2xug - Revision history

OCA at 10:39, 20 December 2023

OCA — Wed, 20 Dec 2023 10:39:20 GMT

←Older revision		Revision as of 10:39, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=TZ4:3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM'>TZ4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=TZ4:3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM'>TZ4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xug OCA], [https://pdbe.org/2xug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xug RCSB], [https://www.ebi.ac.uk/pdbsum/2xug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xug ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xug OCA], [https://pdbe.org/2xug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xug RCSB], [https://www.ebi.ac.uk/pdbsum/2xug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xug ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:15, 15 February 2023

OCA — Wed, 15 Feb 2023 11:15:46 GMT

←Older revision		Revision as of 11:15, 15 February 2023
Line 3:		Line 3:
	<StructureSection load='2xug' size='340' side='right'caption='[[2xug]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2xug' size='340' side='right'caption='[[2xug]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=TZ4:3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM'>TZ4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=TZ4:3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM'>TZ4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2whq\|2whq]], [[2jgh\|2jgh]], [[1mah\|1mah]], [[1maa\|1maa]], [[2ha6\|2ha6]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[1q83\|1q83]], [[2jge\|2jge]], [[2wls\|2wls]], [[2ha3\|2ha3]], [[1c2b\|1c2b]], [[2ha0\|2ha0]], [[2wu3\|2wu3]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2c0p\|2c0p]], [[2jf0\|2jf0]], [[2h9y\|2h9y]], [[2whr\|2whr]], [[1n5m\|1n5m]], [[2ha5\|2ha5]], [[2ha2\|2ha2]], [[2whp\|2whp]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2ha7\|2ha7]], [[2jgf\|2jgf]], [[2wu4\|2wu4]], [[1c2o\|1c2o]], [[2xud\|2xud]], [[2xup\|2xup]], [[2xui\|2xui]], [[2xuk\|2xuk]], [[2xuj\|2xuj]], [[2xuo\|2xuo]], [[2xuh\|2xuh]], [[2xuf\|2xuf]], [[2xuq\|2xuq]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xug OCA], [https://pdbe.org/2xug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xug RCSB], [https://www.ebi.ac.uk/pdbsum/2xug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xug ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xug OCA], [https://pdbe.org/2xug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xug RCSB], [https://www.ebi.ac.uk/pdbsum/2xug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acetylcholinesterase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Bourne, Y]]	+	[[Category: Bourne Y]]
-	[[Category: Marchot, P]]	+	[[Category: Marchot P]]
-	[[Category: Radic, Z]]	+	[[Category: Radic Z]]
-	[[Category: Taylor, P]]	+	[[Category: Taylor P]]
-	~~[[Category: Click chemistry]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase fold~~]]	+

