2xul - Revision history

OCA at 13:59, 1 February 2024

OCA — Thu, 01 Feb 2024 13:59:51 GMT

←Older revision		Revision as of 13:59, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='2xul' size='340' side='right'caption='[[2xul]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2xul' size='340' side='right'caption='[[2xul]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xul]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Anacystis_nidulans_r2 Anacystis nidulans r2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xul]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus_PCC_7942_=_FACHB-805 Synechococcus elongatus PCC 7942 = FACHB-805]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xg8\|2xg8]], [[1qy7\|1qy7]], [[2xun\|2xun]], [[2xbp\|2xbp]], [[2jj4\|2jj4]], [[2v5h\|2v5h]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xul OCA], [https://pdbe.org/2xul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xul RCSB], [https://www.ebi.ac.uk/pdbsum/2xul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xul ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xul OCA], [https://pdbe.org/2xul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xul RCSB], [https://www.ebi.ac.uk/pdbsum/2xul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xul ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GLNB_SYNE7 GLNB_SYNE7]] P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.	+	[https://www.uniprot.org/uniprot/GLNB_SYNE7 GLNB_SYNE7] P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Anacystis nidulans r2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chellamuthu, V R]]	+	[[Category: Synechococcus elongatus PCC 7942 = FACHB-805]]
-	[[Category: Fokina, O]]	+	[[Category: Chellamuthu V-R]]
-	[[Category: Forchhammer, K]]	+	[[Category: Fokina O]]
-	[[Category: Zeth, K]]	+	[[Category: Forchhammer K]]
-	~~[[Category: Glnk]]~~	+	[[Category: Zeth K]]
-	~~[[Category: Signaling protein~~]]	+

OCA at 12:17, 27 April 2022

OCA — Wed, 27 Apr 2022 12:17:31 GMT

←Older revision		Revision as of 12:17, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xul' size='340' side='right'caption='[[2xul]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2xul' size='340' side='right'caption='[[2xul]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xul]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xul]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XUL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xg8\|2xg8]], [[1qy7\|1qy7]], [[2xun\|2xun]], [[2xbp\|2xbp]], [[2jj4\|2jj4]], [[2v5h\|2v5h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xg8\|2xg8]], [[1qy7\|1qy7]], [[2xun\|2xun]], [[2xbp\|2xbp]], [[2jj4\|2jj4]], [[2v5h\|2v5h]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xul OCA], [~~http~~://pdbe.org/2xul PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xul RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xul PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xul ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xul OCA], [https://pdbe.org/2xul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xul RCSB], [https://www.ebi.ac.uk/pdbsum/2xul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xul ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GLNB_SYNE7 GLNB_SYNE7]] P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.	+	[[https://www.uniprot.org/uniprot/GLNB_SYNE7 GLNB_SYNE7]] P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:21, 22 July 2020

OCA — Wed, 22 Jul 2020 12:21:32 GMT

←Older revision		Revision as of 12:21, 22 July 2020
Line 1:		Line 1:

	==Structure of PII from Synechococcus elongatus in complex with 2- oxoglutarate at high 2-OG concentrations==		==Structure of PII from Synechococcus elongatus in complex with 2- oxoglutarate at high 2-OG concentrations==
-	<StructureSection load='2xul' size='340' side='right' caption='[[2xul]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2xul' size='340' side='right'caption='[[2xul]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xul]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xul]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XUL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xg8\|2xg8]], [[1qy7\|1qy7]], [[2xun\|2xun]], [[2xbp\|2xbp]], [[2jj4\|2jj4]], [[2v5h\|2v5h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xg8\|2xg8]], [[1qy7\|1qy7]], [[2xun\|2xun]], [[2xbp\|2xbp]], [[2jj4\|2jj4]], [[2v5h\|2v5h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xul OCA], [http://pdbe.org/2xul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xul RCSB], [http://www.ebi.ac.uk/pdbsum/2xul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xul ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xul OCA], [http://pdbe.org/2xul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xul RCSB], [http://www.ebi.ac.uk/pdbsum/2xul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xul ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Anacystis nidulans r2]]		[[Category: Anacystis nidulans r2]]
		+	[[Category: Large Structures]]
	[[Category: Chellamuthu, V R]]		[[Category: Chellamuthu, V R]]
	[[Category: Fokina, O]]		[[Category: Fokina, O]]

