2xxi - Revision history

OCA at 14:01, 1 February 2024

OCA — Thu, 01 Feb 2024 14:01:13 GMT

←Older revision		Revision as of 14:01, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='2xxi' size='340' side='right'caption='[[2xxi]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2xxi' size='340' side='right'caption='[[2xxi]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xxi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XXI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xxi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XXI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=JAC:1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE'>JAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m5c\|1m5c]], [[1p1o\|1p1o]], [[1mqh\|1mqh]], [[1lb8\|1lb8]], [[1p1u\|1p1u]], [[1mm7\|1mm7]], [[1nnp\|1nnp]], [[1m5d\|1m5d]], [[1syi\|1syi]], [[1p1q\|1p1q]], [[1mqd\|1mqd]], [[2i3w\|2i3w]], [[1p1w\|1p1w]], [[1mxu\|1mxu]], [[1my4\|1my4]], [[2i3v\|2i3v]], [[1n0t\|1n0t]], [[1mqi\|1mqi]], [[1ftk\|1ftk]], [[1my3\|1my3]], [[1fto\|1fto]], [[2anj\|2anj]], [[1mxv\|1mxv]], [[1p1n\|1p1n]], [[2xx9\|2xx9]], [[1ftj\|1ftj]], [[1syh\|1syh]], [[1m5e\|1m5e]], [[1lbb\|1lbb]], [[1fw0\|1fw0]], [[1mxz\|1mxz]], [[1mxy\|1mxy]], [[1mqg\|1mqg]], [[2xx8\|2xx8]], [[2aix\|2aix]], [[1m5b\|1m5b]], [[1mxw\|1mxw]], [[1ms7\|1ms7]], [[2xx7\|2xx7]], [[2xxh\|2xxh]], [[1my0\|1my0]], [[1m5f\|1m5f]], [[1xhy\|1xhy]], [[1my1\|1my1]], [[1mm6\|1mm6]], [[2cmo\|2cmo]], [[2uxa\|2uxa]], [[1ftl\|1ftl]], [[1mxx\|1mxx]], [[2al4\|2al4]], [[1wvj\|1wvj]], [[1ftm\|1ftm]], [[1lb9\|1lb9]], [[1lbc\|1lbc]], [[1nnk\|1nnk]], [[1my2\|1my2]], [[1mqj\|1mqj]], [[2al5\|2al5]], [[1gr2\|1gr2]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=JAC:1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE'>JAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [https://pdbe.org/2xxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [https://www.ebi.ac.uk/pdbsum/2xxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [https://pdbe.org/2xxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [https://www.ebi.ac.uk/pdbsum/2xxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>	+	[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aldegheri, L]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Austin~~, N E~~]]	+	[[Category: Aldegheri L]]
-	[[Category: Ballantine, S]]	+	[[Category: Austin NE]]
-	[[Category: Ballini, E]]	+	[[Category: Ballantine S]]
-	[[Category: Bax~~, B D~~]]	+	[[Category: Ballini E]]
-	[[Category: Bradley~~, D M~~]]	+	[[Category: Bax BD]]
-	[[Category: Clarke~~, B P~~]]	+	[[Category: Bradley DM]]
-	[[Category: DalNegro, G]]	+	[[Category: Clarke BP]]
-	[[Category: Harries, M]]	+	[[Category: DalNegro G]]
-	[[Category: Harris~~, A J~~]]	+	[[Category: Harries M]]
-	[[Category: Harrison~~, S A~~]]	+	[[Category: Harris AJ]]
-	[[Category: Melarange~~, R A~~]]	+	[[Category: Harrison SA]]
-	[[Category: Mookherjee, C]]	+	[[Category: Melarange RA]]
-	[[Category: Mosley, J]]	+	[[Category: Mookherjee C]]
-	[[Category: Oliosi, B]]	+	[[Category: Mosley J]]
-	[[Category: Smith~~, K J~~]]	+	[[Category: Oliosi B]]
-	[[Category: Thewlis~~, K M~~]]	+	[[Category: Smith KJ]]
-	[[Category: Ward~~, S E~~]]	+	[[Category: Thewlis KM]]
-	[[Category: Woollard~~, P M~~]]	+	[[Category: Ward SE]]
-	[[Category: Yusaf~~, S P]]~~	+	[[Category: Woollard PM]]
-	~~[[Category: Ampa receptor ligand-binding core]]~~	+	[[Category: Yusaf SP]]
-	~~[[Category: Ion channel]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 12:19, 27 April 2022

