2xvs - Revision history

OCA at 14:00, 1 February 2024

OCA — Thu, 01 Feb 2024 14:00:07 GMT

←Older revision		Revision as of 14:00, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='2xvs' size='340' side='right'caption='[[2xvs]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2xvs' size='340' side='right'caption='[[2xvs]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [https://pdbe.org/2xvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [https://www.ebi.ac.uk/pdbsum/2xvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [https://pdbe.org/2xvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [https://www.ebi.ac.uk/pdbsum/2xvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TTC5_HUMAN TTC5_HUMAN]] Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).	+	[https://www.uniprot.org/uniprot/TTC5_HUMAN TTC5_HUMAN] Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adams, J]]	+	[[Category: Adams J]]
-	[[Category: Bullock~~, A N~~]]	+	[[Category: Bullock AN]]
-	[[Category: Coutts~~, A S~~]]	+	[[Category: Coutts AS]]
-	[[Category: Knapp, S]]	+	[[Category: Knapp S]]
-	[[Category: ~~Maniam, S]]~~	+	[[Category: La Thangue B]]
-	~~[[Category: Pike, A C.W]]~~	+	[[Category: Maniam S]]
-	~~[[Category: Sharpe, T D]]~~	+	[[Category: Pike ACW]]
-	~~[[Category:~~ Thangue, B La]]	+	[[Category: Sharpe TD]]
-	[[Category: ~~Antitumor protein~~]]	+
-	[[Category: ~~P300~~]]	+
-	[[Category: ~~P53 cofactor]]~~	+
-	~~[[Category: Stress-response~~]]	+

OCA at 12:18, 27 April 2022

OCA — Wed, 27 Apr 2022 12:18:08 GMT

←Older revision		Revision as of 12:18, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xvs' size='340' side='right'caption='[[2xvs]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2xvs' size='340' side='right'caption='[[2xvs]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [~~http~~://pdbe.org/2xvs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xvs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [https://pdbe.org/2xvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [https://www.ebi.ac.uk/pdbsum/2xvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TTC5_HUMAN TTC5_HUMAN]] Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).	+	[[https://www.uniprot.org/uniprot/TTC5_HUMAN TTC5_HUMAN]] Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:22, 22 July 2020

OCA — Wed, 22 Jul 2020 12:22:49 GMT

←Older revision		Revision as of 12:22, 22 July 2020
Line 1:		Line 1:

	==Crystal structure of human TTC5 (Strap) C-terminal OB domain==		==Crystal structure of human TTC5 (Strap) C-terminal OB domain==
-	<StructureSection load='2xvs' size='340' side='right' caption='[[2xvs]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2xvs' size='340' side='right'caption='[[2xvs]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XVS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [http://pdbe.org/2xvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [http://www.ebi.ac.uk/pdbsum/2xvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [http://pdbe.org/2xvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [http://www.ebi.ac.uk/pdbsum/2xvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Adams, J]]		[[Category: Adams, J]]
	[[Category: Bullock, A N]]		[[Category: Bullock, A N]]

OCA at 09:35, 4 August 2016

OCA — Thu, 04 Aug 2016 09:35:11 GMT

←Older revision		Revision as of 09:35, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human TTC5 (Strap) C-terminal OB domain==		==Crystal structure of human TTC5 (Strap) C-terminal OB domain==
	<StructureSection load='2xvs' size='340' side='right' caption='[[2xvs]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2xvs' size='340' side='right' caption='[[2xvs]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XVS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XVS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [http://www.ebi.ac.uk/pdbsum/2xvs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [http://pdbe.org/2xvs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [http://www.ebi.ac.uk/pdbsum/2xvs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xvs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Adams, J]]		[[Category: Adams, J]]
	[[Category: Bullock, A N]]		[[Category: Bullock, A N]]