OCA at 09:14, 10 October 2018

OCA — Wed, 10 Oct 2018 09:14:51 GMT

←Older revision		Revision as of 09:14, 10 October 2018
Line 1:		Line 1:

-	==~~STRUCTURE OF~~ PII ~~FROM SYNECHOCOCCUS ELONGATUS IN COMPLEX WITH~~ 2-~~OXOGLUTARATE AT HIGH~~ 2-OG ~~CONCENTRATIONS~~==	+	==Structure of PII from Synechococcus elongatus in complex with 2- oxoglutarate at high 2-OG concentrations==
	<StructureSection load='2xul' size='340' side='right' caption='[[2xul]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2xul' size='340' side='right' caption='[[2xul]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 12:18, 5 August 2016

OCA — Fri, 05 Aug 2016 12:18:21 GMT

←Older revision		Revision as of 12:18, 5 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF PII FROM SYNECHOCOCCUS ELONGATUS IN COMPLEX WITH 2-OXOGLUTARATE AT HIGH 2-OG CONCENTRATIONS==		==STRUCTURE OF PII FROM SYNECHOCOCCUS ELONGATUS IN COMPLEX WITH 2-OXOGLUTARATE AT HIGH 2-OG CONCENTRATIONS==
	<StructureSection load='2xul' size='340' side='right' caption='[[2xul]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2xul' size='340' side='right' caption='[[2xul]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xul]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Synechococcus_elongatus Synechococcus elongatus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xul]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XUL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xg8\|2xg8]], [[1qy7\|1qy7]], [[2xun\|2xun]], [[2xbp\|2xbp]], [[2jj4\|2jj4]], [[2v5h\|2v5h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xg8\|2xg8]], [[1qy7\|1qy7]], [[2xun\|2xun]], [[2xbp\|2xbp]], [[2jj4\|2jj4]], [[2v5h\|2v5h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xul OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xul RCSB], [http://www.ebi.ac.uk/pdbsum/2xul PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xul OCA], [http://pdbe.org/2xul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xul RCSB], [http://www.ebi.ac.uk/pdbsum/2xul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xul ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xul" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Synechococcus elongatus~~]]	+	[[Category: Anacystis nidulans r2]]
	[[Category: Chellamuthu, V R]]		[[Category: Chellamuthu, V R]]
	[[Category: Fokina, O]]		[[Category: Fokina, O]]

OCA at 18:46, 25 December 2014

OCA — Thu, 25 Dec 2014 18:46:47 GMT

←Older revision		Revision as of 18:46, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xul OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xul RCSB], [http://www.ebi.ac.uk/pdbsum/2xul PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xul OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xul RCSB], [http://www.ebi.ac.uk/pdbsum/2xul PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLNB_SYNE7 GLNB_SYNE7]] P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Synechococcus elongatus]]		[[Category: Synechococcus elongatus]]
-	[[Category: Chellamuthu, V R.]]	+	[[Category: Chellamuthu, V R]]
-	[[Category: Fokina, O.]]	+	[[Category: Fokina, O]]
-	[[Category: Forchhammer, K.]]	+	[[Category: Forchhammer, K]]
-	[[Category: Zeth, K.]]	+	[[Category: Zeth, K]]
	[[Category: Glnk]]		[[Category: Glnk]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 13:25, 22 October 2014

