2xxw - Revision history

OCA at 10:41, 20 December 2023

OCA — Wed, 20 Dec 2023 10:41:14 GMT

←Older revision		Revision as of 10:41, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xxw' size='340' side='right'caption='[[2xxw]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2xxw' size='340' side='right'caption='[[2xxw]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xxw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xxw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XXW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2i0c\|2i0c]]~~, ~~[[1tt1\|1tt1]], [[1s7y\|1s7y]], [[2i0b\|2i0b]], [[1s9t\|1s9t]], [[2xxy\|2xxy]], [[1yae\|1yae]], [[2xxr\|2xxr]], [[2xxx\|2xxx]], [[1s50\|1s50]], [[1sd3\|1sd3]], [[2xxu\|2xxu]], [[2xxt\|2xxt]], [[2xxv\|2xxv]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxw OCA], [https://pdbe.org/2xxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xxw RCSB], [https://www.ebi.ac.uk/pdbsum/2xxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxw OCA], [https://pdbe.org/2xxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xxw RCSB], [https://www.ebi.ac.uk/pdbsum/2xxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>	+	[https://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Green, T~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Mayans, O~~]]	+	[[Category: Green T]]
-	[[Category: ~~Nayeem, N~~]]	+	[[Category: Mayans O]]
-	[[Category: ~~Transport protein~~]]	+	[[Category: Nayeem N]]

OCA at 05:25, 10 August 2022

OCA — Wed, 10 Aug 2022 05:25:42 GMT

←Older revision		Revision as of 05:25, 10 August 2022
Line 3:		Line 3:
	<StructureSection load='2xxw' size='340' side='right'caption='[[2xxw]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2xxw' size='340' side='right'caption='[[2xxw]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xxw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xxw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XXW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i0c\|2i0c]], [[1tt1\|1tt1]], [[1s7y\|1s7y]], [[2i0b\|2i0b]], [[1s9t\|1s9t]], [[2xxy\|2xxy]], [[1yae\|1yae]], [[2xxr\|2xxr]], [[2xxx\|2xxx]], [[1s50\|1s50]], [[1sd3\|1sd3]], [[2xxu\|2xxu]], [[2xxt\|2xxt]], [[2xxv\|2xxv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2i0c\|2i0c]], [[1tt1\|1tt1]], [[1s7y\|1s7y]], [[2i0b\|2i0b]], [[1s9t\|1s9t]], [[2xxy\|2xxy]], [[1yae\|1yae]], [[2xxr\|2xxr]], [[2xxx\|2xxx]], [[1s50\|1s50]], [[1sd3\|1sd3]], [[2xxu\|2xxu]], [[2xxt\|2xxt]], [[2xxv\|2xxv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxw OCA], [~~http~~://pdbe.org/2xxw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xxw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xxw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxw OCA], [https://pdbe.org/2xxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xxw RCSB], [https://www.ebi.ac.uk/pdbsum/2xxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>	+	[[https://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:03, 4 November 2020

OCA — Wed, 04 Nov 2020 08:03:39 GMT

←Older revision		Revision as of 08:03, 4 November 2020
Line 1:		Line 1:

	==Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate==		==Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate==
-	<StructureSection load='2xxw' size='340' side='right' caption='[[2xxw]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2xxw' size='340' side='right'caption='[[2xxw]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xxw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xxw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XXW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i0c\|2i0c]], [[1tt1\|1tt1]], [[1s7y\|1s7y]], [[2i0b\|2i0b]], [[1s9t\|1s9t]], [[2xxy\|2xxy]], [[1yae\|1yae]], [[2xxr\|2xxr]], [[2xxx\|2xxx]], [[1s50\|1s50]], [[1sd3\|1sd3]], [[2xxu\|2xxu]], [[2xxt\|2xxt]], [[2xxv\|2xxv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i0c\|2i0c]], [[1tt1\|1tt1]], [[1s7y\|1s7y]], [[2i0b\|2i0b]], [[1s9t\|1s9t]], [[2xxy\|2xxy]], [[1yae\|1yae]], [[2xxr\|2xxr]], [[2xxx\|2xxx]], [[1s50\|1s50]], [[1sd3\|1sd3]], [[2xxu\|2xxu]], [[2xxt\|2xxt]], [[2xxv\|2xxv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxw OCA], [http://pdbe.org/2xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xxw RCSB], [http://www.ebi.ac.uk/pdbsum/2xxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxw OCA], [http://pdbe.org/2xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xxw RCSB], [http://www.ebi.ac.uk/pdbsum/2xxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[~~Ionotropic~~ Glutamate ~~Receptors~~\|~~Ionotropic~~ Glutamate ~~Receptors~~]]	+	*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Green, T]]		[[Category: Green, T]]
	[[Category: Mayans, O]]		[[Category: Mayans, O]]
	[[Category: Nayeem, N]]		[[Category: Nayeem, N]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 22:13, 4 August 2016