OCA — Wed, 27 Apr 2022 12:19:07 GMT

←Older revision		Revision as of 12:19, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xxi' size='340' side='right'caption='[[2xxi]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2xxi' size='340' side='right'caption='[[2xxi]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xxi]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XXI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xxi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XXI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=JAC:1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE'>JAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=JAC:1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE'>JAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m5c\|1m5c]], [[1p1o\|1p1o]], [[1mqh\|1mqh]], [[1lb8\|1lb8]], [[1p1u\|1p1u]], [[1mm7\|1mm7]], [[1nnp\|1nnp]], [[1m5d\|1m5d]], [[1syi\|1syi]], [[1p1q\|1p1q]], [[1mqd\|1mqd]], [[2i3w\|2i3w]], [[1p1w\|1p1w]], [[1mxu\|1mxu]], [[1my4\|1my4]], [[2i3v\|2i3v]], [[1n0t\|1n0t]], [[1mqi\|1mqi]], [[1ftk\|1ftk]], [[1my3\|1my3]], [[1fto\|1fto]], [[2anj\|2anj]], [[1mxv\|1mxv]], [[1p1n\|1p1n]], [[2xx9\|2xx9]], [[1ftj\|1ftj]], [[1syh\|1syh]], [[1m5e\|1m5e]], [[1lbb\|1lbb]], [[1fw0\|1fw0]], [[1mxz\|1mxz]], [[1mxy\|1mxy]], [[1mqg\|1mqg]], [[2xx8\|2xx8]], [[2aix\|2aix]], [[1m5b\|1m5b]], [[1mxw\|1mxw]], [[1ms7\|1ms7]], [[2xx7\|2xx7]], [[2xxh\|2xxh]], [[1my0\|1my0]], [[1m5f\|1m5f]], [[1xhy\|1xhy]], [[1my1\|1my1]], [[1mm6\|1mm6]], [[2cmo\|2cmo]], [[2uxa\|2uxa]], [[1ftl\|1ftl]], [[1mxx\|1mxx]], [[2al4\|2al4]], [[1wvj\|1wvj]], [[1ftm\|1ftm]], [[1lb9\|1lb9]], [[1lbc\|1lbc]], [[1nnk\|1nnk]], [[1my2\|1my2]], [[1mqj\|1mqj]], [[2al5\|2al5]], [[1gr2\|1gr2]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m5c\|1m5c]], [[1p1o\|1p1o]], [[1mqh\|1mqh]], [[1lb8\|1lb8]], [[1p1u\|1p1u]], [[1mm7\|1mm7]], [[1nnp\|1nnp]], [[1m5d\|1m5d]], [[1syi\|1syi]], [[1p1q\|1p1q]], [[1mqd\|1mqd]], [[2i3w\|2i3w]], [[1p1w\|1p1w]], [[1mxu\|1mxu]], [[1my4\|1my4]], [[2i3v\|2i3v]], [[1n0t\|1n0t]], [[1mqi\|1mqi]], [[1ftk\|1ftk]], [[1my3\|1my3]], [[1fto\|1fto]], [[2anj\|2anj]], [[1mxv\|1mxv]], [[1p1n\|1p1n]], [[2xx9\|2xx9]], [[1ftj\|1ftj]], [[1syh\|1syh]], [[1m5e\|1m5e]], [[1lbb\|1lbb]], [[1fw0\|1fw0]], [[1mxz\|1mxz]], [[1mxy\|1mxy]], [[1mqg\|1mqg]], [[2xx8\|2xx8]], [[2aix\|2aix]], [[1m5b\|1m5b]], [[1mxw\|1mxw]], [[1ms7\|1ms7]], [[2xx7\|2xx7]], [[2xxh\|2xxh]], [[1my0\|1my0]], [[1m5f\|1m5f]], [[1xhy\|1xhy]], [[1my1\|1my1]], [[1mm6\|1mm6]], [[2cmo\|2cmo]], [[2uxa\|2uxa]], [[1ftl\|1ftl]], [[1mxx\|1mxx]], [[2al4\|2al4]], [[1wvj\|1wvj]], [[1ftm\|1ftm]], [[1lb9\|1lb9]], [[1lbc\|1lbc]], [[1nnk\|1nnk]], [[1my2\|1my2]], [[1mqj\|1mqj]], [[2al5\|2al5]], [[1gr2\|1gr2]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [~~http~~://pdbe.org/2xxi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xxi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [https://pdbe.org/2xxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [https://www.ebi.ac.uk/pdbsum/2xxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>	+	[[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:25, 22 July 2020

