2y8g - Revision history

OCA at 14:02, 1 February 2024

OCA — Thu, 01 Feb 2024 14:02:57 GMT

←Older revision		Revision as of 14:02, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='2y8g' size='340' side='right'caption='[[2y8g]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='2y8g' size='340' side='right'caption='[[2y8g]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y8G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y8g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y8G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.61Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2y8f\|2y8f]], [[2crf\|2crf]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8g OCA], [https://pdbe.org/2y8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y8g RCSB], [https://www.ebi.ac.uk/pdbsum/2y8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8g OCA], [https://pdbe.org/2y8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y8g RCSB], [https://www.ebi.ac.uk/pdbsum/2y8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/RANB3_HUMAN RANB3_HUMAN]] Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.<ref>PMID:9637251</ref> <ref>PMID:11571268</ref> <ref>PMID:11425870</ref> <ref>PMID:11932251</ref> <ref>PMID:19289081</ref>	+	[https://www.uniprot.org/uniprot/RANB3_HUMAN RANB3_HUMAN] Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.<ref>PMID:9637251</ref> <ref>PMID:11571268</ref> <ref>PMID:11425870</ref> <ref>PMID:11932251</ref> <ref>PMID:19289081</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dian, C]]	+	[[Category: Dian C]]
-	[[Category: Langer, K]]	+	[[Category: Langer K]]
-	[[Category: Muller~~, C W~~]]	+	[[Category: Muller CW]]
-	[[Category: Petosa, C]]	+	[[Category: Petosa C]]
-	[[Category: Rybin, V]]	+	[[Category: Rybin V]]
-	~~[[Category: Crm1-mediated nuclear export]]~~	+
-	~~[[Category: Protein transport~~]]	+

OCA at 12:25, 27 April 2022

OCA — Wed, 27 Apr 2022 12:25:05 GMT

←Older revision		Revision as of 12:25, 27 April 2022
Line 3:		Line 3:
	<StructureSection load='2y8g' size='340' side='right'caption='[[2y8g]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='2y8g' size='340' side='right'caption='[[2y8g]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8g]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2Y8G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y8g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y8G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8f\|2y8f]], [[2crf\|2crf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y8f\|2y8f]], [[2crf\|2crf]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2y8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8g OCA], [~~http~~://pdbe.org/2y8g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2y8g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2y8g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8g OCA], [https://pdbe.org/2y8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y8g RCSB], [https://www.ebi.ac.uk/pdbsum/2y8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RANB3_HUMAN RANB3_HUMAN]] Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.<ref>PMID:9637251</ref> <ref>PMID:11571268</ref> <ref>PMID:11425870</ref> <ref>PMID:11932251</ref> <ref>PMID:19289081</ref>	+	[[https://www.uniprot.org/uniprot/RANB3_HUMAN RANB3_HUMAN]] Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.<ref>PMID:9637251</ref> <ref>PMID:11571268</ref> <ref>PMID:11425870</ref> <ref>PMID:11932251</ref> <ref>PMID:19289081</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:39, 22 July 2020

OCA — Wed, 22 Jul 2020 12:39:12 GMT

←Older revision		Revision as of 12:39, 22 July 2020
Line 1:		Line 1:

	==Structure of the Ran-binding domain from human RanBP3 (E352A-R353V double mutant)==		==Structure of the Ran-binding domain from human RanBP3 (E352A-R353V double mutant)==
-	<StructureSection load='2y8g' size='340' side='right' caption='[[2y8g]], [[Resolution\|resolution]] 1.61Å' scene=''>	+	<StructureSection load='2y8g' size='340' side='right'caption='[[2y8g]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Y8G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y8g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Y8G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8f\|2y8f]], [[2crf\|2crf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8f\|2y8f]], [[2crf\|2crf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2y8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8g OCA], [http://pdbe.org/2y8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y8g RCSB], [http://www.ebi.ac.uk/pdbsum/2y8g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2y8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8g OCA], [http://pdbe.org/2y8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y8g RCSB], [http://www.ebi.ac.uk/pdbsum/2y8g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dian, C]]		[[Category: Dian, C]]
	[[Category: Langer, K]]		[[Category: Langer, K]]

