2xs8 - Revision history

OCA at 10:38, 20 December 2023

OCA — Wed, 20 Dec 2023 10:38:19 GMT

←Older revision		Revision as of 10:38, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xs8' size='340' side='right'caption='[[2xs8]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xs8' size='340' side='right'caption='[[2xs8]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xs8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XS8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xs8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XS8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [https://pdbe.org/2xs8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [https://www.ebi.ac.uk/pdbsum/2xs8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xs8 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.498Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [https://pdbe.org/2xs8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [https://www.ebi.ac.uk/pdbsum/2xs8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xs8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PDC6I_HUMAN PDC6I_HUMAN]] Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.<ref>PMID:14505569</ref> <ref>PMID:14505570</ref> <ref>PMID:14739459</ref> <ref>PMID:17853893</ref> <ref>PMID:17428861</ref> <ref>PMID:17556548</ref>	+	[https://www.uniprot.org/uniprot/PDC6I_HUMAN PDC6I_HUMAN] Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.<ref>PMID:14505569</ref> <ref>PMID:14505570</ref> <ref>PMID:14739459</ref> <ref>PMID:17853893</ref> <ref>PMID:17428861</ref> <ref>PMID:17556548</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hill~~, C P~~]]	+	[[Category: Simian immunodeficiency virus]]
-	[[Category: Landesman, M]]	+	[[Category: Hill CP]]
-	[[Category: Robinson, H]]	+	[[Category: Landesman M]]
-	[[Category: Sundquist~~, W I~~]]	+	[[Category: Robinson H]]
-	[[Category: Zhai, Q]]	+	[[Category: Sundquist WI]]
-	~~[[Category: Cell cycle]]~~	+	[[Category: Zhai Q]]
-	~~[[Category: Protein transport-viral protein complex~~]]	+

OCA at 12:16, 27 April 2022

OCA — Wed, 27 Apr 2022 12:16:19 GMT

←Older revision		Revision as of 12:16, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xs8' size='340' side='right'caption='[[2xs8]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xs8' size='340' side='right'caption='[[2xs8]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xs8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XS8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xs8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XS8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [~~http~~://pdbe.org/2xs8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xs8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xs8 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [https://pdbe.org/2xs8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [https://www.ebi.ac.uk/pdbsum/2xs8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xs8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PDC6I_HUMAN PDC6I_HUMAN]] Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.<ref>PMID:14505569</ref> <ref>PMID:14505570</ref> <ref>PMID:14739459</ref> <ref>PMID:17853893</ref> <ref>PMID:17428861</ref> <ref>PMID:17556548</ref>	+	[[https://www.uniprot.org/uniprot/PDC6I_HUMAN PDC6I_HUMAN]] Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.<ref>PMID:14505569</ref> <ref>PMID:14505570</ref> <ref>PMID:14739459</ref> <ref>PMID:17853893</ref> <ref>PMID:17428861</ref> <ref>PMID:17556548</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:18, 22 July 2020

OCA — Wed, 22 Jul 2020 12:18:38 GMT

←Older revision		Revision as of 12:18, 22 July 2020
Line 1:		Line 1:

	==Crystal Structure of ALIX in complex with the SIVagmTan-1 AYDPARKLL Late Domain==		==Crystal Structure of ALIX in complex with the SIVagmTan-1 AYDPARKLL Late Domain==
-	<StructureSection load='2xs8' size='340' side='right' caption='[[2xs8]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2xs8' size='340' side='right'caption='[[2xs8]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xs8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XS8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xs8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XS8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [http://pdbe.org/2xs8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xs8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xs8 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [http://pdbe.org/2xs8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xs8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xs8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hill, C P]]		[[Category: Hill, C P]]
	[[Category: Landesman, M]]		[[Category: Landesman, M]]

OCA at 09:36, 10 October 2018

OCA — Wed, 10 Oct 2018 09:36:17 GMT

←Older revision		Revision as of 09:36, 10 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF~~ ALIX ~~IN COMPLEX WITH THE SIVAGMTAN~~-1 AYDPARKLL ~~LATE DOMAIN~~==	+	==Crystal Structure of ALIX in complex with the SIVagmTan-1 AYDPARKLL Late Domain==
	<StructureSection load='2xs8' size='340' side='right' caption='[[2xs8]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xs8' size='340' side='right' caption='[[2xs8]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 15:28, 4 August 2016

OCA — Thu, 04 Aug 2016 15:28:30 GMT

←Older revision		Revision as of 15:28, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF ALIX IN COMPLEX WITH THE SIVAGMTAN-1 AYDPARKLL LATE DOMAIN==		==CRYSTAL STRUCTURE OF ALIX IN COMPLEX WITH THE SIVAGMTAN-1 AYDPARKLL LATE DOMAIN==
	<StructureSection load='2xs8' size='340' side='right' caption='[[2xs8]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xs8' size='340' side='right' caption='[[2xs8]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xs8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XS8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xs8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XS8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xs8 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [http://pdbe.org/2xs8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xs8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xs8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xs8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Hill, C P]]		[[Category: Hill, C P]]
	[[Category: Landesman, M]]		[[Category: Landesman, M]]

