2y8c - Revision history

OCA at 10:47, 20 December 2023

OCA — Wed, 20 Dec 2023 10:47:44 GMT

←Older revision		Revision as of 10:47, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2y8c' size='340' side='right'caption='[[2y8c]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2y8c' size='340' side='right'caption='[[2y8c]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y8C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y8c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y8C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUQ:(2S)-2-[(2,4-DIOXOPYRIMIDIN-1-YL)METHYL]-N-(2-HYDROXYETHYL)-4-TRITYLOXY-BUTANAMIDE'>DUQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vyq\|1vyq]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUQ:(2S)-2-[(2,4-DIOXOPYRIMIDIN-1-YL)METHYL]-N-(2-HYDROXYETHYL)-4-TRITYLOXY-BUTANAMIDE'>DUQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8c OCA], [https://pdbe.org/2y8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y8c RCSB], [https://www.ebi.ac.uk/pdbsum/2y8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8c OCA], [https://pdbe.org/2y8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y8c RCSB], [https://www.ebi.ac.uk/pdbsum/2y8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8c ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8II92_PLAF7 Q8II92_PLAF7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plaf7]]~~	+	[[Category: Plasmodium falciparum 3D7]]
-	~~[[Category: DUTP diphosphatase~~]]	+	[[Category: Baragana B]]
-	[[Category: Baragana, B]]	+	[[Category: Bosch C]]
-	[[Category: Bosch, C]]	+	[[Category: Brun R]]
-	[[Category: Brun, R]]	+	[[Category: Gilbert IH]]
-	[[Category: Gilbert~~, I H~~]]	+	[[Category: Gonzalez-Pacanowska D]]
-	[[Category: Gonzalez-Pacanowska, D]]	+	[[Category: Johansson NG]]
-	[[Category: Johansson~~, N G~~]]	+	[[Category: Kaiser M]]
-	[[Category: Kaiser, M]]	+	[[Category: McCarthy O]]
-	[[Category: McCarthy, O]]	+	[[Category: Roberts S]]
-	[[Category: Roberts, S]]	+	[[Category: Sanchez P]]
-	[[Category: Sanchez, P]]	+	[[Category: Whittingham JL]]
-	[[Category: Whittingham~~, J L~~]]	+	[[Category: Wilson KS]]
-	[[Category: Wilson~~, K S~~]]	+	[[Category: Zhou X-X]]
-	[[Category: Zhou, X X]]	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Malaria~~]]	+

OCA at 12:24, 27 April 2022

OCA — Wed, 27 Apr 2022 12:24:58 GMT

←Older revision		Revision as of 12:24, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2y8c' size='340' side='right'caption='[[2y8c]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2y8c' size='340' side='right'caption='[[2y8c]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8c]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2Y8C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y8c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y8C FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUQ:(2S)-2-[(2,4-DIOXOPYRIMIDIN-1-YL)METHYL]-N-(2-HYDROXYETHYL)-4-TRITYLOXY-BUTANAMIDE'>DUQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUQ:(2S)-2-[(2,4-DIOXOPYRIMIDIN-1-YL)METHYL]-N-(2-HYDROXYETHYL)-4-TRITYLOXY-BUTANAMIDE'>DUQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyq\|1vyq]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vyq\|1vyq]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2y8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8c OCA], [~~http~~://pdbe.org/2y8c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2y8c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2y8c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8c OCA], [https://pdbe.org/2y8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y8c RCSB], [https://www.ebi.ac.uk/pdbsum/2y8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:38, 22 July 2020

OCA — Wed, 22 Jul 2020 12:38:59 GMT

←Older revision		Revision as of 12:38, 22 July 2020
Line 1:		Line 1:

	==Plasmodium falciparum dUTPase in complex with a trityl ligand==		==Plasmodium falciparum dUTPase in complex with a trityl ligand==
-	<StructureSection load='2y8c' size='340' side='right' caption='[[2y8c]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2y8c' size='340' side='right'caption='[[2y8c]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Y8C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y8c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Y8C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUQ:(2S)-2-[(2,4-DIOXOPYRIMIDIN-1-YL)METHYL]-N-(2-HYDROXYETHYL)-4-TRITYLOXY-BUTANAMIDE'>DUQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUQ:(2S)-2-[(2,4-DIOXOPYRIMIDIN-1-YL)METHYL]-N-(2-HYDROXYETHYL)-4-TRITYLOXY-BUTANAMIDE'>DUQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyq\|1vyq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyq\|1vyq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2y8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8c OCA], [http://pdbe.org/2y8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y8c RCSB], [http://www.ebi.ac.uk/pdbsum/2y8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2y8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8c OCA], [http://pdbe.org/2y8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y8c RCSB], [http://www.ebi.ac.uk/pdbsum/2y8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[~~Deoxyuridine 5'-triphosphate nucleotidohydrolase~~\|~~Deoxyuridine 5'-triphosphate nucleotidohydrolase~~]]	+	*[[DUTPase 3D structures\|DUTPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plaf7]]		[[Category: Plaf7]]
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]

