2xwm - Revision history

OCA at 08:05, 23 August 2023

OCA — Wed, 23 Aug 2023 08:05:03 GMT

←Older revision		Revision as of 08:05, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='2xwm' size='340' side='right'caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2xwm' size='340' side='right'caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Mycs2 Mycs2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XWM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=C5P:CYTIDINE~~-~~5-MONOPHOSPHATE'>C5P</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2xwl\|2xwl]], [[2xwn\|2xwn]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/2~~-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwm OCA], [https://pdbe.org/2xwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xwm RCSB], [https://www.ebi.ac.uk/pdbsum/2xwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwm OCA], [https://pdbe.org/2xwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xwm RCSB], [https://www.ebi.ac.uk/pdbsum/2xwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/A0R560_MYCS2 A0R560_MYCS2]] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).[SAAS:SAAS018294_004_010899][HAMAP-Rule:MF_00108]	+	[https://www.uniprot.org/uniprot/A0R560_MYCS2 A0R560_MYCS2] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).[SAAS:SAAS018294_004_010899][HAMAP-Rule:MF_00108]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycs2~~]]	+	[[Category: Mycolicibacterium smegmatis MC2 155]]
-	[[Category: Bergfors, T]]	+	[[Category: Bergfors T]]
-	[[Category: Bjorkelid, C]]	+	[[Category: Bjorkelid C]]
-	[[Category: Jones~~, T A~~]]	+	[[Category: Jones TA]]
-	[[Category: Unge, T]]	+	[[Category: Unge T]]
-	~~[[Category: Mep pathway]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 14:55, 17 November 2021

OCA — Wed, 17 Nov 2021 14:55:39 GMT

←Older revision		Revision as of 14:55, 17 November 2021
Line 3:		Line 3:
	<StructureSection load='2xwm' size='340' side='right'caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2xwm' size='340' side='right'caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XWM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwl\|2xwl]], [[2xwn\|2xwn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xwl\|2xwl]], [[2xwn\|2xwn]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwm OCA], [~~http~~://pdbe.org/2xwm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xwm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xwm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwm OCA], [https://pdbe.org/2xwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xwm RCSB], [https://www.ebi.ac.uk/pdbsum/2xwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/A0R560_MYCS2 A0R560_MYCS2]] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).[SAAS:SAAS018294_004_010899][HAMAP-Rule:MF_00108]	+	[[https://www.uniprot.org/uniprot/A0R560_MYCS2 A0R560_MYCS2]] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).[SAAS:SAAS018294_004_010899][HAMAP-Rule:MF_00108]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[MEP cytidylyltransferase\|MEP cytidylyltransferase]]	+	*[[MEP cytidylyltransferase 3D structures\|MEP cytidylyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:51, 21 May 2019

OCA — Tue, 21 May 2019 07:51:54 GMT

←Older revision		Revision as of 07:51, 21 May 2019
Line 1:		Line 1:

	==Crystal structure of IspD from Mycobacterium smegmatis in complex with CMP==		==Crystal structure of IspD from Mycobacterium smegmatis in complex with CMP==
-	<StructureSection load='2xwm' size='340' side='right' caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2xwm' size='340' side='right'caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWM FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]		[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Mycs2]]		[[Category: Mycs2]]
	[[Category: Bergfors, T]]		[[Category: Bergfors, T]]

OCA at 07:58, 6 March 2019

OCA — Wed, 06 Mar 2019 07:58:45 GMT

←Older revision		Revision as of 07:58, 6 March 2019
Line 1:		Line 1:

	==Crystal structure of IspD from Mycobacterium smegmatis in complex with CMP==		==Crystal structure of IspD from Mycobacterium smegmatis in complex with CMP==
-	<StructureSection load='2xwm' size='340' side='right' caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2xwm' size='340' side='right' caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWM FirstGlance]. <br>

OCA at 21:29, 4 August 2016

OCA — Thu, 04 Aug 2016 21:29:31 GMT

←Older revision		Revision as of 21:29, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of IspD from Mycobacterium smegmatis in complex with CMP==		==Crystal structure of IspD from Mycobacterium smegmatis in complex with CMP==
	<StructureSection load='2xwm' size='340' side='right' caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2xwm' size='340' side='right' caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_smegmatis Mycobacterium smegmatis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwl\|2xwl]], [[2xwn\|2xwn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwl\|2xwl]], [[2xwn\|2xwn]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xwm RCSB], [http://www.ebi.ac.uk/pdbsum/2xwm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwm OCA], [http://pdbe.org/2xwm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xwm RCSB], [http://www.ebi.ac.uk/pdbsum/2xwm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xwm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]		[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
-	[[Category: ~~Mycobacterium smegmatis~~]]	+	[[Category: Mycs2]]
	[[Category: Bergfors, T]]		[[Category: Bergfors, T]]
	[[Category: Bjorkelid, C]]		[[Category: Bjorkelid, C]]