OCA at 09:26, 12 May 2021

OCA — Wed, 12 May 2021 09:26:09 GMT

←Older revision		Revision as of 09:26, 12 May 2021
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF MACHE~~-Y337A-TZ2PA6 ~~ANTI COMPLEX~~ (1 WK)==	+	==Crystal structure of mAChE-Y337A-TZ2PA6 anti complex (1 wk)==
-	<StructureSection load='2xug' size='340' side='right' caption='[[2xug]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='2xug' size='340' side='right'caption='[[2xug]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xug]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XUG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=TZ4:3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM'>TZ4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=TZ4:3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM'>TZ4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2whq\|2whq]], [[2jgh\|2jgh]], [[1mah\|1mah]], [[1maa\|1maa]], [[2ha6\|2ha6]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[1q83\|1q83]], [[2jge\|2jge]], [[2wls\|2wls]], [[2ha3\|2ha3]], [[1c2b\|1c2b]], [[2ha0\|2ha0]], [[2wu3\|2wu3]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2c0p\|2c0p]], [[2jf0\|2jf0]], [[2h9y\|2h9y]], [[2whr\|2whr]], [[1n5m\|1n5m]], [[2ha5\|2ha5]], [[2ha2\|2ha2]], [[2whp\|2whp]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2ha7\|2ha7]], [[2jgf\|2jgf]], [[2wu4\|2wu4]], [[1c2o\|1c2o]], [[2xud\|2xud]], [[2xup\|2xup]], [[2xui\|2xui]], [[2xuk\|2xuk]], [[2xuj\|2xuj]], [[2xuo\|2xuo]], [[2xuh\|2xuh]], [[2xuf\|2xuf]], [[2xuq\|2xuq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2whq\|2whq]], [[2jgh\|2jgh]], [[1mah\|1mah]], [[1maa\|1maa]], [[2ha6\|2ha6]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[1q83\|1q83]], [[2jge\|2jge]], [[2wls\|2wls]], [[2ha3\|2ha3]], [[1c2b\|1c2b]], [[2ha0\|2ha0]], [[2wu3\|2wu3]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2c0p\|2c0p]], [[2jf0\|2jf0]], [[2h9y\|2h9y]], [[2whr\|2whr]], [[1n5m\|1n5m]], [[2ha5\|2ha5]], [[2ha2\|2ha2]], [[2whp\|2whp]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2ha7\|2ha7]], [[2jgf\|2jgf]], [[2wu4\|2wu4]], [[1c2o\|1c2o]], [[2xud\|2xud]], [[2xup\|2xup]], [[2xui\|2xui]], [[2xuk\|2xuk]], [[2xuj\|2xuj]], [[2xuo\|2xuo]], [[2xuh\|2xuh]], [[2xuf\|2xuf]], [[2xuq\|2xuq]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xug OCA], [~~http~~://pdbe.org/2xug PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xug RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xug PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xug ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xug OCA], [https://pdbe.org/2xug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xug RCSB], [https://www.ebi.ac.uk/pdbsum/2xug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.	+	[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Acetylcholinesterase~~\|Acetylcholinesterase]]~~	+	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
-	*[[3D structures ~~of acetylcholinesterase~~\|3D structures ~~of acetylcholinesterase~~]]	+
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Bourne, Y]]		[[Category: Bourne, Y]]

OCA at 17:08, 5 August 2016

OCA — Fri, 05 Aug 2016 17:08:49 GMT

←Older revision		Revision as of 17:08, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 ANTI COMPLEX (1 WK)==		==CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 ANTI COMPLEX (1 WK)==
	<StructureSection load='2xug' size='340' side='right' caption='[[2xug]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2xug' size='340' side='right' caption='[[2xug]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XUG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XUG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=TZ4:3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM'>TZ4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=TZ4:3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM'>TZ4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2whq\|2whq]], [[2jgh\|2jgh]], [[1mah\|1mah]], [[1maa\|1maa]], [[2ha6\|2ha6]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[1q83\|1q83]], [[2jge\|2jge]], [[2wls\|2wls]], [[2ha3\|2ha3]], [[1c2b\|1c2b]], [[2ha0\|2ha0]], [[2wu3\|2wu3]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2c0p\|2c0p]], [[2jf0\|2jf0]], [[2h9y\|2h9y]], [[2whr\|2whr]], [[1n5m\|1n5m]], [[2ha5\|2ha5]], [[2ha2\|2ha2]], [[2whp\|2whp]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2ha7\|2ha7]], [[2jgf\|2jgf]], [[2wu4\|2wu4]], [[1c2o\|1c2o]], [[2xud\|2xud]], [[2xup\|2xup]], [[2xui\|2xui]], [[2xuk\|2xuk]], [[2xuj\|2xuj]], [[2xuo\|2xuo]], [[2xuh\|2xuh]], [[2xuf\|2xuf]], [[2xuq\|2xuq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2whq\|2whq]], [[2jgh\|2jgh]], [[1mah\|1mah]], [[1maa\|1maa]], [[2ha6\|2ha6]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[1q83\|1q83]], [[2jge\|2jge]], [[2wls\|2wls]], [[2ha3\|2ha3]], [[1c2b\|1c2b]], [[2ha0\|2ha0]], [[2wu3\|2wu3]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2c0p\|2c0p]], [[2jf0\|2jf0]], [[2h9y\|2h9y]], [[2whr\|2whr]], [[1n5m\|1n5m]], [[2ha5\|2ha5]], [[2ha2\|2ha2]], [[2whp\|2whp]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2ha7\|2ha7]], [[2jgf\|2jgf]], [[2wu4\|2wu4]], [[1c2o\|1c2o]], [[2xud\|2xud]], [[2xup\|2xup]], [[2xui\|2xui]], [[2xuk\|2xuk]], [[2xuj\|2xuj]], [[2xuo\|2xuo]], [[2xuh\|2xuh]], [[2xuf\|2xuf]], [[2xuq\|2xuq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xug RCSB], [http://www.ebi.ac.uk/pdbsum/2xug PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xug OCA], [http://pdbe.org/2xug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xug RCSB], [http://www.ebi.ac.uk/pdbsum/2xug PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xug" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
		+	*[[3D structures of acetylcholinesterase\|3D structures of acetylcholinesterase]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Bourne, Y]]		[[Category: Bourne, Y]]
	[[Category: Marchot, P]]		[[Category: Marchot, P]]