OCA at 09:04, 10 October 2018

OCA — Wed, 10 Oct 2018 09:04:37 GMT

←Older revision		Revision as of 09:04, 10 October 2018
Line 34:		Line 34:
	[[Category: Johansson, N G]]		[[Category: Johansson, N G]]
	[[Category: Kaiser, M]]		[[Category: Kaiser, M]]
-	[[Category: ~~Mccarthy~~, O]]	+	[[Category: McCarthy, O]]
	[[Category: Roberts, S]]		[[Category: Roberts, S]]
	[[Category: Sanchez, P]]		[[Category: Sanchez, P]]

OCA at 11:12, 4 August 2016

OCA — Thu, 04 Aug 2016 11:12:34 GMT

←Older revision		Revision as of 11:12, 4 August 2016
Line 1:		Line 1:
		+
	==Plasmodium falciparum dUTPase in complex with a trityl ligand==		==Plasmodium falciparum dUTPase in complex with a trityl ligand==
	<StructureSection load='2y8c' size='340' side='right' caption='[[2y8c]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2y8c' size='340' side='right' caption='[[2y8c]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y8c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8C FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUQ:(2S)-2-[(2,4-DIOXOPYRIMIDIN-1-YL)METHYL]-N-(2-HYDROXYETHYL)-4-TRITYLOXY-BUTANAMIDE'>DUQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUQ:(2S)-2-[(2,4-DIOXOPYRIMIDIN-1-YL)METHYL]-N-(2-HYDROXYETHYL)-4-TRITYLOXY-BUTANAMIDE'>DUQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyq\|1vyq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyq\|1vyq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8c RCSB], [http://www.ebi.ac.uk/pdbsum/2y8c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8c OCA], [http://pdbe.org/2y8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y8c RCSB], [http://www.ebi.ac.uk/pdbsum/2y8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2y8c" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plaf7]]
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]
	[[Category: Baragana, B]]		[[Category: Baragana, B]]

OCA at 22:48, 3 January 2015

OCA — Sat, 03 Jan 2015 22:48:27 GMT

←Older revision		Revision as of 22:48, 3 January 2015
Line 1:		Line 1:
-	[[~~Image:~~2y8c.~~png~~\|~~left~~\|~~200px~~]]	+	==Plasmodium falciparum dUTPase in complex with a trityl ligand==
		+	<StructureSection load='2y8c' size='340' side='right' caption='[[2y8c]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2y8c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8C FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DUQ:(2S)-2-[(2,4-DIOXOPYRIMIDIN-1-YL)METHYL]-N-(2-HYDROXYETHYL)-4-TRITYLOXY-BUTANAMIDE'>DUQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyq\|1vyq]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8c RCSB], [http://www.ebi.ac.uk/pdbsum/2y8c PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report a series of beta-branched acyclic tritylated deoxyuridine analogues as inhibitors of Plasmodium falciparum deoxyuridine-5'-triphosphate nucleotidohydrolase (PfdUTPase), an enzyme involved in nucleotide metabolism that acts as first line of defence against uracil incorporation into DNA. Compounds were assayed against both PfdUTPase and intact parasites showing a correlation between enzyme inhibition and cellular assays. beta-Branched acyclic uridine analogues described here showed equal or slightly better potency and selectivity compared with previously reported analogues. The best inhibitor gave a K(i) of 0.5 muM against PfdUTPase with selectivity greater than 200-fold compared to the corresponding human enzyme and sub-micromolar growth inhibition of P. falciparum (EC(50) 0.6 muM). A crystal structure of the complex of PfdUTPase with one of the inhibitors shows that this acyclic derivative binds to the active site in a similar manner to that previously reported for a tritylated cyclic deoxyuridine derivative.

-	~~{{STRUCTURE_2y8c\| PDB=2y8c \| SCENE= }}~~	+	beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.,Baragana B, McCarthy O, Sanchez P, Bosch-Navarrete C, Kaiser M, Brun R, Whittingham JL, Roberts SM, Zhou XX, Wilson KS, Johansson NG, Gonzalez-Pacanowska D, Gilbert IH Bioorg Med Chem. 2011 Apr 1;19(7):2378-91. Epub 2011 Feb 17. PMID:21411327<ref>PMID:21411327</ref>

-	~~===Plasmodium falciparum dUTPase in complex with~~ a ~~trityl ligand===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21411327}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2y8c]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA].~~	+