OCA — Wed, 22 Oct 2014 13:25:50 GMT

←Older revision		Revision as of 13:25, 22 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xul.~~png~~\|~~left~~\|~~200px~~]]	+	==STRUCTURE OF PII FROM SYNECHOCOCCUS ELONGATUS IN COMPLEX WITH 2-OXOGLUTARATE AT HIGH 2-OG CONCENTRATIONS==
		+	<StructureSection load='2xul' size='340' side='right' caption='[[2xul]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xul]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XUL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xg8\|2xg8]], [[1qy7\|1qy7]], [[2xun\|2xun]], [[2xbp\|2xbp]], [[2jj4\|2jj4]], [[2v5h\|2v5h]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xul OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xul RCSB], [http://www.ebi.ac.uk/pdbsum/2xul PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	P(II) proteins control key processes of nitrogen metabolism in bacteria, archaea, and plants in response to the central metabolites ATP, ADP, and 2-oxoglutarate (2-OG), signaling cellular energy and carbon and nitrogen abundance. This metabolic information is integrated by P(II) and transmitted to regulatory targets (key enzymes, transporters, and transcription factors), modulating their activity. In oxygenic phototrophs, the controlling enzyme of arginine synthesis, N-acetyl-glutamate kinase (NAGK), is a major P(II) target, whose activity responds to 2-OG via P(II). Here we show structures of the Synechococcus elongatus P(II) protein in complex with ATP, Mg(2+), and 2-OG, which clarify how 2-OG affects P(II)-NAGK interaction. P(II) trimers with all three sites fully occupied were obtained as well as structures with one or two 2-OG molecules per P(II) trimer. These structures identify the site of 2-OG located in the vicinity between the subunit clefts and the base of the T loop. The 2-OG is bound to a Mg(2+) ion, which is coordinated by three phosphates of ATP, and by ionic interactions with the highly conserved residues K58 and Q39 together with B- and T-loop backbone interactions. These interactions impose a unique T-loop conformation that affects the interactions with the P(II) target. Structures of P(II) trimers with one or two bound 2-OG molecules reveal the basis for anticooperative 2-OG binding and shed light on the intersubunit signaling mechanism by which P(II) senses effectors in a wide range of concentrations.

-	~~{{STRUCTURE_2xul\| PDB=2xul \| SCENE= }}~~	+	Mechanism of 2-oxoglutarate signaling by the Synechococcus elongatus PII signal transduction protein.,Fokina O, Chellamuthu VR, Forchhammer K, Zeth K Proc Natl Acad Sci U S A. 2010 Nov 1. PMID:21041661<ref>PMID:21041661</ref>

-	~~===STRUCTURE OF PII FROM SYNECHOCOCCUS ELONGATUS IN COMPLEX WITH 2-OXOGLUTARATE AT HIGH 2-OG CONCENTRATIONS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21041661}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2xul]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Synechococcus_elongatus Synechococcus elongatus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021041661<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Synechococcus elongatus]]		[[Category: Synechococcus elongatus]]
	[[Category: Chellamuthu, V R.]]		[[Category: Chellamuthu, V R.]]

OCA: Protected "2xul" [edit=sysop:move=sysop]

OCA — Mon, 07 Jan 2013 22:58:32 GMT

Protected "2xul" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:58, 7 January 2013

OCA at 22:58, 7 January 2013

OCA — Mon, 07 Jan 2013 22:58:29 GMT

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	[[Image:2xul.png\|left\|200px]]		[[Image:2xul.png\|left\|200px]]

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	{{STRUCTURE_2xul\| PDB=2xul \| SCENE= }}		{{STRUCTURE_2xul\| PDB=2xul \| SCENE= }}

	===STRUCTURE OF PII FROM SYNECHOCOCCUS ELONGATUS IN COMPLEX WITH 2-OXOGLUTARATE AT HIGH 2-OG CONCENTRATIONS===		===STRUCTURE OF PII FROM SYNECHOCOCCUS ELONGATUS IN COMPLEX WITH 2-OXOGLUTARATE AT HIGH 2-OG CONCENTRATIONS===

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	{{ABSTRACT_PUBMED_21041661}}		{{ABSTRACT_PUBMED_21041661}}

	==About this Structure==		==About this Structure==
-	~~2XUL~~ is a 6 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA].	+	[[2xul]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUL OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21041661~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021041661</ref><references group="xtra"/>
	[[Category: Synechococcus elongatus]]		[[Category: Synechococcus elongatus]]
	[[Category: Chellamuthu, V R.]]		[[Category: Chellamuthu, V R.]]
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	[[Category: Glnk]]		[[Category: Glnk]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
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OCA at 07:51, 1 December 2010

OCA — Wed, 01 Dec 2010 07:51:09 GMT

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