2y1d - Revision history

OCA at 08:06, 23 August 2023

OCA — Wed, 23 Aug 2023 08:06:57 GMT

←Older revision		Revision as of 08:06, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='2y1d' size='340' side='right'caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2y1d' size='340' side='right'caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y1d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y1D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y1d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y1D FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=34F:(1S)~~-~~1-(3~~,~~4-DICHLOROPHENYL)-3-~~[~~FORMYL(HYDROXY)AMINO~~]~~PROPYL}PHOSPHONIC+ACID'>34F</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>[[2y1c\|2y1c]]~~, [~~[2y1e\|2y1e~~]~~], [[2y1f\|2y1f]], [[2y1g\|2y1g]]</div~~></td><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=34F:(1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC+ACID'>34F</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y1d OCA], [https://pdbe.org/2y1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y1d RCSB], [https://www.ebi.ac.uk/pdbsum/2y1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y1d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y1d OCA], [https://pdbe.org/2y1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y1d RCSB], [https://www.ebi.ac.uk/pdbsum/2y1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y1d ProSAT]</span></td></tr>
	</table>		</table>
-	== Function ==
-	[[https://www.uniprot.org/uniprot/A2VLK3_MYCTX A2VLK3_MYCTX]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183][SAAS:SAAS00007111]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 19:

	==See Also==		==See Also==
-	*[[DXP reductoisomerase\|DXP reductoisomerase]]	+	*[[DXP reductoisomerase 3D Structures\|DXP reductoisomerase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Bergfors, T]]	+	[[Category: Bergfors T]]
-	[[Category: Bjorkelid, C]]	+	[[Category: Bjorkelid C]]
-	[[Category: Henriksson~~, L M~~]]	+	[[Category: Henriksson LM]]
-	[[Category: Jones~~, T A~~]]	+	[[Category: Jones TA]]
-	[[Category: Larsson~~, A M.S~~]]	+	[[Category: Larsson AMS]]
-	[[Category: Mowbray~~, S L~~]]	+	[[Category: Mowbray SL]]
-	[[Category: Unge, T]]	+	[[Category: Unge T]]
-	~~[[Category: Doxp/mep pathway]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 14:57, 17 November 2021

OCA — Wed, 17 Nov 2021 14:57:54 GMT

←Older revision		Revision as of 14:57, 17 November 2021
Line 3:		Line 3:
	<StructureSection load='2y1d' size='340' side='right'caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2y1d' size='340' side='right'caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y1d]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Y1D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y1d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y1D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34F:(1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC+ACID'>34F</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=34F:(1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC+ACID'>34F</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1c\|2y1c]], [[2y1e\|2y1e]], [[2y1f\|2y1f]], [[2y1g\|2y1g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y1c\|2y1c]], [[2y1e\|2y1e]], [[2y1f\|2y1f]], [[2y1g\|2y1g]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2y1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y1d OCA], [~~http~~://pdbe.org/2y1d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2y1d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2y1d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2y1d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y1d OCA], [https://pdbe.org/2y1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y1d RCSB], [https://www.ebi.ac.uk/pdbsum/2y1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y1d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/A2VLK3_MYCTX A2VLK3_MYCTX]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183][SAAS:SAAS00007111]	+	[[https://www.uniprot.org/uniprot/A2VLK3_MYCTX A2VLK3_MYCTX]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183][SAAS:SAAS00007111]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:34, 25 December 2019

OCA — Wed, 25 Dec 2019 13:34:20 GMT

←Older revision		Revision as of 13:34, 25 December 2019
Line 1:		Line 1:

	==X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4- dichlorophenyl-substituted fosmidomycin analogue and manganese.==		==X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4- dichlorophenyl-substituted fosmidomycin analogue and manganese.==
-	<StructureSection load='2y1d' size='340' side='right' caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='2y1d' size='340' side='right'caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2y1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y1D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2y1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y1D FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 2y1d" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2y1d" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DXP reductoisomerase\|DXP reductoisomerase]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]		[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Bergfors, T]]		[[Category: Bergfors, T]]

OCA at 07:33, 17 January 2018

OCA — Wed, 17 Jan 2018 07:33:16 GMT

←Older revision		Revision as of 07:33, 17 January 2018
Line 1:		Line 1:

-	==X-~~RAY STRUCTURE OF~~ 1-~~DEOXY~~-D-~~XYLULOSE~~ 5-~~PHOSPHATE REDUCTOISOMERASE~~, DXR, ~~RV2870C~~, ~~FROM MYCOBACTERIUM TUBERCULOSIS~~, ~~IN COMPLEX WITH A~~ 3,4-~~DICHLOROPHENYL~~-~~SUBSTITUTED FOSMIDOMYCIN ANALOGUE AND MANGANESE~~.==	+	==X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4- dichlorophenyl-substituted fosmidomycin analogue and manganese.==
	<StructureSection load='2y1d' size='340' side='right' caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2y1d' size='340' side='right' caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 2y1d" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2y1d" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DXP reductoisomerase\|DXP reductoisomerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:00, 5 August 2016

