2xz5 - Revision history

OCA at 10:42, 20 December 2023

OCA — Wed, 20 Dec 2023 10:42:05 GMT

←Older revision		Revision as of 10:42, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2xz5' size='340' side='right'caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2xz5' size='340' side='right'caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xz5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Aplca Aplca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xz5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XZ5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2xz6\|2xz6]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2xyt\|2xyt]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2xys\|2xys]], [[2xnv\|2xnv]], [[2byr\|2byr]], [[2bys\|2bys]], [[2byn\|2byn]], [[2xnt\|2xnt]], [[2w8e\|2w8e]], [[2wnj\|2wnj]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnu\|2xnu]]</div></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz5 OCA], [https://pdbe.org/2xz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz5 OCA], [https://pdbe.org/2xz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aplca~~]]	+	[[Category: Aplysia californica]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brams, M]]	+	[[Category: Brams M]]
-	[[Category: ~~Elk, R van~~]]	+	[[Category: Colon Saez J]]
-	[[Category: Gay~~, E A~~]]	+	[[Category: Gay EA]]
-	[[Category: Guskov, A]]	+	[[Category: Guskov A]]
-	[[Category: Peigneur, S]]	+	[[Category: Peigneur S]]
-	~~[[Category: Saez, J Colon]]~~	+	[[Category: Smit AB]]
-	~~[[Category: Schors, R C.van der~~]]	+	[[Category: Strelkov SV]]
-	[[Category: Smit~~, A B~~]]	+	[[Category: Tytgat J]]
-	[[Category: Strelkov~~, S V~~]]	+	[[Category: Ulens C]]
-	[[Category: Tytgat, J]]	+	[[Category: Yakel JL]]
-	[[Category: Ulens, C]]	+	[[Category: Van Elk R]]
-	[[Category: Yakel~~, J L~~]]	+	[[Category: Van der Schors RC]]
-	[[Category: ~~Amidation~~]]	+
-	[[Category: ~~Conformational flexibility]]~~	+
-	~~[[Category: Conotoxin]]~~	+
-	~~[[Category: Neurotoxinnicotinic]]~~	+
-	~~[[Category: Postsynaptic neurotoxin]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Receptor/toxin~~]]	+

OCA at 12:20, 27 April 2022

OCA — Wed, 27 Apr 2022 12:20:17 GMT

←Older revision		Revision as of 12:20, 27 April 2022
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	<StructureSection load='2xz5' size='340' side='right'caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2xz5' size='340' side='right'caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xz5]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xz5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XZ5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2xz6\|2xz6]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2xyt\|2xyt]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2xys\|2xys]], [[2xnv\|2xnv]], [[2byr\|2byr]], [[2bys\|2bys]], [[2byn\|2byn]], [[2xnt\|2xnt]], [[2w8e\|2w8e]], [[2wnj\|2wnj]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnu\|2xnu]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2xz6\|2xz6]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2xyt\|2xyt]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2xys\|2xys]], [[2xnv\|2xnv]], [[2byr\|2byr]], [[2bys\|2bys]], [[2byn\|2byn]], [[2xnt\|2xnt]], [[2w8e\|2w8e]], [[2wnj\|2wnj]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnu\|2xnu]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz5 OCA], [~~http~~://pdbe.org/2xz5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xz5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xz5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz5 OCA], [https://pdbe.org/2xz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:27, 22 July 2020

OCA — Wed, 22 Jul 2020 12:27:30 GMT

←Older revision		Revision as of 12:27, 22 July 2020
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	==MMTS-modified Y53C mutant of Aplysia AChBP in complex with acetylcholine==		==MMTS-modified Y53C mutant of Aplysia AChBP in complex with acetylcholine==
-	<StructureSection load='2xz5' size='340' side='right' caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2xz5' size='340' side='right'caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xz5]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xz5]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XZ5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2xz6\|2xz6]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2xyt\|2xyt]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2xys\|2xys]], [[2xnv\|2xnv]], [[2byr\|2byr]], [[2bys\|2bys]], [[2byn\|2byn]], [[2xnt\|2xnt]], [[2w8e\|2w8e]], [[2wnj\|2wnj]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnu\|2xnu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2xz6\|2xz6]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2xyt\|2xyt]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2xys\|2xys]], [[2xnv\|2xnv]], [[2byr\|2byr]], [[2bys\|2bys]], [[2byn\|2byn]], [[2xnt\|2xnt]], [[2w8e\|2w8e]], [[2wnj\|2wnj]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnu\|2xnu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz5 OCA], [http://pdbe.org/2xz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz5 OCA], [http://pdbe.org/2xz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]	+	*[[Acetylcholine binding protein 3D structures\|Acetylcholine binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Aplca]]		[[Category: Aplca]]
		+	[[Category: Large Structures]]
	[[Category: Brams, M]]		[[Category: Brams, M]]
	[[Category: Elk, R van]]		[[Category: Elk, R van]]

