-	==~~NEUTRON STRUCTURE OF THE PERDEUTERATED TOHO~~-1 R274N R276N ~~DOUBLE MUTANT BETA~~-~~LACTAMASE~~==	+	==Neutron structure of the perdeuterated Toho-1 R274N R276N double mutant beta-lactamase==
	<StructureSection load='2xqz' size='340' side='right' caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xqz' size='340' side='right' caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[2xr0\|2xr0]], [[1bza\|1bza]], [[1iyq\|1iyq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[2xr0\|2xr0]], [[1bza\|1bza]], [[1iyq\|1iyq]]</td></tr>
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Blakeley, M P]]		[[Category: Blakeley, M P]]

OCA at 16:30, 5 August 2016

OCA — Fri, 05 Aug 2016 16:30:27 GMT

←Older revision		Revision as of 16:30, 5 August 2016
Line 1:		Line 1:
		+
	==NEUTRON STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE==		==NEUTRON STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE==
	<StructureSection load='2xqz' size='340' side='right' caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2xqz' size='340' side='right' caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[2xr0\|2xr0]], [[1bza\|1bza]], [[1iyq\|1iyq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[2xr0\|2xr0]], [[1bza\|1bza]], [[1iyq\|1iyq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqz RCSB], [http://www.ebi.ac.uk/pdbsum/2xqz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqz OCA], [http://pdbe.org/2xqz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xqz RCSB], [http://www.ebi.ac.uk/pdbsum/2xqz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xqz" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Escherichia coli]]
	[[Category: Blakeley, M P]]		[[Category: Blakeley, M P]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]

OCA at 04:01, 25 December 2014

OCA — Thu, 25 Dec 2014 04:01:04 GMT

←Older revision		Revision as of 04:01, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqz RCSB], [http://www.ebi.ac.uk/pdbsum/2xqz PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqz RCSB], [http://www.ebi.ac.uk/pdbsum/2xqz PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Blakeley, M P.]]	+	[[Category: Blakeley, M P]]
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Coates, L.]]	+	[[Category: Coates, L]]
-	[[Category: Cooper, J.]]	+	[[Category: Cooper, J]]
-	[[Category: Tomanicek, S J.]]	+	[[Category: Tomanicek, S J]]
-	[[Category: Wang, K K.]]	+	[[Category: Wang, K K]]
-	[[Category: Weiss, K L.]]	+	[[Category: Weiss, K L]]
	[[Category: Ctx-m-type esbl]]		[[Category: Ctx-m-type esbl]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 13:06, 22 October 2014

OCA — Wed, 22 Oct 2014 13:06:50 GMT

←Older revision		Revision as of 13:06, 22 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xqz.~~png~~\|~~left~~\|~~200px~~]]	+	==NEUTRON STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE==
		+	<StructureSection load='2xqz' size='340' side='right' caption='[[2xqz]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[2xr0\|2xr0]], [[1bza\|1bza]], [[1iyq\|1iyq]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xqz RCSB], [http://www.ebi.ac.uk/pdbsum/2xqz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Room temperature neutron diffraction data of the fully perdeuterated Toho-1 R274N/R276N double mutant beta-lactamase in the apo form were used to visualize deuterium atoms within the active site of the enzyme. This perdeuterated neutron structure of the Toho-1 R274N/R276N reveals the clearest picture yet of the ground-state active site protonation states and the complete hydrogen-bonding network in a beta-lactamase enzyme. The ground-state active site protonation states detailed in this neutron diffraction study are consistent with previous high-resolution X-ray studies that support the role of Glu166 as the general base during the acylation reaction in the class A beta-lactamase reaction pathway.

-	~~{{STRUCTURE_2xqz\| PDB=2xqz \| SCENE= }}~~	+	The active site protonation states of perdeuterated Toho-1 beta-lactamase determined by neutron diffraction support a role for Glu166 as the general base in acylation.,Tomanicek SJ, Wang KK, Weiss KL, Blakeley MP, Cooper J, Chen Y, Coates L FEBS Lett. 2010 Dec 17. PMID:21168411<ref>PMID:21168411</ref>

-	~~===NEUTRON STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21168411}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xqz]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-lactamase\|Beta-lactamase]]		*[[Beta-lactamase\|Beta-lactamase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021168411<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]

OCA at 12:26, 20 October 2012

OCA — Sat, 20 Oct 2012 12:26:58 GMT

←Older revision		Revision as of 12:26, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2xqz]] is a 1 chain structure ~~of [[Beta-lactamase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA].	+	[[2xqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA].

	==See Also==		==See Also==

OCA at 08:45, 26 July 2012

OCA — Thu, 26 Jul 2012 08:45:04 GMT

←Older revision		Revision as of 08:45, 26 July 2012
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	[[Image:2xqz.png\|left\|200px]]		[[Image:2xqz.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xqz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xqz\| PDB=2xqz \| SCENE= }}		{{STRUCTURE_2xqz\| PDB=2xqz \| SCENE= }}

	===NEUTRON STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE===		===NEUTRON STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21168411}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21168411 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21168411}}		{{ABSTRACT_PUBMED_21168411}}

	==About this Structure==		==About this Structure==
-	[[2xqz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA].	+	[[2xqz]] is a 1 chain structure of [[Beta-lactamase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQZ OCA].
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21168411~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021168411</ref><references group="xtra"/>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
Line 32:		Line 24:
	[[Category: Wang, K K.]]		[[Category: Wang, K K.]]
	[[Category: Weiss, K L.]]		[[Category: Weiss, K L.]]
		+	[[Category: Ctx-m-type esbl]]
		+	[[Category: Hydrolase]]