OCA at 10:33, 25 December 2014

OCA — Thu, 25 Dec 2014 10:33:39 GMT

←Older revision		Revision as of 10:33, 25 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xs8 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xs8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDC6I_HUMAN PDC6I_HUMAN]] Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.<ref>PMID:14505569</ref> <ref>PMID:14505570</ref> <ref>PMID:14739459</ref> <ref>PMID:17853893</ref> <ref>PMID:17428861</ref> <ref>PMID:17556548</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Hill, C P.]]	+	[[Category: Hill, C P]]
-	[[Category: Landesman, M.]]	+	[[Category: Landesman, M]]
-	[[Category: Robinson, H.]]	+	[[Category: Robinson, H]]
-	[[Category: Sundquist, W I.]]	+	[[Category: Sundquist, W I]]
-	[[Category: Zhai, Q.]]	+	[[Category: Zhai, Q]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Protein transport-viral protein complex]]		[[Category: Protein transport-viral protein complex]]

OCA at 13:21, 22 October 2014

OCA — Wed, 22 Oct 2014 13:21:13 GMT

←Older revision		Revision as of 13:21, 22 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2xs8.~~png\|left\|200px~~]]	+	==CRYSTAL STRUCTURE OF ALIX IN COMPLEX WITH THE SIVAGMTAN-1 AYDPARKLL LATE DOMAIN==
		+	<StructureSection load='2xs8' size='340' side='right' caption='[[2xs8]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xs8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XS8 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xs8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xs8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xs8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Retroviral Gag proteins contain short late domain motifs that recruit cellular ESCRT pathway proteins to facilitate virus budding. ALIX-binding late domains often contain the core consensus sequence: "YPXnL" (where Xn can vary in sequence and length). However, some SIV Gag proteins lack this consensus sequence, yet still bind ALIX. We mapped divergent, ALIX-binding late domains within the p6(Gag) proteins of SIVmac239 (40SREKPYKEVTEDLLHLNSLF59) and SIVagmTan-1 (24AAGAYDPARKLLEQYAKK41). Crystal structures revealed that anchoring tyrosines (bold) and nearby hydrophobic residues (underlined) contact the ALIX V domain, revealing how lentiviruses employ a diverse family of late domain sequences to bind ALIX and promote virus budding.

-	~~{{STRUCTURE_2xs8\| PDB=2xs8 \| SCENE= }}~~	+	Identification and Structural Characterization of the ALIX-Binding Late Domains of SIVmac239 and SIVagmTan-1.,Zhai Q, Landesman M, Robinson H, Sundquist WI, Hill CP J Virol. 2010 Oct 20. PMID:20962096<ref>PMID:20962096</ref>

-	~~===CRYSTAL STRUCTURE OF ALIX IN COMPLEX WITH THE SIVAGMTAN-1 AYDPARKLL LATE DOMAIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20962096}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2xs8]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020962096<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hill, C P.]]		[[Category: Hill, C P.]]

OCA: Protected "2xs8" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:35:52 GMT

Protected "2xs8" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:35, 7 January 2013

OCA at 22:35, 7 January 2013

OCA — Mon, 07 Jan 2013 22:35:50 GMT

←Older revision		Revision as of 22:35, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2xs8.png\|left\|200px]]		[[Image:2xs8.png\|left\|200px]]

-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xs8\| PDB=2xs8 \| SCENE= }}		{{STRUCTURE_2xs8\| PDB=2xs8 \| SCENE= }}

	===CRYSTAL STRUCTURE OF ALIX IN COMPLEX WITH THE SIVAGMTAN-1 AYDPARKLL LATE DOMAIN===		===CRYSTAL STRUCTURE OF ALIX IN COMPLEX WITH THE SIVAGMTAN-1 AYDPARKLL LATE DOMAIN===

-
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	{{ABSTRACT_PUBMED_20962096}}		{{ABSTRACT_PUBMED_20962096}}

	==About this Structure==		==About this Structure==
-	~~2XS8~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA].	+	[[2xs8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS8 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20962096~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020962096</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Hill, C P.]]		[[Category: Hill, C P.]]
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	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Protein transport-viral protein complex]]		[[Category: Protein transport-viral protein complex]]
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OCA at 06:09, 22 December 2010

OCA — Wed, 22 Dec 2010 06:09:53 GMT

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-	[[Image:2xs8.~~jpg~~\|left\|200px]]	+	[[Image:2xs8.png\|left\|200px]]

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