OCA at 09:39, 10 October 2018

OCA — Wed, 10 Oct 2018 09:39:45 GMT

←Older revision		Revision as of 09:39, 10 October 2018
Line 3:		Line 3:
	<StructureSection load='2xz5' size='340' side='right' caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2xz5' size='340' side='right' caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xz5]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xz5]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XZ5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Aplca]]
	[[Category: Brams, M]]		[[Category: Brams, M]]
	[[Category: Elk, R van]]		[[Category: Elk, R van]]

OCA at 11:44, 15 December 2016

OCA — Thu, 15 Dec 2016 11:44:01 GMT

←Older revision		Revision as of 11:44, 15 December 2016
Line 3:		Line 3:
	<StructureSection load='2xz5' size='340' side='right' caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2xz5' size='340' side='right' caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xz5]] is a 5 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XZ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xz5]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XZ5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aplca]]
	[[Category: Brams, M]]		[[Category: Brams, M]]
	[[Category: Elk, R van]]		[[Category: Elk, R van]]

OCA at 21:23, 11 August 2016

OCA — Thu, 11 Aug 2016 21:23:27 GMT

←Older revision		Revision as of 21:23, 11 August 2016
Line 1:		Line 1:
		+
	==MMTS-modified Y53C mutant of Aplysia AChBP in complex with acetylcholine==		==MMTS-modified Y53C mutant of Aplysia AChBP in complex with acetylcholine==
	<StructureSection load='2xz5' size='340' side='right' caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2xz5' size='340' side='right' caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2xz6\|2xz6]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2xyt\|2xyt]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2xys\|2xys]], [[2xnv\|2xnv]], [[2byr\|2byr]], [[2bys\|2bys]], [[2byn\|2byn]], [[2xnt\|2xnt]], [[2w8e\|2w8e]], [[2wnj\|2wnj]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnu\|2xnu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2xz6\|2xz6]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2xyt\|2xyt]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2xys\|2xys]], [[2xnv\|2xnv]], [[2byr\|2byr]], [[2bys\|2bys]], [[2byn\|2byn]], [[2xnt\|2xnt]], [[2w8e\|2w8e]], [[2wnj\|2wnj]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnu\|2xnu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz5 OCA], [http://pdbe.org/2xz5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xz5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:53, 20 January 2015

OCA — Tue, 20 Jan 2015 11:53:01 GMT

←Older revision		Revision as of 11:53, 20 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_2xz5\| PDB=2xz5 \| SCENE= }}~~	+	==MMTS-modified Y53C mutant of Aplysia AChBP in complex with acetylcholine==
-	===MMTS-modified Y53C mutant of Aplysia AChBP in complex with acetylcholine===	+	<StructureSection load='2xz5' size='340' side='right' caption='[[2xz5]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21115477}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xz5]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XZ5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wn9\|2wn9]], [[2w8f\|2w8f]], [[2xz6\|2xz6]], [[2byp\|2byp]], [[2c9t\|2c9t]], [[2xyt\|2xyt]], [[2byq\|2byq]], [[2w8g\|2w8g]], [[2x00\|2x00]], [[2uz6\|2uz6]], [[2wnl\|2wnl]], [[2br7\|2br7]], [[2br8\|2br8]], [[2xys\|2xys]], [[2xnv\|2xnv]], [[2byr\|2byr]], [[2bys\|2bys]], [[2byn\|2byn]], [[2xnt\|2xnt]], [[2w8e\|2w8e]], [[2wnj\|2wnj]], [[2wzy\|2wzy]], [[2wnc\|2wnc]], [[2xnu\|2xnu]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xz5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz5 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Covalent modification of alpha7 W55C nicotinic acetylcholine receptors (nAChR) with the cysteine-modifying reagent MTSET(+) produces receptors that are unresponsive to acetylcholine, whereas MMTS produces enhanced acetylcholine-gated currents. Here, we investigate structural changes that underlie these opposite effects of MTSET(+) and MMTS using acetylcholine binding protein (AChBP), a homolog of the extracellular domain of the nAChR. Crystal structures of Y53C AChBP show that MTSET(+)-modification stabilizes loop C in an extended conformation that resembles the antagonist-bound state, which parallels our observation that MTSET(+) produces unresponsive W55C nAChRs. The MMTS-modified mutant in complex with acetylcholine is characterized by a contracted C loop, similar to other agonist-bound complexes. Surprisingly, we find two acetylcholine molecules bound in the ligand-binding site, which might explain the potentiating effect of MMTS-modification in W55C nAChRs. Unexpectedly, we observed in the MMTS-Y53C structure that ten phosphate ions arranged in two rings at adjacent sites are bound in the vestibule of AChBP. We mutated homologous residues in the vestibule of alpha1 GlyR and observed a reduction in the single channel conductance, suggesting a role of this site in ion permeation. Taken together, our results demonstrate that targeted modification of a conserved aromatic residue in loop D is sufficient for a conformational switch of AChBP and that a defined region in the vestibule of the extracellular domain contributes to ion conduction in anion-selective cys-loop receptors.