OCA at 07:55, 25 December 2014

OCA — Thu, 25 Dec 2014 07:55:05 GMT

←Older revision		Revision as of 07:55, 25 December 2014
Line 2:		Line 2:
	<StructureSection load='2xvs' size='340' side='right' caption='[[2xvs]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2xvs' size='340' side='right' caption='[[2xvs]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. <br>	+	<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XVS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene~~><br>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [http://www.ebi.ac.uk/pdbsum/2xvs PDBsum]</span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [http://www.ebi.ac.uk/pdbsum/2xvs PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TTC5_HUMAN TTC5_HUMAN]] Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 14:
	The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.,Adams CJ, Pike AC, Maniam S, Sharpe TD, Coutts AS, Knapp S, La Thangue NB, Bullock AN Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3778-83. Epub 2012 Feb 23. PMID:22362889<ref>PMID:22362889</ref>		The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.,Adams CJ, Pike AC, Maniam S, Sharpe TD, Coutts AS, Knapp S, La Thangue NB, Bullock AN Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3778-83. Epub 2012 Feb 23. PMID:22362889<ref>PMID:22362889</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Adams, J.]]	+	[[Category: Adams, J]]
-	[[Category: Bullock, A N.]]	+	[[Category: Bullock, A N]]
-	[[Category: Coutts, A S.]]	+	[[Category: Coutts, A S]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: Maniam, S.]]	+	[[Category: Maniam, S]]
-	[[Category: Pike, A C.W.]]	+	[[Category: Pike, A C.W]]
-	[[Category: Sharpe, T D.]]	+	[[Category: Sharpe, T D]]
-	[[Category: Thangue, B La.]]	+	[[Category: Thangue, B La]]
	[[Category: Antitumor protein]]		[[Category: Antitumor protein]]
	[[Category: P300]]		[[Category: P300]]
	[[Category: P53 cofactor]]		[[Category: P53 cofactor]]
	[[Category: Stress-response]]		[[Category: Stress-response]]

OCA at 07:51, 14 May 2014

OCA — Wed, 14 May 2014 07:51:08 GMT

←Older revision		Revision as of 07:51, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2xvs.~~png~~\|~~left\|200px~~]]	+	==Crystal structure of human TTC5 (Strap) C-terminal OB domain==
		+	<StructureSection load='2xvs' size='340' side='right' caption='[[2xvs]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvs RCSB], [http://www.ebi.ac.uk/pdbsum/2xvs PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Activation of p53 target genes for tumor suppression depends on the stress-specific regulation of transcriptional coactivator complexes. Strap (stress-responsive activator of p300) is activated upon DNA damage by ataxia telangiectasia mutated (ATM) and Chk2 kinases and is a key regulator of the p53 response. In addition to antagonizing Mdm2, Strap facilitates the recruitment of p53 coactivators, including JMY and p300. Strap is a predicted TPR-repeat protein, but shows only limited sequence identity with any protein of known structure. To address this and to elucidate the molecular mechanism of Strap activity we determined the crystal structure of the full-length protein at 2.05 A resolution. The structure of Strap reveals an atypical six tetratricopeptide repeat (TPR) protein that also contains an unexpected oligonucleotide/oligosaccharide-binding (OB)-fold domain. This previously unseen domain organization provides an extended superhelical scaffold allowing for protein-protein as well as protein-DNA interaction. We show that both of the TPR and OB-fold domains localize to the chromatin of p53 target genes and exhibit intrinsic regulatory activity necessary for the Strap-dependent p53 response.

-	<!--	+	The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.,Adams CJ, Pike AC, Maniam S, Sharpe TD, Coutts AS, Knapp S, La Thangue NB, Bullock AN Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3778-83. Epub 2012 Feb 23. PMID:22362889<ref>PMID:22362889</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2xvs"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_2xvs\| PDB=2xvs \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~human TTC5 (Strap) C-terminal OB domain===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22362889}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22362889 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22362889}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xvs]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022362889<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Adams, J.]]		[[Category: Adams, J.]]

OCA at 06:45, 21 March 2012

OCA — Wed, 21 Mar 2012 06:45:02 GMT

←Older revision		Revision as of 06:45, 21 March 2012
Line 11:		Line 11:
	===Crystal structure of human TTC5 (Strap) C-terminal OB domain===		===Crystal structure of human TTC5 (Strap) C-terminal OB domain===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22362889}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22362889 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22362889}}

	==About this Structure==		==About this Structure==
	[[2xvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA].		[[2xvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022362889</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Adams, J.]]		[[Category: Adams, J.]]

