2xwn - Revision history

OCA at 08:05, 23 August 2023

OCA — Wed, 23 Aug 2023 08:05:06 GMT

←Older revision		Revision as of 08:05, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='2xwn' size='340' side='right'caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2xwn' size='340' side='right'caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XWN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CTP:CYTIDINE~~-~~5-TRIPHOSPHATE'>CTP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2xwm\|2xwm]], [[2xwl\|2xwl]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwn OCA], [https://pdbe.org/2xwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xwn RCSB], [https://www.ebi.ac.uk/pdbsum/2xwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwn OCA], [https://pdbe.org/2xwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xwn RCSB], [https://www.ebi.ac.uk/pdbsum/2xwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ISPD_MYCTU ISPD_MYCTU]] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).	+	[https://www.uniprot.org/uniprot/ISPD_MYCTU ISPD_MYCTU] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Bergfors, T]]	+	[[Category: Bergfors T]]
-	[[Category: Bjorkelid, C]]	+	[[Category: Bjorkelid C]]
-	[[Category: Jones~~, T A~~]]	+	[[Category: Jones TA]]
-	[[Category: Unge, T]]	+	[[Category: Unge T]]
-	~~[[Category: Mep pathway]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 14:55, 17 November 2021

OCA — Wed, 17 Nov 2021 14:55:45 GMT

←Older revision		Revision as of 14:55, 17 November 2021
Line 3:		Line 3:
	<StructureSection load='2xwn' size='340' side='right'caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2xwn' size='340' side='right'caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XWN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwm\|2xwm]], [[2xwl\|2xwl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xwm\|2xwm]], [[2xwl\|2xwl]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwn OCA], [~~http~~://pdbe.org/2xwn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xwn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xwn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwn OCA], [https://pdbe.org/2xwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xwn RCSB], [https://www.ebi.ac.uk/pdbsum/2xwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ISPD_MYCTU ISPD_MYCTU]] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).	+	[[https://www.uniprot.org/uniprot/ISPD_MYCTU ISPD_MYCTU]] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[MEP cytidylyltransferase\|MEP cytidylyltransferase]]	+	*[[MEP cytidylyltransferase 3D structures\|MEP cytidylyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:51, 21 May 2019

OCA — Tue, 21 May 2019 07:51:58 GMT

←Older revision		Revision as of 07:51, 21 May 2019
Line 1:		Line 1:

	==Crystal structure of IspD from Mycobacterium tuberculosis in complex with CTP and Mg==		==Crystal structure of IspD from Mycobacterium tuberculosis in complex with CTP and Mg==
-	<StructureSection load='2xwn' size='340' side='right' caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='2xwn' size='340' side='right'caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWN FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]		[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Bergfors, T]]		[[Category: Bergfors, T]]

OCA at 07:58, 6 March 2019

OCA — Wed, 06 Mar 2019 07:58:45 GMT

←Older revision		Revision as of 07:58, 6 March 2019
Line 1:		Line 1:

	==Crystal structure of IspD from Mycobacterium tuberculosis in complex with CTP and Mg==		==Crystal structure of IspD from Mycobacterium tuberculosis in complex with CTP and Mg==
-	<StructureSection load='2xwn' size='340' side='right' caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='2xwn' size='340' side='right' caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWN FirstGlance]. <br>

OCA at 09:20, 5 August 2016

OCA — Fri, 05 Aug 2016 09:20:37 GMT

←Older revision		Revision as of 09:20, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of IspD from Mycobacterium tuberculosis in complex with CTP and Mg==		==Crystal structure of IspD from Mycobacterium tuberculosis in complex with CTP and Mg==
	<StructureSection load='2xwn' size='340' side='right' caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2xwn' size='340' side='right' caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwm\|2xwm]], [[2xwl\|2xwl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwm\|2xwm]], [[2xwl\|2xwl]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xwn RCSB], [http://www.ebi.ac.uk/pdbsum/2xwn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwn OCA], [http://pdbe.org/2xwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xwn RCSB], [http://www.ebi.ac.uk/pdbsum/2xwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xwn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]		[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Bergfors, T]]		[[Category: Bergfors, T]]
	[[Category: Bjorkelid, C]]		[[Category: Bjorkelid, C]]