OCA — Thu, 04 Aug 2016 22:13:07 GMT

←Older revision		Revision as of 22:13, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate==		==Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate==
	<StructureSection load='2xxw' size='340' side='right' caption='[[2xxw]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2xxw' size='340' side='right' caption='[[2xxw]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xxw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xxw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XXW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i0c\|2i0c]], [[1tt1\|1tt1]], [[1s7y\|1s7y]], [[2i0b\|2i0b]], [[1s9t\|1s9t]], [[2xxy\|2xxy]], [[1yae\|1yae]], [[2xxr\|2xxr]], [[2xxx\|2xxx]], [[1s50\|1s50]], [[1sd3\|1sd3]], [[2xxu\|2xxu]], [[2xxt\|2xxt]], [[2xxv\|2xxv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i0c\|2i0c]], [[1tt1\|1tt1]], [[1s7y\|1s7y]], [[2i0b\|2i0b]], [[1s9t\|1s9t]], [[2xxy\|2xxy]], [[1yae\|1yae]], [[2xxr\|2xxr]], [[2xxx\|2xxx]], [[1s50\|1s50]], [[1sd3\|1sd3]], [[2xxu\|2xxu]], [[2xxt\|2xxt]], [[2xxv\|2xxv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xxw RCSB], [http://www.ebi.ac.uk/pdbsum/2xxw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxw OCA], [http://pdbe.org/2xxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xxw RCSB], [http://www.ebi.ac.uk/pdbsum/2xxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xxw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xxw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Green, T]]		[[Category: Green, T]]
	[[Category: Mayans, O]]		[[Category: Mayans, O]]
	[[Category: Nayeem, N]]		[[Category: Nayeem, N]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 20:08, 24 December 2014

OCA — Wed, 24 Dec 2014 20:08:24 GMT

←Older revision		Revision as of 20:08, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xxw RCSB], [http://www.ebi.ac.uk/pdbsum/2xxw PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xxw RCSB], [http://www.ebi.ac.uk/pdbsum/2xxw PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Green, T.]]	+	[[Category: Green, T]]
-	[[Category: Mayans, O.]]	+	[[Category: Mayans, O]]
-	[[Category: Nayeem, N.]]	+	[[Category: Nayeem, N]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 13:10, 22 October 2014

