2xrq - Revision history

OCA at 10:38, 20 December 2023

OCA — Wed, 20 Dec 2023 10:38:02 GMT

←Older revision		Revision as of 10:38, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xrq' size='340' side='right'caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2xrq' size='340' side='right'caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xrs\|2xrs]]</div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [https://pdbe.org/2xrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [https://www.ebi.ac.uk/pdbsum/2xrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [https://pdbe.org/2xrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [https://www.ebi.ac.uk/pdbsum/2xrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~ELBH_ECOLX ELBH_ECOLX]~~] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.	+	[https://www.uniprot.org/uniprot/ELBP_ECOLX ELBP_ECOLX] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Holmner, A]]	+	[[Category: Holmner A]]
-	[[Category: Jansson, L]]	+	[[Category: Jansson L]]
-	[[Category: Krengel, U]]	+	[[Category: Krengel U]]
-	[[Category: Lebens, M]]	+	[[Category: Lebens M]]
-	[[Category: Mackenzie, A]]	+	[[Category: Mackenzie A]]
-	[[Category: Okvist, M]]	+	[[Category: Okvist M]]
-	[[Category: Teneberg, S]]	+	[[Category: Teneberg S]]
-	~~[[Category: Host-pathogen interaction]]~~	+
-	~~[[Category: Molecular recognition]]~~	+
-	~~[[Category: Protein-carbohydrate interaction]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 12:16, 27 April 2022

OCA — Wed, 27 Apr 2022 12:16:07 GMT

←Older revision		Revision as of 12:16, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xrq' size='340' side='right'caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2xrq' size='340' side='right'caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XRQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XRQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xrs\|2xrs]]</td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [~~http~~://pdbe.org/2xrq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xrq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrq ProSAT]</span></td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xrs\|2xrs]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [https://pdbe.org/2xrq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [https://www.ebi.ac.uk/pdbsum/2xrq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ELBH_ECOLX ELBH_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.	+	[[https://www.uniprot.org/uniprot/ELBH_ECOLX ELBH_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:17, 22 July 2020

OCA — Wed, 22 Jul 2020 12:17:59 GMT

←Older revision		Revision as of 12:17, 22 July 2020
Line 1:		Line 1:

	==Crystal structures exploring the origins of the broader specificity of escherichia coli heat-labile enterotoxin compared to cholera toxin==		==Crystal structures exploring the origins of the broader specificity of escherichia coli heat-labile enterotoxin compared to cholera toxin==
-	<StructureSection load='2xrq' size='340' side='right' caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2xrq' size='340' side='right'caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XRQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XRQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xrs\|2xrs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xrs\|2xrs]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [http://pdbe.org/2xrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [http://www.ebi.ac.uk/pdbsum/2xrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [http://pdbe.org/2xrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [http://www.ebi.ac.uk/pdbsum/2xrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Holmner, A]]		[[Category: Holmner, A]]
	[[Category: Jansson, L]]		[[Category: Jansson, L]]

OCA at 09:01, 10 October 2018

OCA — Wed, 10 Oct 2018 09:01:16 GMT

←Older revision		Revision as of 09:01, 10 October 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xrs\|2xrs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xrs\|2xrs]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [http://pdbe.org/2xrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [http://www.ebi.ac.uk/pdbsum/2xrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [http://pdbe.org/2xrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [http://www.ebi.ac.uk/pdbsum/2xrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrq ProSAT]</span></td></tr>

OCA at 16:59, 2 January 2017

OCA — Mon, 02 Jan 2017 16:59:22 GMT

←Older revision		Revision as of 16:59, 2 January 2017
Line 1:		Line 1:
		+
	==Crystal structures exploring the origins of the broader specificity of escherichia coli heat-labile enterotoxin compared to cholera toxin==		==Crystal structures exploring the origins of the broader specificity of escherichia coli heat-labile enterotoxin compared to cholera toxin==
	<StructureSection load='2xrq' size='340' side='right' caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2xrq' size='340' side='right' caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xrs\|2xrs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xrs\|2xrs]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [http://www.ebi.ac.uk/pdbsum/2xrq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [http://pdbe.org/2xrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [http://www.ebi.ac.uk/pdbsum/2xrq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xrq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:28, 1 April 2015

OCA — Wed, 01 Apr 2015 07:28:16 GMT

←Older revision		Revision as of 07:28, 1 April 2015
Line 2:		Line 2:
	<StructureSection load='2xrq' size='340' side='right' caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2xrq' size='340' side='right' caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Holmner, A]]		[[Category: Holmner, A]]
	[[Category: Jansson, L]]		[[Category: Jansson, L]]

