2xu3 - Revision history

OCA at 10:39, 20 December 2023

OCA — Wed, 20 Dec 2023 10:39:14 GMT

←Older revision		Revision as of 10:39, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xu3' size='340' side='right'caption='[[2xu3]], [[Resolution\|resolution]] 0.90Å' scene=''>		<StructureSection load='2xu3' size='340' side='right'caption='[[2xu3]], [[Resolution\|resolution]] 0.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xu3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XU3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xu3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XU3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XU3:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-1-[1-(5-CHLOROTHIOPHEN-2-YL)CYCLOPROPYL]CARBONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE'>XU3</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.9Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cjl\|1cjl]], [[1mhw\|1mhw]], [[1cs8\|1cs8]], [[2vhs\|2vhs]], [[1icf\|1icf]], [[2xu5\|2xu5]], [[2xu4\|2xu4]], [[2xu1\|2xu1]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XU3:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-1-[1-(5-CHLOROTHIOPHEN-2-YL)CYCLOPROPYL]CARBONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE'>XU3</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [https://pdbe.org/2xu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xu3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [https://pdbe.org/2xu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xu3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.	+	[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.

	==See Also==		==See Also==
Line 16:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cathepsin L]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Banner~~, D W~~]]	+	[[Category: Banner DW]]
-	[[Category: Benz~~, J M~~]]	+	[[Category: Benz JM]]
-	[[Category: Haap, W]]	+	[[Category: Haap W]]
-	~~[[Category: Drug design]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Thiol protease~~]]	+

OCA at 12:17, 27 April 2022

OCA — Wed, 27 Apr 2022 12:17:17 GMT

←Older revision		Revision as of 12:17, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xu3' size='340' side='right'caption='[[2xu3]], [[Resolution\|resolution]] 0.90Å' scene=''>		<StructureSection load='2xu3' size='340' side='right'caption='[[2xu3]], [[Resolution\|resolution]] 0.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xu3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XU3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xu3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XU3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XU3:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-1-[1-(5-CHLOROTHIOPHEN-2-YL)CYCLOPROPYL]CARBONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE'>XU3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XU3:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-1-[1-(5-CHLOROTHIOPHEN-2-YL)CYCLOPROPYL]CARBONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE'>XU3</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjl\|1cjl]], [[1mhw\|1mhw]], [[1cs8\|1cs8]], [[2vhs\|2vhs]], [[1icf\|1icf]], [[2xu5\|2xu5]], [[2xu4\|2xu4]], [[2xu1\|2xu1]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cjl\|1cjl]], [[1mhw\|1mhw]], [[1cs8\|1cs8]], [[2vhs\|2vhs]], [[1icf\|1icf]], [[2xu5\|2xu5]], [[2xu4\|2xu4]], [[2xu1\|2xu1]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [~~http~~://pdbe.org/2xu3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xu3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xu3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [https://pdbe.org/2xu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [https://www.ebi.ac.uk/pdbsum/2xu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xu3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.	+	[[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.

	==See Also==		==See Also==

OCA at 12:21, 22 July 2020

OCA — Wed, 22 Jul 2020 12:21:03 GMT

←Older revision		Revision as of 12:21, 22 July 2020
Line 1:		Line 1:

	==CATHEPSIN L WITH A NITRILE INHIBITOR==		==CATHEPSIN L WITH A NITRILE INHIBITOR==
-	<StructureSection load='2xu3' size='340' side='right' caption='[[2xu3]], [[Resolution\|resolution]] 0.90Å' scene=''>	+	<StructureSection load='2xu3' size='340' side='right'caption='[[2xu3]], [[Resolution\|resolution]] 0.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XU3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XU3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XU3:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-1-[1-(5-CHLOROTHIOPHEN-2-YL)CYCLOPROPYL]CARBONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE'>XU3</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XU3:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-1-[1-(5-CHLOROTHIOPHEN-2-YL)CYCLOPROPYL]CARBONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE'>XU3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjl\|1cjl]], [[1mhw\|1mhw]], [[1cs8\|1cs8]], [[2vhs\|2vhs]], [[1icf\|1icf]], [[2xu5\|2xu5]], [[2xu4\|2xu4]], [[2xu1\|2xu1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjl\|1cjl]], [[1mhw\|1mhw]], [[1cs8\|1cs8]], [[2vhs\|2vhs]], [[1icf\|1icf]], [[2xu5\|2xu5]], [[2xu4\|2xu4]], [[2xu1\|2xu1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [http://pdbe.org/2xu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xu3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [http://pdbe.org/2xu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xu3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 13:

	==See Also==		==See Also==
-	*[[Cathepsin\|Cathepsin]]	+	*[[Cathepsin 3D structures\|Cathepsin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Cathepsin L]]		[[Category: Cathepsin L]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Banner, D W]]		[[Category: Banner, D W]]
	[[Category: Benz, J M]]		[[Category: Benz, J M]]

OCA at 13:29, 5 August 2016

OCA — Fri, 05 Aug 2016 13:29:01 GMT

←Older revision		Revision as of 13:29, 5 August 2016
Line 1:		Line 1:
		+
	==CATHEPSIN L WITH A NITRILE INHIBITOR==		==CATHEPSIN L WITH A NITRILE INHIBITOR==
	<StructureSection load='2xu3' size='340' side='right' caption='[[2xu3]], [[Resolution\|resolution]] 0.90Å' scene=''>		<StructureSection load='2xu3' size='340' side='right' caption='[[2xu3]], [[Resolution\|resolution]] 0.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XU3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XU3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XU3:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-1-[1-(5-CHLOROTHIOPHEN-2-YL)CYCLOPROPYL]CARBONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE'>XU3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XU3:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-1-[1-(5-CHLOROTHIOPHEN-2-YL)CYCLOPROPYL]CARBONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE'>XU3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjl\|1cjl]], [[1mhw\|1mhw]], [[1cs8\|1cs8]], [[2vhs\|2vhs]], [[1icf\|1icf]], [[2xu5\|2xu5]], [[2xu4\|2xu4]], [[2xu1\|2xu1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjl\|1cjl]], [[1mhw\|1mhw]], [[1cs8\|1cs8]], [[2vhs\|2vhs]], [[1icf\|1icf]], [[2xu5\|2xu5]], [[2xu4\|2xu4]], [[2xu1\|2xu1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xu3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [http://pdbe.org/2xu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xu3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	</StructureSection>		</StructureSection>
	[[Category: Cathepsin L]]		[[Category: Cathepsin L]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Banner, D W]]		[[Category: Banner, D W]]
	[[Category: Benz, J M]]		[[Category: Benz, J M]]

OCA at 19:12, 25 December 2014

OCA — Thu, 25 Dec 2014 19:12:29 GMT

←Older revision		Revision as of 19:12, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xu3 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xu3 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN]] Important for the overall degradation of proteins in lysosomes.

	==See Also==		==See Also==
Line 15:		Line 17:
	[[Category: Cathepsin L]]		[[Category: Cathepsin L]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Banner, D W.]]	+	[[Category: Banner, D W]]
-	[[Category: Benz, J M.]]	+	[[Category: Benz, J M]]
-	[[Category: Haap, W.]]	+	[[Category: Haap, W]]
	[[Category: Drug design]]		[[Category: Drug design]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Thiol protease]]		[[Category: Thiol protease]]