OCA at 20:32, 25 December 2014

OCA — Thu, 25 Dec 2014 20:32:14 GMT

←Older revision		Revision as of 20:32, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xug RCSB], [http://www.ebi.ac.uk/pdbsum/2xug PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xug RCSB], [http://www.ebi.ac.uk/pdbsum/2xug PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 27:
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Bourne, Y.]]	+	[[Category: Bourne, Y]]
-	[[Category: Marchot, P.]]	+	[[Category: Marchot, P]]
-	[[Category: Radic, Z.]]	+	[[Category: Radic, Z]]
-	[[Category: Taylor, P.]]	+	[[Category: Taylor, P]]
	[[Category: Click chemistry]]		[[Category: Click chemistry]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase fold]]		[[Category: Hydrolase fold]]

OCA at 13:07, 22 October 2014

OCA — Wed, 22 Oct 2014 13:07:12 GMT

←Older revision		Revision as of 13:07, 22 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xug.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 ANTI COMPLEX (1 WK)==
		+	<StructureSection load='2xug' size='340' side='right' caption='[[2xug]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XUG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=TZ4:3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM'>TZ4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2whq\|2whq]], [[2jgh\|2jgh]], [[1mah\|1mah]], [[1maa\|1maa]], [[2ha6\|2ha6]], [[2c0q\|2c0q]], [[2jgg\|2jgg]], [[2jgl\|2jgl]], [[1q84\|1q84]], [[2jgm\|2jgm]], [[1q83\|1q83]], [[2jge\|2jge]], [[2wls\|2wls]], [[2ha3\|2ha3]], [[1c2b\|1c2b]], [[2ha0\|2ha0]], [[2wu3\|2wu3]], [[2jey\|2jey]], [[2jgi\|2jgi]], [[1n5r\|1n5r]], [[2jgj\|2jgj]], [[1j06\|1j06]], [[2c0p\|2c0p]], [[2jf0\|2jf0]], [[2h9y\|2h9y]], [[2whr\|2whr]], [[1n5m\|1n5m]], [[2ha5\|2ha5]], [[2ha2\|2ha2]], [[2whp\|2whp]], [[2jez\|2jez]], [[2jgk\|2jgk]], [[1ku6\|1ku6]], [[2ha4\|2ha4]], [[1j07\|1j07]], [[2ha7\|2ha7]], [[2jgf\|2jgf]], [[2wu4\|2wu4]], [[1c2o\|1c2o]], [[2xud\|2xud]], [[2xup\|2xup]], [[2xui\|2xui]], [[2xuk\|2xuk]], [[2xuj\|2xuj]], [[2xuo\|2xuo]], [[2xuh\|2xuh]], [[2xuf\|2xuf]], [[2xuq\|2xuq]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xug RCSB], [http://www.ebi.ac.uk/pdbsum/2xug PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The active center of acetylcholinesterase (AChE), a target site for competitive inhibitors, resides centrosymmetric to the subunit at the base of a deep, narrow gorge lined by aromatic residues. At the gorge entry, a peripheral site encompasses overlapping binding loci for noncompetitive inhibitors, which alter substrate access to the gorge. The click-chemistry inhibitor TZ2PA6 links the active center ligand, tacrine, to the peripheral site ligand, propidium, through a biorthogonal reaction of an acetylene and an azide that forms either a syn1 or an anti1 triazole. Compared with wild-type mouse AChE, a Tyr337Ala mutant displays full catalytic activity, albeit with 2-3 orders of magnitude higher affinities for the TZ2PA6 syn1 and anti1 regioisomers, reflected in low femtomolar K(d) values, diffusion-limited association, and dissociation half-times greater than 1 month and 1 week, respectively. Three structures of each of the co-crystallized syn1 and anti1 complexes of the Tyr337Ala mutant were solved at three distinct times of crystal maturation, consistent with or exceeding the half-lives of the complexes in solution, while crystalline complexes obtained from soaked Tyr337Ala crystals led to picturing "freshly formed" complexes. The structures, at 2.55-2.75A resolution, reveal a range of unprecedented conformations of the bound regioisomers, not observed in the wild-type AChE complexes, associated with concerted positional rearrangements of side chains in the enzyme gorge. Moreover, time-dependent conformational remodeling of the crystalline complexes appears to correlate with the dissociation half-times of the solution complexes. Hence, for the tight-binding TZ2PA6 inhibitors, the initial complexes kinetically driven in solution slowly form more stable complexes governed by thermodynamic equilibrium and observable in mature crystals.

