2y8s - Revision history

OCA at 08:10, 23 August 2023

OCA — Wed, 23 Aug 2023 08:10:46 GMT

←Older revision		Revision as of 08:10, 23 August 2023
Line 3:		Line 3:
	<StructureSection load='2y8s' size='340' side='right'caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2y8s' size='340' side='right'caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Toxgo Toxgo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y8S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y8s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y8S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y8t\|2y8t]], [[2y8r\|2y8r]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8s OCA], [https://pdbe.org/2y8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y8s RCSB], [https://www.ebi.ac.uk/pdbsum/2y8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8s OCA], [https://pdbe.org/2y8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y8s RCSB], [https://www.ebi.ac.uk/pdbsum/2y8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~AMA1_TOXGO AMA1_TOXGO]~~] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:11087913</ref> <ref>PMID:16000372</ref> <ref>PMID:16102004</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref>	+	[https://www.uniprot.org/uniprot/AMA1_TOXGV AMA1_TOXGV] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:11087913</ref> <ref>PMID:16000372</ref> <ref>PMID:16102004</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Toxgo~~]]	+	[[Category: Toxoplasma gondii]]
-	[[Category: Boulanger~~, M J~~]]	+	[[Category: Boulanger MJ]]
-	[[Category: Crawford, J]]	+	[[Category: Crawford J]]
-	[[Category: Douguet, D]]	+	[[Category: Douguet D]]
-	[[Category: Lamarque~~, M H~~]]	+	[[Category: Lamarque MH]]
-	[[Category: Lebrun, M]]	+	[[Category: Lebrun M]]
-	[[Category: Pugniere, M]]	+	[[Category: Pugniere M]]
-	[[Category: Roques, M]]	+	[[Category: Roques M]]
-	[[Category: Tonkin~~, M L]]~~	+	[[Category: Tonkin ML]]
-	~~[[Category: Invasion]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Moving junction~~]]	+

OCA at 15:02, 17 November 2021

OCA — Wed, 17 Nov 2021 15:02:10 GMT

←Older revision		Revision as of 15:02, 17 November 2021
Line 3:		Line 3:
	<StructureSection load='2y8s' size='340' side='right'caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2y8s' size='340' side='right'caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8s]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2Y8S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y8s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y8S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8t\|2y8t]], [[2y8r\|2y8r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y8t\|2y8t]], [[2y8r\|2y8r]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2y8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8s OCA], [~~http~~://pdbe.org/2y8s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2y8s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2y8s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8s OCA], [https://pdbe.org/2y8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y8s RCSB], [https://www.ebi.ac.uk/pdbsum/2y8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AMA1_TOXGO AMA1_TOXGO]] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:11087913</ref> <ref>PMID:16000372</ref> <ref>PMID:16102004</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref>	+	[[https://www.uniprot.org/uniprot/AMA1_TOXGO AMA1_TOXGO]] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:11087913</ref> <ref>PMID:16000372</ref> <ref>PMID:16102004</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:37, 3 April 2019

OCA — Wed, 03 Apr 2019 07:37:35 GMT

←Older revision		Revision as of 07:37, 3 April 2019
Line 1:		Line 1:

	==Co-structure of an AMA1 mutant (Y230A) with a surface exposed region of RON2 from Toxoplasma gondii==		==Co-structure of an AMA1 mutant (Y230A) with a surface exposed region of RON2 from Toxoplasma gondii==
-	<StructureSection load='2y8s' size='340' side='right' caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='2y8s' size='340' side='right'caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2y8s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8S FirstGlance]. <br>		<table><tr><td colspan='2'>[[2y8s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8S FirstGlance]. <br>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Toxgo]]		[[Category: Toxgo]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]

OCA at 08:49, 10 October 2018

OCA — Wed, 10 Oct 2018 08:49:45 GMT

←Older revision		Revision as of 08:49, 10 October 2018
Line 1:		Line 1:

-	==CO-~~STRUCTURE OF AN~~ AMA1 ~~MUTANT~~ (Y230A) ~~WITH A SURFACE EXPOSED REGION OF~~ RON2 ~~FROM TOXOPLASMA GONDII~~==	+	==Co-structure of an AMA1 mutant (Y230A) with a surface exposed region of RON2 from Toxoplasma gondii==
	<StructureSection load='2y8s' size='340' side='right' caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2y8s' size='340' side='right' caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 22:37, 4 August 2016

OCA — Thu, 04 Aug 2016 22:37:33 GMT

←Older revision		Revision as of 22:37, 4 August 2016
Line 1:		Line 1:
		+
	==CO-STRUCTURE OF AN AMA1 MUTANT (Y230A) WITH A SURFACE EXPOSED REGION OF RON2 FROM TOXOPLASMA GONDII==		==CO-STRUCTURE OF AN AMA1 MUTANT (Y230A) WITH A SURFACE EXPOSED REGION OF RON2 FROM TOXOPLASMA GONDII==
	<StructureSection load='2y8s' size='340' side='right' caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2y8s' size='340' side='right' caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Toxoplasma_gondii Toxoplasma gondii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2y8s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8t\|2y8t]], [[2y8r\|2y8r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8t\|2y8t]], [[2y8r\|2y8r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8s RCSB], [http://www.ebi.ac.uk/pdbsum/2y8s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8s OCA], [http://pdbe.org/2y8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y8s RCSB], [http://www.ebi.ac.uk/pdbsum/2y8s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y8s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AMA1_TOXGO AMA1_TOXGO]] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:11087913</ref> <ref>PMID:16000372</ref> <ref>PMID:16102004</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2y8s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Toxoplasma gondii~~]]	+	[[Category: Toxgo]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]
	[[Category: Crawford, J]]		[[Category: Crawford, J]]

OCA at 22:29, 3 January 2015

OCA — Sat, 03 Jan 2015 22:29:20 GMT

←Older revision		Revision as of 22:29, 3 January 2015
Line 2:		Line 2:
	<StructureSection load='2y8s' size='340' side='right' caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='2y8s' size='340' side='right' caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2y8s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA]. <br>	+	<table><tr><td colspan='2'>[[2y8s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y8S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8t\|2y8t]], [[2y8r\|2y8r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8t\|2y8t]], [[2y8r\|2y8r]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8s RCSB], [http://www.ebi.ac.uk/pdbsum/2y8s PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8s RCSB], [http://www.ebi.ac.uk/pdbsum/2y8s PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 14:		Line 13:
	Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.,Tonkin ML, Roques M, Lamarque MH, Pugniere M, Douguet D, Crawford J, Lebrun M, Boulanger MJ Science. 2011 Jul 22;333(6041):463-7. PMID:21778402<ref>PMID:21778402</ref>		Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.,Tonkin ML, Roques M, Lamarque MH, Pugniere M, Douguet D, Crawford J, Lebrun M, Boulanger MJ Science. 2011 Jul 22;333(6041):463-7. PMID:21778402<ref>PMID:21778402</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 21:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
-	[[Category: Boulanger, M J.]]	+	[[Category: Boulanger, M J]]
-	[[Category: Crawford, J.]]	+	[[Category: Crawford, J]]
-	[[Category: Douguet, D.]]	+	[[Category: Douguet, D]]
-	[[Category: Lamarque, M H.]]	+	[[Category: Lamarque, M H]]
-	[[Category: Lebrun, M.]]	+	[[Category: Lebrun, M]]
-	[[Category: Pugniere, M.]]	+	[[Category: Pugniere, M]]
-	[[Category: Roques, M.]]	+	[[Category: Roques, M]]
-	[[Category: Tonkin, M L.]]	+	[[Category: Tonkin, M L]]
	[[Category: Invasion]]		[[Category: Invasion]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Moving junction]]		[[Category: Moving junction]]