OCA — Wed, 22 Jul 2020 12:25:08 GMT

←Older revision		Revision as of 12:25, 22 July 2020
Line 1:		Line 1:

	==Crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3- c(pyrazol-1(4H)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.6A resolution.==		==Crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3- c(pyrazol-1(4H)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.6A resolution.==
-	<StructureSection load='2xxi' size='340' side='right' caption='[[2xxi]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='2xxi' size='340' side='right'caption='[[2xxi]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xxi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XXI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xxi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XXI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=JAC:1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE'>JAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=JAC:1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE'>JAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m5c\|1m5c]], [[1p1o\|1p1o]], [[1mqh\|1mqh]], [[1lb8\|1lb8]], [[1p1u\|1p1u]], [[1mm7\|1mm7]], [[1nnp\|1nnp]], [[1m5d\|1m5d]], [[1syi\|1syi]], [[1p1q\|1p1q]], [[1mqd\|1mqd]], [[2i3w\|2i3w]], [[1p1w\|1p1w]], [[1mxu\|1mxu]], [[1my4\|1my4]], [[2i3v\|2i3v]], [[1n0t\|1n0t]], [[1mqi\|1mqi]], [[1ftk\|1ftk]], [[1my3\|1my3]], [[1fto\|1fto]], [[2anj\|2anj]], [[1mxv\|1mxv]], [[1p1n\|1p1n]], [[2xx9\|2xx9]], [[1ftj\|1ftj]], [[1syh\|1syh]], [[1m5e\|1m5e]], [[1lbb\|1lbb]], [[1fw0\|1fw0]], [[1mxz\|1mxz]], [[1mxy\|1mxy]], [[1mqg\|1mqg]], [[2xx8\|2xx8]], [[2aix\|2aix]], [[1m5b\|1m5b]], [[1mxw\|1mxw]], [[1ms7\|1ms7]], [[2xx7\|2xx7]], [[2xxh\|2xxh]], [[1my0\|1my0]], [[1m5f\|1m5f]], [[1xhy\|1xhy]], [[1my1\|1my1]], [[1mm6\|1mm6]], [[2cmo\|2cmo]], [[2uxa\|2uxa]], [[1ftl\|1ftl]], [[1mxx\|1mxx]], [[2al4\|2al4]], [[1wvj\|1wvj]], [[1ftm\|1ftm]], [[1lb9\|1lb9]], [[1lbc\|1lbc]], [[1nnk\|1nnk]], [[1my2\|1my2]], [[1mqj\|1mqj]], [[2al5\|2al5]], [[1gr2\|1gr2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m5c\|1m5c]], [[1p1o\|1p1o]], [[1mqh\|1mqh]], [[1lb8\|1lb8]], [[1p1u\|1p1u]], [[1mm7\|1mm7]], [[1nnp\|1nnp]], [[1m5d\|1m5d]], [[1syi\|1syi]], [[1p1q\|1p1q]], [[1mqd\|1mqd]], [[2i3w\|2i3w]], [[1p1w\|1p1w]], [[1mxu\|1mxu]], [[1my4\|1my4]], [[2i3v\|2i3v]], [[1n0t\|1n0t]], [[1mqi\|1mqi]], [[1ftk\|1ftk]], [[1my3\|1my3]], [[1fto\|1fto]], [[2anj\|2anj]], [[1mxv\|1mxv]], [[1p1n\|1p1n]], [[2xx9\|2xx9]], [[1ftj\|1ftj]], [[1syh\|1syh]], [[1m5e\|1m5e]], [[1lbb\|1lbb]], [[1fw0\|1fw0]], [[1mxz\|1mxz]], [[1mxy\|1mxy]], [[1mqg\|1mqg]], [[2xx8\|2xx8]], [[2aix\|2aix]], [[1m5b\|1m5b]], [[1mxw\|1mxw]], [[1ms7\|1ms7]], [[2xx7\|2xx7]], [[2xxh\|2xxh]], [[1my0\|1my0]], [[1m5f\|1m5f]], [[1xhy\|1xhy]], [[1my1\|1my1]], [[1mm6\|1mm6]], [[2cmo\|2cmo]], [[2uxa\|2uxa]], [[1ftl\|1ftl]], [[1mxx\|1mxx]], [[2al4\|2al4]], [[1wvj\|1wvj]], [[1ftm\|1ftm]], [[1lb9\|1lb9]], [[1lbc\|1lbc]], [[1nnk\|1nnk]], [[1my2\|1my2]], [[1mqj\|1mqj]], [[2al5\|2al5]], [[1gr2\|1gr2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [http://pdbe.org/2xxi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [http://www.ebi.ac.uk/pdbsum/2xxi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxi ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [http://pdbe.org/2xxi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [http://www.ebi.ac.uk/pdbsum/2xxi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[~~Ionotropic~~ Glutamate ~~Receptors~~\|~~Ionotropic~~ Glutamate ~~Receptors~~]]	+	*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Aldegheri, L]]		[[Category: Aldegheri, L]]
	[[Category: Austin, N E]]		[[Category: Austin, N E]]

