2y75 - Revision history

OCA at 08:09, 23 August 2023

OCA — Wed, 23 Aug 2023 08:09:38 GMT

←Older revision		Revision as of 08:09, 23 August 2023
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	<StructureSection load='2y75' size='340' side='right'caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2y75' size='340' side='right'caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [https://pdbe.org/2y75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [https://www.ebi.ac.uk/pdbsum/2y75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y75 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [https://pdbe.org/2y75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [https://www.ebi.ac.uk/pdbsum/2y75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y75 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CYMR_BACSU CYMR_BACSU]] Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression.<ref>PMID:16513748</ref> <ref>PMID:18974048</ref>	+	[https://www.uniprot.org/uniprot/CYMR_BACSU CYMR_BACSU] Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression.<ref>PMID:16513748</ref> <ref>PMID:18974048</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Courtois, E]]	+	[[Category: Courtois E]]
-	[[Category: England, P]]	+	[[Category: England P]]
-	[[Category: Haouz, A]]	+	[[Category: Haouz A]]
-	[[Category: Martin-Verstraete, I]]	+	[[Category: Martin-Verstraete I]]
-	[[Category: Shepard, W]]	+	[[Category: Shepard W]]
-	[[Category: Soutourina, O]]	+	[[Category: Soutourina O]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 15:00, 17 November 2021

OCA — Wed, 17 Nov 2021 15:00:55 GMT

←Older revision		Revision as of 15:00, 17 November 2021
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	<StructureSection load='2y75' size='340' side='right'caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2y75' size='340' side='right'caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [~~http~~://pdbe.org/2y75 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2y75 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2y75 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [https://pdbe.org/2y75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [https://www.ebi.ac.uk/pdbsum/2y75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y75 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CYMR_BACSU CYMR_BACSU]] Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression.<ref>PMID:16513748</ref> <ref>PMID:18974048</ref>	+	[[https://www.uniprot.org/uniprot/CYMR_BACSU CYMR_BACSU]] Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression.<ref>PMID:16513748</ref> <ref>PMID:18974048</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:27, 10 May 2019

OCA — Fri, 10 May 2019 12:27:22 GMT

←Older revision		Revision as of 12:27, 10 May 2019
Line 1:		Line 1:

	==The Structure of CymR (YrzC) the Global Cysteine Regulator of B. subtilis==		==The Structure of CymR (YrzC) the Global Cysteine Regulator of B. subtilis==
-	<StructureSection load='2y75' size='340' side='right' caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2y75' size='340' side='right'caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Vibrio subtilis ehrenberg 1835]]		[[Category: Vibrio subtilis ehrenberg 1835]]
		+	[[Category: Large Structures]]
	[[Category: Courtois, E]]		[[Category: Courtois, E]]
	[[Category: England, P]]		[[Category: England, P]]

OCA at 09:21, 10 October 2018

OCA — Wed, 10 Oct 2018 09:21:49 GMT

←Older revision		Revision as of 09:21, 10 October 2018
Line 1:		Line 1:

-	==~~THE STRUCTURE OF CYMR~~ (~~YRZC~~) ~~THE GLOBAL CYSTEINE REGULATOR OF~~ B. ~~SUBTILIS~~==	+	==The Structure of CymR (YrzC) the Global Cysteine Regulator of B. subtilis==
	<StructureSection load='2y75' size='340' side='right' caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2y75' size='340' side='right' caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [http://pdbe.org/2y75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [http://www.ebi.ac.uk/pdbsum/2y75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y75 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [http://pdbe.org/2y75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [http://www.ebi.ac.uk/pdbsum/2y75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y75 ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Courtois, E]]		[[Category: Courtois, E]]
	[[Category: England, P]]		[[Category: England, P]]

OCA at 03:19, 5 August 2016

OCA — Fri, 05 Aug 2016 03:19:14 GMT

←Older revision		Revision as of 03:19, 5 August 2016
Line 1:		Line 1:
		+
	==THE STRUCTURE OF CYMR (YRZC) THE GLOBAL CYSTEINE REGULATOR OF B. SUBTILIS==		==THE STRUCTURE OF CYMR (YRZC) THE GLOBAL CYSTEINE REGULATOR OF B. SUBTILIS==
	<StructureSection load='2y75' size='340' side='right' caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2y75' size='340' side='right' caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [http://www.ebi.ac.uk/pdbsum/2y75 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [http://pdbe.org/2y75 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [http://www.ebi.ac.uk/pdbsum/2y75 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y75 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2y75" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Courtois, E]]		[[Category: Courtois, E]]
	[[Category: England, P]]		[[Category: England, P]]

OCA at 22:26, 24 December 2014

OCA — Wed, 24 Dec 2014 22:26:24 GMT

←Older revision		Revision as of 22:26, 24 December 2014
Line 2:		Line 2:
	<StructureSection load='2y75' size='340' side='right' caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2y75' size='340' side='right' caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. <br>	+	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y75 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~><br>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [http://www.ebi.ac.uk/pdbsum/2y75 PDBsum]</span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [http://www.ebi.ac.uk/pdbsum/2y75 PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CYMR_BACSU CYMR_BACSU]] Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression.<ref>PMID:16513748</ref> <ref>PMID:18974048</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 14:
	Insights into the Rrf2 repressor family - the structure of CymR, the global cysteine regulator of Bacillus subtilis.,Shepard W, Soutourina O, Courtois E, England P, Haouz A, Martin-Verstraete I FEBS J. 2011 Aug;278(15):2689-701. doi: 10.1111/j.1742-4658.2011.08195.x., Epub 2011 Jul 1. PMID:21624051<ref>PMID:21624051</ref>		Insights into the Rrf2 repressor family - the structure of CymR, the global cysteine regulator of Bacillus subtilis.,Shepard W, Soutourina O, Courtois E, England P, Haouz A, Martin-Verstraete I FEBS J. 2011 Aug;278(15):2689-701. doi: 10.1111/j.1742-4658.2011.08195.x., Epub 2011 Jul 1. PMID:21624051<ref>PMID:21624051</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Courtois, E.]]	+	[[Category: Courtois, E]]
-	[[Category: England, P.]]	+	[[Category: England, P]]
-	[[Category: Haouz, A.]]	+	[[Category: Haouz, A]]
-	[[Category: Martin-Verstraete, I.]]	+	[[Category: Martin-Verstraete, I]]
-	[[Category: Shepard, W.]]	+	[[Category: Shepard, W]]
-	[[Category: Soutourina, O.]]	+	[[Category: Soutourina, O]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Transcription]]		[[Category: Transcription]]