-	~~==About this Structure==~~	+	Crystal structures of a cysteine-modified mutant in loop D of acetylcholine binding protein.,Brams M, Gay EA, Saez JC, Guskov A, van Elk R, van der Schors RC, Peigneur S, Tytgat J, Strelkov SV, Smit AB, Yakel JL, Ulens C J Biol Chem. 2010 Nov 29. PMID:21115477<ref>PMID:21115477</ref>
-	~~[[2xz5]] is~~ a ~~5 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aplca Aplca]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2XZ5 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]		*[[Acetylcholine binding protein\|Acetylcholine binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021115477</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aplca]]		[[Category: Aplca]]
-	[[Category: Brams, M.]]	+	[[Category: Brams, M]]
-	[[Category: Elk, R van.]]	+	[[Category: Elk, R van]]
-	[[Category: Gay, E A.]]	+	[[Category: Gay, E A]]
-	[[Category: Guskov, A.]]	+	[[Category: Guskov, A]]
-	[[Category: Peigneur, S.]]	+	[[Category: Peigneur, S]]
-	[[Category: Saez, J Colon.]]	+	[[Category: Saez, J Colon]]
-	[[Category: Schors, R C.van der.]]	+	[[Category: Schors, R C.van der]]
-	[[Category: Smit, A B.]]	+	[[Category: Smit, A B]]
-	[[Category: Strelkov, S V.]]	+	[[Category: Strelkov, S V]]
-	[[Category: Tytgat, J.]]	+	[[Category: Tytgat, J]]
-	[[Category: Ulens, C.]]	+	[[Category: Ulens, C]]
-	[[Category: Yakel, J L.]]	+	[[Category: Yakel, J L]]
	[[Category: Amidation]]		[[Category: Amidation]]
	[[Category: Conformational flexibility]]		[[Category: Conformational flexibility]]

OCA at 09:27, 5 February 2014

OCA — Wed, 05 Feb 2014 09:27:12 GMT

←Older revision		Revision as of 09:27, 5 February 2014
Line 1:		Line 1:
-	[[Image:2xz5.png\|left\|200px]]
-
	{{STRUCTURE_2xz5\| PDB=2xz5 \| SCENE= }}		{{STRUCTURE_2xz5\| PDB=2xz5 \| SCENE= }}
-		+	===MMTS-modified Y53C mutant of Aplysia AChBP in complex with acetylcholine===
-	===MMTS-~~MODIFIED~~ Y53C ~~MUTANT OF APLYSIA ACHBP IN COMPLEX WITH ACETYLCHOLINE~~===	+
-		+
	{{ABSTRACT_PUBMED_21115477}}		{{ABSTRACT_PUBMED_21115477}}

	==About this Structure==		==About this Structure==
-	[[2xz5]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Aplysia_californica Aplysia californica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA].	+	[[2xz5]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplca Aplca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA].

	==See Also==		==See Also==
Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021115477</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021115477</ref><references group="xtra"/><references/>
-	[[Category: ~~Aplysia californica~~]]	+	[[Category: Aplca]]
	[[Category: Brams, M.]]		[[Category: Brams, M.]]
-	[[Category: Elk, R ~~Van~~.]]	+	[[Category: Elk, R van.]]
	[[Category: Gay, E A.]]		[[Category: Gay, E A.]]
	[[Category: Guskov, A.]]		[[Category: Guskov, A.]]
	[[Category: Peigneur, S.]]		[[Category: Peigneur, S.]]
	[[Category: Saez, J Colon.]]		[[Category: Saez, J Colon.]]
-	[[Category: Schors, R C.~~Van Der~~.]]	+	[[Category: Schors, R C.van der.]]
	[[Category: Smit, A B.]]		[[Category: Smit, A B.]]
	[[Category: Strelkov, S V.]]		[[Category: Strelkov, S V.]]

OCA at 22:36, 20 October 2012

OCA — Sat, 20 Oct 2012 22:36:12 GMT

←Older revision		Revision as of 22:36, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xz5]] is a 5 chain structure ~~of [[Acetylcholine binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA].	+	[[2xz5]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA].

	==See Also==		==See Also==

OCA at 16:52, 27 July 2012

OCA — Fri, 27 Jul 2012 16:52:07 GMT

←Older revision		Revision as of 16:52, 27 July 2012
Line 1:		Line 1:
	[[Image:2xz5.png\|left\|200px]]		[[Image:2xz5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xz5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xz5\| PDB=2xz5 \| SCENE= }}		{{STRUCTURE_2xz5\| PDB=2xz5 \| SCENE= }}

	===MMTS-MODIFIED Y53C MUTANT OF APLYSIA ACHBP IN COMPLEX WITH ACETYLCHOLINE===		===MMTS-MODIFIED Y53C MUTANT OF APLYSIA ACHBP IN COMPLEX WITH ACETYLCHOLINE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21115477}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21115477 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21115477}}		{{ABSTRACT_PUBMED_21115477}}

	==About this Structure==		==About this Structure==
-	[[2xz5]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA].	+	[[2xz5]] is a 5 chain structure of [[Acetylcholine binding protein]] with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ5 OCA].
		+
		+	==See Also==
		+	*[[Acetylcholine binding protein\|Acetylcholine binding protein]]

	==Reference==		==Reference==