OCA at 09:20, 10 October 2018

OCA — Wed, 10 Oct 2018 09:20:42 GMT

←Older revision		Revision as of 09:20, 10 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF~~ 1-((4-(3-(~~TRIFLUOROMETHYL~~)-6,7-~~DIHYDROPYRANO~~(4,3 -C(~~PYRAZOL~~-1(4H)-YL)~~PHENYL~~)~~METHYL~~)-2-~~PYRROLIDINONE IN COMPLEX WITH THE LIGAND BINDING DOMAIN OF THE RAT GLUA2 RECEPTOR AND GLUTAMATE AT~~ 1.6A ~~RESOLUTION~~.==	+	==Crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3- c(pyrazol-1(4H)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.6A resolution.==
	<StructureSection load='2xxi' size='340' side='right' caption='[[2xxi]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2xxi' size='340' side='right' caption='[[2xxi]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 34:		Line 34:
	[[Category: Bradley, D M]]		[[Category: Bradley, D M]]
	[[Category: Clarke, B P]]		[[Category: Clarke, B P]]
-	[[Category: ~~Dalnegro~~, G]]	+	[[Category: DalNegro, G]]
	[[Category: Harries, M]]		[[Category: Harries, M]]
	[[Category: Harris, A J]]		[[Category: Harris, A J]]