OCA: Protected "2xvs" [edit=sysop:move=sysop]

OCA — Wed, 14 Mar 2012 05:46:48 GMT

Protected "2xvs" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:46, 14 March 2012

OCA at 05:46, 14 March 2012

OCA — Wed, 14 Mar 2012 05:46:46 GMT

←Older revision		Revision as of 05:46, 14 March 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2xvs.png\|left\|200px]]
-	[[Image:2xvs.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 10:		Line 9:
	{{STRUCTURE_2xvs\| PDB=2xvs \| SCENE= }}		{{STRUCTURE_2xvs\| PDB=2xvs \| SCENE= }}

-	===~~CRYSTAL STRUCTURE OF HUMAN~~ TTC5 (~~STRAP~~) C-~~TERMINAL~~ OB ~~DOMAIN~~===	+	===Crystal structure of human TTC5 (Strap) C-terminal OB domain===


	==About this Structure==		==About this Structure==
-	~~2XVS~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA].	+	[[2xvs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Arrowsmith~~, ~~C H.]]~~	+	[[Category: Adams, J.]]
-	~~[[Category: Bountra, C~~.]]	+	[[Category: Bullock, A N.]]
-	[[Category: Bullock, A~~.]]~~	+	[[Category: Coutts, A S.]]
-	~~[[Category: Burgess-Brown,~~ N.]]	+
-	[[Category: ~~Chaikuad~~, A~~.]]~~	+
-	~~[[Category: Delft, F Von.]]~~	+
-	~~[[Category: Edwards, A M.]]~~	+
-	~~[[Category: Kleinekofort, W~~.]]	+
	[[Category: Knapp, S.]]		[[Category: Knapp, S.]]
-	[[Category: ~~Muniz~~, ~~J R.C~~.]]	+	[[Category: Maniam, S.]]
	[[Category: Pike, A C.W.]]		[[Category: Pike, A C.W.]]
-	[[Category: Roos, A K.]]
	[[Category: Sharpe, T D.]]		[[Category: Sharpe, T D.]]
-	[[Category: ~~Weigelt~~, J.]]	+	[[Category: Thangue, B La.]]
	[[Category: Antitumor protein]]		[[Category: Antitumor protein]]
	[[Category: P300]]		[[Category: P300]]
	[[Category: P53 cofactor]]		[[Category: P53 cofactor]]
	[[Category: Stress-response]]		[[Category: Stress-response]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:47:13 2010''

OCA at 21:36, 17 November 2010

OCA — Wed, 17 Nov 2010 21:36:00 GMT

←Older revision		Revision as of 21:36, 17 November 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2xvs.jpg\|left\|200px]]

-	The ~~entry 2xvs~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xvs", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xvs\| PDB=2xvs \| SCENE= }}

-	~~Authors: Pike, A.~~C~~.W., Sharpe, T.D., Burgess~~-~~Brown, N., Kleinekofort, W., Roos, A.K., Muniz, J.R.C., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Bullock, A., Knapp, S.~~	+	===CRYSTAL STRUCTURE OF HUMAN TTC5 (STRAP) C-TERMINAL OB DOMAIN===

-	Description: Crystal structure of human TTC5 (Strap) C-terminal OB domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed~~ Nov ~~10 06~~:25:04 2010''	+	==About this Structure==
		+	2XVS is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVS OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Bullock, A.]]
		+	[[Category: Burgess-Brown, N.]]
		+	[[Category: Chaikuad, A.]]
		+	[[Category: Delft, F Von.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Kleinekofort, W.]]
		+	[[Category: Knapp, S.]]
		+	[[Category: Muniz, J R.C.]]
		+	[[Category: Pike, A C.W.]]
		+	[[Category: Roos, A K.]]
		+	[[Category: Sharpe, T D.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Antitumor protein]]
		+	[[Category: P300]]
		+	[[Category: P53 cofactor]]
		+	[[Category: Stress-response]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:47:13 2010''