	==See Also==		==See Also==
	*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase\|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]		*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase\|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021411327<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: DUTP diphosphatase]]		[[Category: DUTP diphosphatase]]
-	[[Category: Baragana, B.]]	+	[[Category: Baragana, B]]
-	[[Category: Bosch, C.]]	+	[[Category: Bosch, C]]
-	[[Category: Brun, R.]]	+	[[Category: Brun, R]]
-	[[Category: Gilbert, I H.]]	+	[[Category: Gilbert, I H]]
-	[[Category: Gonzalez-Pacanowska, D.]]	+	[[Category: Gonzalez-Pacanowska, D]]
-	[[Category: Johansson, N G.]]	+	[[Category: Johansson, N G]]
-	[[Category: Kaiser, M.]]	+	[[Category: Kaiser, M]]
-	[[Category: Mccarthy, O.]]	+	[[Category: Mccarthy, O]]
-	[[Category: Roberts, S.]]	+	[[Category: Roberts, S]]
-	[[Category: Sanchez, P.]]	+	[[Category: Sanchez, P]]
-	[[Category: Whittingham, J L.]]	+	[[Category: Whittingham, J L]]
-	[[Category: Wilson, K S.]]	+	[[Category: Wilson, K S]]
-	[[Category: Zhou, X X.]]	+	[[Category: Zhou, X X]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Malaria]]		[[Category: Malaria]]

OCA at 06:08, 20 October 2012

OCA — Sat, 20 Oct 2012 06:08:24 GMT

←Older revision		Revision as of 06:08, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2y8c]] is a 3 chain structure ~~of [[Deoxyuridine 5'-triphosphate nucleotidohydrolase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA].	+	[[2y8c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA].

	==See Also==		==See Also==

OCA at 12:14, 25 July 2012

OCA — Wed, 25 Jul 2012 12:14:26 GMT

←Older revision		Revision as of 12:14, 25 July 2012
Line 1:		Line 1:
-	[[Image:2y8c.~~jpg~~\|left\|200px]]	+	[[Image:2y8c.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2y8c", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2y8c\| PDB=2y8c \| SCENE= }}		{{STRUCTURE_2y8c\| PDB=2y8c \| SCENE= }}

	===Plasmodium falciparum dUTPase in complex with a trityl ligand===		===Plasmodium falciparum dUTPase in complex with a trityl ligand===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21411327}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21411327 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21411327}}		{{ABSTRACT_PUBMED_21411327}}

	==About this Structure==		==About this Structure==
-	[[2y8c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA].	+	[[2y8c]] is a 3 chain structure of [[Deoxyuridine 5'-triphosphate nucleotidohydrolase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA].
		+
		+	==See Also==
		+	*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase\|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]

	==Reference==		==Reference==

OCA at 05:44, 8 March 2012

OCA — Thu, 08 Mar 2012 05:44:01 GMT

←Older revision		Revision as of 05:44, 8 March 2012
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2y8c.jpg\|left\|200px]]

-	The ~~entry 2y8c~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2y8c", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2y8c\| PDB=2y8c \| SCENE= }}

-	~~Authors: Baragana, B., McCarthy, O., Sanchez, P., Bosch, C., Kaiser, M., Brun, R., Whittingham, J.L., Roberts, S., Zhou, X.-X., Wilson, K.S., Johansson, N.G., Gonzalez-Pacanowska, D., Gilbert, I.H.~~	+	===Plasmodium falciparum dUTPase in complex with a trityl ligand===

-	~~Description~~: Plasmodium falciparum ~~dUTPase in complex with a trityl ligand~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21411327}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21411327 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21411327}}
		+
		+	==About this Structure==
		+	[[2y8c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8C OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021411327</ref><references group="xtra"/>
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: DUTP diphosphatase]]
		+	[[Category: Baragana, B.]]
		+	[[Category: Bosch, C.]]
		+	[[Category: Brun, R.]]
		+	[[Category: Gilbert, I H.]]
		+	[[Category: Gonzalez-Pacanowska, D.]]
		+	[[Category: Johansson, N G.]]
		+	[[Category: Kaiser, M.]]
		+	[[Category: Mccarthy, O.]]
		+	[[Category: Roberts, S.]]
		+	[[Category: Sanchez, P.]]
		+	[[Category: Whittingham, J L.]]
		+	[[Category: Wilson, K S.]]
		+	[[Category: Zhou, X X.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Malaria]]

OCA at 05:12, 16 February 2011

OCA — Wed, 16 Feb 2011 05:12:04 GMT

←Older revision		Revision as of 05:12, 16 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2y8c is ON HOLD ~~until sometime in the future~~	+	The entry 2y8c is ON HOLD

	Authors: Baragana, B., McCarthy, O., Sanchez, P., Bosch, C., Kaiser, M., Brun, R., Whittingham, J.L., Roberts, S., Zhou, X.-X., Wilson, K.S., Johansson, N.G., Gonzalez-Pacanowska, D., Gilbert, I.H.		Authors: Baragana, B., McCarthy, O., Sanchez, P., Bosch, C., Kaiser, M., Brun, R., Whittingham, J.L., Roberts, S., Zhou, X.-X., Wilson, K.S., Johansson, N.G., Gonzalez-Pacanowska, D., Gilbert, I.H.

	Description: Plasmodium falciparum dUTPase in complex with a trityl ligand		Description: Plasmodium falciparum dUTPase in complex with a trityl ligand