OCA at 04:19, 25 December 2014

OCA — Thu, 25 Dec 2014 04:19:01 GMT

←Older revision		Revision as of 04:19, 25 December 2014
Line 2:		Line 2:
	<StructureSection load='2xrq' size='340' side='right' caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2xrq' size='340' side='right' caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. <br>	+	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XRQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xrs\|2xrs]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xrs\|2xrs]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [http://www.ebi.ac.uk/pdbsum/2xrq PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [http://www.ebi.ac.uk/pdbsum/2xrq PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ELBH_ECOLX ELBH_ECOLX]] The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 16:
	Crystal Structures Exploring the Origins of the Broader Specificity of Escherichia coli Heat-Labile Enterotoxin Compared to Cholera Toxin.,Holmner A, Mackenzie A, Okvist M, Jansson L, Lebens M, Teneberg S, Krengel U J Mol Biol. 2011 Feb 25;406(3):387-402. Epub 2010 Dec 17. PMID:21168418<ref>PMID:21168418</ref>		Crystal Structures Exploring the Origins of the Broader Specificity of Escherichia coli Heat-Labile Enterotoxin Compared to Cholera Toxin.,Holmner A, Mackenzie A, Okvist M, Jansson L, Lebens M, Teneberg S, Krengel U J Mol Biol. 2011 Feb 25;406(3):387-402. Epub 2010 Dec 17. PMID:21168418<ref>PMID:21168418</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Holmner, A.]]	+	[[Category: Holmner, A]]
-	[[Category: Jansson, L.]]	+	[[Category: Jansson, L]]
-	[[Category: Krengel, U.]]	+	[[Category: Krengel, U]]
-	[[Category: Lebens, M.]]	+	[[Category: Lebens, M]]
-	[[Category: Mackenzie, A.]]	+	[[Category: Mackenzie, A]]
-	[[Category: Okvist, M.]]	+	[[Category: Okvist, M]]
-	[[Category: Teneberg, S.]]	+	[[Category: Teneberg, S]]
	[[Category: Host-pathogen interaction]]		[[Category: Host-pathogen interaction]]
	[[Category: Molecular recognition]]		[[Category: Molecular recognition]]
	[[Category: Protein-carbohydrate interaction]]		[[Category: Protein-carbohydrate interaction]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 07:46, 14 May 2014

OCA — Wed, 14 May 2014 07:46:28 GMT

←Older revision		Revision as of 07:46, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2xrq.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structures exploring the origins of the broader specificity of escherichia coli heat-labile enterotoxin compared to cholera toxin==
		+	<StructureSection load='2xrq' size='340' side='right' caption='[[2xrq]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xrq]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xrs\|2xrs]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xrq RCSB], [http://www.ebi.ac.uk/pdbsum/2xrq PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cholera toxin (CT) and Escherichia coli heat-labile enterotoxin (LT) are structurally and functionally related and share the same primary receptor, the GM1 ganglioside. Despite their extensive similarities, these two toxins exhibit distinct ligand specificities, with LT being more promiscuous than CT. Here, we have attempted to rationalize the broader binding specificity of LT and the subtle differences between the binding characteristics of LTs from human and porcine origins (mediated by their B subunit pentamers, hLTB and pLTB, respectively). The analysis is based on two crystal structures of pLTB in complexes with the pentasaccharide of its primary ligand, GM1, and with neolactotetraose, the carbohydrate determinant of a typical secondary ligand of LTs, respectively. Important molecular determinants underlying the different binding specificities of LTB and CTB are found to be contributed by Ser95, Tyr18 and Thr4 (or Ser4 of hLTB), which together prestabilize the binding site by positioning Lys91, Glu51 and the adjacent loop region (50-61) containing Ile58 for ligand binding. Glu7 and Ala1 may also play an important role. Many of these residues are closely connected with a recently identified second binding site, and there appears to be cross-talk between the two sites. Binding to N-acetyllactosamine-terminated receptors is further augmented by Arg13 (present in pLT and some hLT variants), as previously predicted.

-	<!--	+	Crystal Structures Exploring the Origins of the Broader Specificity of Escherichia coli Heat-Labile Enterotoxin Compared to Cholera Toxin.,Holmner A, Mackenzie A, Okvist M, Jansson L, Lebens M, Teneberg S, Krengel U J Mol Biol. 2011 Feb 25;406(3):387-402. Epub 2010 Dec 17. PMID:21168418<ref>PMID:21168418</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2xrq"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2xrq\| PDB=2xrq \| SCENE= }}~~	+

-	~~===Crystal structures exploring the origins~~ of the ~~broader specificity of escherichia coli heat-labile enterotoxin compared to cholera toxin===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21168418}}, adds the Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21168418 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21168418}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xrq]] is a 5 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XRQ OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021168418<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Holmner, A.]]		[[Category: Holmner, A.]]

OCA at 07:01, 6 June 2012

OCA — Wed, 06 Jun 2012 07:01:28 GMT

←Older revision		Revision as of 07:01, 6 June 2012
Line 9:		Line 9:
	{{STRUCTURE_2xrq\| PDB=2xrq \| SCENE= }}		{{STRUCTURE_2xrq\| PDB=2xrq \| SCENE= }}

-	===~~CRYSTAL STRUCTURES EXPLORING THE ORIGINS OF THE BROADER SPECIFICITY OF ESCHERICHIA COLI HEAT~~-~~LABILE ENTEROTOXIN COMPARED TO CHOLERA TOXIN~~===	+	===Crystal structures exploring the origins of the broader specificity of escherichia coli heat-labile enterotoxin compared to cholera toxin===


Line 22:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21168418~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021168418</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Holmner, A.]]		[[Category: Holmner, A.]]
Line 31:		Line 31:
	[[Category: Okvist, M.]]		[[Category: Okvist, M.]]
	[[Category: Teneberg, S.]]		[[Category: Teneberg, S.]]
		+	[[Category: Host-pathogen interaction]]
		+	[[Category: Molecular recognition]]
		+	[[Category: Protein-carbohydrate interaction]]
		+	[[Category: Toxin]]

OCA: Protected "2xrq" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2011 05:08:11 GMT

Protected "2xrq" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:08, 16 February 2011