2y6w - Revision history

OCA at 10:46, 20 December 2023

OCA — Wed, 20 Dec 2023 10:46:53 GMT

←Older revision		Revision as of 10:46, 20 December 2023
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	<StructureSection load='2y6w' size='340' side='right'caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2y6w' size='340' side='right'caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y6W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y6W FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~, ~~<scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1o0l\|1o0l]]~~, ~~[[1zy3\|1zy3]], [[1mk3\|1mk3]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [https://pdbe.org/2y6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [https://www.ebi.ac.uk/pdbsum/2y6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [https://pdbe.org/2y6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [https://www.ebi.ac.uk/pdbsum/2y6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/B2CL2_HUMAN B2CL2_HUMAN]] Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.<ref>PMID:8761287</ref>	+	[https://www.uniprot.org/uniprot/B2CL2_HUMAN B2CL2_HUMAN] Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.<ref>PMID:8761287</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Colman~~, P M~~]]	+	[[Category: Colman PM]]
-	[[Category: Dogovski, C]]	+	[[Category: Dogovski C]]
-	[[Category: Evangelista, M]]	+	[[Category: Evangelista M]]
-	[[Category: Fairlie~~, W D~~]]	+	[[Category: Fairlie WD]]
-	[[Category: Lee~~, E F~~]]	+	[[Category: Lee EF]]
-	[[Category: Perugini~~, M A~~]]	+	[[Category: Perugini MA]]
-	[[Category: Pettikiriarachchi, A]]	+	[[Category: Pettikiriarachchi A]]
-	~~[[Category: Apoptosis~~]]	+

OCA at 12:24, 27 April 2022

OCA — Wed, 27 Apr 2022 12:24:12 GMT

←Older revision		Revision as of 12:24, 27 April 2022
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	<StructureSection load='2y6w' size='340' side='right'caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2y6w' size='340' side='right'caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2Y6W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y6W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o0l\|1o0l]], [[1zy3\|1zy3]], [[1mk3\|1mk3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1o0l\|1o0l]], [[1zy3\|1zy3]], [[1mk3\|1mk3]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [~~http~~://pdbe.org/2y6w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2y6w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [https://pdbe.org/2y6w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [https://www.ebi.ac.uk/pdbsum/2y6w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/B2CL2_HUMAN B2CL2_HUMAN]] Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.<ref>PMID:8761287</ref>	+	[[https://www.uniprot.org/uniprot/B2CL2_HUMAN B2CL2_HUMAN]] Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.<ref>PMID:8761287</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:37, 22 July 2020

OCA — Wed, 22 Jul 2020 12:37:09 GMT

←Older revision		Revision as of 12:37, 22 July 2020
Line 1:		Line 1:

	==Structure of a Bcl-w dimer==		==Structure of a Bcl-w dimer==
-	<StructureSection load='2y6w' size='340' side='right' caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2y6w' size='340' side='right'caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Y6W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Y6W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o0l\|1o0l]], [[1zy3\|1zy3]], [[1mk3\|1mk3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o0l\|1o0l]], [[1zy3\|1zy3]], [[1mk3\|1mk3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [http://pdbe.org/2y6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [http://www.ebi.ac.uk/pdbsum/2y6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [http://pdbe.org/2y6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [http://www.ebi.ac.uk/pdbsum/2y6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[B-cell lymphoma ~~protein~~\|B-cell lymphoma ~~protein~~]]	+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Colman, P M]]		[[Category: Colman, P M]]
	[[Category: Dogovski, C]]		[[Category: Dogovski, C]]

OCA at 09:13, 10 October 2018

OCA — Wed, 10 Oct 2018 09:13:45 GMT

←Older revision		Revision as of 09:13, 10 October 2018
Line 1:		Line 1:

-	==~~STRUCTURE OF A BCL~~-~~W DIMER~~==	+	==Structure of a Bcl-w dimer==
	<StructureSection load='2y6w' size='340' side='right' caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2y6w' size='340' side='right' caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 2y6w" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2y6w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma protein\|B-cell lymphoma protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:59, 4 August 2016

OCA — Thu, 04 Aug 2016 08:59:01 GMT

←Older revision		Revision as of 08:59, 4 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF A BCL-W DIMER==		==STRUCTURE OF A BCL-W DIMER==
	<StructureSection load='2y6w' size='340' side='right' caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2y6w' size='340' side='right' caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y6W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y6W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o0l\|1o0l]], [[1zy3\|1zy3]], [[1mk3\|1mk3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o0l\|1o0l]], [[1zy3\|1zy3]], [[1mk3\|1mk3]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [http://www.ebi.ac.uk/pdbsum/2y6w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [http://pdbe.org/2y6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [http://www.ebi.ac.uk/pdbsum/2y6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2y6w" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Colman, P M]]		[[Category: Colman, P M]]
	[[Category: Dogovski, C]]		[[Category: Dogovski, C]]