OCA at 09:30, 10 October 2018

OCA — Wed, 10 Oct 2018 09:30:10 GMT

←Older revision		Revision as of 09:30, 10 October 2018
Line 1:		Line 1:

-	==~~STRUCTURE OF THE RAN~~-~~BINDING DOMAIN FROM HUMAN RANBP3~~ (E352A-R353V ~~DOUBLE MUTANT~~)==	+	==Structure of the Ran-binding domain from human RanBP3 (E352A-R353V double mutant)==
	<StructureSection load='2y8g' size='340' side='right' caption='[[2y8g]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='2y8g' size='340' side='right' caption='[[2y8g]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 08:10, 4 August 2016

OCA — Thu, 04 Aug 2016 08:10:09 GMT

←Older revision		Revision as of 08:10, 4 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF THE RAN-BINDING DOMAIN FROM HUMAN RANBP3 (E352A-R353V DOUBLE MUTANT)==		==STRUCTURE OF THE RAN-BINDING DOMAIN FROM HUMAN RANBP3 (E352A-R353V DOUBLE MUTANT)==
	<StructureSection load='2y8g' size='340' side='right' caption='[[2y8g]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='2y8g' size='340' side='right' caption='[[2y8g]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y8g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8f\|2y8f]], [[2crf\|2crf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8f\|2y8f]], [[2crf\|2crf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8g RCSB], [http://www.ebi.ac.uk/pdbsum/2y8g PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8g OCA], [http://pdbe.org/2y8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y8g RCSB], [http://www.ebi.ac.uk/pdbsum/2y8g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2y8g" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dian, C]]		[[Category: Dian, C]]
	[[Category: Langer, K]]		[[Category: Langer, K]]

OCA at 07:27, 24 December 2014

OCA — Wed, 24 Dec 2014 07:27:48 GMT

←Older revision		Revision as of 07:27, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8g RCSB], [http://www.ebi.ac.uk/pdbsum/2y8g PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8g RCSB], [http://www.ebi.ac.uk/pdbsum/2y8g PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RANB3_HUMAN RANB3_HUMAN]] Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.<ref>PMID:9637251</ref> <ref>PMID:11571268</ref> <ref>PMID:11425870</ref> <ref>PMID:11932251</ref> <ref>PMID:19289081</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 08:09, 12 November 2014

OCA — Wed, 12 Nov 2014 08:09:28 GMT

←Older revision		Revision as of 08:09, 12 November 2014
Line 1:		Line 1:
-	[[~~Image:~~2y8g.~~png~~\|~~left~~\|~~200px~~]]	+	==STRUCTURE OF THE RAN-BINDING DOMAIN FROM HUMAN RANBP3 (E352A-R353V DOUBLE MUTANT)==
		+	<StructureSection load='2y8g' size='340' side='right' caption='[[2y8g]], [[Resolution\|resolution]] 1.61Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2y8g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8G FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8f\|2y8f]], [[2crf\|2crf]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8g RCSB], [http://www.ebi.ac.uk/pdbsum/2y8g PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Proteins bearing a leucine-rich nuclear export signal (NES) are exported from the nucleus by the transport factor CRM1, which forms a cooperative ternary complex with the NES-bearing cargo and with the small GTPase Ran. CRM1-mediated export is regulated by RanBP3, a Ran-interacting nuclear protein. Unlike the related proteins RanBP1 and RanBP2, which promote disassembly of the export complex in the cytosol, RanBP3 acts as a CRM1 cofactor, enhancing NES export by stabilizing the export complex in the nucleus. RanBP3 also alters the cargo selectivity of CRM1, promoting recognition of the NES of HIV-1 Rev and of other cargos while deterring recognition of the import adaptor protein Snurportin1. Here we report the crystal structure of the Ran-binding domain (RBD) from RanBP3 and compare it to RBD structures from RanBP1 and RanBP2 in complex with Ran and CRM1. Differences among these structures suggest why RanBP3 binds Ran with unusually low affinity, how RanBP3 modulates the cargo selectivity of CRM1, and why RanBP3 promotes assembly rather than disassembly of the export complex. The comparison of RBD structures thus provides an insight into the functional diversity of Ran-binding proteins.