-	~~{{STRUCTURE_2xug\| PDB=2xug \| SCENE= }}~~	+	Conformational Remodeling of Femtomolar Inhibitor-Acetylcholinesterase Complexes in the Crystalline State.,Bourne Y, Radic Z, Taylor P, Marchot P J Am Chem Soc. 2010 Nov 19. PMID:21090615<ref>PMID:21090615</ref>

-	~~===CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 ANTI COMPLEX (1 WK)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_21090615}}~~	+	==See Also==
-		+	*[[Acetylcholinesterase\|Acetylcholinesterase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2xug~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:021090615<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 20:00, 7 January 2013

OCA — Mon, 07 Jan 2013 20:00:09 GMT

←Older revision		Revision as of 20:00, 7 January 2013
Line 1:		Line 1:
	[[Image:2xug.png\|left\|200px]]		[[Image:2xug.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xug", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xug\| PDB=2xug \| SCENE= }}		{{STRUCTURE_2xug\| PDB=2xug \| SCENE= }}

	===CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 ANTI COMPLEX (1 WK)===		===CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 ANTI COMPLEX (1 WK)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21090615}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21090615 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21090615}}		{{ABSTRACT_PUBMED_21090615}}

Line 22:		Line 11:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21090615~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021090615</ref><references group="xtra"/>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
Line 29:		Line 18:
	[[Category: Radic, Z.]]		[[Category: Radic, Z.]]
	[[Category: Taylor, P.]]		[[Category: Taylor, P.]]
		+	[[Category: Click chemistry]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase fold]]

OCA: Protected "2xug" [edit=sysop:move=sysop]

OCA — Wed, 12 Jan 2011 05:22:05 GMT

Protected "2xug" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:22, 12 January 2011

OCA at 05:22, 12 January 2011

OCA — Wed, 12 Jan 2011 05:22:03 GMT

←Older revision		Revision as of 05:22, 12 January 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2xug.png\|left\|200px]]
-	[[Image:2xug.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~2XUG~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA].	+	[[2xug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA].

	==Reference==		==Reference==
Line 30:		Line 29:
	[[Category: Radic, Z.]]		[[Category: Radic, Z.]]
	[[Category: Taylor, P.]]		[[Category: Taylor, P.]]
-	[[Category: Click chemistry]]
-	[[Category: Hydrolase]]
-	[[Category: Hydrolase fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:46:22 2010''

OCA at 08:34, 8 December 2010

OCA — Wed, 08 Dec 2010 08:34:20 GMT

←Older revision		Revision as of 08:34, 8 December 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2xug.jpg\|left\|200px]]

-	The ~~entry 2xug~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xug", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xug\| PDB=2xug \| SCENE= }}

-	~~Authors: Bourne, Y., Radic, Z., Taylor, P., Marchot, P.~~	+	===CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 ANTI COMPLEX (1 WK)===

-	Description: Crystal structure of mAChE-Y337A-TZ2PA6 anti complex (1 wk)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 1 11:06:32 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21090615}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21090615 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21090615}}
		+
		+	==About this Structure==
		+	2XUG is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21090615</ref><references group="xtra"/>
		+	[[Category: Acetylcholinesterase]]
		+	[[Category: Mus musculus]]
		+	[[Category: Bourne, Y.]]
		+	[[Category: Marchot, P.]]
		+	[[Category: Radic, Z.]]
		+	[[Category: Taylor, P.]]
		+	[[Category: Click chemistry]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase fold]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 8 11:46:22 2010''