2xz9 - Revision history

OCA at 08:46, 15 November 2023

OCA — Wed, 15 Nov 2023 08:46:50 GMT

←Older revision		Revision as of 08:46, 15 November 2023
Line 3:		Line 3:
	<StructureSection load='2xz9' size='340' side='right'caption='[[2xz9]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='2xz9' size='340' side='right'caption='[[2xz9]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xz9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~As_1~~.~~2430 As 1~~.~~2430~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XZ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xz9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XZ9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.677Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2bg5\|2bg5]], [[2xz7\|2xz7]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/Phosphoenolpyruvate--protein_phosphotransferase Phosphoenolpyruvate--protein phosphotransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.9 2.7.3.9] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz9 OCA], [https://pdbe.org/2xz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xz9 RCSB], [https://www.ebi.ac.uk/pdbsum/2xz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz9 OCA], [https://pdbe.org/2xz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xz9 RCSB], [https://www.ebi.ac.uk/pdbsum/2xz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~Q8R7R4_THETN Q8R7R4_THETN]~~] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).[PIRNR:PIRNR000732]	+	[https://www.uniprot.org/uniprot/Q8R7R4_CALS4 Q8R7R4_CALS4] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).[PIRNR:PIRNR000732]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~As 1 2430~~]]	+	[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphoenolpyruvate--protein phosphotransferase]]~~	+	[[Category: Baumann U]]
-	[[Category: Baumann, U]]	+	[[Category: Erni B]]
-	[[Category: Erni, B]]	+	[[Category: Oberholzer AE]]
-	[[Category: Oberholzer~~, A E~~]]	+	[[Category: Schneider P]]
-	[[Category: Schneider, P]]	+	[[Category: Waltersperger SM]]
-	[[Category: Waltersperger~~, S M]]~~	+
-	~~[[Category: Pep-utilising enzyme]]~~	+
-	~~[[Category: Thermophilic]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:20, 27 April 2022

OCA — Wed, 27 Apr 2022 12:20:20 GMT

←Older revision		Revision as of 12:20, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2xz9' size='340' side='right'caption='[[2xz9]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='2xz9' size='340' side='right'caption='[[2xz9]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xz9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/As_1.2430 As 1.2430]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XZ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xz9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/As_1.2430 As 1.2430]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XZ9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bg5\|2bg5]], [[2xz7\|2xz7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bg5\|2bg5]], [[2xz7\|2xz7]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphoenolpyruvate--protein_phosphotransferase Phosphoenolpyruvate--protein phosphotransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.9 2.7.3.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoenolpyruvate--protein_phosphotransferase Phosphoenolpyruvate--protein phosphotransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.9 2.7.3.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz9 OCA], [~~http~~://pdbe.org/2xz9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xz9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xz9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz9 OCA], [https://pdbe.org/2xz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xz9 RCSB], [https://www.ebi.ac.uk/pdbsum/2xz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q8R7R4_THETN Q8R7R4_THETN]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).[PIRNR:PIRNR000732]	+	[[https://www.uniprot.org/uniprot/Q8R7R4_THETN Q8R7R4_THETN]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).[PIRNR:PIRNR000732]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:27, 22 July 2020

OCA — Wed, 22 Jul 2020 12:27:48 GMT

←Older revision		Revision as of 12:27, 22 July 2020
Line 1:		Line 1:

	==CRYSTAL STRUCTURE FROM THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)==		==CRYSTAL STRUCTURE FROM THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)==
-	<StructureSection load='2xz9' size='340' side='right' caption='[[2xz9]], [[Resolution\|resolution]] 1.68Å' scene=''>	+	<StructureSection load='2xz9' size='340' side='right'caption='[[2xz9]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xz9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_1.2430 As 1.2430]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XZ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xz9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_1.2430 As 1.2430]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XZ9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bg5\|2bg5]], [[2xz7\|2xz7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bg5\|2bg5]], [[2xz7\|2xz7]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoenolpyruvate--protein_phosphotransferase Phosphoenolpyruvate--protein phosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.9 2.7.3.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoenolpyruvate--protein_phosphotransferase Phosphoenolpyruvate--protein phosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.9 2.7.3.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz9 OCA], [http://pdbe.org/2xz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xz9 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz9 OCA], [http://pdbe.org/2xz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xz9 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Phosphotransferase\|Phosphotransferase]]	+	*[[Phosphotransferase 3D structures\|Phosphotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: As 1 2430]]		[[Category: As 1 2430]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoenolpyruvate--protein phosphotransferase]]		[[Category: Phosphoenolpyruvate--protein phosphotransferase]]
	[[Category: Baumann, U]]		[[Category: Baumann, U]]