OCA at 07:39, 14 May 2014

OCA — Wed, 14 May 2014 07:39:28 GMT

←Older revision		Revision as of 07:39, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2y8s.~~jpg~~\|~~left~~\|~~200px~~]]	+	==CO-STRUCTURE OF AN AMA1 MUTANT (Y230A) WITH A SURFACE EXPOSED REGION OF RON2 FROM TOXOPLASMA GONDII==
		+	<StructureSection load='2y8s' size='340' side='right' caption='[[2y8s]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2y8s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y8t\|2y8t]], [[2y8r\|2y8r]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8s RCSB], [http://www.ebi.ac.uk/pdbsum/2y8s PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Apicomplexan parasites such as Toxoplasma gondii and Plasmodium species actively invade host cells through a moving junction (MJ) complex assembled at the parasite-host cell interface. MJ assembly is initiated by injection of parasite rhoptry neck proteins (RONs) into the host cell, where RON2 spans the membrane and functions as a receptor for apical membrane antigen 1 (AMA1) on the parasite. We have determined the structure of TgAMA1 complexed with a RON2 peptide at 1.95 angstrom resolution. A stepwise assembly mechanism results in an extensive buried surface area, enabling the MJ complex to resist the mechanical forces encountered during host cell invasion. Besides providing insights into host cell invasion by apicomplexan parasites, the structure offers a basis for designing therapeutics targeting these global pathogens.

-	<!--	+	Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptide.,Tonkin ML, Roques M, Lamarque MH, Pugniere M, Douguet D, Crawford J, Lebrun M, Boulanger MJ Science. 2011 Jul 22;333(6041):463-7. PMID:21778402<ref>PMID:21778402</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2y8s"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2y8s\| PDB=2y8s \| SCENE= }}~~	+

-	~~===CO-STRUCTURE OF AN AMA1 MUTANT (Y230A) WITH A SURFACE EXPOSED REGION OF RON2 FROM TOXOPLASMA GONDII===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21778402}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21778402 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21778402}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2y8s]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021778402<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
	[[Category: Boulanger, M J.]]		[[Category: Boulanger, M J.]]

OCA at 08:44, 3 August 2011

OCA — Wed, 03 Aug 2011 08:44:08 GMT

←Older revision		Revision as of 08:44, 3 August 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2y8s.jpg\|left\|200px]]

-	The ~~entry 2y8s~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2y8s", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2y8s\| PDB=2y8s \| SCENE= }}

-	~~Authors: Tonkin, M.L., Roques, M., Lamarque, M.H., Pugniere, M., Douguet, D., Crawford, J., Lebrun, M., Boulanger, M.J.~~	+	===CO-STRUCTURE OF AN AMA1 MUTANT (Y230A) WITH A SURFACE EXPOSED REGION OF RON2 FROM TOXOPLASMA GONDII===

-	~~Description~~:	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21778402}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21778402 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21778402}}
		+
		+	==About this Structure==
		+	[[2y8s]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8S OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021778402</ref><references group="xtra"/>
		+	[[Category: Toxoplasma gondii]]
		+	[[Category: Boulanger, M J.]]
		+	[[Category: Crawford, J.]]
		+	[[Category: Douguet, D.]]
		+	[[Category: Lamarque, M H.]]
		+	[[Category: Lebrun, M.]]
		+	[[Category: Pugniere, M.]]
		+	[[Category: Roques, M.]]
		+	[[Category: Tonkin, M L.]]
		+	[[Category: Invasion]]
		+	[[Category: Membrane protein]]
		+	[[Category: Moving junction]]

OCA at 09:29, 23 February 2011

OCA — Wed, 23 Feb 2011 09:29:37 GMT

←Older revision		Revision as of 09:29, 23 February 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2y8s is ON HOLD ~~until sometime in the future~~	+	The entry 2y8s is ON HOLD

	Authors: Tonkin, M.L., Roques, M., Lamarque, M.H., Pugniere, M., Douguet, D., Crawford, J., Lebrun, M., Boulanger, M.J.		Authors: Tonkin, M.L., Roques, M., Lamarque, M.H., Pugniere, M., Douguet, D., Crawford, J., Lebrun, M., Boulanger, M.J.

-	Description: ~~Co-structure of an AMA1 mutant (Y230A) with a surface exposed region of RON2 from Toxoplasma gondii~~	+	Description:

OCA: Protected "2y8s" [edit=sysop:move=sysop]

OCA — Wed, 16 Feb 2011 05:12:21 GMT

Protected "2y8s" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:12, 16 February 2011