OCA — Fri, 05 Aug 2016 17:00:49 GMT

←Older revision		Revision as of 17:00, 5 August 2016
Line 1:		Line 1:
		+
	==X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH A 3,4-DICHLOROPHENYL-SUBSTITUTED FOSMIDOMYCIN ANALOGUE AND MANGANESE.==		==X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH A 3,4-DICHLOROPHENYL-SUBSTITUTED FOSMIDOMYCIN ANALOGUE AND MANGANESE.==
	<StructureSection load='2y1d' size='340' side='right' caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2y1d' size='340' side='right' caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y1D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y1D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34F:(1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC+ACID'>34F</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34F:(1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC+ACID'>34F</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1c\|2y1c]], [[2y1e\|2y1e]], [[2y1f\|2y1f]], [[2y1g\|2y1g]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1c\|2y1c]], [[2y1e\|2y1e]], [[2y1f\|2y1f]], [[2y1g\|2y1g]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y1d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y1d RCSB], [http://www.ebi.ac.uk/pdbsum/2y1d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y1d OCA], [http://pdbe.org/2y1d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y1d RCSB], [http://www.ebi.ac.uk/pdbsum/2y1d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y1d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~A2VLK3_MYCTU A2VLK3_MYCTU~~]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP~~) (By similarity~~).[HAMAP-Rule:MF_00183][SAAS:~~SAAS003821_004_013509~~]	+	[[http://www.uniprot.org/uniprot/A2VLK3_MYCTX A2VLK3_MYCTX]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183][SAAS:SAAS00007111]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2y1d" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DXP reductoisomerase\|DXP reductoisomerase]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]		[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Bergfors, T]]		[[Category: Bergfors, T]]
	[[Category: Bjorkelid, C]]		[[Category: Bjorkelid, C]]

OCA at 04:14, 25 December 2014

OCA — Thu, 25 Dec 2014 04:14:50 GMT

←Older revision		Revision as of 04:14, 25 December 2014
Line 2:		Line 2:
	<StructureSection load='2y1d' size='340' side='right' caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2y1d' size='340' side='right' caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA]. <br>	+	<table><tr><td colspan='2'>[[2y1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y1D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34F:(1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC+ACID'>34F</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34F:(1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC+ACID'>34F</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1c\|2y1c]], [[2y1e\|2y1e]], [[2y1f\|2y1f]], [[2y1g\|2y1g]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1c\|2y1c]], [[2y1e\|2y1e]], [[2y1f\|2y1f]], [[2y1g\|2y1g]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.~~2 2~~.7.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y1d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y1d RCSB], [http://www.ebi.ac.uk/pdbsum/2y1d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y1d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y1d RCSB], [http://www.ebi.ac.uk/pdbsum/2y1d PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A2VLK3_MYCTU A2VLK3_MYCTU]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity).[HAMAP-Rule:MF_00183][SAAS:SAAS003821_004_013509]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 16:
	Design, Synthesis and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase.,Andaloussi M, Henriksson LM, Wieckowska A, Lindh M, Bjorkelid C, Larsson AM, Suresh S, Iyer H, Srinivasa BR, Bergfors T, Unge T, Mowbray SL, Larhed ML, Jones AT, Karlen AB J Med Chem. 2011 Jun 16. PMID:21678907<ref>PMID:21678907</ref>		Design, Synthesis and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase.,Andaloussi M, Henriksson LM, Wieckowska A, Lindh M, Bjorkelid C, Larsson AM, Suresh S, Iyer H, Srinivasa BR, Bergfors T, Unge T, Mowbray SL, Larhed ML, Jones AT, Karlen AB J Med Chem. 2011 Jun 16. PMID:21678907<ref>PMID:21678907</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 22:		Line 24:
	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]		[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Bergfors, T.]]	+	[[Category: Bergfors, T]]
-	[[Category: Bjorkelid, C.]]	+	[[Category: Bjorkelid, C]]
-	[[Category: Henriksson, L M.]]	+	[[Category: Henriksson, L M]]
-	[[Category: Jones, T A.]]	+	[[Category: Jones, T A]]
-	[[Category: Larsson, A M.S.]]	+	[[Category: Larsson, A M.S]]
-	[[Category: Mowbray, S L.]]	+	[[Category: Mowbray, S L]]
-	[[Category: Unge, T.]]	+	[[Category: Unge, T]]
	[[Category: Doxp/mep pathway]]		[[Category: Doxp/mep pathway]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 07:42, 14 May 2014