OCA at 17:30, 4 August 2016

OCA — Thu, 04 Aug 2016 17:30:26 GMT

←Older revision		Revision as of 17:30, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF 1-((4-(3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO(4,3 -C(PYRAZOL-1(4H)-YL)PHENYL)METHYL)-2-PYRROLIDINONE IN COMPLEX WITH THE LIGAND BINDING DOMAIN OF THE RAT GLUA2 RECEPTOR AND GLUTAMATE AT 1.6A RESOLUTION.==		==CRYSTAL STRUCTURE OF 1-((4-(3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO(4,3 -C(PYRAZOL-1(4H)-YL)PHENYL)METHYL)-2-PYRROLIDINONE IN COMPLEX WITH THE LIGAND BINDING DOMAIN OF THE RAT GLUA2 RECEPTOR AND GLUTAMATE AT 1.6A RESOLUTION.==
	<StructureSection load='2xxi' size='340' side='right' caption='[[2xxi]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2xxi' size='340' side='right' caption='[[2xxi]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xxi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XXI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xxi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XXI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=JAC:1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE'>JAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=JAC:1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE'>JAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m5c\|1m5c]], [[1p1o\|1p1o]], [[1mqh\|1mqh]], [[1lb8\|1lb8]], [[1p1u\|1p1u]], [[1mm7\|1mm7]], [[1nnp\|1nnp]], [[1m5d\|1m5d]], [[1syi\|1syi]], [[1p1q\|1p1q]], [[1mqd\|1mqd]], [[2i3w\|2i3w]], [[1p1w\|1p1w]], [[1mxu\|1mxu]], [[1my4\|1my4]], [[2i3v\|2i3v]], [[1n0t\|1n0t]], [[1mqi\|1mqi]], [[1ftk\|1ftk]], [[1my3\|1my3]], [[1fto\|1fto]], [[2anj\|2anj]], [[1mxv\|1mxv]], [[1p1n\|1p1n]], [[2xx9\|2xx9]], [[1ftj\|1ftj]], [[1syh\|1syh]], [[1m5e\|1m5e]], [[1lbb\|1lbb]], [[1fw0\|1fw0]], [[1mxz\|1mxz]], [[1mxy\|1mxy]], [[1mqg\|1mqg]], [[2xx8\|2xx8]], [[2aix\|2aix]], [[1m5b\|1m5b]], [[1mxw\|1mxw]], [[1ms7\|1ms7]], [[2xx7\|2xx7]], [[2xxh\|2xxh]], [[1my0\|1my0]], [[1m5f\|1m5f]], [[1xhy\|1xhy]], [[1my1\|1my1]], [[1mm6\|1mm6]], [[2cmo\|2cmo]], [[2uxa\|2uxa]], [[1ftl\|1ftl]], [[1mxx\|1mxx]], [[2al4\|2al4]], [[1wvj\|1wvj]], [[1ftm\|1ftm]], [[1lb9\|1lb9]], [[1lbc\|1lbc]], [[1nnk\|1nnk]], [[1my2\|1my2]], [[1mqj\|1mqj]], [[2al5\|2al5]], [[1gr2\|1gr2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m5c\|1m5c]], [[1p1o\|1p1o]], [[1mqh\|1mqh]], [[1lb8\|1lb8]], [[1p1u\|1p1u]], [[1mm7\|1mm7]], [[1nnp\|1nnp]], [[1m5d\|1m5d]], [[1syi\|1syi]], [[1p1q\|1p1q]], [[1mqd\|1mqd]], [[2i3w\|2i3w]], [[1p1w\|1p1w]], [[1mxu\|1mxu]], [[1my4\|1my4]], [[2i3v\|2i3v]], [[1n0t\|1n0t]], [[1mqi\|1mqi]], [[1ftk\|1ftk]], [[1my3\|1my3]], [[1fto\|1fto]], [[2anj\|2anj]], [[1mxv\|1mxv]], [[1p1n\|1p1n]], [[2xx9\|2xx9]], [[1ftj\|1ftj]], [[1syh\|1syh]], [[1m5e\|1m5e]], [[1lbb\|1lbb]], [[1fw0\|1fw0]], [[1mxz\|1mxz]], [[1mxy\|1mxy]], [[1mqg\|1mqg]], [[2xx8\|2xx8]], [[2aix\|2aix]], [[1m5b\|1m5b]], [[1mxw\|1mxw]], [[1ms7\|1ms7]], [[2xx7\|2xx7]], [[2xxh\|2xxh]], [[1my0\|1my0]], [[1m5f\|1m5f]], [[1xhy\|1xhy]], [[1my1\|1my1]], [[1mm6\|1mm6]], [[2cmo\|2cmo]], [[2uxa\|2uxa]], [[1ftl\|1ftl]], [[1mxx\|1mxx]], [[2al4\|2al4]], [[1wvj\|1wvj]], [[1ftm\|1ftm]], [[1lb9\|1lb9]], [[1lbc\|1lbc]], [[1nnk\|1nnk]], [[1my2\|1my2]], [[1mqj\|1mqj]], [[2al5\|2al5]], [[1gr2\|1gr2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [http://www.ebi.ac.uk/pdbsum/2xxi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [http://pdbe.org/2xxi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [http://www.ebi.ac.uk/pdbsum/2xxi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xxi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Aldegheri, L]]		[[Category: Aldegheri, L]]
	[[Category: Austin, N E]]		[[Category: Austin, N E]]