OCA at 01:08, 25 December 2014

OCA — Thu, 25 Dec 2014 01:08:09 GMT

←Older revision		Revision as of 01:08, 25 December 2014
Line 2:		Line 2:
	<StructureSection load='2xwn' size='340' side='right' caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2xwn' size='340' side='right' caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. <br>	+	<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XWN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwm\|2xwm]], [[2xwl\|2xwl]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwm\|2xwm]], [[2xwl\|2xwl]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xwn RCSB], [http://www.ebi.ac.uk/pdbsum/2xwn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xwn RCSB], [http://www.ebi.ac.uk/pdbsum/2xwn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ISPD_MYCTU ISPD_MYCTU]] Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Structural and functional studies of mycobacterial IspD enzymes.,Bjorkelid C, Bergfors T, Henriksson LM, Stern AL, Unge T, Mowbray SL, Jones TA Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):403-14. Epub 2011, Apr 8. PMID:21543842<ref>PMID:21543842</ref>		Structural and functional studies of mycobacterial IspD enzymes.,Bjorkelid C, Bergfors T, Henriksson LM, Stern AL, Unge T, Mowbray SL, Jones TA Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):403-14. Epub 2011, Apr 8. PMID:21543842<ref>PMID:21543842</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[MEP cytidylyltransferase\|MEP cytidylyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 27:
	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]		[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Bergfors, T.]]	+	[[Category: Bergfors, T]]
-	[[Category: Bjorkelid, C.]]	+	[[Category: Bjorkelid, C]]
-	[[Category: Jones, T A.]]	+	[[Category: Jones, T A]]
-	[[Category: Unge, T.]]	+	[[Category: Unge, T]]
	[[Category: Mep pathway]]		[[Category: Mep pathway]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:42, 14 May 2014

OCA — Wed, 14 May 2014 07:42:48 GMT

←Older revision		Revision as of 07:42, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2xwn.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of IspD from Mycobacterium tuberculosis in complex with CTP and Mg==
		+	<StructureSection load='2xwn' size='340' side='right' caption='[[2xwn]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xwm\|2xwm]], [[2xwl\|2xwl]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xwn RCSB], [http://www.ebi.ac.uk/pdbsum/2xwn PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize isopentenyl diphosphate via the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway rather than the classical mevalonate pathway found in humans. As part of a structure-based drug-discovery program against tuberculosis, IspD, the enzyme that carries out the third step in the MEP pathway, was targeted. Constructs of both the Mycobacterium smegmatis and the Mycobacterium tuberculosis enzymes that were suitable for structural and inhibitor-screening studies were engineered. Two crystal structures of the M. smegmatis enzyme were produced, one in complex with CTP and the other in complex with CMP. In addition, the M. tuberculosis enzyme was crystallized in complex with CTP. Here, the structure determination and crystallographic refinement of these crystal forms and the enzymatic characterization of the M. tuberculosis enzyme construct are reported. A comparison with known IspD structures allowed the definition of the structurally conserved core of the enzyme. It indicates potential flexibility in the enzyme and in particular in areas close to the active site. These well behaved constructs provide tools for future target-based screening of potential inhibitors. The conserved nature of the extended active site suggests that any new inhibitor will potentially exhibit broad-spectrum activity.

-	~~<!--~~	+	Structural and functional studies of mycobacterial IspD enzymes.,Bjorkelid C, Bergfors T, Henriksson LM, Stern AL, Unge T, Mowbray SL, Jones TA Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):403-14. Epub 2011, Apr 8. PMID:21543842<ref>PMID:21543842</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2xwn"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded~~),	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2xwn\| PDB=2xwn \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~IspD from Mycobacterium tuberculosis in complex with CTP and Mg===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21543842}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21543842 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21543842}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xwn]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021543842<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]		[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 06:18, 1 February 2012

OCA — Wed, 01 Feb 2012 06:18:37 GMT

←Older revision		Revision as of 06:18, 1 February 2012
Line 1:		Line 1:
-	[[Image:2xwn.~~jpg~~\|left\|200px]]	+	[[Image:2xwn.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 9:
	{{STRUCTURE_2xwn\| PDB=2xwn \| SCENE= }}		{{STRUCTURE_2xwn\| PDB=2xwn \| SCENE= }}

-	===~~CRYSTAL STRUCTURE OF ISPD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH~~ CTP ~~AND MG~~===	+	===Crystal structure of IspD from Mycobacterium tuberculosis in complex with CTP and Mg===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21543842}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21543842 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21543842}}

	==About this Structure==		==About this Structure==
	[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA].		[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021543842</ref><references group="xtra"/>
	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]		[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
Line 20:		Line 29:
	[[Category: Jones, T A.]]		[[Category: Jones, T A.]]
	[[Category: Unge, T.]]		[[Category: Unge, T.]]
		+	[[Category: Mep pathway]]
		+	[[Category: Transferase]]

OCA: Protected "2xwn" [edit=sysop:move=sysop]

OCA — Wed, 27 Apr 2011 07:20:54 GMT

Protected "2xwn" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:20, 27 April 2011

OCA at 07:20, 27 April 2011

OCA — Wed, 27 Apr 2011 07:20:49 GMT

←Older revision		Revision as of 07:20, 27 April 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2xwn.jpg\|left\|200px]]

-	The ~~entry 2xwn~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xwn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xwn\| PDB=2xwn \| SCENE= }}

-	~~Authors: Bjorkelid, C., Bergfors, T., Unge, T., Jones, T.A.~~	+	===CRYSTAL STRUCTURE OF ISPD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH CTP AND MG===

-	Description: Crystal structure of IspD from Mycobacterium tuberculosis in complex with CTP and Mg

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Thu Nov 18 00~~:26:~~48 2010''~~	+	==About this Structure==
		+	[[2xwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWN OCA].
		+	[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Bergfors, T.]]
		+	[[Category: Bjorkelid, C.]]
		+	[[Category: Jones, T A.]]
		+	[[Category: Unge, T.]]