OCA at 16:27, 5 August 2016

OCA — Fri, 05 Aug 2016 16:27:36 GMT

←Older revision		Revision as of 16:27, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE FROM THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)==		==CRYSTAL STRUCTURE FROM THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)==
	<StructureSection load='2xz9' size='340' side='right' caption='[[2xz9]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='2xz9' size='340' side='right' caption='[[2xz9]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xz9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Caldanaerobacter_subterraneus_subsp~~.~~_tengcongensis Caldanaerobacter subterraneus subsp~~. ~~tengcongensis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XZ9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xz9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_1.2430 As 1.2430]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XZ9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bg5\|2bg5]], [[2xz7\|2xz7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bg5\|2bg5]], [[2xz7\|2xz7]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoenolpyruvate--protein_phosphotransferase Phosphoenolpyruvate--protein phosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.9 2.7.3.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoenolpyruvate--protein_phosphotransferase Phosphoenolpyruvate--protein phosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.9 2.7.3.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xz9 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz9 OCA], [http://pdbe.org/2xz9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xz9 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xz9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xz9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caldanaerobacter subterraneus subsp. tengcongensis~~]]	+	[[Category: As 1 2430]]
	[[Category: Phosphoenolpyruvate--protein phosphotransferase]]		[[Category: Phosphoenolpyruvate--protein phosphotransferase]]
	[[Category: Baumann, U]]		[[Category: Baumann, U]]

OCA at 03:59, 25 December 2014

OCA — Thu, 25 Dec 2014 03:59:24 GMT

←Older revision		Revision as of 03:59, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xz9 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xz9 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q8R7R4_THETN Q8R7R4_THETN]] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).[PIRNR:PIRNR000732]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 27:
	[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]		[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
	[[Category: Phosphoenolpyruvate--protein phosphotransferase]]		[[Category: Phosphoenolpyruvate--protein phosphotransferase]]
-	[[Category: Baumann, U.]]	+	[[Category: Baumann, U]]
-	[[Category: Erni, B.]]	+	[[Category: Erni, B]]
-	[[Category: Oberholzer, A E.]]	+	[[Category: Oberholzer, A E]]
-	[[Category: Schneider, P.]]	+	[[Category: Schneider, P]]
-	[[Category: Waltersperger, S M.]]	+	[[Category: Waltersperger, S M]]
	[[Category: Pep-utilising enzyme]]		[[Category: Pep-utilising enzyme]]
	[[Category: Thermophilic]]		[[Category: Thermophilic]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 13:04, 22 October 2014

OCA — Wed, 22 Oct 2014 13:04:44 GMT

←Older revision		Revision as of 13:04, 22 October 2014
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-	[[~~Image:~~2xz9.~~png~~\|~~left~~\|~~200px~~]]	+	==CRYSTAL STRUCTURE FROM THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)==
		+	<StructureSection load='2xz9' size='340' side='right' caption='[[2xz9]], [[Resolution\|resolution]] 1.68Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xz9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XZ9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bg5\|2bg5]], [[2xz7\|2xz7]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoenolpyruvate--protein_phosphotransferase Phosphoenolpyruvate--protein phosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.3.9 2.7.3.9] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xz9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xz9 RCSB], [http://www.ebi.ac.uk/pdbsum/2xz9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thermoanaerobacter tengcongensis is a thermophilic eubacterium that has a phosphoenolpyruvate (PEP) sugar phosphotransferase system (PTS) of 22 proteins. The general PTS proteins, enzyme I and HPr, and the transporters for N-acetylglucosamine (EIICB(GlcNAc)) and fructose (EIIBC(Fru)) have thermal unfolding transitions at approximately 90 degrees C and a temperature optimum for in vitro sugar phosphotransferase activity of 65 degrees C. The phosphocysteine of a EIICB(GlcNAc) mutant is unusually stable at room temperature with a t(1/2) of 60 h. The PEP binding C-terminal domain of enzyme I (EIC) forms a metastable covalent adduct with PEP at 65 degrees C. Crystallization of this adduct afforded the 1.68 A resolution structure of EIC with a molecule of pyruvate in the active site. We also report the 1.83 A crystal structure of the EIC-PEP complex. The comparison of the two structures with the apo form and with full-length EI shows differences between the active site side chain conformations of the PEP and pyruvate states but not between the pyruvate and apo states. In the presence of PEP, Arg465 forms a salt bridge with the phosphate moiety while Glu504 forms salt bridges with Arg186 and Arg195 of the N-terminal domain of enzyme I (EIN), which stabilizes a conformation appropriate for the in-line transfer of the phosphoryl moiety from PEP to His191. After transfer, Arg465 swings 4.8 A away to form an alternative salt bridge with the carboxylate of Glu504. Glu504 loses the grip of Arg186 and Arg195, and the EIN domain can swing away to hand on the phosphoryl group to the phosphoryl carrier protein HPr.

