2xr0 - Revision history

OCA at 10:37, 20 December 2023

OCA — Wed, 20 Dec 2023 10:37:33 GMT

←Older revision		Revision as of 10:37, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xr0' size='340' side='right'caption='[[2xr0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2xr0' size='340' side='right'caption='[[2xr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xr0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XR0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xr0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XR0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[1bza\|1bza]], [[1iyq\|1iyq]], [[2xqz\|2xqz]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr0 OCA], [https://pdbe.org/2xr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xr0 RCSB], [https://www.ebi.ac.uk/pdbsum/2xr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xr0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr0 OCA], [https://pdbe.org/2xr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xr0 RCSB], [https://www.ebi.ac.uk/pdbsum/2xr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xr0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity.	+	[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX] Has strong cefotaxime-hydrolyzing activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Beta-lactamase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blakeley~~, M P~~]]	+	[[Category: Blakeley MP]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Coates, L]]	+	[[Category: Coates L]]
-	[[Category: Cooper, J]]	+	[[Category: Cooper J]]
-	[[Category: Tomanicek~~, S J~~]]	+	[[Category: Tomanicek SJ]]
-	[[Category: Wang~~, K K~~]]	+	[[Category: Wang KK]]
-	[[Category: Weiss~~, K L]]~~	+	[[Category: Weiss KL]]
-	~~[[Category: Ctx-m-type esbl]]~~	+
-	~~[[Category: Esbl]]~~	+
-	~~[[Category: Extended-spectrum beta-lactamase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 12:15, 27 April 2022

OCA — Wed, 27 Apr 2022 12:15:32 GMT

←Older revision		Revision as of 12:15, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xr0' size='340' side='right'caption='[[2xr0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2xr0' size='340' side='right'caption='[[2xr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xr0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XR0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xr0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XR0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[1bza\|1bza]], [[1iyq\|1iyq]], [[2xqz\|2xqz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[1bza\|1bza]], [[1iyq\|1iyq]], [[2xqz\|2xqz]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr0 OCA], [~~http~~://pdbe.org/2xr0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xr0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xr0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xr0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr0 OCA], [https://pdbe.org/2xr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xr0 RCSB], [https://www.ebi.ac.uk/pdbsum/2xr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xr0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity.	+	[[https://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:16, 22 July 2020

OCA — Wed, 22 Jul 2020 12:16:49 GMT

←Older revision		Revision as of 12:16, 22 July 2020
Line 1:		Line 1:

	==Room temperature X-ray structure of the perdeuterated Toho-1 R274N R276N double mutant beta-lactamase==		==Room temperature X-ray structure of the perdeuterated Toho-1 R274N R276N double mutant beta-lactamase==
-	<StructureSection load='2xr0' size='340' side='right' caption='[[2xr0]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2xr0' size='340' side='right'caption='[[2xr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XR0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XR0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[1bza\|1bza]], [[1iyq\|1iyq]], [[2xqz\|2xqz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[1bza\|1bza]], [[1iyq\|1iyq]], [[2xqz\|2xqz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr0 OCA], [http://pdbe.org/2xr0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xr0 RCSB], [http://www.ebi.ac.uk/pdbsum/2xr0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xr0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr0 OCA], [http://pdbe.org/2xr0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xr0 RCSB], [http://www.ebi.ac.uk/pdbsum/2xr0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xr0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Blakeley, M P]]		[[Category: Blakeley, M P]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]

OCA at 09:01, 10 October 2018

OCA — Wed, 10 Oct 2018 09:01:03 GMT

←Older revision		Revision as of 09:01, 10 October 2018
Line 1:		Line 1:

-	==~~ROOM TEMPERATURE~~ X-~~RAY STRUCTURE OF THE PERDEUTERATED TOHO~~-1 R274N R276N ~~DOUBLE MUTANT BETA~~-~~LACTAMASE~~==	+	==Room temperature X-ray structure of the perdeuterated Toho-1 R274N R276N double mutant beta-lactamase==
	<StructureSection load='2xr0' size='340' side='right' caption='[[2xr0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2xr0' size='340' side='right' caption='[[2xr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 12:20, 4 August 2016

OCA — Thu, 04 Aug 2016 12:20:46 GMT

←Older revision		Revision as of 12:20, 4 August 2016
Line 1:		Line 1:
		+
	==ROOM TEMPERATURE X-RAY STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE==		==ROOM TEMPERATURE X-RAY STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE==
	<StructureSection load='2xr0' size='340' side='right' caption='[[2xr0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2xr0' size='340' side='right' caption='[[2xr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XR0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XR0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[1bza\|1bza]], [[1iyq\|1iyq]], [[2xqz\|2xqz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[1bza\|1bza]], [[1iyq\|1iyq]], [[2xqz\|2xqz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xr0 RCSB], [http://www.ebi.ac.uk/pdbsum/2xr0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr0 OCA], [http://pdbe.org/2xr0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xr0 RCSB], [http://www.ebi.ac.uk/pdbsum/2xr0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xr0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xr0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Escherichia coli]]
	[[Category: Blakeley, M P]]		[[Category: Blakeley, M P]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]