OCA at 13:17, 25 December 2014

OCA — Thu, 25 Dec 2014 13:17:48 GMT

←Older revision		Revision as of 13:17, 25 December 2014
Line 2:		Line 2:
	<StructureSection load='2xwm' size='340' side='right' caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2xwm' size='340' side='right' caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. <br>	+	<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwl\|2xwl]], [[2xwn\|2xwn]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwl\|2xwl]], [[2xwn\|2xwn]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xwm RCSB], [http://www.ebi.ac.uk/pdbsum/2xwm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xwm RCSB], [http://www.ebi.ac.uk/pdbsum/2xwm PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0R560_MYCS2 A0R560_MYCS2]] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).[SAAS:SAAS018294_004_010899][HAMAP-Rule:MF_00108]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Structural and functional studies of mycobacterial IspD enzymes.,Bjorkelid C, Bergfors T, Henriksson LM, Stern AL, Unge T, Mowbray SL, Jones TA Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):403-14. Epub 2011, Apr 8. PMID:21543842<ref>PMID:21543842</ref>		Structural and functional studies of mycobacterial IspD enzymes.,Bjorkelid C, Bergfors T, Henriksson LM, Stern AL, Unge T, Mowbray SL, Jones TA Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):403-14. Epub 2011, Apr 8. PMID:21543842<ref>PMID:21543842</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[MEP cytidylyltransferase\|MEP cytidylyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 27:
	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]		[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]
-	[[Category: Bergfors, T.]]	+	[[Category: Bergfors, T]]
-	[[Category: Bjorkelid, C.]]	+	[[Category: Bjorkelid, C]]
-	[[Category: Jones, T A.]]	+	[[Category: Jones, T A]]
-	[[Category: Unge, T.]]	+	[[Category: Unge, T]]
	[[Category: Mep pathway]]		[[Category: Mep pathway]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:46, 14 May 2014

OCA — Wed, 14 May 2014 07:46:07 GMT

←Older revision		Revision as of 07:46, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2xwm.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of IspD from Mycobacterium smegmatis in complex with CMP==
		+	<StructureSection load='2xwm' size='340' side='right' caption='[[2xwm]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwl\|2xwl]], [[2xwn\|2xwn]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xwm RCSB], [http://www.ebi.ac.uk/pdbsum/2xwm PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize isopentenyl diphosphate via the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway rather than the classical mevalonate pathway found in humans. As part of a structure-based drug-discovery program against tuberculosis, IspD, the enzyme that carries out the third step in the MEP pathway, was targeted. Constructs of both the Mycobacterium smegmatis and the Mycobacterium tuberculosis enzymes that were suitable for structural and inhibitor-screening studies were engineered. Two crystal structures of the M. smegmatis enzyme were produced, one in complex with CTP and the other in complex with CMP. In addition, the M. tuberculosis enzyme was crystallized in complex with CTP. Here, the structure determination and crystallographic refinement of these crystal forms and the enzymatic characterization of the M. tuberculosis enzyme construct are reported. A comparison with known IspD structures allowed the definition of the structurally conserved core of the enzyme. It indicates potential flexibility in the enzyme and in particular in areas close to the active site. These well behaved constructs provide tools for future target-based screening of potential inhibitors. The conserved nature of the extended active site suggests that any new inhibitor will potentially exhibit broad-spectrum activity.

-	~~<!--~~	+	Structural and functional studies of mycobacterial IspD enzymes.,Bjorkelid C, Bergfors T, Henriksson LM, Stern AL, Unge T, Mowbray SL, Jones TA Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):403-14. Epub 2011, Apr 8. PMID:21543842<ref>PMID:21543842</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2xwm"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded~~),	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2xwm\| PDB=2xwm \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~IspD from Mycobacterium smegmatis in complex with CMP===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21543842}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21543842 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21543842}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xwm]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021543842<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]		[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]

OCA at 06:34, 1 February 2012

OCA — Wed, 01 Feb 2012 06:34:00 GMT

←Older revision		Revision as of 06:34, 1 February 2012
Line 1:		Line 1:
-	[[Image:2xwm.~~jpg~~\|left\|200px]]	+	[[Image:2xwm.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 9:
	{{STRUCTURE_2xwm\| PDB=2xwm \| SCENE= }}		{{STRUCTURE_2xwm\| PDB=2xwm \| SCENE= }}

-	===~~CRYSTAL STRUCTURE OF ISPD FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH~~ CMP===	+	===Crystal structure of IspD from Mycobacterium smegmatis in complex with CMP===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21543842}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21543842 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21543842}}

	==About this Structure==		==About this Structure==
	[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA].		[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021543842</ref><references group="xtra"/>
	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]		[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
	[[Category: Mycobacterium smegmatis]]		[[Category: Mycobacterium smegmatis]]
Line 20:		Line 29:
	[[Category: Jones, T A.]]		[[Category: Jones, T A.]]
	[[Category: Unge, T.]]		[[Category: Unge, T.]]
		+	[[Category: Mep pathway]]
		+	[[Category: Transferase]]

OCA: Protected "2xwm" [edit=sysop:move=sysop]

OCA — Wed, 27 Apr 2011 07:20:46 GMT

Protected "2xwm" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:20, 27 April 2011

OCA at 07:20, 27 April 2011

OCA — Wed, 27 Apr 2011 07:20:41 GMT

←Older revision		Revision as of 07:20, 27 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2xwm.jpg\|left\|200px]]

-	The ~~entry 2xwm~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xwm", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xwm\| PDB=2xwm \| SCENE= }}

-	~~Authors: Bjorkelid, C., Bergfors, T., Unge, T., Jones, T.A.~~	+	===CRYSTAL STRUCTURE OF ISPD FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH CMP===

-	Description: Crystal structure of IspD from Mycobacterium smegmatis in complex with CMP

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Thu Nov 18 00~~:26:~~47 2010''~~	+	==About this Structure==
		+	[[2xwm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWM OCA].
		+	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
		+	[[Category: Mycobacterium smegmatis]]
		+	[[Category: Bergfors, T.]]
		+	[[Category: Bjorkelid, C.]]
		+	[[Category: Jones, T A.]]
		+	[[Category: Unge, T.]]