-	~~{{STRUCTURE_2xz9\| PDB=2xz9 \| SCENE= }}~~	+	Phosphoenolpyruvate: sugar phosphotransferase system from the hyperthermophilic Thermoanaerobacter tengcongensis.,Navdaeva V, Zurbriggen A, Waltersperger S, Schneider P, Oberholzer AE, Bahler P, Bachler C, Grieder A, Baumann U, Erni B Biochemistry. 2011 Feb 22;50(7):1184-93. Epub 2011 Jan 20. PMID:21250658<ref>PMID:21250658</ref>

-	~~===CRYSTAL STRUCTURE FROM THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21250658}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xz9]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Caldanaerobacter_subterraneus_subsp~~.~~_tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA].~~	+

	==See Also==		==See Also==
	*[[Phosphotransferase\|Phosphotransferase]]		*[[Phosphotransferase\|Phosphotransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021250658<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]		[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
	[[Category: Phosphoenolpyruvate--protein phosphotransferase]]		[[Category: Phosphoenolpyruvate--protein phosphotransferase]]

OCA at 12:26, 20 October 2012

OCA — Sat, 20 Oct 2012 12:26:20 GMT

←Older revision		Revision as of 12:26, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2xz9]] is a 2 chain structure ~~of [[Phosphotransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA].	+	[[2xz9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA].

	==See Also==		==See Also==

OCA at 08:42, 26 July 2012

OCA — Thu, 26 Jul 2012 08:42:43 GMT

←Older revision		Revision as of 08:42, 26 July 2012
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-	[[Image:2xz9.~~jpg~~\|left\|200px]]	+	[[Image:2xz9.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2xz9\| PDB=2xz9 \| SCENE= }}		{{STRUCTURE_2xz9\| PDB=2xz9 \| SCENE= }}

	===CRYSTAL STRUCTURE FROM THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)===		===CRYSTAL STRUCTURE FROM THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21250658}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21250658 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21250658}}		{{ABSTRACT_PUBMED_21250658}}

	==About this Structure==		==About this Structure==
-	[[2xz9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA].	+	[[2xz9]] is a 2 chain structure of [[Phosphotransferase]] with sequence from [http://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA].
		+
		+	==See Also==
		+	*[[Phosphotransferase\|Phosphotransferase]]

	==Reference==		==Reference==

OCA: Protected "2xz9" [edit=sysop:move=sysop]

OCA — Wed, 15 Jun 2011 06:18:05 GMT

Protected "2xz9" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:18, 15 June 2011

OCA at 06:18, 15 June 2011

OCA — Wed, 15 Jun 2011 06:18:03 GMT

←Older revision		Revision as of 06:18, 15 June 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:2xz9.jpg\|left\|200px]]

-	The ~~entry 2xz9~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xz9", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xz9\| PDB=2xz9 \| SCENE= }}

-	~~Authors: Oberholzer, A.E., Waltersperger, S.M., Schneider, P., Baumann, U., Erni, B.~~	+	===CRYSTAL STRUCTURE FROM THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)===

-	Description: CRYSTAL STRUCTURE FROM THE PHOSPHOENOLPYRUVATE-BINDING DOMAIN OF ENZYME I IN COMPLEX WITH PYRUVATE FROM THE THERMOANAEROBACTER TENGCONGENSIS PEP-SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS)

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Dec 1 11~~:07:~~13 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21250658}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21250658 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21250658}}
		+
		+	==About this Structure==
		+	[[2xz9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZ9 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021250658</ref><references group="xtra"/>
		+	[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
		+	[[Category: Phosphoenolpyruvate--protein phosphotransferase]]
		+	[[Category: Baumann, U.]]
		+	[[Category: Erni, B.]]
		+	[[Category: Oberholzer, A E.]]
		+	[[Category: Schneider, P.]]
		+	[[Category: Waltersperger, S M.]]
		+	[[Category: Pep-utilising enzyme]]
		+	[[Category: Thermophilic]]
		+	[[Category: Transferase]]