OCA at 09:15, 25 December 2014

OCA — Thu, 25 Dec 2014 09:15:13 GMT

←Older revision		Revision as of 09:15, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xr0 RCSB], [http://www.ebi.ac.uk/pdbsum/2xr0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xr0 RCSB], [http://www.ebi.ac.uk/pdbsum/2xr0 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BLT1_ECOLX BLT1_ECOLX]] Has strong cefotaxime-hydrolyzing activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 27:
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Blakeley, M P.]]	+	[[Category: Blakeley, M P]]
-	[[Category: Chen, Y.]]	+	[[Category: Chen, Y]]
-	[[Category: Coates, L.]]	+	[[Category: Coates, L]]
-	[[Category: Cooper, J.]]	+	[[Category: Cooper, J]]
-	[[Category: Tomanicek, S J.]]	+	[[Category: Tomanicek, S J]]
-	[[Category: Wang, K K.]]	+	[[Category: Wang, K K]]
-	[[Category: Weiss, K L.]]	+	[[Category: Weiss, K L]]
	[[Category: Ctx-m-type esbl]]		[[Category: Ctx-m-type esbl]]
	[[Category: Esbl]]		[[Category: Esbl]]
	[[Category: Extended-spectrum beta-lactamase]]		[[Category: Extended-spectrum beta-lactamase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 13:09, 22 October 2014

OCA — Wed, 22 Oct 2014 13:09:17 GMT

←Older revision		Revision as of 13:09, 22 October 2014
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-	[[~~Image:~~2xr0.~~png~~\|~~left~~\|~~200px~~]]	+	==ROOM TEMPERATURE X-RAY STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE==
		+	<StructureSection load='2xr0' size='340' side='right' caption='[[2xr0]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XR0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1iyp\|1iyp]], [[1we4\|1we4]], [[2wyx\|2wyx]], [[1iys\|1iys]], [[1iyo\|1iyo]], [[1bza\|1bza]], [[1iyq\|1iyq]], [[2xqz\|2xqz]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xr0 RCSB], [http://www.ebi.ac.uk/pdbsum/2xr0 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Room temperature neutron diffraction data of the fully perdeuterated Toho-1 R274N/R276N double mutant beta-lactamase in the apo form were used to visualize deuterium atoms within the active site of the enzyme. This perdeuterated neutron structure of the Toho-1 R274N/R276N reveals the clearest picture yet of the ground-state active site protonation states and the complete hydrogen-bonding network in a beta-lactamase enzyme. The ground-state active site protonation states detailed in this neutron diffraction study are consistent with previous high-resolution X-ray studies that support the role of Glu166 as the general base during the acylation reaction in the class A beta-lactamase reaction pathway.

-	~~{{STRUCTURE_2xr0\| PDB=2xr0 \| SCENE= }}~~	+	The active site protonation states of perdeuterated Toho-1 beta-lactamase determined by neutron diffraction support a role for Glu166 as the general base in acylation.,Tomanicek SJ, Wang KK, Weiss KL, Blakeley MP, Cooper J, Chen Y, Coates L FEBS Lett. 2010 Dec 17. PMID:21168411<ref>PMID:21168411</ref>

-	~~===ROOM TEMPERATURE X-RAY STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21168411}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xr0]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-lactamase\|Beta-lactamase]]		*[[Beta-lactamase\|Beta-lactamase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021168411<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]

OCA at 14:59, 20 October 2012

OCA — Sat, 20 Oct 2012 14:59:41 GMT

←Older revision		Revision as of 14:59, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2xr0]] is a 1 chain structure ~~of [[Beta-lactamase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA].	+	[[2xr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA].

	==See Also==		==See Also==

OCA at 16:56, 26 July 2012

OCA — Thu, 26 Jul 2012 16:56:48 GMT

←Older revision		Revision as of 16:56, 26 July 2012
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	[[Image:2xr0.png\|left\|200px]]		[[Image:2xr0.png\|left\|200px]]

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	{{STRUCTURE_2xr0\| PDB=2xr0 \| SCENE= }}		{{STRUCTURE_2xr0\| PDB=2xr0 \| SCENE= }}

	===ROOM TEMPERATURE X-RAY STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE===		===ROOM TEMPERATURE X-RAY STRUCTURE OF THE PERDEUTERATED TOHO-1 R274N R276N DOUBLE MUTANT BETA-LACTAMASE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21168411}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21168411 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21168411}}		{{ABSTRACT_PUBMED_21168411}}

	==About this Structure==		==About this Structure==
-	[[2xr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA].	+	[[2xr0]] is a 1 chain structure of [[Beta-lactamase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR0 OCA].
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21168411~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021168411</ref><references group="xtra"/>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
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	[[Category: Wang, K K.]]		[[Category: Wang, K K.]]
	[[Category: Weiss, K L.]]		[[Category: Weiss, K L.]]
		+	[[Category: Ctx-m-type esbl]]
		+	[[Category: Esbl]]
		+	[[Category: Extended-spectrum beta-lactamase]]
		+	[[Category: Hydrolase]]

OCA at 05:08, 16 February 2011

OCA — Wed, 16 Feb 2011 05:08:03 GMT

←Older revision		Revision as of 05:08, 16 February 2011
Line 32:		Line 32:
	[[Category: Wang, K K.]]		[[Category: Wang, K K.]]
	[[Category: Weiss, K L.]]		[[Category: Weiss, K L.]]
-	[[Category: Ctx-m-type esbl]]
-	[[Category: Esbl]]
-	[[Category: Extended-spectrum beta-lactamase]]
-	[[Category: Hydrolase]]