OCA at 11:25, 25 December 2014

OCA — Thu, 25 Dec 2014 11:25:36 GMT

←Older revision		Revision as of 11:25, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [http://www.ebi.ac.uk/pdbsum/2xxi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [http://www.ebi.ac.uk/pdbsum/2xxi PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Aldegheri, L.]]	+	[[Category: Aldegheri, L]]
-	[[Category: Austin, N E.]]	+	[[Category: Austin, N E]]
-	[[Category: Ballantine, S.]]	+	[[Category: Ballantine, S]]
-	[[Category: Ballini, E.]]	+	[[Category: Ballini, E]]
-	[[Category: Bax, B D.]]	+	[[Category: Bax, B D]]
-	[[Category: Bradley, D M.]]	+	[[Category: Bradley, D M]]
-	[[Category: Clarke, B P.]]	+	[[Category: Clarke, B P]]
-	[[Category: Dalnegro, G.]]	+	[[Category: Dalnegro, G]]
-	[[Category: Harries, M.]]	+	[[Category: Harries, M]]
-	[[Category: Harris, A J.]]	+	[[Category: Harris, A J]]
-	[[Category: Harrison, S A.]]	+	[[Category: Harrison, S A]]
-	[[Category: Melarange, R A.]]	+	[[Category: Melarange, R A]]
-	[[Category: Mookherjee, C.]]	+	[[Category: Mookherjee, C]]
-	[[Category: Mosley, J.]]	+	[[Category: Mosley, J]]
-	[[Category: Oliosi, B.]]	+	[[Category: Oliosi, B]]
-	[[Category: Smith, K J.]]	+	[[Category: Smith, K J]]
-	[[Category: Thewlis, K M.]]	+	[[Category: Thewlis, K M]]
-	[[Category: Ward, S E.]]	+	[[Category: Ward, S E]]
-	[[Category: Woollard, P M.]]	+	[[Category: Woollard, P M]]
-	[[Category: Yusaf, S P.]]	+	[[Category: Yusaf, S P]]
	[[Category: Ampa receptor ligand-binding core]]		[[Category: Ampa receptor ligand-binding core]]
	[[Category: Ion channel]]		[[Category: Ion channel]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 12:56, 22 October 2014

OCA — Wed, 22 Oct 2014 12:56:00 GMT

←Older revision		Revision as of 12:56, 22 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xxi.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE OF 1-((4-(3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO(4,3 -C(PYRAZOL-1(4H)-YL)PHENYL)METHYL)-2-PYRROLIDINONE IN COMPLEX WITH THE LIGAND BINDING DOMAIN OF THE RAT GLUA2 RECEPTOR AND GLUTAMATE AT 1.6A RESOLUTION.==
		+	<StructureSection load='2xxi' size='340' side='right' caption='[[2xxi]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xxi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XXI FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=JAC:1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE'>JAC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m5c\|1m5c]], [[1p1o\|1p1o]], [[1mqh\|1mqh]], [[1lb8\|1lb8]], [[1p1u\|1p1u]], [[1mm7\|1mm7]], [[1nnp\|1nnp]], [[1m5d\|1m5d]], [[1syi\|1syi]], [[1p1q\|1p1q]], [[1mqd\|1mqd]], [[2i3w\|2i3w]], [[1p1w\|1p1w]], [[1mxu\|1mxu]], [[1my4\|1my4]], [[2i3v\|2i3v]], [[1n0t\|1n0t]], [[1mqi\|1mqi]], [[1ftk\|1ftk]], [[1my3\|1my3]], [[1fto\|1fto]], [[2anj\|2anj]], [[1mxv\|1mxv]], [[1p1n\|1p1n]], [[2xx9\|2xx9]], [[1ftj\|1ftj]], [[1syh\|1syh]], [[1m5e\|1m5e]], [[1lbb\|1lbb]], [[1fw0\|1fw0]], [[1mxz\|1mxz]], [[1mxy\|1mxy]], [[1mqg\|1mqg]], [[2xx8\|2xx8]], [[2aix\|2aix]], [[1m5b\|1m5b]], [[1mxw\|1mxw]], [[1ms7\|1ms7]], [[2xx7\|2xx7]], [[2xxh\|2xxh]], [[1my0\|1my0]], [[1m5f\|1m5f]], [[1xhy\|1xhy]], [[1my1\|1my1]], [[1mm6\|1mm6]], [[2cmo\|2cmo]], [[2uxa\|2uxa]], [[1ftl\|1ftl]], [[1mxx\|1mxx]], [[2al4\|2al4]], [[1wvj\|1wvj]], [[1ftm\|1ftm]], [[1lb9\|1lb9]], [[1lbc\|1lbc]], [[1nnk\|1nnk]], [[1my2\|1my2]], [[1mqj\|1mqj]], [[2al5\|2al5]], [[1gr2\|1gr2]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xxi RCSB], [http://www.ebi.ac.uk/pdbsum/2xxi PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel series of AMPAR positive modulators is described that were identified by high throughput screening. The molecules of the series have been optimized from a high quality starting point hit to afford excellent developability, tolerability, and efficacy profiles, leading to identification of a clinical candidate. Unusually for an ion channel target, this optimization was integrated with regular generation of ligand-bound crystal structures and uncovered a novel chemotype with a unique and highly conserved mode of interaction via a trifluoromethyl group.