OCA at 07:57, 24 December 2014

OCA — Wed, 24 Dec 2014 07:57:39 GMT

←Older revision		Revision as of 07:57, 24 December 2014
Line 2:		Line 2:
	<StructureSection load='2y6w' size='340' side='right' caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2y6w' size='340' side='right' caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. <br>	+	<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y6W FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o0l\|1o0l]], [[1zy3\|1zy3]], [[1mk3\|1mk3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o0l\|1o0l]], [[1zy3\|1zy3]], [[1mk3\|1mk3]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [http://www.ebi.ac.uk/pdbsum/2y6w PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [http://www.ebi.ac.uk/pdbsum/2y6w PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/B2CL2_HUMAN B2CL2_HUMAN]] Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.<ref>PMID:8761287</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 15:
	Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins.,Lee EF, Dewson G, Smith BJ, Evangelista M, Pettikiriarachchi A, Dogovski C, Perugini MA, Colman PM, Fairlie WD Structure. 2011 Oct 12;19(10):1467-76. PMID:22000515<ref>PMID:22000515</ref>		Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins.,Lee EF, Dewson G, Smith BJ, Evangelista M, Pettikiriarachchi A, Dogovski C, Perugini MA, Colman PM, Fairlie WD Structure. 2011 Oct 12;19(10):1467-76. PMID:22000515<ref>PMID:22000515</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Colman, P M.]]	+	[[Category: Colman, P M]]
-	[[Category: Dogovski, C.]]	+	[[Category: Dogovski, C]]
-	[[Category: Evangelista, M.]]	+	[[Category: Evangelista, M]]
-	[[Category: Fairlie, W D.]]	+	[[Category: Fairlie, W D]]
-	[[Category: Lee, E F.]]	+	[[Category: Lee, E F]]
-	[[Category: Perugini, M A.]]	+	[[Category: Perugini, M A]]
-	[[Category: Pettikiriarachchi, A.]]	+	[[Category: Pettikiriarachchi, A]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]

OCA at 07:52, 14 May 2014

OCA — Wed, 14 May 2014 07:52:24 GMT

←Older revision		Revision as of 07:52, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2y6w.~~png~~\|~~left~~\|~~200px~~]]	+	==STRUCTURE OF A BCL-W DIMER==
		+	<StructureSection load='2y6w' size='340' side='right' caption='[[2y6w]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2y6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1o0l\|1o0l]], [[1zy3\|1zy3]], [[1mk3\|1mk3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y6w RCSB], [http://www.ebi.ac.uk/pdbsum/2y6w PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The prosurvival and proapoptotic proteins of the BCL-2 family share a similar three-dimensional fold despite their opposing functions. However, many biochemical studies highlight the requirement for conformational changes for the functioning of both types of proteins, although structural data to support such changes remain elusive. Here, we describe the X-ray structure of dimeric BCL-W that reveals a major conformational change involving helices alpha3 and alpha4 hinging away from the core of the protein. Biochemical and functional studies reveal that the alpha4-alpha5 hinge region is required for dimerization of BCL-W, and functioning of both pro- and antiapoptotic BCL-2 proteins. Hence, this structure reveals a conformational flexibility not seen in previous BCL-2 protein structures and provides insights into how these regulators of apoptosis can change conformation to exert their function.

-	<!--	+	Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins.,Lee EF, Dewson G, Smith BJ, Evangelista M, Pettikiriarachchi A, Dogovski C, Perugini MA, Colman PM, Fairlie WD Structure. 2011 Oct 12;19(10):1467-76. PMID:22000515<ref>PMID:22000515</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2y6w"~~, ~~creates the "~~Structure ~~Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2y6w\| PDB=2y6w \| SCENE= }}~~	+

-	~~===STRUCTURE OF A BCL-W DIMER===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_22000515}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 22000515 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_22000515}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2y6w]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:022000515<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Colman, P M.]]		[[Category: Colman, P M.]]

OCA at 09:25, 30 October 2011

OCA — Sun, 30 Oct 2011 09:25:48 GMT

←Older revision		Revision as of 09:25, 30 October 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2y6w.png\|left\|200px]]

-	The ~~entry 2y6w~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2y6w", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2y6w\| PDB=2y6w \| SCENE= }}

-	~~Authors: Lee, E.F., Evangelista, M., Pettikiriarachchi,~~ A~~., Dogovski, C., Perugini, M.A., Colman, P.M., Fairlie,~~ W~~.D.~~	+	===STRUCTURE OF A BCL-W DIMER===

-	~~Description~~: Structure of a ~~Bcl~~-~~w dimer~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22000515}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22000515 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22000515}}
		+
		+	==About this Structure==
		+	[[2y6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6W OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022000515</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Colman, P M.]]
		+	[[Category: Dogovski, C.]]
		+	[[Category: Evangelista, M.]]
		+	[[Category: Fairlie, W D.]]
		+	[[Category: Lee, E F.]]
		+	[[Category: Perugini, M A.]]
		+	[[Category: Pettikiriarachchi, A.]]
		+	[[Category: Apoptosis]]

OCA at 05:39, 9 February 2011

OCA — Wed, 09 Feb 2011 05:39:49 GMT

←Older revision		Revision as of 05:39, 9 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2y6w is ON HOLD	+	The entry 2y6w is ON HOLD until Paper Publication

	Authors: Lee, E.F., Evangelista, M., Pettikiriarachchi, A., Dogovski, C., Perugini, M.A., Colman, P.M., Fairlie, W.D.		Authors: Lee, E.F., Evangelista, M., Pettikiriarachchi, A., Dogovski, C., Perugini, M.A., Colman, P.M., Fairlie, W.D.

	Description: Structure of a Bcl-w dimer		Description: Structure of a Bcl-w dimer

OCA: Protected "2y6w" [edit=sysop:move=sysop]

OCA — Wed, 02 Feb 2011 06:01:45 GMT

Protected "2y6w" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:01, 2 February 2011