OCA — Wed, 14 May 2014 07:42:39 GMT

←Older revision		Revision as of 07:42, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2y1d.~~png~~\|~~left~~\|~~200px~~]]	+	==X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH A 3,4-DICHLOROPHENYL-SUBSTITUTED FOSMIDOMYCIN ANALOGUE AND MANGANESE.==
		+	<StructureSection load='2y1d' size='340' side='right' caption='[[2y1d]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2y1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34F:(1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC+ACID'>34F</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y1c\|2y1c]], [[2y1e\|2y1e]], [[2y1f\|2y1f]], [[2y1g\|2y1g]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y1d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y1d RCSB], [http://www.ebi.ac.uk/pdbsum/2y1d PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The natural antibiotic fosmidomycin acts via inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), an essential enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. Fosmidomycin is active on Mycobacterium tuberculosis DXR (MtDXR) but it lacks antibacterial activity, probably because of poor uptake. alpha-Aryl substituted fosmidomycin analogues have more favorable physicochemical properties, and are also more active in inhibiting malaria parasite growth. We have solved crystal structures of MtDXR in complex with 3,4-dichlorophenyl substituted fosmidomycin analogues; these show important differences compared to our previously described forsmidomycin-DXR complex. Our best inhibitor has an IC50 = 0.15 muM on MtDXR but still lacked activity in a mycobacterial growth assay (MICs > 32 mug/ml). The combined results, however, provide insights into how DXR accommodates the new inhibitors and serve as an excellent starting point for the design of other novel and more potent inhibitors, particularly against pathogens where uptake is less of a problem, such as the malaria parasite.

-	<!--	+	Design, Synthesis and X-ray Crystallographic Studies of alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium tuberculosis 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase.,Andaloussi M, Henriksson LM, Wieckowska A, Lindh M, Bjorkelid C, Larsson AM, Suresh S, Iyer H, Srinivasa BR, Bergfors T, Unge T, Mowbray SL, Larhed ML, Jones AT, Karlen AB J Med Chem. 2011 Jun 16. PMID:21678907<ref>PMID:21678907</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2y1d"~~, ~~creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2y1d\| PDB=2y1d \| SCENE= }}~~	+

-	~~===X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE~~, ~~DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH A 3,4-DICHLOROPHENYL-SUBSTITUTED FOSMIDOMYCIN ANALOGUE AND MANGANESE.===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21678907}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21678907 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21678907}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2y1d]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021678907<~~/~~ref~~><~~ref group="xtra">PMID:016790937</ref><ref group="xtra">PMID:017491006</ref><references group="xtra"~~/>	+
	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]		[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA at 07:57, 3 August 2011

OCA — Wed, 03 Aug 2011 07:57:01 GMT

←Older revision		Revision as of 07:57, 3 August 2011
Line 1:		Line 1:
-	[[Image:2y1d.~~jpg~~\|left\|200px]]	+	[[Image:2y1d.png\|left\|200px]]

	<!--		<!--

OCA: Protected "2y1d" [edit=sysop:move=sysop]

OCA — Wed, 29 Jun 2011 06:05:38 GMT

Protected "2y1d" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:05, 29 June 2011

OCA at 06:05, 29 June 2011

OCA — Wed, 29 Jun 2011 06:05:34 GMT

←Older revision		Revision as of 06:05, 29 June 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2y1d.jpg\|left\|200px]]

-	The ~~entry 2y1d~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2y1d", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2y1d\| PDB=2y1d \| SCENE= }}

-	~~Authors: Henriksson~~, ~~L.M.~~, ~~Larsson~~, A~~.M.S.~~, ~~Bergfors, T., Bjorkelid, C., Unge, T., Mowbray, S.L., Jones, T.A~~.	+	===X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH A 3,4-DICHLOROPHENYL-SUBSTITUTED FOSMIDOMYCIN ANALOGUE AND MANGANESE.===

-	Description: X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4-dichlorophenyl-substituted fosmidomycin analogue and manganese.

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Dec 15 08~~:17:~~30 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21678907}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21678907 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21678907}}
		+
		+	==About this Structure==
		+	[[2y1d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1D OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021678907</ref><ref group="xtra">PMID:016790937</ref><ref group="xtra">PMID:017491006</ref><references group="xtra"/>
		+	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Bergfors, T.]]
		+	[[Category: Bjorkelid, C.]]
		+	[[Category: Henriksson, L M.]]
		+	[[Category: Jones, T A.]]
		+	[[Category: Larsson, A M.S.]]
		+	[[Category: Mowbray, S L.]]
		+	[[Category: Unge, T.]]
		+	[[Category: Doxp/mep pathway]]
		+	[[Category: Oxidoreductase]]