-	~~{{STRUCTURE_2xxi\| PDB=2xxi \| SCENE= }}~~	+	Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators.,Ward SE, Harries M, Aldegheri L, Austin NE, Ballantine S, Ballini E, Bradley DM, Bax BD, Clarke BP, Harris AJ, Harrison SA, Melarange RA, Mookherjee C, Mosley J, Dal Negro G, Oliosi B, Smith KJ, Thewlis KM, Woollard PM, Yusaf SP J Med Chem. 2010 Dec 3. PMID:21128618<ref>PMID:21128618</ref>

-	~~===CRYSTAL STRUCTURE OF 1-((4-(3-(TRIFLUOROMETHYL)-6~~,~~7-DIHYDROPYRANO(4,3 -C(PYRAZOL-1(4H)-YL)PHENYL)METHYL)-2-PYRROLIDINONE IN COMPLEX WITH THE LIGAND BINDING DOMAIN OF THE RAT GLUA2 RECEPTOR AND GLUTAMATE AT 1.6A RESOLUTION.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21128618}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xxi]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA].~~	+

	==See Also==		==See Also==
	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]		*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021128618<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Aldegheri, L.]]		[[Category: Aldegheri, L.]]

OCA at 16:08, 20 October 2012

OCA — Sat, 20 Oct 2012 16:08:42 GMT

←Older revision		Revision as of 16:08, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xxi]] is a 3 chain structure ~~of [[Ionotropic Glutamate Receptors]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA].	+	[[2xxi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA].

	==See Also==		==See Also==

OCA at 20:44, 26 July 2012

OCA — Thu, 26 Jul 2012 20:44:27 GMT

←Older revision		Revision as of 20:44, 26 July 2012
Line 1:		Line 1:
	[[Image:2xxi.png\|left\|200px]]		[[Image:2xxi.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xxi", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xxi\| PDB=2xxi \| SCENE= }}		{{STRUCTURE_2xxi\| PDB=2xxi \| SCENE= }}

	===CRYSTAL STRUCTURE OF 1-((4-(3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO(4,3 -C(PYRAZOL-1(4H)-YL)PHENYL)METHYL)-2-PYRROLIDINONE IN COMPLEX WITH THE LIGAND BINDING DOMAIN OF THE RAT GLUA2 RECEPTOR AND GLUTAMATE AT 1.6A RESOLUTION.===		===CRYSTAL STRUCTURE OF 1-((4-(3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO(4,3 -C(PYRAZOL-1(4H)-YL)PHENYL)METHYL)-2-PYRROLIDINONE IN COMPLEX WITH THE LIGAND BINDING DOMAIN OF THE RAT GLUA2 RECEPTOR AND GLUTAMATE AT 1.6A RESOLUTION.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21128618}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21128618 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21128618}}		{{ABSTRACT_PUBMED_21128618}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Ionotropic Glutamate Receptors]]	+	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]

	==Reference==		==Reference==

OCA at 04:50, 28 September 2011

OCA — Wed, 28 Sep 2011 04:50:19 GMT

←Older revision		Revision as of 04:50, 28 September 2011
Line 1:		Line 1:
-	[[Image:2xxi.~~jpg~~\|left\|200px]]	+	[[Image:2xxi.png\|left\|200px]]

	<!--		<!--
Line 19:		Line 19:

	==About this Structure==		==About this Structure==
-	[[2xxi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA].	+	[[2xxi]] is a 3 chain structure of [[Ionotropic Glutamate Receptors]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXI OCA].
		+
		+	==See Also==
		+	*[[Ionotropic Glutamate Receptors]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21128618~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021128618</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Aldegheri, L.]]		[[Category: Aldegheri, L.]]
Line 44:		Line 47:
	[[Category: Woollard, P M.]]		[[Category: Woollard, P M.]]
	[[Category: Yusaf, S P.]]		[[Category: Yusaf, S P.]]
		+	[[Category: Ampa receptor ligand-binding core]]
		+	[[Category: Ion channel]]
		+	[[Category: Transport protein]]