OCA at 07:42, 14 May 2014

OCA — Wed, 14 May 2014 07:42:50 GMT

←Older revision		Revision as of 07:42, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2y75.~~jpg~~\|~~left\|200px~~]]	+	==THE STRUCTURE OF CYMR (YRZC) THE GLOBAL CYSTEINE REGULATOR OF B. SUBTILIS==
		+	<StructureSection load='2y75' size='340' side='right' caption='[[2y75]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y75 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y75 RCSB], [http://www.ebi.ac.uk/pdbsum/2y75 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The global regulator CymR represses the transcription of a large set of genes involved in cystine uptake and cysteine biosynthesis in Bacillus subtilis and Staphylococcus aureus. This repressor belongs to the widespread and poorly characterized Rrf2 family of regulators. The crystal structure of CymR from B. subtilis reveals a biologically active dimer, where each monomer folds into two tightly packed domains: a DNA-binding domain, which houses a winged helix-turn-helix (wHTH) motif; and a long dimerization domain, which places the wHTH motifs at the extremes. This architecture explains how these small regulators can span 23-27-bp DNA targets. The wHTH motif of CymR resembles those of the GntR superfamily of regulators, such as FadR and HutC. Superimposing the FadR wHTH motifs bound to their DNA fragments onto the wHTH motifs of the CymR dimer structure suggests that the DNA target and/or the protein must undergo some conformational changes upon binding. The CymR structure also hints at a possible location of the Fe-S centre associated with several Rrf2-type regulators. Structured digital abstract * CymR binds to CymR by x-ray crystallography (View Interaction 1, 2).

-	~~<!--~~	+	Insights into the Rrf2 repressor family - the structure of CymR, the global cysteine regulator of Bacillus subtilis.,Shepard W, Soutourina O, Courtois E, England P, Haouz A, Martin-Verstraete I FEBS J. 2011 Aug;278(15):2689-701. doi: 10.1111/j.1742-4658.2011.08195.x., Epub 2011 Jul 1. PMID:21624051<ref>PMID:21624051</ref>
-	~~The line below this paragraph, containing "STRUCTURE_2y75", creates the "Structure Box" on the page.~~	+
-	~~You may change the PDB parameter (which sets the PDB file loaded~~ into the ~~applet)~~	+
-	or the ~~SCENE parameter (which sets the initial scene displayed when the page is loaded)~~,	+
-	~~or leave~~ the ~~SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2y75\| PDB=2y75 \| SCENE= }}~~	+

-	~~===THE STRUCTURE OF CYMR (YRZC) THE GLOBAL CYSTEINE REGULATOR OF B. SUBTILIS===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21624051}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21624051 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21624051}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2y75]] is a 6 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021624051<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Courtois, E.]]		[[Category: Courtois, E.]]

OCA at 08:47, 3 August 2011

OCA — Wed, 03 Aug 2011 08:47:22 GMT

←Older revision		Revision as of 08:47, 3 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2y75.jpg\|left\|200px]]

-	The ~~entry 2y75~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2y75", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2y75\| PDB=2y75 \| SCENE= }}

-	~~Authors: Shepard, W., Soutourina, O., Courtois, E., England, P., Haouz, A., Martin-Verstraete, I~~.	+	===THE STRUCTURE OF CYMR (YRZC) THE GLOBAL CYSTEINE REGULATOR OF B. SUBTILIS===

-	~~Description:~~ The ~~Structure of CymR~~ (~~YrzC~~) the ~~Global Cysteine Regulator of B~~. subtilis	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21624051}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21624051 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21624051}}
		+
		+	==About this Structure==
		+	[[2y75]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y75 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021624051</ref><references group="xtra"/>
		+	[[Category: Bacillus subtilis]]
		+	[[Category: Courtois, E.]]
		+	[[Category: England, P.]]
		+	[[Category: Haouz, A.]]
		+	[[Category: Martin-Verstraete, I.]]
		+	[[Category: Shepard, W.]]
		+	[[Category: Soutourina, O.]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Transcription]]

OCA at 05:11, 16 February 2011

OCA — Wed, 16 Feb 2011 05:11:38 GMT

←Older revision		Revision as of 05:11, 16 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2y75 is ON HOLD	+	The entry 2y75 is ON HOLD until Paper Publication

	Authors: Shepard, W., Soutourina, O., Courtois, E., England, P., Haouz, A., Martin-Verstraete, I.		Authors: Shepard, W., Soutourina, O., Courtois, E., England, P., Haouz, A., Martin-Verstraete, I.

	Description: The Structure of CymR (YrzC) the Global Cysteine Regulator of B. subtilis		Description: The Structure of CymR (YrzC) the Global Cysteine Regulator of B. subtilis

OCA: Protected "2y75" [edit=sysop:move=sysop]

OCA — Wed, 09 Feb 2011 05:40:00 GMT

Protected "2y75" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:40, 9 February 2011