OCA — Wed, 22 Oct 2014 13:10:44 GMT

←Older revision		Revision as of 13:10, 22 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xxw.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate==
		+	<StructureSection load='2xxw' size='340' side='right' caption='[[2xxw]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xxw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XXW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2i0c\|2i0c]], [[1tt1\|1tt1]], [[1s7y\|1s7y]], [[2i0b\|2i0b]], [[1s9t\|1s9t]], [[2xxy\|2xxy]], [[1yae\|1yae]], [[2xxr\|2xxr]], [[2xxx\|2xxx]], [[1s50\|1s50]], [[1sd3\|1sd3]], [[2xxu\|2xxu]], [[2xxt\|2xxt]], [[2xxv\|2xxv]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xxw RCSB], [http://www.ebi.ac.uk/pdbsum/2xxw PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	AMPA- and kainate (KA)-selective ionotropic glutamate receptors (iGluRs) respond to agonist by opening (gating), then closing (desensitizing) in quick succession. Gating has been linked to agonist-induced changes within the ligand-binding domain (LBD), and desensitization to rearrangement of a dimer formed by neighboring LBDs. To explore the role of dimer conformation in both gating and desensitization, we compared the conformational effects of two kainate receptor mutants. The first, GluK2-D776K, blocks desensitization of macroscopic current responses ("macroscopic desensitization"). The second, GluK2-M770K, accelerates macroscopic desensitization and eliminates the effects of external ions on channel kinetics. Using structures determined by x-ray crystallography, we found that in both mutants the introduced lysines act as tethered cations, displacing sodium ions from their binding sites within the dimer interface. This results in new inter- and intra-protomer contacts in D776K and M770K respectively, explaining the effects of these mutations on dimer stability and desensitization kinetics. Further, chloride binding was unaffected by the M770K mutation, even though binding of sodium ions has been proposed to promote dimer stability by stabilizing anion binding. This suggests sodium binding may affect receptor function more directly than currently supposed. Notably, we also observed a ligand-specific shift in dimer conformation when comparing LBD dimers in complex with glutamate or the partial agonist KA, revealing a previously unidentified role for dimer orientation in iGluR gating.

-	~~{{STRUCTURE_2xxw\| PDB=2xxw \| SCENE= }}~~	+	Conformational flexibility of the ligand-binding domain dimer in kainate receptor gating and desensitization.,Nayeem N, Mayans O, Green T J Neurosci. 2011 Feb 23;31(8):2916-24. PMID:21414913<ref>PMID:21414913</ref>

-	~~===Crystal structure~~ of the ~~GluK2 (GluR6) D776K LBD dimer in complex with glutamate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21414913}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xxw]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA].~~	+

	==See Also==		==See Also==
	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]		*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021414913<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Green, T.]]		[[Category: Green, T.]]

OCA at 08:42, 20 October 2012

OCA — Sat, 20 Oct 2012 08:42:19 GMT

←Older revision		Revision as of 08:42, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2xxw]] is a 2 chain structure ~~of [[Ionotropic Glutamate Receptors]]~~ with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA].	+	[[2xxw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA].

	==See Also==		==See Also==

OCA at 20:29, 25 July 2012

OCA — Wed, 25 Jul 2012 20:29:22 GMT

←Older revision		Revision as of 20:29, 25 July 2012
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	[[Image:2xxw.png\|left\|200px]]		[[Image:2xxw.png\|left\|200px]]

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	{{STRUCTURE_2xxw\| PDB=2xxw \| SCENE= }}		{{STRUCTURE_2xxw\| PDB=2xxw \| SCENE= }}

	===Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate===		===Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate===

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OCA at 05:04, 4 April 2012

OCA — Wed, 04 Apr 2012 05:04:03 GMT

←Older revision		Revision as of 05:04, 4 April 2012
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	{{STRUCTURE_2xxw\| PDB=2xxw \| SCENE= }}		{{STRUCTURE_2xxw\| PDB=2xxw \| SCENE= }}

-	===~~CRYSTAL STRUCTURE OF THE GLUK2~~ (~~GLUR6~~) D776K LBD ~~DIMER IN COMPLEX WITH GLUTAMATE~~===	+	===Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate===

		+
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		+	The line below this paragraph, {{ABSTRACT_PUBMED_21414913}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21414913 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21414913}}

	==About this Structure==		==About this Structure==
-	[[2xxw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA].	+	[[2xxw]] is a 2 chain structure of [[Ionotropic Glutamate Receptors]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXW OCA].
		+
		+	==See Also==
		+	*[[Ionotropic Glutamate Receptors\|Ionotropic Glutamate Receptors]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021414913</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Green, T.]]		[[Category: Green, T.]]
	[[Category: Mayans, O.]]		[[Category: Mayans, O.]]
	[[Category: Nayeem, N.]]		[[Category: Nayeem, N.]]
		+	[[Category: Transport protein]]

OCA at 05:40, 9 March 2011

OCA — Wed, 09 Mar 2011 05:40:46 GMT

←Older revision		Revision as of 05:40, 9 March 2011
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-	[[Image:2xxw.~~jpg~~\|left\|200px]]	+	[[Image:2xxw.png\|left\|200px]]

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