-	~~{{STRUCTURE_2y8g\| PDB=2y8g \| SCENE= }}~~	+	Insights into the Function of the CRM1 Cofactor RanBP3 from the Structure of Its Ran-Binding Domain.,Langer K, Dian C, Rybin V, Muller CW, Petosa C PLoS One. 2011 Feb 25;6(2):e17011. PMID:21364925<ref>PMID:21364925</ref>

-	~~===STRUCTURE OF THE RAN-BINDING DOMAIN FROM HUMAN RANBP3 (E352A-R353V DOUBLE MUTANT)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_21364925}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2y8g]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021364925<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dian, C.]]	+	[[Category: Dian, C]]
-	[[Category: Langer, K.]]	+	[[Category: Langer, K]]
-	[[Category: Muller, C W.]]	+	[[Category: Muller, C W]]
-	[[Category: Petosa, C.]]	+	[[Category: Petosa, C]]
-	[[Category: Rybin, V.]]	+	[[Category: Rybin, V]]
	[[Category: Crm1-mediated nuclear export]]		[[Category: Crm1-mediated nuclear export]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 13:33, 6 February 2013

OCA — Wed, 06 Feb 2013 13:33:53 GMT

←Older revision		Revision as of 13:33, 6 February 2013
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	[[Image:2y8g.png\|left\|200px]]		[[Image:2y8g.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2y8g", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2y8g\| PDB=2y8g \| SCENE= }}		{{STRUCTURE_2y8g\| PDB=2y8g \| SCENE= }}

	===STRUCTURE OF THE RAN-BINDING DOMAIN FROM HUMAN RANBP3 (E352A-R353V DOUBLE MUTANT)===		===STRUCTURE OF THE RAN-BINDING DOMAIN FROM HUMAN RANBP3 (E352A-R353V DOUBLE MUTANT)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21364925}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21364925 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_21364925}}		{{ABSTRACT_PUBMED_21364925}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21364925~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021364925</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dian, C.]]		[[Category: Dian, C.]]
Line 29:		Line 18:
	[[Category: Petosa, C.]]		[[Category: Petosa, C.]]
	[[Category: Rybin, V.]]		[[Category: Rybin, V.]]
		+	[[Category: Crm1-mediated nuclear export]]
		+	[[Category: Protein transport]]

OCA at 07:35, 16 March 2011

OCA — Wed, 16 Mar 2011 07:35:14 GMT

←Older revision		Revision as of 07:35, 16 March 2011
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-	[[Image:2y8g.~~jpg~~\|left\|200px]]	+	[[Image:2y8g.png\|left\|200px]]

	<!--		<!--
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	===STRUCTURE OF THE RAN-BINDING DOMAIN FROM HUMAN RANBP3 (E352A-R353V DOUBLE MUTANT)===		===STRUCTURE OF THE RAN-BINDING DOMAIN FROM HUMAN RANBP3 (E352A-R353V DOUBLE MUTANT)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21364925}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21364925 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21364925}}

	==About this Structure==		==About this Structure==
	[[2y8g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA].		[[2y8g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8G OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21364925</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dian, C.]]		[[Category: Dian, C.]]

OCA: Protected "2y8g" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2011 05:37:04 GMT

Protected "2y8g" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 16 February 2011