OCA at 13:22, 22 October 2014

OCA — Wed, 22 Oct 2014 13:22:07 GMT

←Older revision		Revision as of 13:22, 22 October 2014
Line 1:		Line 1:
-	~~[[Image:2xu3.png\|left\|200px]]~~	+	==CATHEPSIN L WITH A NITRILE INHIBITOR==
-		+	<StructureSection load='2xu3' size='340' side='right' caption='[[2xu3]], [[Resolution\|resolution]] 0.90Å' scene=''>
-	~~{{STRUCTURE_2xu3\| PDB=2xu3 \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[2xu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XU3 FirstGlance]. <br>
-	===CATHEPSIN L WITH A NITRILE INHIBITOR===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=XU3:(2S,4R)-4-(2-CHLOROPHENYL)SULFONYL-1-[1-(5-CHLOROTHIOPHEN-2-YL)CYCLOPROPYL]CARBONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]PYRROLIDINE-2-CARBOXAMIDE'>XU3</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cjl\|1cjl]], [[1mhw\|1mhw]], [[1cs8\|1cs8]], [[2vhs\|2vhs]], [[1icf\|1icf]], [[2xu5\|2xu5]], [[2xu4\|2xu4]], [[2xu1\|2xu1]]</td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_L Cathepsin L], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.15 3.4.22.15] </span></td></tr>
-	==~~About this Structure~~==	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xu3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xu3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xu3 PDBsum]</span></td></tr>
-	[[2xu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA].	+	</table>

	==See Also==		==See Also==
	*[[Cathepsin\|Cathepsin]]		*[[Cathepsin\|Cathepsin]]
-		+	__TOC__
-	~~==Reference==~~	+	</StructureSection>
-	~~<ref group="xtra">PMID:021184410</ref>~~<~~references group="xtra"~~/>	+
	[[Category: Cathepsin L]]		[[Category: Cathepsin L]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 20:24, 20 October 2012

OCA — Sat, 20 Oct 2012 20:24:49 GMT

←Older revision		Revision as of 20:24, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2xu3]] is a 1 chain structure ~~of [[Cathepsin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA].	+	[[2xu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA].

	==See Also==		==See Also==

OCA at 10:24, 27 July 2012

OCA — Fri, 27 Jul 2012 10:24:06 GMT

←Older revision		Revision as of 10:24, 27 July 2012
Line 1:		Line 1:
-	[[Image:2xu3.~~jpg~~\|left\|200px]]	+	[[Image:2xu3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xu3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xu3\| PDB=2xu3 \| SCENE= }}		{{STRUCTURE_2xu3\| PDB=2xu3 \| SCENE= }}

Line 13:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2xu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA].	+	[[2xu3]] is a 1 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA].
		+
		+	==See Also==
		+	*[[Cathepsin\|Cathepsin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21184410~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021184410</ref><references group="xtra"/>
	[[Category: Cathepsin L]]		[[Category: Cathepsin L]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 22:		Line 19:
	[[Category: Benz, J M.]]		[[Category: Benz, J M.]]
	[[Category: Haap, W.]]		[[Category: Haap, W.]]
		+	[[Category: Drug design]]
		+	[[Category: Hydrolase]]
		+	[[Category: Thiol protease]]

OCA: Protected "2xu3" [edit=sysop:move=sysop]

OCA — Wed, 12 Jan 2011 05:10:11 GMT

Protected "2xu3" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:10, 12 January 2011

OCA at 05:10, 12 January 2011

OCA — Wed, 12 Jan 2011 05:10:09 GMT

←Older revision		Revision as of 05:10, 12 January 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2xu3.jpg\|left\|200px]]

-	The ~~entry 2xu3~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xu3", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xu3\| PDB=2xu3 \| SCENE= }}

-	~~Authors: Banner, D.W., Benz, J.M., Haap, W.~~	+	===CATHEPSIN L WITH A NITRILE INHIBITOR===

-	Description: CATHEPSIN L WITH A NITRILE INHIBITOR

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Dec 8 11~~:24:~~52 2010''~~	+	==About this Structure==
		+	[[2xu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XU3 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21184410</ref><references group="xtra"/>
		+	[[Category: Cathepsin L]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Banner, D W.]]
		+	[[Category: Benz, J M.]]
		+	[[Category: Haap, W.]]